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1. 发明申请

WO2010047500A3 COMPOSITION FOR PREVENTION OR TREATMENT OF EYE DISEASES 审中-公开
标题翻译：预防或治疗眼部疾病的组合物
公开(公告)号：WO2010047500A3
公开(公告)日：2010-08-19
申请号：PCT/KR2009005983
申请日：2009-10-16
申请人： BENEBIOSIS CO LTD , UNIV SUNGKYUNKWAN FOUND , KANG SEUNG WOO , KIM CHEORL-HO , KIM SEOK-JO
发明人： KANG SEUNG WOO , KIM CHEORL-HO , KIM SEOK-JO
IPC分类号： A61K31/7016
CPC分类号： A61K31/7016 , A23L33/10 , A23V2002/00 , C11D3/0078 , C11D3/221 , C11D3/227 , A23V2200/30
摘要： The present invention relates to a composition for the prevention or treatment of eye diseases, comprising as an active ingredient a compound represented by the following general formula I: IS-(MS)p-(MS)q, wherein S is sialic acid and (MS)p and (MS)q are independent monosaccharide residues. The compound used as an active ingredient in the present invention suppresses the expression of MMP-9 and inflammation-causing cytokines (IL-1ß and TNF-a) on corneal epithelial cells, and suppresses the activity of VEGF-mediated VEGFR-2 on human retinal endothelial cells, thereby ultimately preventing and treating eye diseases such as xerophthalmia, inflammatory eye diseases, eye diseases caused by newly-generated blood vessels and side effects caused by the use of contact lenses. Additionally, the composition of the present invention does not have cell toxicity and does not cause skin problems, and thus can be safely used in pharmaceutical, nutraceutical or food compositions. Further, the composition of the present invention can be used as a cleanser to treat non-bacterial inflammations caused by the use of contact lenses, and as a lubricant to facilitate ocular lubrication.
摘要翻译：本发明涉及用于预防或治疗眼病的组合物，其包含作为活性成分的由以下通式I表示的化合物：IS-（MS）p-（MS）q，其中S是唾液酸和（ MS）p和（MS）q是独立的单糖残基。在本发明中用作活性成分的化合物抑制角膜上皮细胞上MMP-9和引起炎症的细胞因子（IL-1β和TNF-α）的表达，并抑制VEGF介导的VEGFR-2对人的活性从而最终预防和治疗眼睛疾病，例如干眼症，炎症性眼病，由新生血管引起的眼部疾病和由使用隐形眼镜引起的副作用。此外，本发明的组合物不具有细胞毒性并且不会引起皮肤问题，因此可以安全地用于药物，营养食品或食品组合物中。此外，本发明的组合物可以用作清洁剂来治疗由使用隐形眼镜引起的非细菌性炎症，并作为促进眼部润滑的润滑剂。

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