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1. 发明申请

WO0011190A2 UDP-N-ACETYL GLUCOSAMINYL: beta 1,4 GALACTOSIDE: beta 1,3N-ACETYL GLUCOSAMINYL TRANSFERASE (POLYLACTOSAMINYL TYPE) 审中-公开
标题翻译： UDP-N-乙酰GLUKOSAMINYL：β-1,4半乳糖：测试1.3N乙酰GLUKOSAMINYL转移酶（POLYLAKTOSAMINYL TYPE）
公开(公告)号：WO0011190A2
公开(公告)日：2000-03-02
申请号：PCT/CH9900365
申请日：1999-08-06
申请人： BERGER ERIC G , HENNET THIERRY
发明人： BERGER ERIC G , HENNET THIERRY
IPC分类号： C12N9/10 , C12N15/54 , C12P19/26
CPC分类号： C12N9/1051 , C12P19/26
摘要： The invention relates to a new gene which codes for UDP-N-acetyl glucosaminyl: beta 1,4 galactoside: beta 1,3(N-acetyl glucosaminyl transferase (3GnT). Its enzymatic activity and specificity differ from those of all glycosyl transferases published so far. The invention further relates to isolated DNA molecules and constructs, including their derivatives, which code for 3GnT (referred to as 3GnT-DNA), cloning and expression vectors containing the above 3GnT-DNA, cells transfected with said vectors and recombination methods for obtaining said DNA. The invention also relates to a method for the synthesis of di-, oligo- and polysaccharides with the repetitive element N-acetyl glucosamine ( beta 1}3)galactose( beta 1}4) by obtaining and using the recombinant enzyme from transfected cells which were transfected with 3GnT-DNA, including its derivatives. The invention also relates to methods for diagnosing genetic changes in animals and humans and to the production of antisense samples and targeting vectors for producing transgenic animals.
摘要翻译：本发明是用于对UDP-N- Acetylglukosaminyl一个新的基因编码：1.4的β半乳糖苷：β-内1.3N Acetylglukosaminyltransferase（3GnT）编码。酶活性和特异性不同于所有以前公布的糖基转移酶。本发明包括转染用这些载体的分离的DNA分子和构建体，包括它们的衍生物，其编码的3GnT（下文3GnT DNA），以及含有这些DNA 3GnT，克隆和表达载体，以及细胞以及重组该DNA的方法。本发明还（4测试1}）通过从与3GnT-处理的转染的细胞提取和重组酶的应用涉及用于二糖，寡糖和与重复元件N-乙酰葡糖胺多糖（测试1} 3）半乳糖的合成方法转染DNA及其衍生物。本发明还包括用于诊断动物和人的遗传改变的方法，用于生产基因修饰动物的反义样品和“靶向”载体的生产。

2. 发明申请

WO0022096A9 CHINESE HAMSTER OVARY CELLS FOR PRODUCING PROTEINS 审中-公开
公开(公告)号：WO0022096A9
公开(公告)日：2000-08-24
申请号：PCT/EP9907606
申请日：1999-10-11
申请人： FORSCHUNGSZENTRUM JUELICH GMBH , EISENKRAETZER DETLEF , DINTER ANDRE , KIESEWETER ANDRE , ZENG STEFFEN , BISELLI MANFRED , BERGER ERIC G
发明人： EISENKRAETZER DETLEF , DINTER ANDRE , KIESEWETER ANDRE , ZENG STEFFEN , BISELLI MANFRED , BERGER ERIC G
IPC分类号： C12M1/00 , C12M1/40 , C12N5/10 , C12N9/10 , C12N11/00 , C12R1/91 , C12N5/06 , C12N15/67
CPC分类号： C12N9/1051 , C12N2510/02
摘要： The invention relates to Chinese hamster ovary cells for producing proteins which are characterized in that the growth phase and production phase thereof are separated from one another. The invention also relates to a method for producing the Chinese hamster ovary cells, and to the use of the Chinese hamster ovary cells for producing proteins.

3. 发明申请

WO0022096A2 CHINESE HAMSTER OVARY CELLS FOR PRODUCING PROTEINS 审中-公开
标题翻译：用于生产蛋白质的中国仓鼠卵巢细胞
公开(公告)号：WO0022096A2
公开(公告)日：2000-04-20
申请号：PCT/EP9907606
申请日：1999-10-11
申请人： FORSCHUNGSZENTRUM JUELICH GMBH , EISENKRAETZER DETLEF , DINTER ANDRE , KIESEWETER ANDRE , ZENG STEFFEN , BISELLI MANFRED , BERGER ERIC G
发明人： EISENKRAETZER DETLEF , DINTER ANDRE , KIESEWETER ANDRE , ZENG STEFFEN , BISELLI MANFRED , BERGER ERIC G
IPC分类号： C12M1/00 , C12M1/40 , C12N5/10 , C12N9/10 , C12N11/00 , C12R1/91 , C12N5/00
CPC分类号： C12N9/1051 , C12N2510/02
摘要： The invention relates to Chinese hamster ovary cells for producing proteins which are characterized in that the growth phase and production phase thereof are separated from one another. The invention also relates to a method for producing the Chinese hamster ovary cells, and to the use of the Chinese hamster ovary cells for producing proteins.
摘要翻译：本发明涉及用于生产蛋白质的中国仓鼠卵巢细胞，其特征在于它们的生长和生产阶段彼此分离。本发明进一步提供了用于生产中国仓鼠卵巢细胞的方法以及中国仓鼠卵巢细胞用于蛋白质生产的用途。

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