专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2005033334A3 METHOD FOR DETERMINING AN ACTIVE INGREDIENT DOSAGE 审中-公开
标题翻译：方法确定活性剂量
公开(公告)号：WO2005033334A3
公开(公告)日：2005-09-29
申请号：PCT/EP2004010560
申请日：2004-09-21
申请人： BAYER TECHNOLOGY SERVICES GMBH , SCHMITT WALTER , WILLMANN STEFAN , DIESSEL EDGAR , DORN INGMAR , BURMEISTER JENS
发明人： SCHMITT WALTER , WILLMANN STEFAN , DIESSEL EDGAR , DORN INGMAR , BURMEISTER JENS
IPC分类号： G06F19/18 , G06Q50/24 , G06F19/00
CPC分类号： G06F19/18 , G06Q50/24
摘要： The invention relates to a method for determining the dosage of at least one active ingredient based on a genetic analysis. The method comprises the following steps: a) analysis (101) of specific genetic sequences, using a genetic sequence-specific analysis device, in particular a sequence-specific sensor, or determination of the expression of proteins, either by RNA transcription using quantitative RNA-specific identification methods or by the direct measurement of the protein expression by a protein analysis device; b) assignment of the genetic sequences to physiological functions of the human or animal body, in particular to those physiological functions that influence the decomposition, absorption, release or distribution behaviour of the active ingredient in the body; c) transmission of the genetic and assignment data to a physiology-based pharmacokinetic model (PBPK model) (108); d) input of active ingredient-specific data into the PBPK model (108); e) input of characteristic patient data, optionally from direct measurements on the body; f) calculation of physiological influence parameters that are required for the PBPK model from the patient data, using information contained in the knowledge database and transmission of said parameters to the PBPK model (108); g) calculation of the individual dose from the data in steps c), d) and f), using the PBPK model (108).
摘要翻译：一种用于确定至少一种活性成分的基于描述的遗传分析的剂量方法。该方法包括以下步骤：使用基因序列特异性分析器具中的）特定的基因序列的分析（101），特别是序列特异性的传感器，或测定蛋白质的任一上通过定量特定RNA的检测方法或直接测量RNA转录的表达通过蛋白质分析仪b蛋白表达）具有基因序列与人体或动物体的生理功能，特别是影响记录的降解那些生理功能的分配，以传送或在药物在体内，c中的分配行为）遗传和分配数据到基于生理学-药代动力学模型的公开内容（PBPK）模型（108）中，d）从直接在PBPK模型（108）的特征的患者数据物质，e）输入，特定药物的数据的输入可能身体的测量，F）贝雷使用包含在知识数据库中的信息所必需的来自患者的数据PBPK模型生理影响参数tatements和传递参数到PBPK模型（108）中，g）从所述数据中的单个剂量的计算的步骤c）之后，D ）和f）使用所述PBPK模型（108）。

2. 发明申请

WO2005043441A8 METHOD FOR VISUALISING THE ADME CHARACTERISTICS OF CHEMICAL SUBSTANCES 审中-公开
标题翻译：方法的显示化学物质ADME性能的影响
公开(公告)号：WO2005043441A8
公开(公告)日：2005-12-29
申请号：PCT/EP2004011810
申请日：2004-10-19
申请人： BAYER TECHNOLOGY SERVICES GMBH , LIPPERT JOERG , SEVESTRE MICHAEL , SCHMITT WALTER , WILLMANN STEFAN
发明人： LIPPERT JOERG , SEVESTRE MICHAEL , SCHMITT WALTER , WILLMANN STEFAN
IPC分类号： A01N25/00 , A01N61/00 , G01N33/48 , G01N33/50 , G06F17/50 , G06F19/00 , G06F19/24 , G06F19/26
CPC分类号： G06F19/708 , G06F19/704 , G06F19/707
摘要： A method is described for selecting chemical compounds and visualizing their ADME properties using an indication-specific target profile. In one embodiment, the method comprises determining and/or selecting molecular properties of one or more compounds in a computer database. This information is used to generate one or more ADME maps describing the compounds' behaviour in a biophysical model. An indication-specific target profile of the desired ADME properties is defined and compared with the compounds' actual ADME profile or map to make an optimized selection of compounds.

3. 发明申请

WO2005033982A2 METHOD FOR SIMULATING THE INTERACTION OF CHEMICAL SUBSTANCES AND LIVING ORGANISMS 审中-公开
标题翻译：模拟化学物质与生物体相互作用的方法
公开(公告)号：WO2005033982A2
公开(公告)日：2005-04-14
申请号：PCT/EP2004010607
申请日：2004-09-22
申请人： BAYER TECHNOLOGY SERVICES GMBH , WILLMANN STEFAN , SCHMITT WALTER , FOIS FRANCO
发明人： WILLMANN STEFAN , SCHMITT WALTER , FOIS FRANCO
IPC分类号： G01N33/15 , G06F19/00 , G06F19/12 , G06F17/50
CPC分类号： G06F19/704 , G06F19/12 , G06F19/3456 , G16H10/40 , G16H50/50
摘要： The invention relates to a computer method for calculating the pharmacokinetic and pharmacodynamic behavior of chemical substances in living organisms, e.g. in mammals, insects or plants.
摘要翻译：本发明涉及用于计算活体中化学物质的药代动力学和药效学行为的计算机方法，在哺乳动物，昆虫或植物中。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式