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1. 发明申请

WO2008064259A3 SOLID DISPERSION COMPOSITION COMPRISING FLUVASTATIN 审中-公开
公开(公告)号：WO2008064259A3
公开(公告)日：2008-05-29
申请号：PCT/US2007/085293
申请日：2007-11-20
申请人： BIOKEY, INC. , CHOW, San-Laung , WONG, David , LIN, Edward , GARCIA, Damian , AGUILAR, Jose
发明人： CHOW, San-Laung , WONG, David , LIN, Edward , GARCIA, Damian , AGUILAR, Jose
IPC分类号： A61K9/16 , A61K9/50
摘要： A solid dispersion composition containing fluvastatin and a polymer is provided. Optionally, a surfactant is included. The fluvastatin appears to be amorphous and the solid dispersion composition enables fluvastatin to be constantly released over a time period.

2. 发明申请

WO2006053089A2 METHODS AND FORMULATIONS FOR MAKING PHARMACEUTICAL COMPOSITIONS CONTAINING BUPROPION 审中-公开
标题翻译：制备含有支架的药物组合物的方法和制剂
公开(公告)号：WO2006053089A2
公开(公告)日：2006-05-18
申请号：PCT/US2005/040665
申请日：2005-11-08
申请人： BIOKEY, INC. , CHOW, San-Laung , WONG, David , GARCIA, Damian
发明人： CHOW, San-Laung , WONG, David , GARCIA, Damian
IPC分类号： A61K9/24
CPC分类号： A61K31/137 , A61K9/2013 , A61K9/2054 , A61K9/2846
摘要： Embodiments of the invention generally provide pharmaceutical drug compositions, methods of preparing oral drug compositions, such as extended release dosage compositions, and methods for treating antidepressant or smoking cessation. In one aspect, the invention provides a pharmaceutical formulation comprising a core, including bupropion and its salt derivatives, and a coating. The coating may include from about 5 % to about 99% by weight of the coating of a pharmaceutically acceptable pH-independent polymer. The coating may further include from about 0.001% to about 30% by weight of the coating of a surfactant. In another aspect, the invention provides methods for preparing and administering a pharmaceutical composition in oral dosage form, such as a tablet.
摘要翻译：本发明的实施方案通常提供药物组合物，制备口服药物组合物的方法，例如延长释放剂量组合物，以及治疗抗抑郁药或戒烟的方法。一方面，本发明提供了包含核心的药物制剂，包括安非他酮及其盐衍生物和涂层。涂层可以包括约5％至约99％重量的药学上可接受的不依赖于pH的聚合物的涂层。涂层可以进一步包括表面活性剂涂层的约0.001重量％至约30重量％。另一方面，本发明提供了制备和施用口服剂型（例如片剂）的药物组合物的方法。

3. 发明申请

WO2010108077A3 CONTROLLED RELEASE PARTICULATES CONTAINING WATER-INSOLUBLE DRUG 审中-公开
公开(公告)号：WO2010108077A3
公开(公告)日：2010-09-23
申请号：PCT/US2010/027935
申请日：2010-03-19
申请人： BIOKEY, INC. , WONG, David , CHENG, Xiufang , CHOW, San-Laung
发明人： WONG, David , CHENG, Xiufang , CHOW, San-Laung
IPC分类号： A61K9/22 , A61K9/20 , A61K47/30 , A61K31/05
摘要： A pharmaceutical composition. The composition has a plurality of controlled release particulates. Each particulate includes a coating layer and a core partially coated with the coating layer, in which the core contains a water-insoluble drug 5-80 wt.% and a first polymer 0.2-80 wt.% and the coating layer contains the water-insoluble drug 0-50 wt.% and a second polymer 0.2-50 wt.%. Each of the first and second polymers, independently, is a water-insoluble polymer, an enteric polymer, or a combination thereof. A method of making the composition is also disclosed herein.

4. 发明申请

WO2004108162A2 PHARMACEUTICAL COMPOSITION AND METHOD FOR TREATING 审中-公开
标题翻译：药物组合物和治疗方法
公开(公告)号：WO2004108162A2
公开(公告)日：2004-12-16
申请号：PCT/US2004/015953
申请日：2004-05-21
申请人： BIOKEY, INC. , LIN, Jenny, Li-Ying , WONG, David , CHOW, San-Laung
发明人： LIN, Jenny, Li-Ying , WONG, David , CHOW, San-Laung
IPC分类号： A61K47/00
CPC分类号： A61K9/2013 , A61K9/2018 , A61K9/2054 , A61K31/43 , A61K31/545 , A61K31/60 , A61K31/65 , A61K31/704 , A61K31/7048
摘要： Embodiments of the invention generally provide pharmaceutical drug compositions, methods of preparing oral drug compositions, such as extended release dosage compositions, and methods for treating infection. More particularly, the invention relates to formulations containing a drug and a carrier material. In one aspect, the invention provides a pharmaceutical formulation including a therapeutically active agent, from about 0.1% to about 4.9% by weight of a pharmaceutically acceptable polymer, and from about 0.1% to about 30% by weight of a pharmaceutically acceptable acid, wherein the pharmaceutical composition have a zero order release profile of the therapeutically active agent. In another aspect, the invention provides methods for preparing and administering a pharmaceutical antibiotic composition in oral dosage form, such as a tablet.
摘要翻译：本发明的实施方案通常提供药物组合物，制备口服药物组合物的方法，例如缓释剂型组合物，以及治疗感染的方法。更具体地，本发明涉及含有药物和载体材料的制剂。在一个方面，本发明提供药物制剂，其包含治疗活性剂，约0.1重量％至约4.9重量％的药学上可接受的聚合物和约0.1重量％至约30重量％的药学上可接受的酸，其中药物组合物具有治疗活性剂的零级释放曲线。另一方面，本发明提供了制备和施用口服剂型（例如片剂）的药用抗生素组合物的方法。

5. 发明申请

WO2012116066A1 CONTROLLED RELEASE HYDROGEL FORMULATION 审中-公开
标题翻译：控制释放水凝胶制剂
公开(公告)号：WO2012116066A1
公开(公告)日：2012-08-30
申请号：PCT/US2012/026122
申请日：2012-02-22
申请人： BIOKEY, INC. , CHOW, San-Laung , WONG, David
发明人： CHOW, San-Laung , WONG, David
IPC分类号： A61K9/50 , A61K9/14 , A61K31/497 , A01N43/42
CPC分类号： A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K31/47 , A61K31/496
摘要： Embodiments of the invention generally provide pharmaceutical drug compositions, methods of preparing oral drug compositions, such as controlled release dosage compositions for hydrophobic active ingredients. In one aspect, the invention provides a pharmaceutical formulation comprising a therapeutically effective amount of a hydrophobic drug, an adjustable ratio of a non-cross linked hydrogel polymer and a non-gelling insoluble polymer. One example is a controlled release pharmaceutical composition which includes 1% to 80% of a therapeutically amount of cilostazol, 4% to 80% of a water-swelling hydrogel polymer, and 4% to 80% of a non-gelling insoluble polymer. In another aspect, a constant release profile of the pharmaceutical formulation is obtained. In another aspect, a zero degree release profile of the pharmaceutical formulation is obtained. Further, a method for treating intermittent claudication using the pharmaceutical formulation is provided.
摘要翻译：本发明的实施方案通常提供药物组合物，制备口服药物组合物的方法，例如用于疏水性活性成分的控释剂组合物。一方面，本发明提供了包含治疗有效量的疏水性药物，非交联水凝胶聚合物和非胶凝不溶性聚合物的可调节比例的药物制剂。一个实例是控释药物组合物，其包含1％至80％的治疗量的西洛他唑，4％至80％的水溶胀性水凝胶聚合物和4％至80％的非胶凝不溶性聚合物。在另一方面，获得药物制剂的恒定释放曲线。另一方面，获得药物制剂的零度释放曲线。此外，提供了使用药物制剂治疗间歇性跛行的方法。

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