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1. 发明申请

WO2009076455A2 METHODS OF TREATING HEMATOLOGIC CANCERS 审中-公开
标题翻译：治疗肝癌的方法
公开(公告)号：WO2009076455A2
公开(公告)日：2009-06-18
申请号：PCT/US2008086256
申请日：2008-12-10
申请人： BIOCRYST PHARM INC , BANTIA SHANTA , BREITFELD PHILIP , BABU YARLAGADDA S
发明人： BANTIA SHANTA , BREITFELD PHILIP , BABU YARLAGADDA S
IPC分类号： A61K31/4184 , A61K31/4745 , A61K35/00 , A61K39/395 , A61K45/06 , A61P35/02
CPC分类号： A61K31/519 , A61K31/4184 , A61K31/7076 , A61K39/39541 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/545 , C07K16/2887 , A61K2300/00
摘要： The present application relates to treatment of hematologic cancers, which treatments can include, e.g., administration of a purine nucleoside phosphorylase (PNP) inhibitor, an alkylating agent and/or an anti-CD20 agent, and related compositions and kits.
摘要翻译：本申请涉及血液癌的治疗，该治疗可以包括例如给予嘌呤核苷磷酸化酶（PNP）抑制剂，烷化剂和/或抗CD20剂，以及相关组合物和试剂盒。

2. 发明申请

WO2012122532A3 COMPOSITIONS AND METHODS FOR TREATMENT OF HYPERURICEMIA 审中-公开
标题翻译：用于治疗高血压的组合物和方法
公开(公告)号：WO2012122532A3
公开(公告)日：2014-04-24
申请号：PCT/US2012028616
申请日：2012-03-09
申请人： BIOCRYST PHARM INC , HOLLISTER ALAN , SHERIDAN WILLIAM P , BANTIA SHANTA , FLYNT AMY , ELDER JENNA , WAUGH ANITA , LYMAN SCOTT
发明人： HOLLISTER ALAN , SHERIDAN WILLIAM P , BANTIA SHANTA , FLYNT AMY , ELDER JENNA , WAUGH ANITA , LYMAN SCOTT
IPC分类号： A61P19/06
CPC分类号： A61K31/495 , A61K31/519 , A61K31/52 , A61K2300/00
摘要： The present invention is directed to methods and compositions for reduction of uric acid levels in subjects, and methods and compositions that are useful for treating, suppressing and/or preventing afflictions related to elevated uric acid levels in subjects. The methods comprise administering to the subject an effective amount of compound I, or a pharmaceutically acceptable salt or hydrate thereof, or a composition comprising compound I, or a pharmaceutically acceptable salt or hydrate thereof, and a pharmaceutically acceptable carrier. The compositions and/or methods may further comprise administering to the subject an effective amount of xanthine oxidase inhibitor such as allopurinol, or a pharmaceutically acceptable salt or hydrate thereof.
摘要翻译：本发明涉及用于降低受试者的尿酸水平的方法和组合物，以及可用于治疗，抑制和/或预防与受试者中升高的尿酸水平相关的疾病的方法和组合物。所述方法包括向受试者施用有效量的化合物I或其药学上可接受的盐或水合物，或包含化合物I或其药学上可接受的盐或水合物和药学上可接受的载体的组合物。组合物和/或方法还可以包括向受试者施用有效量的黄嘌呤氧化酶抑制剂，例如别嘌呤醇，或其药学上可接受的盐或水合物。

3. 发明申请

WO2014205199A2 COMPOSITIONS AND METHODS FOR POTENTIATING IMMUNE RESPONSE, ENHANCING IMMUNOTHERAPY, AND INCREASING VACCINE POTENCY 审中-公开
标题翻译：潜在的免疫应答组合物和方法，增强免疫力和增加疫苗吸收
公开(公告)号：WO2014205199A2
公开(公告)日：2014-12-24
申请号：PCT/US2014043155
申请日：2014-06-19
申请人： NITOR THERAPEUTICS , BANTIA SHANTA
发明人： BANTIA SHANTA
IPC分类号： A61K47/22 , A61K39/00
CPC分类号： A61K47/22 , A61K31/519 , A61K31/7064 , A61K39/00 , A61K39/08 , A61K39/39 , A61K45/06 , A61K2039/55511 , A61K2300/00
摘要： Compositions including at least one PNP inhibitor or at least one PNP inhibitor in combination with one or more agents identified as endogenous adjuvants useful for enhancing the potency of vaccine and cancer immunotherapies being administered for the prevention or treatment of infectious diseases or cancer. The compositions may be formulated as pharmaceutical dosage forms and components may be assembled as kits. Methods for increasing the levels of endogenous adjuvants to enhance the immunogenicity of an antigen as well as to augment the potency of vaccine and cancer immunotherapies are also disclosed.
摘要翻译：组合物包括至少一种PNP抑制剂或至少一种PNP抑制剂与一种或多种被鉴定为用于增强疫苗和癌症免疫疗法效力的内源性佐剂联合用于预防或治疗感染性疾病或癌症。组合物可以配制成药物剂型，组分可以作为试剂盒组装。还公开了增加内源性佐剂水平以提高抗原免疫原性以及提高疫苗和癌症免疫治疗效力的方法。

4. 发明申请

WO2014078778A3 ANTIVIRAL AZASUGAR-CONTAINING NUCLEOSIDES 审中-公开
标题翻译：抗病毒含AZUGUGAR的核苷
公开(公告)号：WO2014078778A3
公开(公告)日：2014-10-09
申请号：PCT/US2013070537
申请日：2013-11-18
申请人： BIOCRYST PHARM INC
发明人： BABU YARLAGADDA S , KOTIAN PRAVIN L , BANTIA SHANTA , WU MINWAN , KUMAR V SATISH
IPC分类号： A61K31/505
CPC分类号： C07D487/04 , A61K31/519 , C07D401/04 , C07D403/04
摘要： Disclosed are compounds comprising an azasugar attached to a heterocyclic base, including pharmaceutically acceptable salts thereof, suitable for use in inhibiting viral RNA polymerase activity or viral replication, and treating viral infections. The compounds are characterized, in part, by favorable pharmacokinetics for the active pharmaceutical ingredient, particularly in conjunction with enteral administration, including, in particular, oral administration. Also disclosed are pharmaceutical compositions comprising one or more compounds mentioned above, or pharmaceutically acceptable salts thereof, as well as methods for preparing same. Also provided are methods for inhibiting viral RNA polymerase activity, viral replication, and treating viral infections.
摘要翻译：公开了包含与杂环碱基连接的氮杂糖的化合物，包括其药学上可接受的盐，其适用于抑制病毒RNA聚合酶活性或病毒复制，以及治疗病毒感染。这些化合物的部分特征在于对活性药物成分有利的药代动力学，特别是与肠内给药相结合，特别是包括口服给药。还公开了包含一种或多种上述化合物或其药学上可接受的盐的药物组合物，以及其制备方法。还提供了抑制病毒RNA聚合酶活性，病毒复制和治疗病毒感染的方法。

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