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1. 发明申请

WO2007101676A3 TREATMENT, DIAGNOSIS AND IMAGING OF MANTLE CELL LYMPHOMA 审中-公开
标题翻译：治疗，诊断和成像的细胞淋巴瘤
公开(公告)号：WO2007101676A3
公开(公告)日：2008-06-26
申请号：PCT/EP2007001962
申请日：2007-03-07
申请人： BIOINVENT INT AB , BORREBAECK CARL ARNE KRISTER , EK SARA
发明人： BORREBAECK CARL ARNE KRISTER , EK SARA
IPC分类号： A61K38/17 , A61K39/395 , A61P35/00
CPC分类号： A61K38/17 , A61K47/6867 , A61K51/1069 , C07K16/3061
摘要： The present invention provides a use a compound comprising a binding moiety which selectively binds to a protein listed in Table 1 in the treatment, imaging, diagnosis or prognosis of mantle cell lymphomas (MCL). Optionally, the compound also comprises a further moiety. Preferably, the binding moiety is an antibody or antigen- binding fragment thereof. Advantageously, the further moiety is a directly or indirectly cytotoxic moiety or a readily detectable moiety. The invention also provides methods of imaging MCL cells, methods of diagnosing or prognosing MCL in an individual and methods of treating an individual with MCL A further aspect of the present invention provides a method of identifying cells associated with MCL, the method comprising analysing the pattern of gene expression in a sample of cells to be tested and comparing it to the pattern of gene expression in a sample of known MCL cells. Preferably, the cells to be tested are identified as MCL cells if the expression of one or more genes encoding a protein listed in Table 1 is upregulated compared to normal B -cells.
摘要翻译：本发明提供使用包含结合部分的化合物，所述结合部分选择性地结合表1中列出的蛋白质在外套细胞淋巴瘤（MCL）的治疗，成像，诊断或预后中。任选地，化合物还包含另外的部分。优选地，结合部分是抗体或其抗原结合片段。有利地，另外的部分是直接或间接的细胞毒性部分或易于检测的部分。本发明还提供了成像MCL细胞的方法，个体中MCL的诊断或预后的方法以及用MCL治疗个体的方法。本发明的另一方面提供了鉴定与MCL相关的细胞的方法，该方法包括分析模式的基因表达在待测试的细胞样品中，并将其与已知MCL细胞的样品中的基因表达模式进行比较。如果与正常的B细胞相比，如果编码表1中列出的蛋白质的一种或多种基因的表达上调，则优选将待测试的细胞鉴定为MCL细胞。

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