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1. 发明申请

WO1992011815A2 ULTRASONIC ANGIOPLASTY DEVICE INCORPORATING TRANSMISSION MEMBER AND ABLATION PROBE 审中-公开
标题翻译：超声波放射治疗仪
公开(公告)号：WO1992011815A2
公开(公告)日：1992-07-23
申请号：PCT/US1992000136
申请日：1992-01-09
申请人： BAXTER INTERNATIONAL INC. , SONICSTAR INTERNATIONAL, LTD. , SIEGEL, Robert, J.
发明人： BAXTER INTERNATIONAL INC. , SONICSTAR INTERNATIONAL, LTD. , PFLUEGER, Russell , NITA, Henry , BACICH, Steven , BOND, Geoffrey , DE CASTRO, Eugene
IPC分类号： A61B17/22
CPC分类号： A61B17/22012 , A61B18/1206 , A61B2017/00119 , A61B2017/00146 , A61B2017/00849 , A61B2017/00973 , A61B2017/22018 , A61B2017/22039 , A61B2017/22041 , A61B2017/320072 , A61B2017/320088 , A61B2018/00011 , A61B2217/007 , A61F2002/30102 , A61F2210/0042 , A61M3/0279 , A61M2025/0183
摘要： An ultrasonic angioplasty device (10) comprising an elongate ultrasound transmission member (20) having a proximal end attachable to an ultrasound generating device (24) and a bulbous distal head or probe (22) formed on the distal end thereof for effecting ablative treatment of an occluding lesion. The ultrasound transmission member (20) may be formed of one or more superelastic metal alloys such as NiTi (50 at. % Ni). A guidewire lumen (35) may be formed in the distal head or probe (22) to permit passage of a guidewire (34) therethrough. Portions of the ultrasound transmission member (20) may be curved or bent. Portions of the ultrasound transmission member (20) may be tapered or narrowed. One or more surface disruptions (41, 42) may be formed on the distal head or probe (22) to improve treatment efficacy. An increased hardness coating or outer skin (50) may be formed on the ultrasound transmission member (20). The device (10) of the present invention may be incorporated into an angioscopic device (70).

2. 发明申请

WO1993021835A1 ULTRASOUND CATHETER FOR REMOVING OBSTRUCTIONS FROM TUBULAR ANATOMICAL STRUCTURES SUCH AS BLOOD VESSELS 审中-公开
标题翻译：超声波吸管用于从管状解剖结构（如血管）中移除阻塞
公开(公告)号：WO1993021835A1
公开(公告)日：1993-11-11
申请号：PCT/US1993004207
申请日：1993-05-04
申请人： BAXTER INTERNATIONAL INC.
发明人： BAXTER INTERNATIONAL INC. , NITA, Henry , GESSWEIN, Douglas, H. , PASSAFARO, James, D.
IPC分类号： A61B17/22
CPC分类号： A61B17/22012 , A61B17/320758 , A61B90/39 , A61B2017/00101 , A61B2017/00477 , A61B2017/00849 , A61B2017/00867 , A61B2017/22018 , A61B2017/22038 , A61B2017/22039 , A61B2017/22041 , A61B2017/320072 , A61B2017/320088 , A61B2018/00011 , A61B2018/00029 , A61B2217/005 , A61B2217/007 , A61F2002/30093 , A61F2002/30102 , A61F2210/0019 , A61F2210/0042 , A61M3/0279 , A61M2025/0183
摘要： An ultrasound catheter (10) for removing obstructions from tubular anatomic structures such as blood vessels, said catheter comprising an elongate flexible catheter body (20) having an ultrasound transmission member or wire (24) extending longitudinally therethrough. A distal head (26) is formed on the distal end of the ultrasound transmission member or wire (24) and is affixed to the catheter body (20). The ultrasound transmission member or wire may be formed of any material capable of transmitting ultrasonic energy including various superelastic metal alloys such as nickel titanium metal alloys. The distal portion of the ultrasound transmission member or wire (24) may be of reduced diameter to provide enhanced flexibility and/or amplification of the ultrasonic energy through the distal portion of the ultrasound transmission member or wire. A proximal end connector (12) may be provided with a sonic connector to effectively couple the catheter (10) to the ultrasound transducer (14).
摘要翻译：一种用于从管状解剖结构（例如血管）移除障碍物的超声波导管（10），所述导管包括细长的柔性导管主体（20），其具有纵向延伸通过其延伸的超声传递部件或线（24）。远端头部（26）形成在超声波传播构件或线（24）的远端上并且被固定到导管主体（20）。超声波传递部件或导线可以由能够传递超声能量的任何材料形成，包括各种超弹性金属合金如镍钛金属合金。超声波传输构件或导线（24）的远端部分可以具有减小的直径，以通过超声波传输构件或线的远端部分提供超声能量的增强的灵活性和/或放大。近端连接器（12）可以设置有声音连接器以有效地将导管（10）耦合到超声换能器（14）。

3. 发明申请

WO1993008750A2 ULTRASONIC ABLATION DEVICE ADAPTED FOR GUIDEWIRE PASSAGE 审中-公开
标题翻译：适用于指导通过的超声波消除装置
公开(公告)号：WO1993008750A2
公开(公告)日：1993-05-13
申请号：PCT/US1992009452
申请日：1992-11-02
申请人： BAXTER INTERNATIONAL INC.
发明人： BAXTER INTERNATIONAL INC. , NITA, Henry , PFLUEGER, Russell
IPC分类号： A61B17/22
CPC分类号： A61B17/22012 , A61B2017/22038 , A61B2018/00011 , A61F2002/30093 , A61F2210/0019 , A61M2025/0183
摘要： An ultrasonic ablation device for effecting ultrasonic ablation of intravascular obstructions such as plaque or thrombi. The ultrasonic ablation device has a) an elongate catheter body (12), b) a wave guide or ultrasound transmission wire (20) extending through the elongate catheter body (12), and c) a distal head or probe member (22) positioned at the distal end of the catheter body. A guidewire lumen or passageway (14) extends longitudinally through the catheter body (12) and a guidewire aperture or passageway (60) extends through the distal head or probe (22) such that a guidewire (34) may be passed through the distal head or probe (22) and through the catheter body (12). Also disclosed is an improved distal head or probe which may be incorporated in any elongate ultrasonic ablation device, the improvement comprising the formation of a concavity or indentation in the distal or frontal face (23) of the distal head or probe (22) to improve the cavitation created thereby.
摘要翻译：超声消融装置用于超声消融血管内障碍物如斑块或血栓。所述超声波消融装置具有：a）细长的导管主体（12），b）延伸穿过细长导管主体（12）的波导或超声波传输线（20），以及c）远端头部或探针部件在导管主体的远端处。导丝管腔或通道（14）纵向延伸穿过导管主体（12），并且导丝孔或通道（60）延伸通过远端头部或探针（22），使得导丝（34）可以穿过远端头部或探头（22）并穿过导管主体（12）。还公开了可以结合在任何细长超声波消融装置中的改进的远端头部或探针，改进包括在远端头部或探针（22）的远端或正面（23）中形成凹陷或凹陷以改善由此产生的气蚀。

4. 发明申请

WO1995010233A1 ULTRASOUND TRANSMISSION MEMBER HAVING IMPROVED LONGITUDINAL TRANSMISSION PROPERTIES 审中-公开
标题翻译：超声波传输成员具有改进的纵向传输特性
公开(公告)号：WO1995010233A1
公开(公告)日：1995-04-20
申请号：PCT/US1994011550
申请日：1994-10-11
申请人： BAXTER INTERNATIONAL INC.
发明人： BAXTER INTERNATIONAL INC. , NITA, Henry
IPC分类号： A61B17/22
CPC分类号： G10K11/24 , A61B17/22012 , A61B2017/00849 , A61B2017/22018 , A61B2017/22039 , A61B2017/22041 , A61B2017/320072 , A61B2017/320088 , A61B2018/00011 , A61F2002/30102 , A61F2210/0042 , A61M2025/0183
摘要： An elongate ultrasound transmission member (22) having regions (26, 28, 30, 32) of differing cross-sectional dimension or diameter. A sleeve, sheath or other damping member (40) may be positioned around a portion (30) of the ultrasound transmission member (22) to dampen or limit transverse side-to-side movement of such portion (30) of the member (22). The ultrasound transmission member (22) may be incorporated into a flexible catheter body (20) to form an ultrasound delivering medical catheter (10).
摘要翻译：具有不同横截面尺寸或直径的区域（26,28,30,32）的细长超声波传递构件（22）。套筒，鞘或其它阻尼构件（40）可围绕超声波传播构件（22）的一部分（30）定位，以阻尼或限制构件（22）的这种部分（30）的横向侧向运动）。超声波传输构件（22）可以结合到柔性导管体（20）中以形成超声波输送医疗导管（10）。

5. 发明申请

WO1995009572A1 ULTRASOUND CATHETER SYSTEM HAVING MODULATED OUTPUT WITH FEEDBACK CONTROL 审中-公开
标题翻译：具有反馈控制的调制输出超声波导管系统
公开(公告)号：WO1995009572A1
公开(公告)日：1995-04-13
申请号：PCT/US1994011060
申请日：1994-09-30
申请人： BAXTER INTERNATIONAL INC.
发明人： BAXTER INTERNATIONAL INC. , MILLS, Timothy, C. , NITA, Henry
IPC分类号： A61B17/22
CPC分类号： A61B17/22012 , A61B18/1206 , A61B2017/00119 , A61B2017/00146 , A61B2017/00849 , A61B2017/00973 , A61B2017/22039 , A61B2017/22041 , A61B2017/320072 , A61B2018/00011 , A61B2217/007 , A61F2002/30102 , A61F2210/0042 , A61M3/0279 , A61M2025/0183
摘要： A method and apparatus for driving an ultrasound transducer (14) coupled to an ultrasound transmission disposed within an elongate catheter (10) has a modulated output and utilizes feedback control. A modulating signal varying in amplitude and continuous in duration modulates an ultrasound transducer drive signal. The resulting modulated ultrasound transducer drive signal is likewise continuous in duration such that it lacks the abrupt accelerations which cause stress to be applied to the ultrasound transmission member in prior art devices. The current of the modulated drive signal is monitored and the voltage thereof is varied in response to changes in the current in order to provide feedback control. A transmission member breakage alarm provides an indication of transmission member breakage in the event that any comparison of the drive energy to the feedback control signal indicates that the desired ultrasonic vibration has been reached at a drive energy level less than the minimum drive energy level typically desired for such desired ultrasound vibration when the ultrasound transmission member is intact.
摘要翻译：用于驱动耦合到设置在细长导管（10）内的超声波传感器的超声换能器（14）的方法和装置具有调制输出并利用反馈控制。振幅变化和持续时间的调制信号调制超声波换能器驱动信号。所产生的调制的超声换能器驱动信号同样是持续的持续时间，使得它缺少突然的加速度，这导致应力施加到现有技术的装置中的超声波传递部件。监测调制驱动信号的电流，并且其电压响应于电流的变化而变化，以提供反馈控制。传动构件断裂警报提供传动构件断裂的指示，在驱动能量与反馈控制信号的任何比较表明在达到通常期望的最小驱动能级的驱动能级下达到期望的超声波振动的情况下用于当超声波传递部件完整时所需的超声波振动。

6. 发明申请

WO1995009571A1 ULTRASONIC GUIDEWIRE 审中-公开
标题翻译：超声波指南
公开(公告)号：WO1995009571A1
公开(公告)日：1995-04-13
申请号：PCT/US1994010925
申请日：1994-09-27
申请人： BAXTER INTERNATIONAL INC.
发明人： BAXTER INTERNATIONAL INC. , NITA, Henry , GESSWEIN, Douglas, H. , WANG, John, H. , MILLS, Timothy, C.
IPC分类号： A61B17/22
CPC分类号： A61B17/22012 , A61B2017/22038 , A61M25/09041
摘要： An ultrasonic guidewire (14) insertable into a mammalian body for purposes of guiding a medical catheter, scope or other medical device into the body and, additionally, connectable to an external ultrasound generating source (20) to transmit ultrasonic energy into the body. The invention includes methods of using the ultrasonic guidewire for purposes of ablating obstructive matter in a blood vessel or other body cavity and/or for delivering ultrasonic energy to treat vasospasm or muscular spasms with the body.
摘要翻译：超声波导丝（14）可插入到哺乳动物体内，用于将医用导管，范围或其他医疗装置引导到体内，并且另外可连接到外部超声波产生源（20）以将超声波能量传递到体内。本发明包括使用超声波导丝的方法，用于消除血管或其它体腔中的阻塞物质和/或用于输送超声能量以治疗与体内的血管痉挛或肌肉痉挛。

7. 发明申请

WO1995008954A1 METHOD AND DEVICE FOR CONNECTING ULTRASOUND TRANSMISSION MEMBER(S) TO AN ULTRASOUND GENERATING DEVICE 审中-公开
标题翻译：用于将超声波传输部件连接到超声波发生装置的方法和装置
公开(公告)号：WO1995008954A1
公开(公告)日：1995-04-06
申请号：PCT/US1994011274
申请日：1994-09-26
申请人： BAXTER INTERNATIONAL INC.
发明人： BAXTER INTERNATIONAL INC. , NITA, Henry , MILLS, Timothy, C.
IPC分类号： A61B17/22
CPC分类号： A61B17/22012 , A61B17/320758 , A61B90/39 , A61B2017/00101 , A61B2017/00477 , A61B2017/00849 , A61B2017/00867 , A61B2017/22014 , A61B2017/22018 , A61B2017/22038 , A61B2017/22039 , A61B2017/320088 , A61B2018/00029 , A61B2217/005 , A61B2217/007 , A61F2002/30092 , A61F2002/30102 , A61F2210/0014 , A61F2210/0042 , A61M3/0279 , A61M2025/0183
摘要： An ultrasound catheter (10) for removing obstructions from tubular anatomic structures such as blood vessels, said catheter comprising an elongate flexible catheter body (20) having an ultrasound transmission member or wire (24) extending longitudinally therethrough. A distal head (26) is formed on the distal end member of the ultrasound transmission member or wire (24) and is affixed to the catheter body (20). The ultrasound transmission member or wire may be formed of any material capable of transmitting ultrasonic energy including various superelastic metal alloys such as nickel titanium metal alloys. The distal portion of the ultrasound transmission member or wire (24) may be of reduced diameter to provide enhanced flexibility and/or amplification of the ultrasonic energy through the distal portion of the ultrasound transmission member or wire. A proximal end member connector (12) may be provided with a sonic connector to effectively couple the catheter (10) to the ultrasound transducer (14).
摘要翻译：一种用于从管状解剖结构（例如血管）移除障碍物的超声波导管（10），所述导管包括细长的柔性导管主体（20），其具有纵向穿过其中延伸的超声波传播部件或线（24）。远端头部（26）形成在超声波传播构件或线（24）的远端构件上并且固定到导管主体（20）。超声波传递部件或导线可以由能够传递超声能量的任何材料形成，包括各种超弹性金属合金如镍钛金属合金。超声波传输构件或导线（24）的远端部分可以具有减小的直径，以通过超声波传输构件或线的远端部分提供超声能量的增强的灵活性和/或放大。近端构件连接器（12）可以设置有声音连接器以有效地将导管（10）耦合到超声换能器（14）。

8. 发明申请

WO1994001047A1 ULTRASONIC ANGIOPLASTY AND ABLATIVE DEVICES FOR TREATING VASOSPASM 审中-公开
标题翻译：用于治疗VASOSPASM的超声波放射治疗装置
公开(公告)号：WO1994001047A1
公开(公告)日：1994-01-20
申请号：PCT/US1993006320
申请日：1993-07-02
申请人： BAXTER INTERNATIONAL INC.
发明人： BAXTER INTERNATIONAL INC. , PASSAFARO, James, D. , NITA, Henry , SIEGEL, Robert, J. , GESSWEIN, Douglas, H.
IPC分类号： A61B17/22
CPC分类号： A61B17/22012 , A61B17/320758 , A61B18/245 , A61B90/39 , A61B2017/00101 , A61B2017/00477 , A61B2017/00849 , A61B2017/00867 , A61B2017/22018 , A61B2017/22038 , A61B2017/22039 , A61B2017/22041 , A61B2017/320072 , A61B2017/320088 , A61B2018/00011 , A61B2018/00029 , A61B2217/005 , A61B2217/007 , A61F2002/30102 , A61F2210/0042 , A61M3/0279 , A61M25/104 , A61M2025/0183
摘要： A catheter device (10) incorporating combined ultrasound ablation and balloon dilation components. The catheter device (10) generally comprises an elongate catheter body (12) having proximal and distal ends (14, 16) and an outer surface (18). Disposed on the outer surface (18) of the catheter body (12) is a dilation balloon (98). At least one balloon inflation lumen (70) fluidly connects the proximal end (14) of the catheter body (12) to the dilation balloon (98) to permit injection of inflation fluid into the dilation balloon (98). Extending longitudinally through the catheter body (12) is an ultrasound transmission member (28) having a proximal end and a distal end (30), with the proximal end being connectable to an ultrasound transducer (22) such that ultrasonic energy will pass through the ultrasound transmission member (28) to the distal end (30) thereof. In alternative embodiments of the present invention, there are provided catheter devices incorporating combined ultrasound ablation and laser ablation components as well as combined ultrasound ablation and atherectomy ablation components.
摘要翻译：导管装置（10），其结合了超声消融和球囊扩张部件。导管装置（10）通常包括具有近端和远端（14,16）和外表面（18）的细长导管本体（12）。设置在导管体（12）的外表面（18）上的是膨胀气球（98）。至少一个球囊充气腔（70）将导管主体（12）的近端（14）流体地连接到扩张气囊（98），以允许将充气流体注射到扩张气囊（98）中。纵向延伸穿过导管主体（12）的是具有近端和远端（30）的超声波传输构件（28），其中近端可连接到超声换能器（22），使得超声能量将通过超声波传递构件（28）到其远端（30）。在本发明的替代实施例中，提供了包括组合的超声消融和激光消融部件以及组合的超声消融和粥样斑块切除术消融部件的导管装置。

9. 发明申请

WO1992015357A1 METHOD AND DEVICE FOR EXCHANGING CARDIOVASCULAR GUIDE CATHETER WHILE A PREVIOUSLY INSERTED ANGIOPLASTY GUIDE WIRE REMAINS IN PLACE 审中-公开
标题翻译：方法和装置，用于在以前插入的放射治疗指南中替换心脏导管导管
公开(公告)号：WO1992015357A1
公开(公告)日：1992-09-17
申请号：PCT/US1992001477
申请日：1992-02-27
申请人： BAXTER INTERNATIONAL INC. , TEIRSTEIN, Paul, S.
发明人： BAXTER INTERNATIONAL INC. , NITA, Henry , DHUWALIA, Jagdish, C. , EVANS, Scott
IPC分类号： A61M25/01
CPC分类号： A61M25/0169 , A61M25/104
摘要： A method and device for removing a first guide catheter (10) and replacing said first guide catheter with a second guide catheter (10a), without disturbing the placement of a flexible guide wire (32) which has previously been inserted through the first guide catheter. The device of the invention comprises an 'exchange catheter' (58) which may be advanced over the outer surface of the pre-positioned guide wire to provide support and shielding of the guide wire during the catheter exchange procedure. A guide wire exit aperture (74) formed in the 'exchange catheter' permits the guide wire to exit the exchange catheter at a location whereby the operator may hold and manipulate the guide wire to maintain its desired position during the catheter exchange procedure.

10. 发明申请

WO1992015356A1 CARDIOVASCULAR CATHETER HAVING DISCRETE REGIONS OF VARYING FLEXIBILITY 审中-公开
标题翻译：具有变化灵活性的离散区域的心血管
公开(公告)号：WO1992015356A1
公开(公告)日：1992-09-17
申请号：PCT/US1992001590
申请日：1992-02-27
申请人： BAXTER INTERNATIONAL INC.
发明人： BAXTER INTERNATIONAL INC. , NITA, Henry , GUNDERMAN, Fred, L. , DHUWALIA, Jagdish, C.
IPC分类号： A61M25/00
CPC分类号： A61M25/0054
摘要： A flexible cardiovascular catheter (10a) at least a first proximal section, (54a) a second intermediate section (56a) which is more flexible than the first proximal section and a third distal section (58a) which is more flexible than the second intermediate section. The second intermediate section (56a) is of constant rigidity along its entire length. Curvatures may be formed in the catheter to facilitate insertion and positioning of the catheter in desired blood vessels. Presently preferred embodiments of the catheter are particularly usable as coronary artery guiding catheters or coronary angiography catheters.
摘要翻译：柔性心血管导管（10a）至少第一近端部分（54a）比第一近端部分更柔性的第二中间部分（56a）和比第二中间部分更柔性的第三远端部分（58a）。第二中间部分（56a）沿其整个长度具有恒定的刚度。可以在导管中形成曲率，以便于将导管插入和定位在期望的血管中。导管的当前优选实施例特别可用作冠状动脉引导导管或冠状动脉造影导管。

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