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    • 3. 发明申请
    • IMPLICIT REGISTRATION FOR IMPROVING SYNTHESIZED FULL-CONTRAST IMAGE PREDICTION TOOL
    • WO2022223383A1
    • 2022-10-27
    • PCT/EP2022/059836
    • 2022-04-13
    • BAYER AKTIENGESELLSCHAFT
    • CORONA, VeronicaPURTORAB, MarvinLORIO, SaraRAMOS DOS SANTOS, Thiago
    • G06T5/50
    • The invention provides a method of training a prediction tool to generate at least one synthetic full-contrast image from zero-contrast and low-contrast images of a subject, the method comprising the steps of: receiving a training set, the training set comprising a set of images of a set of subjects, for each subject of the set of subjects: i) a full-contrast image acquired with a full-contrast agent dose administered to the subject; ii) a low-contrast image acquired with a low-contrast agent dose administered to the subject, where the low-contrast agent dose is less than the full-contrast agent dose; iii) a first zero-contrast image acquired with no contrast agent dose administered to the subject wherein the first zero-contrast image is acquired prior to the acquisition of the full-contrast image; and iv) a second zero-contrast image acquired with no contrast agent dose administered to the subject wherein the second zero-contrast image is acquired prior to the acquisition of the low-contrast image; and training an artificial neural network with the received training set, by applying the first and second zero-contrast images from the set of images and the low-contrast images from the set of images as input to the artificial neural network and using a cost function to compare the output of the artificial neural network with the full-contrast images from the set of images to train parameters of the artificial neural network using backpropagation.