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1. 发明申请

WO1995006112A1 IN VITRO GROWTH OF NEUTROPHIL AND MEGAKARYOCYTE PRECURSORS IN SERUM-FREE MEDIA 审中-公开
标题翻译：在无血清培养基中的中性粒细胞和巨细胞前体的体外生长
公开(公告)号：WO1995006112A1
公开(公告)日：1995-03-02
申请号：PCT/US1994009622
申请日：1994-08-23
申请人： BAXTER INTERNATIONAL INC.
发明人： BAXTER INTERNATIONAL INC. , SMITH, Stephen, L. , QIAO, Xiaoying , MACIUKAS, Susan, M. , BENDER, James, G. , VAN EPPS, Dennis, E. , LOUDOVARIS, Maureen, F.
IPC分类号： C12N05/08
CPC分类号： C12N5/0644 , A61K35/12 , C12N5/0642 , C12N2500/25 , C12N2500/36 , C12N2500/44 , C12N2500/90 , C12N2500/98 , C12N2501/125 , C12N2501/22 , C12N2501/23 , C12N2501/39
摘要： The invention provides serum-free, animal protein-free media formulations to be used in conjunction with hematopoietic growth factors for the in vitro growth of human neutrophil and megakaryocyte precursors. The medium is comprised of a base medium, corticosteroid, transferrin, insulin, cholesterol, ethanolamine, and human albumin. The invention also provides methods for preparing serum-free, animal protein-free suspensions of human hematopoietic precursor cells wherein the cellular component comprises at least about 16 % neutrophil precursors and at least about 1 % megakaryocyte precursors. Serum-free, animal protein-free suspensions of human hematopoietic cells are provided wherein the cellular component comprises at least about 30 %, preferably greater than 60 % neutrophil precursors. The neutrophil precursors are comprised of blast cells, promyelocytes, neutrophilic myelocytes, and neutrophilic metamyelocytes. Also provided are serum-free, animal protein-free cell suspensions wherein the cellular component comprises at least about 3 %, preferably greater than 8 % megakaryocyte precursors. Also provided are serum-free, animal-protein free cell suspensions wherein the cellular component comprises colony-forming units and cluster-forming units.
摘要翻译：本发明提供了与造血生长因子结合使用的无血清，无动物蛋白质的培养基制剂，用于人嗜中性粒细胞和巨核细胞前体的体外生长。培养基由基础培养基，皮质类固醇，转铁蛋白，胰岛素，胆固醇，乙醇胺和人白蛋白组成。本发明还提供了制备人类造血前体细胞的无血清，无动物蛋白质的悬浮液的方法，其中细胞组分包含至少约16％的嗜中性粒细胞前体和至少约1％的巨核细胞前体。提供人造血细胞的无血清，不含动物蛋白的悬浮液，其中细胞组分包含至少约30％，优选大于60％的嗜中性粒细胞前体。中性粒细胞前体由胚细胞，前髓细胞，嗜中性粒细胞和嗜中性粒细胞组成。还提供了无血清，无动物蛋白的细胞悬浮液，其中细胞组分包含至少约3％，优选大于8％的巨核细胞前体。还提供了无血清，无动物蛋白质的细胞悬浮液，其中细胞组分包含集落形成单位和簇形成单位。

2. 发明申请

WO2011085301A1 BIOMATRICES TO ATTRACT AND RETAIN REGENERATIVE AND REPARATIVE CELLS 审中-公开
标题翻译：诱导和保留再生细胞和再生细胞的生物活性
公开(公告)号：WO2011085301A1
公开(公告)日：2011-07-14
申请号：PCT/US2011/020660
申请日：2011-01-10
申请人： BAXTER INTERNATIONAL INC. , BAXTER HEALTHCARE S.A. , SMITH, Stephen, L. , CAMPO, Loredana , CAMPBELL, Jennifer , WALLACH, Shiri, Uriel , SEYTON, Wanda , DONOVAN, Shane
发明人： SMITH, Stephen, L. , CAMPO, Loredana , CAMPBELL, Jennifer , WALLACH, Shiri, Uriel , SEYTON, Wanda , DONOVAN, Shane
IPC分类号： A61K38/18 , A61K47/42 , A61L24/10 , A61P9/10
CPC分类号： A61K38/18 , A61K38/195 , A61K38/363 , A61K38/4833 , A61L24/0015 , A61L24/106 , A61L2300/252 , A61K38/00
摘要： The invention relates to a pharmaceutical composition which comprises a fibrin clot and a cytokine and methods of delivering the composition to a site of disease or injury in vivo to attract and retain regenerative or reparative stem or myeloid cells and their differentiated progeny.
摘要翻译：本发明涉及包含纤维蛋白凝块和细胞因子的药物组合物以及将组合物递送至体内疾病或损伤部位以吸引并保留再生或修复性干细胞或骨髓细胞及其分化后代的方法。

3. 发明申请

WO1997011233A1 APPARATUS FOR CARRYING FLEXIBLE CONTAINERS AND METHOD OF TRANSFERRING FLUIDS TO CONTAINERS 审中-公开
标题翻译：携带柔性容器的装置和将流体输送到容器的方法
公开(公告)号：WO1997011233A1
公开(公告)日：1997-03-27
申请号：PCT/US1996014505
申请日：1996-09-09
申请人： BAXTER INTERNATIONAL INC.
发明人： BAXTER INTERNATIONAL INC. , SMITH, Stephen, L. , BENDER, James, A. , MARTINSON, Jeffrey , LOUDOVARIS, Maureen , MITSVEN, Orrin, D., Jr. , UNVERZAGT, Kristen
IPC分类号： E03B01/00
CPC分类号： A61J1/1462 , A61J1/16 , A61J3/002 , Y10S435/809
摘要： The present invention provides an apparatus for holding and carrying a plurality of flexible medical containers (15). The carrier has a rack (10) having a plurality of plates (12) positioned in parallel spaced relation, the plates (12) defining a chamber between each pair of adjacent plates (12). A plurality of spacer assemblies (18) each extend through the rack (10) to connect the plates (12) and to maintain their spaced relationship. The spacer assemblies (18) are spaced along marginal edges of the rack (10) to define two opposed end walls (20), a bottom (22), and an opening (24) to the rack to allow access to each of the chambers. A flange (25) extends from one of the plates (12) and has a hole (27) that allows the carrier to be suspended. The invention further provides for a system for transferring fluids and a method for mixing solutions using the carrier.
摘要翻译：本发明提供一种用于保持和携带多个柔性医疗容器（15）的装置。载体具有一个具有以平行间隔的关系定位的多个板（12）的齿条（10），所述板（12）在每对相邻的板（12）之间限定一个室。多个间隔件组件（18）各自延伸通过齿条（10）以连接板（12）并保持它们的间隔关系。间隔件组件（18）沿着齿条（10）的边缘边缘间隔开，以限定两个相对的端壁（20），底部（22）和到机架的开口（24），以允许进入每个室。一个凸缘（25）从其中一个板（12）延伸并具有允许托架悬挂的孔（27）。本发明还提供一种用于输送流体的系统和一种使用该载体混合溶液的方法。

4. 发明申请

WO1998006826A1 DENDRITIC CELLS PRODUCED IN SERUM-FREE CULTURE 审中-公开
标题翻译：在无血清培养物中生产的细胞
公开(公告)号：WO1998006826A1
公开(公告)日：1998-02-19
申请号：PCT/US1997014383
申请日：1997-08-13
申请人： BAXTER INTERNATIONAL INC.
发明人： BAXTER INTERNATIONAL INC. , VACHULA, Mona , ALZONA, Mortimer, T. , AONO, Frederick, M. , KOWALKOWSKI, Kenneth, L. , SMITH, Stephen, L. , UNVERZAGT, Kristen, L. , VAN EPPS, Dennis, E.
IPC分类号： C12N05/08
CPC分类号： C12N5/0639 , A61K38/00 , A61K2039/5154 , A61K2039/5158 , C12N2500/05 , C12N2500/14 , C12N2500/36 , C12N2500/38 , C12N2500/90 , C12N2501/01 , C12N2501/02 , C12N2501/125 , C12N2501/22 , C12N2501/25 , C12N2501/515
摘要： A method for producing human dendritic cells (DC) for therapeutic purposes using serum-free, animal protein-free medium. The method involves culturing mononuclear cells from peripheral or umbilical cord blood or bone marrow of an individual human donor in a culture container having at least one inner surface of polystyrene in the above described medium containing at least one hematopoietic growth factor, and maintaining the culture to produce a culture enriched for DC. The DC enrichment is evidenced by at least about 10% of the total cells in the culture exhibiting DC processes, or at least 2.5 % of the total cells expressing at least one DC antigen such as CD80, CD86, or CD1a. The culture method is preferably carried out in a gas-permeable container in a closed fluid path system. The DC so produced can be pulsed with an antigen such as a viral, bacterial, tumor, or cell surface antigen, and the resulting primed dendritic cells can be co-cultured with T cells to produce antigen-specific human T-cells for therapeutic use. Useful for treatment of viral or bacterial infections, useful as a cancer vaccine, useful to induce tolerance when transplant of allo- or xeno-graft cells or organ is intended.
摘要翻译：用于使用无血清，无动物蛋白质的培养基用于治疗目的的人树突状细胞（DC）的制备方法。该方法包括在含有至少一种造血生长因子的上述培养基中具有聚苯乙烯的至少一个内表面的培养容器中培养单个人供体的外周或脐带血或骨髓的单核细胞，并将培养物保持生产富含DC的培养基。 DC富集由显示DC过程的培养物中的总细胞的至少约10％或表达至少一种DC抗原如CD80，CD86或CD1a的总细胞的至少2.5％来证明。培养方法优选在封闭流体路径系统中的透气性容器中进行。如此产生的DC可用诸如病毒，细菌，肿瘤或细胞表面抗原的抗原脉冲，并且所得引发的树突状细胞可与T细胞共培养以产生用于治疗用途的抗原特异性人T细胞。用于治疗病毒或细菌感染，可用作癌症疫苗，用于诱导同种异体移植或异种移植细胞或器官移植时的耐受性。

5. 发明申请

WO1996013573A1 MULTI-LAYER GAS-PERMEABLE CONTAINER FOR THE CULTURE OF ADHERENT AND NON-ADHERENT CELLS 审中-公开
标题翻译：多层气体渗透性容器，用于培养独立和非附着细胞
公开(公告)号：WO1996013573A1
公开(公告)日：1996-05-09
申请号：PCT/US1995013943
申请日：1995-10-27
申请人： BAXTER INTERNATIONAL INC.
发明人： BAXTER INTERNATIONAL INC. , SMITH, Sidney, T. , BACEHOWSKI, David, V. , KOLANKO, William , ROSENBAUM, Larry , SMITH, Stephen, L.
IPC分类号： C12M03/06
CPC分类号： C12M23/14 , C12M23/24
摘要： A multi-layer, flexible, gas-permeable film (10) suitable for forming a cell culture container (20), the film (10) comprising a first layer (12) composed of a polystyrene having a thickness within the range of 0.0001 inch to about 0.0010 inch and, a second layer (14) adhered to the first layer (12) composed of a polymer material having a thickness within the range of 0.004 inch to about 0.025 inch.
摘要翻译：一种适用于形成细胞培养容器（20）的多层柔性透气薄膜（10），该薄膜（10）包括由厚度在0.0001英寸范围内的聚苯乙烯构成的第一层（12）至约0.0010英寸，以及粘附到第一层（12）的第二层（14），所述第一层（12）由厚度在0.004英寸至约0.025英寸范围内的聚合物材料构成。

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