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    • 2. 发明申请
    • PYRANOPYRANONE DERIVATIVES AS ANTIMICROBIAL AGENTS
    • 吡咯烷酮衍生物作为抗微生物剂
    • WO2011107411A1
    • 2011-09-09
    • PCT/EP2011/052876
    • 2011-02-28
    • BASF SEWAGNER, BarbaraPURSCHWITZ, JaninaBIELER, Karin
    • WAGNER, BarbaraPURSCHWITZ, JaninaBIELER, Karin
    • A01N43/90A61K8/49A61Q19/00A61Q19/10A61Q17/00
    • A61Q15/00A01N43/90A61K8/498A61K2800/74A61Q5/006A61Q5/02A61Q11/00A61Q17/04A61Q19/00A61Q19/005A61Q19/10C11D3/48
    • Disclosed is the use of pyranopyranone derivatives of formula (1), wherein R 1 , R 2 , R 3 , R 4 and R 5 independently of one another are hydrogen; C 1 -C 30 alkyl, C 2 -C 30 alkenyl, or C 3 -C 12 cycloalkyl, which may be substituted by one or more E and/or interrupted by one or more D; C 6 -C 20 aryl, which may be substituted by one or more G; C 4 -C 20 heteroaryl, which may be substituted by one or more G, C 2 -C 18 alkenyl, C 2 - 10 C18alkynyl, C 7 -C 25 aralkyl, or -CO-R 6 ; -SiR 8 R 9 R 10 ; or R 4 and R 5 together form a five or six membered ring; or R 3 and R 4 together form a five or six membered ring; D is -CO-; -COO-; -S-; -SO-; -SO 2 -; -O-; -NR 7 -; -SiR 8 R 9 -; -POR 10 -; -CR 12 =CR 13 -; or -C≡C-; and E is OR 6 ; -SR 6 ; -NR 14 R 15 ; -NR 14 COR 15 ; -COR 6 ; -COOR 6 ; -CONR 14 R 15 ; -CN; halogen; or OSO 3 R 11 ; SO 3 R 11 ; SO 2 R 11 ; PO 3 (R 11 ) 2 ; OPO 3 (R 11 ) 2 ; G is E; C 1 -C 18 alkyl, which is optionally interrupted by D; C1-C18perfluoroalkyl; C 1 -C 18 alkoxy, which is optionally substituted by E and/or interrupted by D; wherein R 6 is H; C 6 -C 18 aryl which is optionally substituted by OH, C 1 -C 30 alkyl or C 1 -C 30 alkoxy; or C 1 -C 30 alkyl which is optionally interrupted by O-; R 7 is H; C 6 -C 18 aryl which is optionally substituted by OH, C 1 -C 30 alkyl or C 1 -C 30 alkoxy; or C 1 -C 30 alkyl which is optionally interrupted by O-; R 8 , R 9 and R 10 independently of each other are hydrogen; C 1 -C 30 alkyl; C 6 -C 18 aryl which is optionally substituted by C 1 -C 30 alkyl; and R 11 is hydrogen; C 6 -C 18 aryl, which is optionally substituted by OH, C 1 -C 30 alkyl or C 1 - C 30 alkoxy; or C 1 -C 30 alkyl, which is optionally interrupted by O-; R 12 , R 13 , R 14 and R 15 independently of each other are hydrogen; C 6 -C 18 aryl which is optionally substituted by OH, C 1 -C 30 alkyl or C 1 -C 30 alkoxy; C 1 -C 30 alkyl, which is optionally interrupted by O-; or R 14 and R 15 together form a five or six membered ring; as antimicrobial and/or preserving agents.
    • 公开了式(1)的吡喃吡喃酮衍生物的用途,其中R 1,R 2,R 3,R 4和R 5彼此独立地是氢; C 1 -C 30烷基,C 2 -C 30烯基或C 3 -C 12环烷基,其可以被一个或多个E取代和/或被一个或多个D中断; 可以被一个或多个G取代的C 6 -C 20芳基; 可以被一个或多个G,C 2 -C 18烯基,C 2-10 C 18炔基,C 7 -C 25芳烷基或-CO-R 6取代的C 4 -C 20杂芳基; -SiR8 R9R10; 或R4和R5一起形成五元或六元环; 或R3和R4一起形成五元或六元环; D是-CO-; -COO-; -S-; -所以-; -SO2-; -O-; -NR7-; -SiR8R9-; -POR10-; -CR12 = CR13-; 或-C = C-; E为OR6; -SR 6; -NR14R15; -NR14COR15; -COR 6; -COOR6; -CONR14R15; -CN; 卤素; 或OSO3R11; SO3R11; SO2R11; PO3(R11)2; OPO 3(R 11)2; G是E 任选地被D中断的C 1 -C 18烷基; C1-C18perfluoroalkyl; 任选被E取代和/或被D中断的C1-C18烷氧基; 其中R6是H; 任选被OH,C 1 -C 30烷基或C 1 -C 30烷氧基取代的C 6 -C 18芳基; 或任选被O-中断的C 1 -C 30烷基; R7为H; 任选被OH,C 1 -C 30烷基或C 1 -C 30烷氧基取代的C 6 -C 18芳基; 或任选被O-中断的C 1 -C 30烷基; R 8,R 9和R 10彼此独立地为氢; C1-C30烷基; 任选被C 1 -C 30烷基取代的C 6 -C 18芳基; R11为氢; 任选被OH,C 1 -C 30烷基或C 1 -C 30烷氧基取代的C 6 -C 18芳基; 或任选被O-中断的C 1 -C 30烷基; R 12,R 13,R 14和R 15彼此独立地为氢; 任选被OH,C 1 -C 30烷基或C 1 -C 30烷氧基取代的C 6 -C 18芳基; 任选被O-中断的C 1 -C 30烷基; 或R 14和R 15一起形成五元或六元环; 作为抗微生物剂和/或防腐剂。
    • 3. 发明申请
    • ANTIMICROBIAL AMINO-SALICYLIC ACID DERIVATIVES
    • 抗微生物氨基磺酸衍生物
    • WO2011023573A1
    • 2011-03-03
    • PCT/EP2010/061804
    • 2010-08-13
    • BASF SEHÖLZL, WernerPURSCHWITZ, Janina
    • HÖLZL, WernerPURSCHWITZ, Janina
    • A61K31/167A61P31/00A61K8/44A61Q5/02A61Q11/02A61Q15/00A61Q19/00A61Q17/00C11D3/00C11D3/32
    • C11D3/48A61K8/42A61Q5/02A61Q11/02A61Q15/00A61Q17/005C11D3/32
    • Disclosed is a novel method for achieving an antimicrobial, preservative and/or microorganism adhesion inhibiting effect, for the protection within an article and/or material or on the surface of an article and/or material. The novel method comprises application of a salicylic compound of the formula (I) wherein one of A and A is a residue of the formula (I'): -NH-CO-R 1 while the other is hydrogen; R 1 is C 1 -C 22 alkyl, C 3 -C 12 cycloalkyl, C 3 -C 12 cycloalkyl interrupted by O and/or NR 5 , C 4 -C 12 aryl, C 5 -C 18 arylalkyl; R 2 is OR 3 or NHR 4 ; R 3 and R 4 are selected from H, C 1 -C 22 alkyl, C 3 -C 12 cycloalkyl, C 3 -C 12 cycloalkyl interrupted by O and/or NR 5 , C 4 -C 12 aryl, C 5 -C 18 arylalkyl; R 5 is H or C 1 -C 8 alkyl; wherein each aryl moiety is unsubstituted or substituted by C 1 -C 4 alkyl, C 1 -C 4 alkoxy, C 1 -C 4 acyl, C 1 -C 4 acyloxy, C 1 -C 4 acylamino, CF 3 , OH, amino, halogen; or an adduct or salt thereof; to said article and/or material.
    • 公开了一种用于实现在制品和/或材料内或制品和/或材料的表面上的保护的抗微生物,防腐和/或微生物粘附抑制作用的新方法。 该新方法包括施用式(I)的水杨酸化合物,其中A和A之一是式(I')的残基:-NH-CO-R 1,而另一个是氢; R1是C1-C22烷基,C3-C12环烷基,被O和/或NR5,C4-C12芳基,C5-C18芳烷基中断的C3-C12环烷基; R2是OR3或NHR4; R 3和R 4选自H,C 1 -C 22烷基,C 3 -C 12环烷基,被O和/或NR 5,C 4 -C 12芳基,C 5 -C 18芳烷基间隔的C 3 -C 12环烷基; R5是H或C1-C8烷基; 其中每个芳基部分是未取代的或被C 1 -C 4烷基,C 1 -C 4烷氧基,C 1 -C 4酰基,C 1 -C 4酰氧基,C 1 -C 4酰氨基,CF 3,OH,氨基,卤素取代。 或其加合物或其盐; 对所述物品和/或材料。