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1. 发明申请

WO2007063543A3 SYSTEM FOR COUNTING BACTERIA AND DETERMINING THEIR SUSCEPTIBILITY TO ANTIBIOTICS 审中-公开
标题翻译：细菌计数系统和确定其对抗生素的敏感性
公开(公告)号：WO2007063543A3
公开(公告)日：2009-04-16
申请号：PCT/IL2006001379
申请日：2006-11-29
申请人： BACTERIOSCAN LTD , WEICHSELBAUM AMNON , DE LA ZERDA JAIME
发明人： WEICHSELBAUM AMNON , DE LA ZERDA JAIME
IPC分类号： C12Q1/68
CPC分类号： G01N21/51 , B01L3/50 , B01L3/508 , B01L2300/04 , B01L2300/0809 , C12Q1/04 , C12Q1/06 , C12Q1/10 , C12Q1/18 , G01N21/03 , G01N21/49 , G01N33/4875 , G01N33/493 , G01N2015/0693 , G01N2021/0346 , G01N2021/0389 , G01N2021/513
摘要： A method for detecting and counting particles suspended in fluids, such as bacteria suspended in urine, utilizing dynamic features of the suspended particles and employing light scattering measurements. The disclosed method is suitable for determining the susceptibility of bacteria to antibiotics. A cuvette for detecting bacteria in fluids, which is especially suited for the light scattering measurements, is provided.
摘要翻译：一种利用悬浮颗粒的动态特征并采用光散射测量来检测和计数悬浮在流体中的悬浮在尿液中的细菌的方法。所公开的方法适用于确定细菌对抗生素的易感性。提供了用于检测流体中的细菌的比色杯，其特别适用于光散射测量。

2. 发明申请

WO2009083963A3 DETECTING AND COUNTING BACTERIA SUSPENDED IN BIOLOGICAL FLUIDS 审中-公开
标题翻译：检测和计数在生物流体中悬浮的细菌
公开(公告)号：WO2009083963A3
公开(公告)日：2010-03-11
申请号：PCT/IL2008001663
申请日：2008-12-24
申请人： BACTERIOSCAN LTD , WEICHSELBAUM AMNON
发明人： WEICHSELBAUM AMNON , DE LA ZERDA JAIME , REGEV ISSAKHAR
IPC分类号： C12M1/34
CPC分类号： G01N21/51 , G01N21/0303 , G01N33/493 , G01N2021/0382 , G01N2021/4769 , G01N2021/479 , G01N2021/513 , G01N2201/064
摘要： System and method for detecting and counting bacteria suspended in a biological fluid by means of light scattering measurements is provided. In accordance with the method of the invention the level of signal to noise of the measured intensities of light scattered by a sample of the biological fluid is significantly enhanced for forwardly scattered light within a range of scattering angles which are smaller compared to a predefined maximal scattering angle. The system of the invention includes a cuvette adapted to contain a sample of the biological fluid whose sidewalls and windows are suitably constructed and arranged to significantly reduce the level of reflected light obscuring the scattering patterns measured within the range of scattering angles considered.
摘要翻译：提供了通过光散射测量来检测和计数悬浮在生物流体中的细菌的系统和方法。根据本发明的方法，在与预定的最大散射相比较小的散射角范围内的向前散射光显着增强了由生物流体样本散射的光的测量强度的信噪比水平角度。本发明的系统包括适于容纳生物流体的样本的比色皿，其侧壁和窗口被适当地构造和布置，以显着降低反射光的水平，遮蔽在所考虑的散射角度范围内测量的散射图案。

3. 发明申请

WO2006018839A2 DETECTION OF BACTERIA IN FLUIDS 审中-公开
标题翻译：检测流体中的细菌
公开(公告)号：WO2006018839A2
公开(公告)日：2006-02-23
申请号：PCT/IL2005000884
申请日：2005-08-16
申请人： BACTERIOSCAN , WEICHSELBAUM AMNON , DE LA ZERDA JAIME , REGEV ISSACHAR
发明人： WEICHSELBAUM AMNON , DE LA ZERDA JAIME , REGEV ISSACHAR
IPC分类号： G01N33/569
CPC分类号： G01N21/51 , C12Q1/04 , G01N15/0205 , G01N21/0303 , G01N33/493 , G01N2021/0321
摘要： A method for the detection of bacteria in aqueous fluids in the form of solutions, emulsions and or suspensions, such as drinking water, liquid food and drinks and biological fluids such as urine, spinal and or amniotic fluids and serums by measuring light scattering The fluid suspected of containing bacteria is filtered first to exclude particles of sizes larger than the size of the expected bacteria. Other filtration methods are used in addition to exclude different constituents of the examined fluid. Ion exchange chromatography is such a method. The verification of bacterial contamination and the derivation of its level is performed by matching measured scattering profiles with pre-stored calibrated scattering profiles. A system for carrying out the measurements including cuvette units suited for light scattering measurements is provided.
摘要翻译：通过测量光散射来检测溶液，乳液和或悬浮液形式的水性流体中的细菌的方法，所述溶液，乳液和或悬浮液例如饮用水，液体食物和饮料以及生物流体例如尿液，脊柱和/或羊水和血清。首先过滤含有细菌的细菌，以排除尺寸大于预期细菌大小的颗粒。除了排除被检流体的不同成分之外，还使用其他过滤方法。离子交换色谱法就是这样一种方法。通过将测量的散射分布与预先存储的校准散射分布匹配来进行细菌污染的验证和其水平的推导。提供了用于执行包括适合于光散射测量的比色杯单元的测量的系统。

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