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1. 发明申请

WO2003068268A3 TREATMENT, DIAGNOSIS AND IMAGING OF DISEASE 审中-公开
公开(公告)号：WO2003068268A3
公开(公告)日：2003-08-21
申请号：PCT/EP2003/001461
申请日：2003-02-13
申请人： BIOINVENT INTERNATIONAL AB , EK, Sara , BORREBAECK, Carl, Arne, Krister , EHINGER, Mats
发明人： EK, Sara , BORREBAECK, Carl, Arne, Krister , EHINGER, Mats
IPC分类号： A61K47/48
摘要： The present invention provides the use of a compound comprising: (i) a binding moiety which selectively binds to a protein listed in Table 1 and (ii) a further moiety in the treatment, imaging, diagnosis or prognosis of mantle cell lymphomas (MCL). Preferably, the binding moiety is an antibody or antigenbinding fragment thereof. Advantageously, the further moiety is a directly or indirectly cytotoxic moiety or a readily detectable moiety. The invention also provides methods of imaging MCL cells, methods of diagnosing or prognosing MCL in an individual and methods of treating an individual with MCL. A further aspect of the present invention provides a method of identifying cells associated with MCL, the method comprising analyzing the pattern of gene expression in a sample of cells to be tested and comparing it to the pattern of gene expression in a sample of known MCL cells. Preferably, the cells to be tested are identified as MCL cells if the expression of one or more genes encoding a protein listed in Table 1 is upregulated compared to normal B-cells.

2. 发明申请

WO2003068268A2 TREATMENT, DIAGNOSIS AND IMAGING OF DISEASE 审中-公开
标题翻译：疾病的治疗，诊断和成像
公开(公告)号：WO2003068268A2
公开(公告)日：2003-08-21
申请号：PCT/EP2003/001461
申请日：2003-02-13
申请人： BIOINVENT INTERNATIONAL AB , EK, Sara , BORREBAECK, Carl, Arne, Krister , EHINGER, Mats
发明人： EK, Sara , BORREBAECK, Carl, Arne, Krister , EHINGER, Mats
IPC分类号： A61K51/00
CPC分类号： A61K47/50
摘要： The present invention provides the use of a compound comprising: (i) a binding moiety which selectively binds to a protein listed in Table 1 and (ii) a further moiety in the treatment, imaging, diagnosis or prognosis of mantle cell lymphomas (MCL). Preferably, the binding moiety is an antibody or antigenbinding fragment thereof. Advantageously, the further moiety is a directly or indirectly cytotoxic moiety or a readily detectable moiety. The invention also provides methods of imaging MCL cells, methods of diagnosing or prognosing MCL in an individual and methods of treating an individual with MCL. A further aspect of the present invention provides a method of identifying cells associated with MCL, the method comprising analyzing the pattern of gene expression in a sample of cells to be tested and comparing it to the pattern of gene expression in a sample of known MCL cells. Preferably, the cells to be tested are identified as MCL cells if the expression of one or more genes encoding a protein listed in Table 1 is upregulated compared to normal B-cells.
摘要翻译：本发明提供了一种化合物的用途，所述化合物包括：选择性结合表1所列蛋白质的结合部分，以及外套细胞淋巴瘤MCL的治疗，成像，诊断或预后的另一部分。优选地，结合部分是抗体或其抗原结合片段。有利地，另外的部分是直接或间接的细胞毒性部分或易于检测的部分。本发明还提供了成像MCL细胞的方法，个体中诊断或预测MCL的方法和用MCL治疗个体的方法。本发明的另一方面提供了鉴定与MCL相关的细胞的方法，所述方法包括分析待测试细胞样品中基因表达的模式，并将其与已知MCL细胞样品中的基因表达模式进行比较。如果与正常B细胞相比，如果编码表1中列出的蛋白质的一种或多种基因的表达上调，则优选将待测试的细胞鉴定为MCL细胞。

3. 发明申请

WO2007101676A2 TREATMENT, DIAGNOSIS AND IMAGING OF DISEASE 审中-公开
标题翻译：疾病的治疗，诊断和成像
公开(公告)号：WO2007101676A2
公开(公告)日：2007-09-13
申请号：PCT/EP2007/001962
申请日：2007-03-07
申请人： BIOINVENT INTERNATIONAL AB , BORREBAECK, Carl, Arne, Krister , EK, Sara
发明人： BORREBAECK, Carl, Arne, Krister , EK, Sara
CPC分类号： A61K38/17 , A61K47/6867 , A61K51/1069 , C07K16/3061
摘要： The present invention provides a use a compound comprising a binding moiety which selectively binds to a protein listed in Table 1 in the treatment, imaging, diagnosis or prognosis of mantle cell lymphomas (MCL). Optionally, the compound also comprises a further moiety. Preferably, the binding moiety is an antibody or antigen- binding fragment thereof. Advantageously, the further moiety is a directly or indirectly cytotoxic moiety or a readily detectable moiety. The invention also provides methods of imaging MCL cells, methods of diagnosing or prognosing MCL in an individual and methods of treating an individual with MCL A further aspect of the present invention provides a method of identifying cells associated with MCL, the method comprising analysing the pattern of gene expression in a sample of cells to be tested and comparing it to the pattern of gene expression in a sample of known MCL cells. Preferably, the cells to be tested are identified as MCL cells if the expression of one or more genes encoding a protein listed in Table 1 is upregulated compared to normal B -cells.
摘要翻译：本发明提供使用包含结合部分的化合物，所述结合部分选择性地结合表1中列出的蛋白质在外套细胞淋巴瘤（MCL）的治疗，成像，诊断或预后中。任选地，化合物还包含另外的部分。优选地，结合部分是抗体或其抗原结合片段。有利地，另外的部分是直接或间接的细胞毒性部分或易于检测的部分。本发明还提供了成像MCL细胞的方法，个体中MCL的诊断或预后的方法以及用MCL治疗个体的方法。本发明的另一方面提供了鉴定与MCL相关的细胞的方法，该方法包括分析模式的基因表达在待测试的细胞样品中，并将其与已知MCL细胞的样品中的基因表达模式进行比较。如果与正常的B细胞相比，如果编码表1中列出的蛋白质的一种或多种基因的表达上调，则优选将待测试的细胞鉴定为MCL细胞。

4. 发明申请

WO2008139169A1 SOX11 EXPRESSION IN MALIGNANT LYMPHOMAS 审中-公开
标题翻译：恶性淋巴瘤中的SOX11表达
公开(公告)号：WO2008139169A1
公开(公告)日：2008-11-20
申请号：PCT/GB2008/001625
申请日：2008-05-12
申请人： IMMUNOVIA AB , BORREBAECK, Carl, Arne, Krister , EK, Sara
发明人： BORREBAECK, Carl, Arne, Krister , EK, Sara
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , A61K51/1069 , C07K16/00 , C07K16/18 , C12Q2600/118 , C12Q2600/158 , G01N33/57496 , G01N2500/20 , G01N2800/52
摘要： The present invention provides a binding moiety which selectively binds to Sox1 1 protein and/or mRNA for imaging, diagnosis or prognosis of lymphomas, such as mantle cell lymphomas (MCL) and diffuse large B-cell lymphoma (DLBCL). Optionally, the moiety is an antibody or antigen-binding fragment thereof. Advantageously, moiety comprises a further, readily detectable moiety. The invention also provides methods of imaging lymphomas cells as well as methods of diagnosing or prognosing lymphomas in an individual. A further aspect of the present invention provides a method of identifying cells associated with lymphomas, the method comprising analysing the pattern of gene expression in a sample of cells to be tested and comparing it to the pattern of gene expression in a sample of known lymphomas cells. Preferably, the cells to be tested are identified as lymphoma cells if the expression of Sox11 is upregulated compared to normal B-cells.
摘要翻译：本发明提供了结合部分，其选择性结合Sox1蛋白和/或mRNA用于淋巴瘤（例如外套细胞淋巴瘤（MCL）和弥漫性大B细胞淋巴瘤（DLBCL））的成像，诊断或预后。任选地，该部分是抗体或其抗原结合片段。有利地，部分包含另外易于检测的部分。本发明还提供了对淋巴瘤细胞进行成像的方法以及诊断或预测个体中淋巴瘤的方法。本发明的另一方面提供了鉴定与淋巴瘤相关的细胞的方法，所述方法包括分析待测试细胞样品中基因表达的模式，并将其与已知淋巴瘤细胞样品中的基因表达模式进行比较。如果与正常B细胞相比，如果Sox11的表达上调，则优选将待测试的细胞识别为淋巴瘤细胞。

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