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1. 发明申请

WO0038770A3 PULMONARY AEROSOL DELIVERY DEVICE AND METHOD 审中-公开
标题翻译：肺部气雾剂递送装置和方法
公开(公告)号：WO0038770A3
公开(公告)日：2001-08-02
申请号：PCT/US9930675
申请日：1999-12-22
申请人： BATTELLE MEMORIAL INSTITUTE
发明人： ZIMLICH WILLIAM C JR , DVORSKY JAMES E , BUSICK DAVID R , PETERS RICHARD D
IPC分类号： A61M11/00 , A01G23/10 , A61M15/00 , A61M15/02 , A62C13/62 , A62C13/66 , A62C35/58 , B05B5/00 , B05B5/025 , B05B5/16
CPC分类号： B05B5/002 , A61M11/007 , A61M15/0065 , A61M15/008 , A61M15/0081 , A61M15/0083 , A61M15/025 , B05B5/0255 , B05B5/1691
摘要： A device (10) and method for delivering an aerosolized liquid having therapeutic properties to a user's lungs. The compact and convenient device (10) includes a housing (12) of such size that it can be held in a user's one hand with an exit opening (14) in the housing (12) for directing the aerosol to the user's mouth. The housing (12) encloses a dispensing system (20) for containing the liquid to be aerosolized and delivering it to an electrohydrodynamic apparatus (30) and an electrohydrodynamic apparatus (30) for aerosolizing the liquid and delivering the aerosol to the exit opening (14). The electrohydrodynamic apparatus (30) produces a cloud of aerosolized liquid droplets having a monodispersed respirable droplet size and near zero velocity. The aerosolizing apparatus includes a plurality of spray sites (34) each having a tip end, the spray sites (34) cooperating with a charge source to result in an aerosolized spray from at least one tip end (48), a plurality of discharge electrodes downstream of the tip ends, and a plurality of reference electrodes (36) downstream of the plurality of discharge electrodes (38).
摘要翻译：一种用于将具有治疗特性的雾化液体输送到使用者肺部的装置（10）和方法。紧凑和方便的装置（10）包括一个壳体（12），其尺寸使得它可以用一只手保持在壳体（12）中的出口（14），用于将气雾剂引导到使用者的嘴中。壳体（12）包围分配系统（20），用于容纳待雾化的液体并将其输送到电流体动力学设备（30）和电流体动力学设备（30），以用于雾化液体并将气雾剂输送到出口开口（14 ）。电流体动力学设备（30）产生具有单分散可呼吸液滴尺寸和接近零速度的雾化液滴。该雾化设备包括多个喷射部位（34），每个喷射部位具有尖端，喷射部位（34）与充电源配合以导致来自至少一个尖端（48）的雾化喷射，多个放电电极在所述尖端的下游，以及所述多个放电电极（38）下游的多个参考电极（36）。

2. 发明申请

WO0166104A3 RETINOID FORMULATIONS FOR AEROSOLIZATION AND INHALATION 审中-公开
标题翻译：用于气化和吸入的制剂
公开(公告)号：WO0166104A3
公开(公告)日：2002-01-24
申请号：PCT/US0107123
申请日：2001-03-07
申请人： BATTELLE MEMORIAL INSTITUTE , DAHL ALAN R , PLACKE MICHAEL E , ZIMLICH WILLIAM C JR , LUCA LUIGI M DE , MULSHINE JAMES L
发明人： DAHL ALAN R , PLACKE MICHAEL E , ZIMLICH WILLIAM C JR , DE LUCA LUIGI M , MULSHINE JAMES L
IPC分类号： A61K9/00 , A61K31/07 , A61K9/72 , A61P35/00
CPC分类号： A61K9/0078 , A61K9/008 , A61K31/07
摘要： Formulations and methods for prevention and treatment of preneoplasia or neoplasia of the aerodigestive tract and lungs by means of inhaled aerosol of retinoids, and 13-cis RA in particular.
摘要翻译：特别是通过吸入型类维生素A的气溶胶预防和治疗消化道和肺的发育不良或瘤形成的制剂和方法。

3. 发明申请

WO0038770A9 PULMONARY AEROSOL DELIVERY DEVICE AND METHOD 审中-公开
标题翻译：脉动气道输送装置及方法
公开(公告)号：WO0038770A9
公开(公告)日：2001-09-20
申请号：PCT/US9930675
申请日：1999-12-22
申请人： BATTELLE MEMORIAL INSTITUTE
发明人： ZIMLICH WILLIAM C JR , DVORSKY JAMES E , BUSICK DAVID R , PETERS RICHARD D
IPC分类号： A61M11/00 , A01G23/10 , A61M15/00 , A61M15/02 , A62C13/62 , A62C13/66 , A62C35/58 , B05B5/00 , B05B5/025 , B05B5/16
CPC分类号： B05B5/002 , A61M11/007 , A61M15/0065 , A61M15/008 , A61M15/0081 , A61M15/0083 , A61M15/025 , B05B5/0255 , B05B5/1691
摘要： A device (10) and method for delivering an aerosolized liquid having therapeutic properties to a user's lungs. The compact and convenient device (10) includes a housing (12) of such size that it can be held in a user's one hand with an exit opening (14) in the housing (12) for directing the aerosol to the user's mouth. The housing (12) encloses a dispensing system (20) for containing the liquid to be aerosolized and delivering it to an electrohydrodynamic apparatus (30) and an electrohydrodynamic apparatus (30) for aerosolizing the liquid and delivering the aerosol to the exit opening (14). The electrohydrodynamic apparatus (30) produces a cloud of aerosolized liquid droplets having a monodispersed respirable droplet size and near zero velocity. The aerosolizing apparatus includes a plurality of spray sites (34) each having a tip end, the spray sites (34) cooperating with a charge source to result in an aerosolized spray from at least one tip end (48), a plurality of discharge electrodes downstream of the tip ends, and a plurality of reference electrodes (36) downstream of the plurality of discharge electrodes (38).
摘要翻译：一种用于将具有治疗性质的雾化液体输送到使用者的肺的装置（10）和方法。紧凑且方便的装置（10）包括具有这样尺寸的壳体（12），使得其可以在使用者的一只手中具有在壳体（12）中的出口（14），用于将气溶胶引导到使用者的嘴部。壳体（12）包围用于容纳要雾化的液体的分配系统（20）并将其输送到电动液压装置（30）和用于使液体雾化并将气溶胶输送到出口（14）的电动液压装置（30））。电动力学装置（30）产生具有单分散的可呼吸液滴尺寸和接近零速度的雾化液滴云。雾化装置包括多个喷射部位（34），每个喷射部分具有尖端，喷射部位（34）与电荷源协作，以产生来自至少一个末端（48）的雾化喷雾，多个放电电极并且在多个放电电极（38）的下游具有多个参考电极（36）。

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