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1. 发明申请

WO2005074460A3 METHODS OF ENHANCING IMMUNE RESPONSE IN THE INTRADERMAL COMPARTMENT AND COMPOUNDS USEFUL IN THE METHODS 审中-公开
标题翻译：在方法中有用的增强室内容物和化合物中的免疫应答的方法
公开(公告)号：WO2005074460A3
公开(公告)日：2005-09-29
申请号：PCT/US2004041021
申请日：2004-12-06
申请人： BECTON DICKINSON CO , CAMPBELL ROBERT , DOLAN KEVIN G , ALARCON JASON , WOODLEY WENDY D , MIKSZTA JOHN
发明人： CAMPBELL ROBERT , DOLAN KEVIN G , ALARCON JASON , WOODLEY WENDY D , MIKSZTA JOHN
IPC分类号： A61K31/7048 , A61K39/00 , A61K39/39 , A61K45/00 , A61K47/00 , G01N33/53
CPC分类号： A61K39/39 , A61K31/7048 , A61K39/12 , A61K39/145 , A61K2039/55511 , A61K2039/55516 , A61K2039/55555 , A61K2039/55588 , C12N2760/16134
摘要： The present invention relates to immunogenic compositions for intradermal delivery of an antigenic or immunogenic agent in combination with one or more excipients. The immunogenic compositions of the invention comprise an antigenic or immunogenic agent and at least one excipient which acts as an adjuvant, i.e., enhances the immune response to the antigenic or immunogenic agent, once delivered to the intradermal compartment of a subject's skin. The immunogenic compositions of the invention comprise an excipient which when administered to the intradermal compartment of skin in accordance with the invention demonstrate adjuvant activity. The immunogenic compositions of the invention have enhanced efficacy as the excipients of the composition cause an asymptomatic skin irritation and recruit antigen presenting cells to the intradermal compartment and thus enhance presentation and/or availability of the antigenic or immunogenic agent to the antigen presenting cells. The enhanced efficacy of the immunogenic compositions of the invention may result in a therapeutically effective immune response after a single intradermal dose, with lower doses of antigenic or immunogenic agent than conventionally used, and without the need for booster immunizations
摘要翻译：本发明涉及用于皮内递送抗原性或免疫原性试剂与一种或多种赋形剂组合的免疫原性组合物。本发明的免疫原性组合物包含抗原或免疫原性试剂和至少一种充当佐剂的赋形剂，即一旦递送到受试者的皮肤的真皮内隔室，则增强对抗原或免疫原性试剂的免疫应答。本发明的免疫原性组合物包含赋形剂，其当根据本发明施用于皮肤的皮内隔室时显示佐剂活性。本发明的免疫原性组合物具有增强的功效，因为组合物的赋形剂引起无症状的皮肤刺激并将抗原呈递细胞募集到皮内区室，从而增强抗原呈递细胞的抗原或免疫原性的呈递和/或可用性。本发明的免疫原性组合物的增强的功效可以在单次真皮内剂量之后产生治疗有效的免疫应答，具有比常规使用的更低剂量的抗原性或免疫原性试剂，并且不需要加强免疫

2. 发明申请

WO2005074460A9 METHODS OF ENHANCING IMMUNE RESPONSE IN THE INTRADERMAL COMPARTMENT AND COMPOUNDS USEFUL IN THE METHODS 审中-公开
标题翻译：在方法中有用的增强室内容物和化合物中的免疫应答的方法
公开(公告)号：WO2005074460A9
公开(公告)日：2006-08-24
申请号：PCT/US2004041021
申请日：2004-12-06
申请人： BECTON DICKINSON CO , CAMPBELL ROBERT , DOLAN KEVIN G , ALARCON JASON , WOODLEY WENDY D , MIKSZTA JOHN
发明人： CAMPBELL ROBERT , DOLAN KEVIN G , ALARCON JASON , WOODLEY WENDY D , MIKSZTA JOHN
IPC分类号： A61K39/00 , A61K31/7048 , A61K39/39 , A61K45/00 , A61K47/00 , G01N33/53
CPC分类号： A61K39/39 , A61K31/7048 , A61K39/12 , A61K39/145 , A61K2039/55511 , A61K2039/55516 , A61K2039/55555 , A61K2039/55588 , C12N2760/16134
摘要： The present invention relates to immunogenic compositions for intradermal delivery of an antigenic or immunogenic agent in combination with one or more excipients. The immunogenic compositions of the invention comprise an antigenic or immunogenic agent and at least one excipient which acts as an adjuvant, i.e., enhances the immune response to the antigenic or immunogenic agent, once delivered to the intradermal compartment of a subject's skin. The immunogenic compositions of the invention comprise an excipient which when administered to the intradermal compartment of skin in accordance with the invention demonstrate adjuvant activity. The immunogenic compositions of the invention have enhanced efficacy as the excipients of the composition cause an asymptomatic skin irritation and recruit antigen presenting cells to the intradermal compartment and thus enhance presentation and/or availability of the antigenic or immunogenic agent to the antigen presenting cells. The enhanced efficacy of the immunogenic compositions of the invention may result in a therapeutically effective immune response after a single intradermal dose, with lower doses of antigenic or immunogenic agent than conventionally used, and without the need for booster immunizations
摘要翻译：本发明涉及用于皮内递送抗原性或免疫原性试剂与一种或多种赋形剂组合的免疫原性组合物。本发明的免疫原性组合物包含抗原或免疫原性试剂和至少一种充当佐剂的赋形剂，即一旦递送到受试者的皮肤的真皮内隔室，则增强对抗原或免疫原性试剂的免疫应答。本发明的免疫原性组合物包含赋形剂，其当根据本发明施用于皮肤的皮内隔室时显示佐剂活性。本发明的免疫原性组合物具有增强的功效，因为组合物的赋形剂引起无症状的皮肤刺激并将抗原呈递细胞募集到皮内区室，从而增强抗原呈递细胞的抗原或免疫原性的呈递和/或可用性。本发明的免疫原性组合物的增强的功效可以在单次真皮内剂量之后产生治疗有效的免疫应答，具有比常规使用的更低剂量的抗原性或免疫原性试剂，并且不需要加强免疫

3. 发明申请

WO2005016401A3 IMPROVED INTRA-DERMAL DELIVERY OF BIOLOGICALLY ACTIVE AGENTS 审中-公开
标题翻译：改进生物活性剂的内部递送
公开(公告)号：WO2005016401A3
公开(公告)日：2005-11-24
申请号：PCT/US2004019121
申请日：2004-06-14
申请人： BECTON DICKINSON CO , NYCZ COLLEEN , VONK GLENN , BRITTINGHAM JOHN , PETTIS RONALD J , HARVEY ALFRED , CAMPBELL ROBERT , MIKSZTA JOHN
发明人： NYCZ COLLEEN , VONK GLENN , BRITTINGHAM JOHN , PETTIS RONALD J , HARVEY ALFRED , CAMPBELL ROBERT , MIKSZTA JOHN
IPC分类号： A61K49/00 , A61M20060101
CPC分类号： A61K49/0034 , A61K9/0021 , A61K49/0043 , A61K49/0058 , A61M5/46 , A61M37/00
摘要： The present invention relates to methods and devices for delivering one or more biologically active agents, particularly a diagnostic agent to the intradermal compartment of a subject's skin. The present invention provides an improved method of delivery of biologically active agents in that it provides among other benefits, rapid uptake into the local lymphatics, improved targeting to a particular tissue, improved bioavailability, improved tissue bioavailability, improved tissue specific kinetics, improved deposition of a pre-selected volume of the agent to be administered, and rapid biological and rapid biological and pharmacodynamics and biological and pharmacokinetics. This invention provides methods for rapid transport of agents through lymphatic vasculature accessed by intradermal delivery of the agent. Methods of the invention are particularly useful for delivery of diagnostic agents.
摘要翻译：本发明涉及用于将一种或多种生物活性剂特别是诊断剂递送到受试者皮肤的真皮内隔室的方法和装置。本发明提供了递送生物活性剂的改进方法，因为它提供了其他益处，快速摄入局部淋巴管，改善对特定组织的靶向，改善的生物利用度，改善的组织生物利用度，改善的组织特异性动力学，改进的沉积预先选定体积的药剂，以及快速生物和快速的生物和药效学以及生物和药代动力学。本发明提供了通过皮内递送试剂获得的通过淋巴脉管系统快速转运药剂的方法。本发明的方法对于递送诊断剂特别有用。

4. 发明申请

WO2004073652A3 POWDER FORMULATIONS OF RECOMBINANT STAPHYLOCOCCAL ENTEROTOXIN B (RSEB) MADE BY ATMOSPHERIC SPRAY-FREEZE DRYING FOR IMPROVED VACCINATION 审中-公开
标题翻译：通过大气喷雾干燥进行改进的疫苗制备重组人血清肠毒素B（ R SEB）的粉末制剂
公开(公告)号：WO2004073652A3
公开(公告)日：2005-02-10
申请号：PCT/US2004005135
申请日：2004-02-20
申请人： BECTON DICKINSON CO , SULLIVAN VINCENT , MIKSZTA JOHN , HWANG ROBIN , MAR KEVIN D , CAMPBELL ROBERT L
发明人： SULLIVAN VINCENT , MIKSZTA JOHN , HWANG ROBIN , MAR KEVIN D , CAMPBELL ROBERT L
IPC分类号： A61K9/00 , A61K9/16 , A61K9/18 , A61K9/19 , A61K38/28 , A61K39/145 , A61K47/26 , A61K47/36 , A61K38/16 , A61K39/085
CPC分类号： A61K47/36 , A61K9/0019 , A61K9/0043 , A61K9/1688 , A61K9/1694 , A61K9/19 , A61K38/28 , A61K39/085 , A61K39/12 , A61K39/145 , A61K47/26 , A61K2039/5252 , A61K2039/53 , A61K2039/543 , A61K2039/545 , A61K2039/55505 , A61K2039/55583 , C12N2760/16134
摘要： A method of preparing a pharmaceutical composition is described, comprising 1) atomizing a liquid formulation of a therapeutic agent to produce an atomized formulation; 2) freezing said atomized formulation to form solid particles; and 3) drying said solid particles to produce a powder. Compositions made by the above methods, and methods of using the compositions, are also described.
摘要翻译：描述了制备药物组合物的方法，其包括：1）雾化治疗剂的液体制剂以产生雾化制剂; 2）冷冻所述雾化制剂以形成固体颗粒; 和3）干燥所述固体颗粒以产生粉末。还描述了通过上述方法制备的组合物以及使用组合物的方法。

5. 发明申请

WO2005023328A3 METHODS FOR INTRADERMAL DELIVERY OF THERAPEUTICS AGENTS 审中-公开
标题翻译：治疗剂的皮内递送方法
公开(公告)号：WO2005023328A3
公开(公告)日：2005-11-10
申请号：PCT/US2004019118
申请日：2004-06-14
申请人： BECTON DICKINSON CO , PETTIS RONALD J , HARVEY ALFRED , CAMPBELL ROBERT , MIKSZTA JOHN , BRITTINGHAM JOHN
发明人： PETTIS RONALD J , HARVEY ALFRED , CAMPBELL ROBERT , MIKSZTA JOHN , BRITTINGHAM JOHN
IPC分类号： A61K31/496 , A61K38/20 , A61K38/21 , A61K39/395 , A61K45/00 , A61M20060101 , A61M23/00
CPC分类号： A61K9/0021 , A61K9/0019
摘要： The present invention relates to methods and devices for delivering one or more biologically active agents, particularly therapeutic agents, the intradermal compartment of a subject's skin. The present invention provides an improved method of delivery of biologically active agents, such as therapeutic agents, through lymphatic vasculature accessed by intradermal delivery. Therapeutic agents to be delivered in accordance with the present invention include, but are not limited ton antineoplastic agents, chemotherapeutic agents, antibodies, antibiotics, anti-angiogenesis agents, anti-inflammatory agents, and immunotherapeutic agents. Therapeutic agents delivered in accordance with the present invention have improved bioavailability, including improved systemic distribution and improved delivery to particular tissues. Therapeutic agents, delivered in accordance with the methods of the invention have an improved clinical utility and therapeutic efficacy relative to other drug delivery methods, including intraperitoneal, intramuscular and subcutaneous delivery. The methods of the present invention provide benefits and improvements over convention drug delivery methods including dose sparing, increased drug efficacy, reduced side effects, reduced metastatic potential and prolonged survival.
摘要翻译：本发明涉及用于递送一种或多种生物活性剂，特别是治疗剂，受试者皮肤的皮内隔室的方法和装置。本发明提供了通过皮内递送进入的淋巴脉管系统递送生物活性剂如治疗剂的改进方法。根据本发明递送的治疗剂包括但不限于抗肿瘤剂，化学治疗剂，抗体，抗生素，抗血管生成剂，抗炎剂和免疫治疗剂。根据本发明递送的治疗剂具有改善的生物利用度，包括改善的全身分布和改善的递送至特定组织。根据本发明的方法递送的治疗剂相对于其他药物递送方法（包括腹膜内，肌肉内和皮下递送）具有改善的临床效用和治疗功效。本发明的方法提供了优于常规药物递送方法的益处和改进，包括剂量节省，药物效力增加，副作用减少，转移潜能降低和存活时间延长。

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