专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2004043950A1 INDOLYL PYRAZINONE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS 审中-公开
标题翻译：用于治疗与增殖性疾病相关的高血压疾病和疾病的吲哚基吡嗪酮衍生物
公开(公告)号：WO2004043950A1
公开(公告)日：2004-05-27
申请号：PCT/US2003/036003
申请日：2003-11-10
申请人： BAYER PHARMACEUTICALS CORPORATION , LADOUCEUR, Gaetan, H. , BEAR, Brian , BI, Cheng , BRITTELLI, David, R. , BURKE, Michael, J. , CHEN, Gang , COOK, James , DUMAS, Jacques , SIBLEY, Robert , TURNER, Michael, R.
发明人： LADOUCEUR, Gaetan, H. , BEAR, Brian , BI, Cheng , BRITTELLI, David, R. , BURKE, Michael, J. , CHEN, Gang , COOK, James , DUMAS, Jacques , SIBLEY, Robert , TURNER, Michael, R.
IPC分类号： C07D403/04
CPC分类号： C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/04
摘要： This invention relates to a compound of Formula I (I)and its use in treating hyper-proliferative disorders and diseases associated with angiogenesis.
摘要翻译：本发明涉及式I（I）的化合物及其在治疗与血管生成相关的高增殖性疾病和疾病中的用途。

2. 发明申请

WO2003027085A3 3-PYRIDYL OR 4-ISOQUINOLINYL THIAZOLES AS C17,20 LYASE INHIBITORS 审中-公开
公开(公告)号：WO2003027085A3
公开(公告)日：2003-04-03
申请号：PCT/US2002/030483
申请日：2002-09-26
申请人： BAYER Pharmaceuticals Corporation , BIERER, Donald , MCCLURE, Andrea , FU, Wenlang , ACHEBE, Furahi , LADOUCEUR, Gaetan, H. , BURKE, Michael, J. , BI, Cheng , HART, Barry , DUMAS, Jacques , SIBLEY, Robert , SCOTT, William, J. , JOHNSON, Jeffrey , ASGARI, Davoud
发明人： BIERER, Donald , MCCLURE, Andrea , FU, Wenlang , ACHEBE, Furahi , LADOUCEUR, Gaetan, H. , BURKE, Michael, J. , BI, Cheng , HART, Barry , DUMAS, Jacques , SIBLEY, Robert , SCOTT, William, J. , JOHNSON, Jeffrey , ASGARI, Davoud
IPC分类号： C07D417/14
摘要： The invention provides novel thiazoles bearing 3-pyridyl or 4-isoquinilinyl substituents, and pharmaceutical compositions thereof. The invention also provides methods of using compounds of the invention and pharmaceutical compositions thereof as inhibitors of lyases, e.g., the 17a-hydroxylase-C17,20 enzyme. The invention further provides methods for treating cancer in a subject, comprising administering to the subject a compound of the invention or a pharmaceutical composition thereof. The cancer can be, e.g., prostate cancer or breast cancer.

3. 发明申请

WO2003027085A2 3-PYRIDYL OR 4-ISOQUINOLINYL THIAZOLES AS C17,20 LYASE INHIBITORS 审中-公开
标题翻译： 3-吡啶基或4-异喹啉基噻唑作为C17,20 LYASE抑制剂
公开(公告)号：WO2003027085A2
公开(公告)日：2003-04-03
申请号：PCT/US2002/030483
申请日：2002-09-26
申请人： BAYER CORPORATION , BIERER, Donald , MCCLURE, Andrea , FU, Wenlang , ACHEBE, Furahi , LADOUCEUR, Gaetan, H. , BURKE, Michael, J. , BI, Cheng , HART, Barry , DUMAS, Jacques , SIBLEY, Robert , SCOTT, William, J. , JOHNSON, Jeffrey , ASGARI, Davoud
发明人： BIERER, Donald , MCCLURE, Andrea , FU, Wenlang , ACHEBE, Furahi , LADOUCEUR, Gaetan, H. , BURKE, Michael, J. , BI, Cheng , HART, Barry , DUMAS, Jacques , SIBLEY, Robert , SCOTT, William, J. , JOHNSON, Jeffrey , ASGARI, Davoud
IPC分类号： C07D277/00
CPC分类号： C07D401/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/14 , C07D513/04
摘要： The invention provides novel thiazoles bearing 3-pyridyl or 4-isoquinilinyl substituents, and pharmaceutical compositions thereof. The invention also provides methods of using compounds of the invention and pharmaceutical compositions thereof as inhibitors of lyases, e.g., the 17a-hydroxylase-C17,20 enzyme. The invention further provides methods for treating cancer in a subject, comprising administering to the subject a compound of the invention or a pharmaceutical composition thereof. The cancer can be, e.g., prostate cancer or breast cancer.
摘要翻译：本发明提供具有3-吡啶基或4-异喹啉基取代基的新型噻唑及其药物组合物。本发明还提供了使用本发明化合物及其药物组合物作为裂解酶抑制剂例如17a-羟化酶-C17,20酶的方法。本发明进一步提供了治疗受试者的癌症的方法，包括向受试者施用本发明化合物或其药物组合物。癌症可以是例如前列腺癌或乳腺癌。

4. 发明申请

WO2003026666A1 2-PHENYLAMINO-4- (5-PYRAZOLYLAMINO)-PYRIMIDINE DERIVATIVES AS KINASE INHIBITORS, IN PARTICULAR, AS SRC KINASE INHIBITORS 审中-公开
标题翻译：作为激酶抑制剂，特别是作为SRC激酶抑制剂的2-苯基氨基-4-（5-吡唑啉氨基） - 嘧啶衍生物
公开(公告)号：WO2003026666A1
公开(公告)日：2003-04-03
申请号：PCT/US2002/030984
申请日：2002-09-26
申请人： BAYER CORPORATION , DIXON, Julie , DUMAS, Jacques , BRENNAN, Catherine , HATOUM-MOKDAD, Holia , LEE, Wendy , SIBLEY, Robert , BEAR, Brian , CHANDLER, Brent , MIRANDA, Karl , CHEN, Gang , CHEN, Zhi , BRITTELLI, David , CLARK, Roger, B.
发明人： DIXON, Julie , DUMAS, Jacques , BRENNAN, Catherine , HATOUM-MOKDAD, Holia , LEE, Wendy , SIBLEY, Robert , BEAR, Brian , CHANDLER, Brent , MIRANDA, Karl , CHEN, Gang , CHEN, Zhi , BRITTELLI, David , CLARK, Roger, B.
IPC分类号： A61K31/506
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： The invention provides novel substituted 2,4-diaminopyrimidine compounds (I), in which L is a linker selected from: -O-(CH 2 ) 1-4 - ; s(O) 0-2 -(CH 2 ) 1-4 - ; -N(R 1 )-(CH 2 ) 1-4 -(CH 2 ) 1-4 -O-(CH 2 ) 1-4 - ; -N(R 1 )-C(O)-(CH 2 ) 1-4 - ; (I) and (I) G represents: Alternatively, L may represent (I) or (I), and in this event, G represents (I) and pharmaceutical compositions thereof. The invention also provides methods of use of the novel substituted 2,4-diaminopyrimidine compounds and pharmaceutical compositions thereof as inhibitors of src kinase enzymes. Exemplary diseases that can be treated by the compounds of the invention include cell proliferative diseases, such as cancer and non-malignant cell proliferative diseases, osteoporosis and inflammatory diseases. Also provided are methods for preparing the compounds of the present invention.
摘要翻译：本发明提供新的取代的2,4-二氨基嘧啶化合物（I），其中L是选自以下的连接体：-O-（CH 2）1-4 - ; s（O）0-2-（CH2）1-4-; -N（R 1） - （CH 2）1-4 - （CH 2）1-4 -O-（CH 2）1-4 - ; -N（R 1）-C（O） - （CH 2）1-4 - ; （I）和（I）G表示：或者，L可以表示（I）或（I），在这种情况下，G表示（I）及其药物组合物。本发明还提供了使用新型取代的2,4-二氨基嘧啶化合物及其药物组合物作为src激酶的抑制剂的方法。可以通过本发明化合物治疗的示例性疾病包括细胞增殖性疾病，例如癌症和非恶性细胞增殖性疾病，骨质疏松症和炎性疾病。还提供了制备本发明化合物的方法。

5. 发明申请

WO2004046118A2 2-4-(DI-PHENYL-AMINO)-PYRIMIDINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS 审中-公开
标题翻译： 2-4-（二苯基氨基） - 嘧啶衍生物用于治疗超增生性疾病
公开(公告)号：WO2004046118A2
公开(公告)日：2004-06-03
申请号：PCT/US2003/014294
申请日：2003-05-06
申请人： BAYER PHARMACEUTICALS CORPORATION , WOOD, Jill, E. , BIERER, Donald , BEAR, Brian , BRENNAN, Catherine , CHANDLER, Brent , CHEN, Gang , CHEN, Yuanwei , DIXON, Julie , FU, Wenlang , GUERNON, Leatte , LIU, Donglei , MCCLURE, Andrea , MIRANDA, Karl , NAGARATHNAM, Dhanapalan , SIBLEY, Robert , TURNER, Michael , VERMA, Sharad , WANG, Chunguang , YI, Lin , ZHAO, Jin , ZHU, Qingming
发明人： WOOD, Jill, E. , BIERER, Donald , BEAR, Brian , BRENNAN, Catherine , CHANDLER, Brent , CHEN, Gang , CHEN, Yuanwei , DIXON, Julie , FU, Wenlang , GUERNON, Leatte , LIU, Donglei , MCCLURE, Andrea , MIRANDA, Karl , NAGARATHNAM, Dhanapalan , SIBLEY, Robert , TURNER, Michael , VERMA, Sharad , WANG, Chunguang , YI, Lin , ZHAO, Jin , ZHU, Qingming
IPC分类号： C07D239/00
CPC分类号： C07D401/12 , C07D401/14 , C07D413/14 , C07D471/04
摘要： The present invention relates to a 2-4-(diphenyl-amino)-pyrimidinyl compound of Formula I useful for treating hyper-proliferative disorders.
摘要翻译：本发明涉及用于治疗过度增殖性疾病的式I的2-4-（二苯基 - 氨基） - 嘧啶基化合物。

6. 发明申请

WO2003026664A1 2-PHENYLAMINO-4- (5-PYRAZOLYLAMINO) -PYRAMIDINE DERIVATIVES AS KINASE INHIBITORS, IN PARTICULAR, SRC KINASE INHIBITORS 审中-公开
标题翻译：作为激酶抑制剂，特别是SRC激酶抑制剂的2-苯基氨基-4-（5-氨基吡啶）吡啶衍生物
公开(公告)号：WO2003026664A1
公开(公告)日：2003-04-03
申请号：PCT/US2002/030836
申请日：2002-09-26
申请人： BAYER CORPORATION , DIXON, Julie , DUMAS, Jacques , BRENNAN, Catherine , HATOUM-MOKDAD, Holia , LEE, Wendy , SIBLEY, Robert , BEAR, Brian
发明人： DIXON, Julie , DUMAS, Jacques , BRENNAN, Catherine , HATOUM-MOKDAD, Holia , LEE, Wendy , SIBLEY, Robert , BEAR, Brian
IPC分类号： A61K31/506
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： The invention provides novel substituted 2,4-diaminopyrimidine compounds (I). In formula (I), the variables are as follows. Y 1 represents H or C 1-4 alkyl. Y 2 represents CF 3 , C 1-6 alkyl; C 3-6 cycloalkyl; or phenyl optionally substituted with halogen, C 1-4 alkyl, or C 1-4 alkoxy. The subscript n is 0, 1, or 2. X represents halogen or C 1-4 alkyl, p is 0, 1, or 2. Z represents halogen, C 1-4 alkyl, or C 1-4 alkoxy; and q is 0, 1, or 2. L represents a chemical bond; C 1-4 alkylene; O; O(C 1-4 alkylene); CH(C 1-6 alkoxy); S(O) 0-2 ; S(O) 0-2 (C 1-4 alkylene); (C 1-4 alkylene)S(O) 0-2 ; NH(C 1-4 alkylene); C(O); or C(O)-(C 1-4 alkylene). D represents pyridinyl; imidazolyl; thiazolyl; pyrrolyl; thienyl; pyrazolyl; furyl; thiadiazolyl; oxazolyl; or benzimidazolyl. The pyridinyl and benzimidazolyl groups D each may be optionally substituted by up to three substituents independently selected from C 1-4 alkyl, OH, C 1-4 alkoxy, CN, NR 1 R 2 , C(O)NR 1 R 2 , halogen, and CO 2 (C 1-6 alkyl), in which R 1 and R 2 are independently selected from H, C 1-4 alkyl, and C 3-6 cycloalkyl. Alternatively, R 1 and R 2 may be joined to form a 5-6 membered saturated heterocycle (II) in which Q represents O, S(O) 0-2 , N-Y 1 , or C(Y 1 ) 2 , pharmaceutical compositions containing them, a method of making them, and methods of using them for treatment of cell proliferative diseases such as cancer, and non-malignant cell proliferative diseases, as well as osteoporosis and inflammatory diseases.
摘要翻译：本发明提供了新的取代的2,4-二氨基嘧啶化合物（I）。在公式（I）中，变量如下。 Y 1表示H或C 1-4烷基。 Y 2表示CF 3，C 1-6烷基; C 3-6环烷基; 或任选被卤素取代的苯基，C 1-4烷基或C 1-4烷氧基。下标n为0,1或2.X为卤素或C 1-4烷基，p为0,1或2.Z为卤素，C 1-4烷基， sb>烷基或C 1-4烷氧基; 且q为0,1或2.L为化学键; C 1-4烷基; O; O（C 1-4烷基）亚烷基; CH（C 1 -C 6烷氧基）; S（O） 0-2 ; S（O） 0-2 （C 1-4 亚烷基）; （C 1-4烷基）亚烷基S（O）sb> 0-2 ; NH（C 1-4烷基）亚烷基; C（O）; 或C（O） - （C 1-4烷基）亚烷基。 D代表吡啶基; 咪唑; 噻唑基; 吡咯; 噻吩; 吡唑; 呋喃; 噻; 恶唑; 或苯并咪唑基。吡啶基和苯并咪唑基D各自可以任选地被至多三个独立地选自C 1-4烷基，OH，C 1-4烷基，CN，NR C（O）NR 1，R 2，卤素和CO 2 S < 其中R 1和R 2各自独立地选自H，C 1 -C 12烷基，其中R 1和R 2独立地选自H，C 1〜 -4个烷基和C 3-6环烷基。或者，R 1和R 2可以连接形成5-6元饱和杂环（II），其中Q表示O，S（O） 0 -2 ，N-Y 1，或C（Y 1），s b> 2 ，含有它们的药物组合物，制备方法它们以及用于治疗细胞增殖性疾病如癌症和非恶性细胞增殖性疾病以及骨质疏松症和炎性疾病的方法。

7. 发明申请

WO2003055489A1 2,4-DIAMINO-PYRIMIDINE DERIVATIVE COMPOUNDS AS INHIBITORS OF PROLYLPEPTIDASE, INDUCERS OF APOPTOSIS AND CANCER TREATMENT AGENTS 审中-公开
标题翻译：作为胰蛋白酶抑制剂的2,4-二氨基 - 吡啶衍生物，杀虫剂和癌症治疗剂
公开(公告)号：WO2003055489A1
公开(公告)日：2003-07-10
申请号：PCT/US2002/041146
申请日：2002-12-20
申请人： BAYER CORPORATION , DUMAS, Jacques , DIXON, Julie , SIBLEY, Robert , WOOD, Jill
发明人： DUMAS, Jacques , DIXON, Julie , SIBLEY, Robert , WOOD, Jill
IPC分类号： A61K31/506
CPC分类号： C07D239/48 , C07D403/04 , C07D405/12 , C07D409/12
摘要： Compounds which are 2,4-diamino-pyrimidine derivatives of formula (I) or (II), wherein A, R1, R2, R3, and R4 are described in the specification. These compounds are useful for the inhibiting prolylpeptidase, inducing apoptosis and treating cancer.
摘要翻译：作为式（I）或（II）的2,4-二氨基 - 嘧啶衍生物的化合物，其中A，R 1，R 2，R 3和R 4在说明书中描述。这些化合物可用于抑制脯氨酰肽酶，诱导凋亡和治疗癌症。

8. 发明申请

WO2003055890A1 THIENOPYRIMIDINE DERIVATIVE COMPOUNDS AS INHIBITORS OF PROLYLPEPTIDASE, INDUCERS OF APOPTOSIS AND CANCER TREATMENT AGENTS 审中-公开
标题翻译：作为丙型肝炎病毒抑制剂的三烯酰基衍生化合物，疫苗诱导剂和癌症治疗剂
公开(公告)号：WO2003055890A1
公开(公告)日：2003-07-10
申请号：PCT/US2002/041168
申请日：2002-12-20
申请人： BAYER CORPORATION , DUMAS, Jacques , SIBLEY, Robert , WOOD, Jill
发明人： DUMAS, Jacques , SIBLEY, Robert , WOOD, Jill
IPC分类号： C07D495/04
CPC分类号： C07D495/04
摘要： The compounds of the invention are thienopyrimidine derivatives of the formula (I):wherein X is OR3 or NR3R4; q, R1, R2, R3, and R4 are described in the specification. These compounds are useful for the inhibiting the prolylpeptidase, inducing apoptosis and treating cancer.
摘要翻译：本发明的化合物是式（I）的噻吩并嘧啶衍生物：其中X是OR 3或NR 3 R 4; 在说明书中描述了q，R1，R2，R3和R4。这些化合物可用于抑制脯氨酰肽酶，诱导凋亡和治疗癌症。

9. 发明申请

WO2003055866A1 QUINAZOLINE AND QUINOLINE DERIVATIVE COMPOUNDS AS INHIBITORS OF PROLYLPEPTIDASE, INDUCERS OF APOPTOSIS AND CANCER TREATMENT AGENTS 审中-公开
标题翻译：喹唑啉和喹啉衍生物作为抑制剂，抑制剂和癌症治疗剂的抑制剂
公开(公告)号：WO2003055866A1
公开(公告)日：2003-07-10
申请号：PCT/US2002/041176
申请日：2002-12-20
申请人： BAYER CORPORATION , DUMAS, Jacques , SIBLEY, Robert , SMITH, Roger , SU, Ning , CHEN, Yuanwei , WOOD, Jill , GUERNON, Leatte , DIXON, Julie , BRENNAN, Catherine , BOYER, Stephen
发明人： DUMAS, Jacques , SIBLEY, Robert , SMITH, Roger , SU, Ning , CHEN, Yuanwei , WOOD, Jill , GUERNON, Leatte , DIXON, Julie , BRENNAN, Catherine , BOYER, Stephen
IPC分类号： C07D239/95
CPC分类号： C07D401/14 , C07D215/42 , C07D231/12 , C07D233/56 , C07D239/95 , C07D249/08 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12
摘要： Quinazoline or quinoline derivatives of formula: (Formula I and II); wherein Z is CH or N; Y is O or S; X is OR 5 or NR 5 R 6 ; R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are as disclosed. Also described is a method for the inhibiting the prolyl peptidase, inducing apoptosis and treating cancer by administering a therapeutically effective amount of compounds of the formula (I) or (II).
摘要翻译：喹唑啉或喹啉衍生物：式（I和II）; 其中Z是CH或N; Y为O或S; X是OR 5或-S 6> 5 6 ; R 1，R 2，R 3，R 4，R 34和R 8各自独立地选自氢， R 6是如所公开的那样。还描述了通过施用治疗有效量的式（I）或（II）的化合物来抑制脯氨酰肽酶，诱导细胞凋亡和治疗癌症的方法。

10. 发明申请

WO2003027096A1 SUBSTITUTED 3-PYRIDYL IMIDAZOLES AS C17,20 LYASE INHIBITORS 审中-公开
标题翻译：作为C17,20 LYASE抑制剂的取代的3-吡啶基咪唑
公开(公告)号：WO2003027096A1
公开(公告)日：2003-04-03
申请号：PCT/US2002/030983
申请日：2002-09-26
申请人： BAYER CORPORATION , HART, Barry , SIBLEY, Robert , DUMAS, Jacques , BIERER, Donald , ZHANG, Chengzhi
发明人： HART, Barry , SIBLEY, Robert , DUMAS, Jacques , BIERER, Donald , ZHANG, Chengzhi
IPC分类号： C07D401/04
CPC分类号： C07D401/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/14 , C07D513/04
摘要： This invention provides 3-pyridyl imidazoles, pharmaceutical compositions containing them, and methods of using these for treatment of cancer.
摘要翻译：本发明提供3-吡啶基咪唑，含有它们的药物组合物，以及使用它们治疗癌症的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式