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1. 发明申请

WO2013124791A1 SOLID FORM OF BOSENTAN 审中-公开
标题翻译：博斯坦的实体形式
公开(公告)号：WO2013124791A1
公开(公告)日：2013-08-29
申请号：PCT/IB2013/051359
申请日：2013-02-20
申请人： BASF SE , BASF (CHINA) COMPANY LIMITED
发明人： CHIODO, Tiziana , HAFNER, Andreas , HINTERMANN, Tobias , SALVADOR, Beate , VOSSEN, Marcus , WEISHAAR, Walter
IPC分类号： C07D239/69 , A61K31/506 , A61P9/12
CPC分类号： A61K31/506 , A61K31/194 , C07D239/69 , A61K2300/00
摘要： A novel solid form of bosentan comprises as the active ingredient the N-[6-(2- Hydroxyethoxy)-5-(2-methoxyphenoxy)-2-pyrimidin-2-yl-pyrimidin-4-yl]-4-tert-butyl- benzenesulfonamide] and maleic acidor gentisic acid, especially as cocrystal former. The composition shows improved properties such as dissolution kinetic and hydration stability.
摘要翻译：一种新型固体形式的波生坦含有作为活性成分的N- [6-（2-羟基乙氧基）-5-（2-甲氧基苯氧基）-2-嘧啶-2-基 - 嘧啶-4-基] -4-叔 - 丁基苯磺酰胺]和马来酸或龙胆酸，特别是共晶体。该组合物显示改进的性质，例如溶解动力学和水合稳定性。

2. 发明申请

WO2012035015A2 COMPOSITION CONTAINING A PYRIPYROPENE INSECTICIDE AND AN ADJUVANT 审中-公开
标题翻译：含有嘧啶类杀虫剂和助剂的组合物
公开(公告)号：WO2012035015A2
公开(公告)日：2012-03-22
申请号：PCT/EP2011/065855
申请日：2011-09-13
申请人： BASF SE , XU, Wen , NEESE, Paul , FLETCHER, William Maurice , ANSPAUGH, Douglas, D. , SAXELL, Heidi Emilia , DIELEMAN, Cedric , WEISHAAR, Walter , KIERKUS, Paul Ch. , BENTON, Kara , LEVY, Tatjana , BERGHAUS, Rainer
发明人： XU, Wen , NEESE, Paul , FLETCHER, William Maurice , ANSPAUGH, Douglas, D. , SAXELL, Heidi Emilia , DIELEMAN, Cedric , WEISHAAR, Walter , KIERKUS, Paul Ch. , BENTON, Kara , LEVY, Tatjana , BERGHAUS, Rainer
IPC分类号： A01N43/90
CPC分类号： A01N43/90 , A01N53/00 , A01N25/30 , A01N2300/00
摘要： Pesticidal composition containing a pyripyropene insecticide and an adjuvant. The present invention relates to a compositions comprising a pyripyropene pesticide of the formula (I) or (II) as defined below Formula (I) Formula (II) and an adjuvant. The present invention relates also to methods of preparing and applying such compositions, as well as several uses thereof, and finally seeds, comprising said composition. The invention also relates to an aqueous pesticide formulation comprising a pesticide compound of the formula I as defined in claim 1 in the form of fine particles suspended in an aqueous liquid.
摘要翻译：含有啶南平杀虫剂和佐剂的农药组合物。本发明涉及包含如下式（I）式（II）所定义的式（I）或（II）的啶南平农药和佐剂的组合物。本发明还涉及制备和应用这种组合物的方法以及其几种用途，最后还涉及包含所述组合物的种子。本发明还涉及含有悬浮于含水液体中的细颗粒形式的权利要求1中定义的式I农药化合物的含水农药制剂。

3. 发明申请

WO2015086596A1 SOLID FORM OF ABIRATERONE ACETATE 审中-公开
标题翻译：醋酸阿贝特龙的固体形式
公开(公告)号：WO2015086596A1
公开(公告)日：2015-06-18
申请号：PCT/EP2014/077044
申请日：2014-12-09
申请人： BASF SE
发明人： CHIODO, Tiziana , SALVADOR, Beate , VOSSEN, Marcus , HAFNER, Andreas , HINTERMANN, Tobias , SZELAGIEWICZ, Martin , BLATTER, Fritz , VIERTELHAUS, Martin , WEISHAAR, Walter
IPC分类号： C07J43/00 , A61K9/14 , A61K31/58 , A61P35/00
CPC分类号： A61K31/58 , A61K9/14 , C07B2200/13 , C07J43/003
摘要： Combinations of (3β)-17-(pyridin-3-yl)androsta-5,16-dien-3-yl acetate (Abiraterone acetate) with acidic substances such as citric acid, ascorbic acid, methyl-4-hydroxy benzoate, saccharin, vanillic acid, adipic acid, maleic acid, malic acid, tartaric acidare useful as pharmaceutical preparations and show improved properties such as aqueous solubility and dissolution kinetics, especially in the form of cocrystals or their combination with a suitable acid.
摘要翻译：（3β）-17-（吡啶-3-基）雄甾-5,16-二烯-3-基乙酸酯（醋酸阿比酮酮）与酸性物质如柠檬酸，抗坏血酸，甲基-4-羟基苯甲酸酯，糖精，香草酸，己二酸，马来酸，苹果酸，酒石酸可用作药物制剂，并显示出改善的性质，例如水溶性和溶解动力学，特别是以共晶体形式或与合适的酸的组合。

4. 发明申请

WO2016020324A1 MULTI-COMPONENT CRYSTALS OF VISMODEGIB AND SELECTED CO-CRYSTAL FORMERS OR SOLVENTS 审中-公开
标题翻译： VISMODEGIB和选择的CO晶体成型剂或溶剂的多组分晶体
公开(公告)号：WO2016020324A1
公开(公告)日：2016-02-11
申请号：PCT/EP2015/067822
申请日：2015-08-03
申请人： BASF SE
发明人： VIERTELHAUS, Martin , CHIODO, Tiziana , SALVADOR, Beate , VOSSEN, Marcus , HAFNER, Andreas , HINTERMANN, Tobias , WEISHAAR, Walter , HELLMANN, Rolf
IPC分类号： C07D213/40
CPC分类号： A61K31/4402 , C07D213/40
摘要： The present invention primarily relates to multi-component crystals comprising a compound of formula 1 and a second compound selected from the group consisting of co-crystal formers and sol-vents. The invention is further related to pharmaceutical compositions comprising such multi-component crystals. Furthermore, the invention relates to processes for preparing said multi-component crystals. The invention also relates to several aspects of using said multi-component crystals or pharmaceutical compositions to treat a disease.
摘要翻译：本发明主要涉及包含式1化合物和选自共晶体形成剂和溶剂的第二种化合物的多组分晶体。本发明还涉及包含这种多组分晶体的药物组合物。此外，本发明涉及制备所述多组分晶体的方法。本发明还涉及使用所述多组分晶体或药物组合物治疗疾病的若干方面。

5. 发明申请

WO2013135606A1 METHOD FOR PRODUCING AN AQUEOUS SUSPENSION CONCENTRATE FORMULATION OF A PYRIPYROPENE INSECTICIDE 审中-公开
标题翻译：生产杀微生物剂的水悬浮浓缩液配方的方法
公开(公告)号：WO2013135606A1
公开(公告)日：2013-09-19
申请号：PCT/EP2013/054828
申请日：2013-03-11
申请人： BASF SE , BASF SCHWEIZ AG
发明人： KNIERIEM, Torsten , CHIODO, Tiziana , KORADIN, Christopher , WEBER, Tanja , WEISHAAR, Walter
IPC分类号： A01N43/90 , A01N53/00 , A01N25/04 , A01P7/04
CPC分类号： A01N53/00 , A01N25/08 , A01N43/90 , A01N25/04 , A01N2300/00
摘要： The present invention relates to a method for producing an aqueous suspension concentrate formulation and novel suspension concentrate formulations of the compound of formula I. The method comprises: a) providing an aqueous slurry of coarse particles of the compound of the formula I, where the compound of the formula I is at least partially present in its crystalline form B, which, in an X-ray powder diffractogram at 25°C and Cu-Kα radiation, shows at least three, preferably at least four, in particular at least 5 or at least 7 or at least 9 or all of the following reflexes, given as 2θ values:8.0± 0.2°, 9.5± 0.2°, 10.7± 0.2°, 11.0± 0.2°, 11.2± 0.2°,11.7± 0.2°, 14.2± 0.2°, 15.6± 0.2°, 6.5± 0.2°, 17.7± 0.2°, 21.5± 0.2°; b) comminuting the coarse particles in the slurry of the compound of formula I, which is at least partially present in its form B, in the presence of the at least one surfactant.
摘要翻译：本发明涉及一种制备水性悬浮液浓缩物制剂的方法和式I化合物的新型悬浮浓缩物制剂。该方法包括：a）提供式I化合物的粗颗粒的含水浆液，其中化合物式I的至少一部分至少部分以其结晶形式B存在，其在25℃的X射线粉末衍射图和Cu-Kalpha辐射中显示出至少三个，优选至少四个，特别是至少5个或至少7或至少9或全部以下反射，以2θ值给出：8.0±0.2°，9.5±0.2°，10.7±0.2°，11.0±0.2°，11.2±0.2°，11.7±0.2°，14.2 ±0.2°，15.6±0.2°，6.5±0.2°，17.7±0.2°，21.5±0.2°; b）在存在至少一种表面活性剂的情况下粉碎至少部分以其B形式存在的式I化合物的浆料中的粗颗粒。

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