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1. 发明申请

WO2005089772A2 PREVENTION OF LOSS OF TIGHT CELL JUNCTIONS USING CARBOHYDRATE-CONTAINING COMPOSITIONS 审中-公开
标题翻译：使用含有含碳酸酯的组合物防止细胞细胞连接的损失
公开(公告)号：WO2005089772A2
公开(公告)日：2005-09-29
申请号：PCT/US2005/008333
申请日：2005-03-11
申请人： BAUSCH & LOMB INCORPORATED , XIA, Erning , SALAMONE, Joseph, C. , MCCANNA, David, J.
发明人： XIA, Erning , SALAMONE, Joseph, C. , MCCANNA, David, J.
IPC分类号： A61K31/70
CPC分类号： A61K31/70 , A61K31/7004 , A61K31/7016 , A61K31/702 , A61K31/715 , A61K31/717 , A61K31/721 , A61K31/723 , A61K31/726 , A61K31/728 , A61K31/729 , A61K31/731 , A61K31/732 , A61K31/734 , A61K31/736 , C11D3/0078 , C11D3/222
摘要： Compositions are described which are useful in preventing the loss of tight epithelial cell junctions upon topical application. Such compositions include one or more carbohydrates in an amount effective to prevent the loss of tight cell junctions and hence improve the management of tissue health.
摘要翻译：描述了可用于在局部施用时防止紧密上皮细胞连接丧失的组合物。这样的组合物包括一种或多种碳水化合物，其量有效地防止紧密细胞连接的丧失，从而改善组织健康的管理。

2. 发明申请

WO2007084975A1 IMPROVING DISINFECTION EFFICACY OF LENS CARE REGIMEN FOR RIGID GAS PERMEABLE CONTACT LENSES 审中-公开
标题翻译：提高刚性透气接触镜的镜片护理程序的消毒效果
公开(公告)号：WO2007084975A1
公开(公告)日：2007-07-26
申请号：PCT/US2007/060751
申请日：2007-01-19
申请人： BAUSCH & LOMB INCORPORATED , XIA, Erning , SALAMONE, Joseph, C. , AMMON, Daniel, M. , BORAZJANI, Roya, N.
发明人： XIA, Erning , SALAMONE, Joseph, C. , AMMON, Daniel, M. , BORAZJANI, Roya, N.
IPC分类号： A61L12/14 , C11D3/00
CPC分类号： C11D3/0078 , A61K9/0048 , A61K31/155 , A61K31/765 , A61K47/10 , A61K47/34 , A61L12/08 , A61L12/142 , C11D1/008 , C11D1/825 , C11D3/30 , C11D3/3707 , C11D3/48
摘要： A rigid gas permeable lens care composition. The composition includes a disinfecting amount of at least one biguanide antimicrobial agent and a straight chain polyether surfactant based upon PEO-PPO-PEO, PPO-PEO-PPO and combinations thereof. In one embodiment, the straight chain polyether surfactant has an HLB value of less than or equal to 15 and an average molecular weight value of between about 5000 and 7000. Preferably, no rubbing is required to disinfect the rigid gas permeable contact lenses is required. Methods of making and using the same are also described.
摘要翻译：刚性透气透镜护理组合物。该组合物包含消毒量的至少一种双胍抗微生物剂和基于PEO-PPO-PEO，PPO-PEO-PPO及其组合的直链聚醚表面活性剂。在一个实施方案中，直链聚醚表面活性剂的HLB值小于或等于15，平均分子量值在约5000和7000之间。优选地，需要摩擦以消毒刚性透气性隐形眼镜。还描述了制备和使用它们的方法。

3. 发明申请

WO2006132870A1 OPHTHALMIC SOLUTION WITH A FLAVORING AGENT 审中-公开
标题翻译：带有变色剂的眼用溶液
公开(公告)号：WO2006132870A1
公开(公告)日：2006-12-14
申请号：PCT/US2006/021037
申请日：2006-05-31
申请人： BAUSCH & LOMB INCORPORATED , SALAMONE, Joseph, C. , XIA, Erning
发明人： SALAMONE, Joseph, C. , XIA, Erning
IPC分类号： A61K9/08 , A61K47/26 , A61K31/415 , A61K31/4402 , A61K31/498
CPC分类号： A61K31/415 , A61K9/0048 , A61K31/00 , A61K31/4402 , A61K31/498 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/26 , A61K47/34 , A61K47/36 , A61K47/44 , A61L12/14
摘要： The invention provides an ophthalmic solution with at least one flavoring agent to mask flavors in the solution or add flavor to the solution. The flavoring agent can be a sweet flavoring agent (sweetener), or combinations of a sweetener with a sour flavoring agent or a bitter flavoring agent or mixtures thereof. The flavoring agent may also be natural flavors, natural fruit flavors, artificial flavors, artificial fruit flavors, flavor enhancers and mixtures thereof, which may be combined with a sweetener, a sour flavoring agent, a bitter flavoring agent, and mixtures thereof. The invention may be utilized as a contact lens solution, an eye drop formulation, and a pharmaceutical composition containing at least one active pharmaceutical ingredient for the treatment of eye diseases.
摘要翻译：本发明提供了一种具有至少一种调味剂的眼用溶液，以掩盖溶液中的味道或向溶液中添加风味。调味剂可以是甜味调味剂（甜味剂）或甜味剂与酸味调味剂或苦味调味剂或其混合物的组合。调味剂还可以是天然香料，天然水果香料，人造香料，人造水果香料，风味增强剂及其混合物，其可与甜味剂，酸味调味剂，苦味调味剂及其混合物组合。本发明可以用作隐形眼镜溶液，滴眼剂制剂和含有至少一种用于治疗眼部疾病的活性药物成分的药物组合物。

4. 发明申请

WO2005115487A1 ENHANCED DISINFECTING COMPOSITIONS FOR MEDICAL DEVICE TREATMENTS 审中-公开
标题翻译：用于医疗器械治疗的增强消毒组合物
公开(公告)号：WO2005115487A1
公开(公告)日：2005-12-08
申请号：PCT/US2005/016181
申请日：2005-05-10
申请人： BAUSCH & LOMB INCORPORATED , XIA, Erning , SALAMONE, Joseph, C.
发明人： XIA, Erning , SALAMONE, Joseph, C.
IPC分类号： A61L12/14
CPC分类号： A61L12/141 , A01N33/12 , A01N47/44 , A61K31/155 , A61L12/142 , A61L12/143 , C11D3/48 , A01N33/08 , A01N61/00 , A01N2300/00
摘要： The use of one or more compositions of one or more disinfecting agents at a relatively high pH to disinfect contact lenses and preserve ophthalmic lens compositions is described. Ophthalmic lens solutions containing one or more compositions of one or more disinfecting agents at a relatively high pH and methods of making and using the same are also described.
摘要翻译：描述了在相对高的pH下使用一种或多种一种或多种消毒剂组合物来消毒隐形眼镜并保护眼用透镜组合物。还描述了在相对高的pH下含有一种或多种一种或多种消毒剂组合物的眼科晶状体溶液，以及制备和使用它们的方法。

5. 发明申请

WO2005097067A1 ZINC PRESERVATIVE COMPOSITION AND METHOD OF USE 审中-公开
标题翻译： ZINC保存组合物及其使用方法
公开(公告)号：WO2005097067A1
公开(公告)日：2005-10-20
申请号：PCT/US2005/009742
申请日：2005-03-24
申请人： BAUSCH & LOMB INCORPORATED , XIA, Erning , SALAMONE, Joseph, C. , BORAZJANI, Roya, N.
发明人： XIA, Erning , SALAMONE, Joseph, C. , BORAZJANI, Roya, N.
IPC分类号： A61K9/00
CPC分类号： A61K9/0048 , A01N59/16 , Y02A50/473 , A01N33/12 , A01N2300/00
摘要： The present invention is a composition comprising a preservative-effective amount of a zinc compound and less than a preservative-effective amount of a primary preservative agent--preferably no primary preservative agent. In one aspect of the present invention, there is a method of enhancing an ophthalmic composition, process for making a composition and a method of treating a patient using one or more compositions according to the present invention.
摘要翻译：本发明是一种组合物，其含有防腐剂有效量的锌化合物，并且小于防腐剂有效量的初级防腐剂 - 优选不含初级防腐剂。在本发明的一个方面，提供一种增强眼用组合物的方法，制备组合物的方法和使用根据本发明的一种或多种组合物治疗患者的方法。

6. 发明申请

WO2005053759A1 GENTLE PRESERVATIVE COMPOSITIONS FOR SELF-PRESERVING SOLUTIONS 审中-公开
标题翻译：用于自我保存解决方案的GENTLE防腐剂组合物
公开(公告)号：WO2005053759A1
公开(公告)日：2005-06-16
申请号：PCT/US2004/039923
申请日：2004-11-29
申请人： BAUSCH & LOMB INCORPORATED , XIA, Erning , SALAMONE, Joseph, C.
发明人： XIA, Erning , SALAMONE, Joseph, C.
IPC分类号： A61L12/08
CPC分类号： C11D3/48 , A01N43/16 , A61L12/08 , A61L12/143 , C11D3/0078 , C11D3/227
摘要： Compositions are described which are useful in preserving any topically applied solution. Compositions including one or more cationic polysaccharides in solution in an amount effective to preserve contact lenses are also described, as well as methods of making and using such solutions.
摘要翻译：描述了可用于保存任何局部施用的溶液的组合物。还描述了包含一种或多种有效保护隐形眼镜的量的溶液中的阳离子多糖的组合物，以及制备和使用这些溶液的方法。

7. 发明申请

WO2006132868A1 OPHTHALMIC SOLUTION WITH A FLAVORING AGENT AS A DOSING INDICATOR AND METHOD FOR INDICATING DOSAGE OF AN OPHTHALMIC SOLUTION 审中-公开
标题翻译：具有作为剂量指示剂的挥发剂的光学溶液和用于指示眼药水的剂量的方法
公开(公告)号：WO2006132868A1
公开(公告)日：2006-12-14
申请号：PCT/US2006/021035
申请日：2006-05-31
申请人： BAUSCH & LOMB INCORPORATED , XIA, Erning , SALAMONE, Joseph, C.
发明人： XIA, Erning , SALAMONE, Joseph, C.
IPC分类号： A61K9/08 , A61K47/26 , A61K31/415 , A61K31/4402 , A61K31/498
CPC分类号： A61K31/415 , A61K9/0048 , A61K31/4402 , A61K31/498 , A61L12/141
摘要： The invention provides an ophthalmic solution with a flavoring agent as a dosing indicator and a method for indicating dosage of an ophthalmic solution. To indicate dosage, a flavoring agent is added to an ophthalmic solution in an amount correlated to the dosage of the ophthalmic solution to be used. The flavoring agent can be a sweet flavoring agent (sweetener), or combinations of a sweetener with a sour flavoring agent or a bitter flavoring agent or mixtures thereof. The flavoring agent may also be natural flavors, natural fruit flavors, artificial flavors, artificial fruit flavors, flavor enhancers and mixtures thereof, which may be combined with a sweetener, a sour flavoring agent, a bitter flavoring agent, and mixtures thereof. The invention may be utilized as a contact lens solution, an eye drop formulation, and a pharmaceutical composition containing at least one active pharmaceutical ingredient for the treatment of eye diseases. The invention also provides to a method of administering a dose of an ophthalmic solution to the person's eye.
摘要翻译：本发明提供了一种具有调味剂作为剂量指示剂的眼用溶液和用于指示眼用溶液剂量的方法。为了表示剂量，将调味剂以与所使用的眼用溶液的剂量相关的量加入到眼用溶液中。调味剂可以是甜味调味剂（甜味剂）或甜味剂与酸味调味剂或苦味调味剂或其混合物的组合。调味剂还可以是天然香料，天然水果香料，人造香料，人造水果香料，风味增强剂及其混合物，其可与甜味剂，酸味调味剂，苦味调味剂及其混合物组合。本发明可以用作隐形眼镜溶液，滴眼剂制剂和含有至少一种用于治疗眼部疾病的活性药物成分的药物组合物。本发明还提供了向眼睛施用眼用溶液剂量的方法。

8. 发明申请

WO2004112848A1 LENS CARE SOLUTIONS FOR HYDROGEL CONTACT LENSES 审中-公开
标题翻译：镜头护目镜解决方案
公开(公告)号：WO2004112848A1
公开(公告)日：2004-12-29
申请号：PCT/US2004/018377
申请日：2004-06-10
申请人： BAUSCH & LOMB INCORPORATED , XIA, Erning , SALAMONE, Joseph, C.
发明人： XIA, Erning , SALAMONE, Joseph, C.
IPC分类号： A61L12/14
CPC分类号： C11D1/008 , A61L12/141 , A61L12/145 , C11D3/0078 , C11D3/323 , C11D3/3707 , C11D3/3723 , C11D3/48
摘要： Contact lens cleaning and disinfecting compositions that reduce or eliminate wearer discomfort comprising a disinfecting amount of Alexidine. The solutions are effective in removing protein and lipid tear film deposits on both hard and soft contact lenses.
摘要翻译：隐形眼镜清洁和消毒组合物，其减少或消除佩戴者的不适，其包含消毒量的Alexidine。这些溶液有效地去除硬和软性隐形眼镜上的蛋白质和脂质泪膜沉积物。

9. 发明申请

WO2006105384A1 COMPOSITION FOR TREATING DRY EYE AND RELATED METHODS OF MANUFACTURE AND METHODS OF USE 审中-公开
标题翻译：用于治疗干眼症的组合物及其制备方法和使用方法
公开(公告)号：WO2006105384A1
公开(公告)日：2006-10-05
申请号：PCT/US2006/011876
申请日：2006-03-30
申请人： BAUSCH & LOMB INCORPORATED , XIA, Erning , SALAMONE, Joseph, C. , LIU, X, Michael
发明人： XIA, Erning , SALAMONE, Joseph, C. , LIU, X, Michael
IPC分类号： A61K9/00 , A61K47/10 , A61K47/38
CPC分类号： A61K31/047 , A61K9/0048 , A61K31/715 , A61K31/717 , A61K31/737 , A61K31/765 , A61K45/06 , A61K47/02 , A61K47/10 , A61K47/26 , A61K47/38 , A61K2300/00
摘要： The present invention is directed to a composition for treating dry eye comprising, in one embodiment, carboxymethylcellulose and a polyol. Such compositions have been found to alleviate the symptoms of dry eye and remain in the eye for a long period of time.
摘要翻译：本发明涉及一种用于治疗干眼症的组合物，在一个实施方案中包括羧甲基纤维素和多元醇。已经发现这样的组合物可以缓解干眼症状并长期保留在眼睛中。

10. 发明申请

WO2006007219A1 GENTLE PRESERVATIVE COMPOSITIONS 审中-公开
标题翻译： GENTLE防腐剂组合物
公开(公告)号：WO2006007219A1
公开(公告)日：2006-01-19
申请号：PCT/US2005/018714
申请日：2005-05-26
申请人： BAUSCH & LOMB INCORPORATED , XIA, Erning , SALAMONE, Joseph, C.
发明人： XIA, Erning , SALAMONE, Joseph, C.
IPC分类号： A61L2/18
CPC分类号： A61L2/186 , A61L12/124 , A61L12/143 , A61L2202/24 , C01B15/037 , C11D3/0078 , C11D3/323 , C11D3/3947
摘要： Compositions are described which are useful in preserving any topically applied solution. Compositions including urea-hydrogen peroxide complex in solution in an amount effective to preserve contact lenses are also described, as well as methods of making and using such solutions. A hydrogen peroxide component of such solutions, when introduced into the eye, is converted to oxygen and water, leaving only the natural product, urea.
摘要翻译：描述了可用于保存任何局部施用的溶液的组合物。还描述了包括有效保护隐形眼镜的量的溶液中的脲 - 过氧化氢络合物的组合物，以及制备和使用这些溶液的方法。这种溶液的过氧化氢组分当被引入眼睛时被转化成氧和水，只剩下天然产物尿素。

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