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1. 发明申请

WO2010011798A3 METHOD AND SYSTEM FOR DETECTION AND/OR CHARACTERIZATION OF A BIOLOGICAL PARTICLE IN A SAMPLE 审中-公开
标题翻译：用于在样品中检测和/或表征生物颗粒的方法和系统
公开(公告)号：WO2010011798A3
公开(公告)日：2010-06-24
申请号：PCT/US2009051473
申请日：2009-07-23
申请人： BIO MERIEUX INC , WALSH JOHN D , HYMAN JONES M , THORPE THURMAN C , CLAY BRADFORD G
发明人： WALSH JOHN D , HYMAN JONES M , THORPE THURMAN C , CLAY BRADFORD G
IPC分类号： B01L3/14 , C12M1/34 , C12Q1/04
CPC分类号： C12Q1/04 , C12Q1/10 , G01N21/31 , G01N21/47 , G01N21/64 , G01N21/6486 , G01N2021/6419 , G01N2021/6421
摘要： The present invention provides a method and system for monitoring, detecting, and/or characterizing a biological particle that may be present in a sample whereby the method may be accomplished non-invasively by utilizing a time-dependent spectroscopic technique to obtain at least two measurements of a growth composition comprising a sample and correlating said measurements for the detection and/or characterization of a biological particle, that may be present in the sample.
摘要翻译：本发明提供了一种用于监测，检测和/或表征可能存在于样品中的生物颗粒的方法和系统，其中所述方法可以非侵入地通过利用时间依赖的光谱技术来获得至少两个测量的生长组合物，其包含样品并将所述测量结果与可能存在于样品中的生物颗粒的检测和/或表征相关联。

2. 发明申请

WO0159060A2 APPARATUS AND METHOD FOR SURFACE CULTURE OF MICROORGANISMS FROM BULK FLUIDS 审中-公开
标题翻译：来自大流行体的微生物表面培养的装置和方法
公开(公告)号：WO0159060A2
公开(公告)日：2001-08-16
申请号：PCT/US0103812
申请日：2001-02-06
申请人： AKZO NOBEL NV , HYMAN JONES M , MATSUMURA PAUL M , JEFFREY SCOTT R , MARESCH MARTIN J , THORPE THURMAN C
发明人： HYMAN JONES M , MATSUMURA PAUL M , JEFFREY SCOTT R , MARESCH MARTIN J , THORPE THURMAN C
IPC分类号： C12M1/16 , C12M1/34 , C12Q1/04 , C12Q1/24
CPC分类号： C12M25/14 , C12Q1/04 , C12Q1/045 , C12Q1/24
摘要： Devices for culturing microorganisms include a container and within the container an immobilization layer made of an interconnected network of polymer chains. The interstitial spaces between the interconnected polymer chains are of a size on average less than an average size of microorganisms to be cultured such that substantially all of the microorganisms in a sample during culturing are immobilized on the surface of the immobilization lawyer. Related methods for detecting microorganisms include providing a device as described above and adding a fluid sample to the device. The fluid sample potentially contains microorganisms and is of a volume of at least .04 ml per each square centimeter of surface area of the immobilization layer. The method then allows the fluid sample to be completely absorbed and immobilized within the immobilization layer, while substantially all microorganisms present within the fluid sample are immobilized on a top surface of the immobilization layer. The device with the fluid sample can be incubated for a period of time so as to allow for growth of any microorganisms present. The method then can detect any microorganisms present on the immobilization layer.
摘要翻译：用于培养微生物的装置包括容器，并且在容器内由聚合物链的互连网络制成的固定层。互连聚合物链之间的间隙空间的平均尺寸小于待培养的微生物的平均尺寸，使得培养期间样品中的基本上所有的微生物固定在固定律师的表面上。用于检测微生物的相关方法包括提供如上所述的装置并将流体样品添加到装置中。流体样品潜在地含有微生物，并且其体积为固定化层每平方厘米表面积至少为0.04ml。该方法然后允许流体样品被完全吸收并固定在固定层内，而流体样品中存在的基本上所有的微生物都固定在固定化层的顶表面上。具有流体样品的装置可以孵育一段时间，以便允许任何存在的微生物的生长。该方法然后可以检测固定层上存在的任何微生物。

3. 发明申请

WO0003035A9 EVACUATED SENSOR DEVICE FOR DETECTING MICROORGANISMS IN BLOOD SAMPLES, AND METHOD THEREFOR 审中-公开
标题翻译：用于检测血液样本中的微生物的消除传感器装置及其方法
公开(公告)号：WO0003035A9
公开(公告)日：2000-10-05
申请号：PCT/US9915599
申请日：1999-07-12
申请人： AKZO NOBEL NV , MARESCH MARTIN J , MATSUMURA PAUL M , JEFFREY SCOTT R , HYMAN JONES M , THORPE THURMAN C
发明人： MARESCH MARTIN J , MATSUMURA PAUL M , JEFFREY SCOTT R , HYMAN JONES M , THORPE THURMAN C
IPC分类号： C12M1/00 , C12M1/28 , C12M1/34 , C12Q1/02 , C12Q1/04 , C12Q1/24 , C12Q1/00
CPC分类号： C12M23/04 , C12M23/22 , C12M23/24 , C12M25/06 , C12M25/14 , C12M41/36 , C12Q1/04 , C12Q1/045 , C12Q1/24
摘要： A device and method allow for collection of a blood specimen and for detecting the presence of microorganisms in the blood specimen. The device is a sensor plate under vacuum which provides an environment to culture microbial organism colonies from a blood sample and a means to facilitate microbial detection and quantification manually or with an instrument. The vacuum sensor plate has a microorganism immobilisation matrix layer and a sensor layer. Detected microbial colonies are immediately available for further testing. A kit is provided having a needle assembly for direct draw of blood from a patient onto the immobilisation layer within the vacuum sensor plate. The sensor plate provides an area for accepting a blood sample, a mechanism to immobilize the blood sample on an interior surface of the plate, nutrients to facilitate growth of microorganisms in the sample, and a sensor layer for allowing the detection and/or enumeration of microorganism colonies within the blood sample. The Figure is an illustration of sensor plate (1) which can be in the form of a flat, shallow container with at least one side being transparent or lucent.
摘要翻译：装置和方法允许收集血液样本并检测血液样本中微生物的存在。该装置是真空下的传感器板，其提供从血液样品中培养微生物菌落的环境，以及手动或用仪器促进微生物检测和量化的手段。真空传感器板具有微生物固定基质层和传感器层。检测到的微生物菌落立即可用于进一步测试。提供了一种套件，其具有用于将血液从患者直接抽取到真空传感器板内的固定层上的针组件。传感器板提供用于接受血液样本的区域，将血液样本固定在板的内表面上的机制，营养物质以促进样品中微生物的生长，以及传感器层，用于允许检测和/或计数血液样品中的微生物菌落。该图是传感器板（1）的图示，其可以是平坦的浅容器的形式，其中至少一侧是透明的或透明的。

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