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1. 发明申请

WO2009016069A2 STABLE LIQUID PHARMACEUTICAL COMPOSITION BASED ON TRAZODONE 审中-公开
标题翻译：基于TRAZODONE的稳定液体药物组合物
公开(公告)号：WO2009016069A2
公开(公告)日：2009-02-05
申请号：PCT/EP2008/059605
申请日：2008-07-22
申请人： AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A. , MARCHETTI, Marcello , MARIOTTI, Francesca , RAGNI, Lorella , SCARPETTI, Paolo , VALENTI, Mauro
发明人： MARCHETTI, Marcello , MARIOTTI, Francesca , RAGNI, Lorella , SCARPETTI, Paolo , VALENTI, Mauro
IPC分类号： A61K9/08 , A61K47/10 , A61P25/24
CPC分类号： A61K9/006 , A61K9/0019 , A61K9/0095 , A61K31/495 , A61K31/496 , A61K47/10
摘要： A stable liquid pharmaceutical composition comprising an aqueous solution of a pharmaceutically acceptable salt of acid addition of trazodone, characterized in that said pharmaceutical composition has a pH value between 5.0 and 6.0, and comprises at least two cosolvents selected from the group comprising glycols and polyglycols.
摘要翻译：一种稳定的液体药物组合物，其包含曲方酮的酸加成盐的药学上可接受的盐的水溶液，其特征在于所述药物组合物的pH值为5.0至6.0，并且包含至少两种选自二醇和聚二醇的助溶剂。

2. 发明申请

WO2009019133A1 TRAZODONE AND TRAZODONE HYDROCHLORIDE IN PURIFIED FORM 审中-公开
标题翻译：固体形式的三唑酮和三唑酮氢氯化物
公开(公告)号：WO2009019133A1
公开(公告)日：2009-02-12
申请号：PCT/EP2008/059640
申请日：2008-07-23
申请人： AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.p.A. , MARCHETTI, Marcello , IACOANGELI, Tommaso , CIOTTOLI, Giovanni Battista , BIONDI, Giuseppe
发明人： MARCHETTI, Marcello , IACOANGELI, Tommaso , CIOTTOLI, Giovanni Battista , BIONDI, Giuseppe
IPC分类号： C07D249/18 , A61K31/4196 , A61P25/22 , A61P25/24
CPC分类号： A61K31/496 , A61K9/0053 , A61K9/08 , A61K47/06 , A61K47/10 , A61K47/14 , A61K47/18 , A61K47/22 , A61K47/26 , A61K47/36 , A61K47/38 , A61K47/44 , C07D249/18
摘要： A process of production of trazodone or trazodone hydrochloride that comprises the steps of: (a) preparing an organic phase comprising trazodone in at least one organic solvent; (b) preparing an aqueous phase comprising at least one basic compound; (c) mixing said aqueous phase with said organic phase; (d) heating at a temperature o at least 40°C for at least 30 minutes; (e) recovering said trazodone; and, optionally, (f) treating said trazodone with hydrochloric acid to obtain trazodone hydrochloride. Trazodone or trazodone hydrochloride comprising less than 15 ppm of alkylating substances, and a pharmaceutical composition comprising said trazodone hydrochloride.
摘要翻译：生产曲唑酮或曲唑酮盐酸盐的方法，包括以下步骤：（a）在至少一种有机溶剂中制备含有曲唑酮的有机相; （b）制备包含至少一种碱性化合物的水相; （c）将所述水相与所述有机相混合; （d）在至少40℃的温度下加热至少30分钟; （e）回收所述曲唑酮; 和（f）用盐酸处理所述曲唑酮以获得盐酸曲唑酮。包含小于15ppm烷基化物质的曲唑酮或曲唑酮盐酸盐，以及包含所述曲唑酮盐酸盐的药物组合物。

3. 发明申请

WO2003055897A1 METHOD FOR PREPARING A GLUCOSAMINE COMPOUND, AND COMPOUND THUS OBTAINED 审中-公开
标题翻译：制备葡萄糖胺化合物的方法和获得的化合物
公开(公告)号：WO2003055897A1
公开(公告)日：2003-07-10
申请号：PCT/EP2002/013570
申请日：2002-12-02
申请人： AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A. , PINZA, Mario , SEGNALINI, Franca , MARCHETTI, Marcello , IACOANGELI, Tommaso , DE VITA, Francesco
发明人： PINZA, Mario , SEGNALINI, Franca , MARCHETTI, Marcello , IACOANGELI, Tommaso , DE VITA, Francesco
IPC分类号： C07H5/06
CPC分类号： A61K31/7008 , C07H5/06
摘要： Method for preparing a compound comprising protonated glucosamine and CI - , Na + and SO 4 2- ions, in which (a) glucosamine hydrochloride and a stoichiometric excess of sodium sulphate are placed in water, (b) the mixture obtained from the preceding step (a) is heated, (c) the mixture is cooled, and (d) the solid present in the said cooled mixture is recovered by filtration. Compound comprising protonated glucosamine and CI - , Na + and SO 4 2- ions and having the X-ray diffraction diagram of Fig. 1.
摘要翻译：制备包含质子化葡糖胺和Cl - ，Na +和SO 4 2-离子的化合物的方法，其中将（a）盐酸葡糖胺和化学计量过量的硫酸钠置于水中，（b）混合物（a）得到的固体被加热，（c）冷却混合物，（d）通过过滤回收存在于所述冷却的混合物中的固体。包含质子化葡糖胺和CI，Na +和SO 4 2-离子的化合物，并具有图1的X射线衍射图。 1。

4. 发明申请

WO2012104139A1 METHOD OF PREPARATION OF METAXALONE 审中-公开
标题翻译：美沙酮的制备方法
公开(公告)号：WO2012104139A1
公开(公告)日：2012-08-09
申请号：PCT/EP2012/050609
申请日：2012-01-17
申请人： AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.p.A. , IACOANGELI, Tommaso , CHIAVARINI, Mario , FAZIO, Antonello , MARCHETTI, Marcello , CIOTTOLI, Giovanni Battista
发明人： IACOANGELI, Tommaso , CHIAVARINI, Mario , FAZIO, Antonello , MARCHETTI, Marcello , CIOTTOLI, Giovanni Battista
IPC分类号： C07D263/24 , C07D405/14 , A61K31/421 , C07D405/06
CPC分类号： C07D263/24 , C07D405/06 , C07D405/14
摘要： The present invention relates to a method of preparation of metaxalone comprising reaction of triglycidyl isocyanurate (TGIC) with m-xylenol, characterized in that said reaction is carried out in a solvent mixture comprising an aprotic polar solvent with dielectric constant greater than or equal to 30 and at least one other solvent selected from the group comprising apolar solvents and aprotic polar solvents with dielectric constant below 30 said solvent mixture comprising from 5 to 40 wt. % of said first solvent and from 95 to 60 wt. % of said second solvent, adding the TGIC at a temperature between 30°C and 50°C, and after adding the TGIC, raising the temperature of the reaction solution to a value between 80°C and 180°C in a time between 120 and 180 minutes at a rate of increase not greater that 1.25°C per minute. The invention also relates to a metaxalone with a reduced content of impurities derived from incomplete reactions and/or side reactions of the method of production.
摘要翻译：本发明涉及一种含有三聚甘油基异氰脲酸酯（TGIC）与间二甲苯酚反应的美他沙酮的方法，其特征在于所述反应在包含介电常数大于或等于30的非质子极性溶剂的溶剂混合物中进行和至少一种其它溶剂，其选自包含非极性溶剂和非质子极性溶剂的介质常数低于30的组，所述溶剂混合物包含5至40wt。所述第一溶剂的％和95至60wt。％的所述第二溶剂，在30℃和50℃之间的温度下加入TGIC，加入TGIC后，将反应溶液的温度升高到80℃至180℃之间，时间为120 并且以不高于1.25℃/分钟的速率增加180分钟。本发明还涉及衍生自生产方法的不完全反应和/或副反应的杂质含量降低的美他沙酮。

5. 发明申请

WO2003013250A1 DISINFECTANT SOLUTION BASED ON SODIUM HYPOCHLORITE, AND PROCESS FOR PREPARING IT 审中-公开
标题翻译：基于硫酸钠的消毒溶液及其制备方法
公开(公告)号：WO2003013250A1
公开(公告)日：2003-02-20
申请号：PCT/EP2002/008338
申请日：2002-07-23
申请人： AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO (A.C.R.A.F.) S.P.A. , PINZA, Mario , MARCHETTI, Marcello
发明人： PINZA, Mario , MARCHETTI, Marcello
IPC分类号： A01N59/00
CPC分类号： C01B11/062 , A01N59/00 , A61L2/18 , A01N2300/00
摘要： Sodium hypochlorite disinfectant solution having a pH of between 10.1 and 10.7 and comprising from 0.021 to 5.76% (w/v) of sodium hypochlorite and, relative to the said amount of sodium hypochlorite, not more than 2% of sodium chlorate.
摘要翻译：次氯酸钠消毒液的pH值介于10.1和10.7之间，含有0.021至5.76％（w / v）次氯酸钠，相对于该次氯酸钠的量不超过氯酸钠的2％。

6. 发明申请

WO2014170836A1 COMPACT TRAILER, PARTICULARLY FOR BICYCLES AND MOTORCYCLES 审中-公开
标题翻译：紧凑型拖车，特别适用于自行车和摩托车
公开(公告)号：WO2014170836A1
公开(公告)日：2014-10-23
申请号：PCT/IB2014/060756
申请日：2014-04-16
申请人： MARCHETTI, Marcello
发明人： MARCHETTI, Marcello
IPC分类号： B62K27/00 , B62M7/14 , B62D63/06
CPC分类号： B62D63/061 , B62D63/08 , B62K27/003
摘要： A compact trailer (1) comprising a connecting element (13) that can be associated with a frame of a bicycle or motorcycle, and a cart (2) that has a loading bed (3) and an edge provided with at least two mutually opposite side walls (6) with which respective wheels (7) for moving the trailer resting on the ground (S) are associated so that they can rotate about respective axes that are transverse to the direction of advancement (A) of the trailer (1). A recessed cavity (8) is provided on each one of the two side walls (6) and at least partially accommodates the respective wheel (7). Each cavity (8) has a depth that is at least equal to the axial space occupation of the respective wheel (7) accommodated inside it, so that in plan view the wheels (7) do not protrude from the outline of the cart (2).
摘要翻译：一种紧凑型拖车（1），包括可与自行车或摩托车的框架相关联的连接元件（13）和具有装载床（3）的手推车（2），以及设置有至少两个相互相对的用于移动搁置在地面（S）上的拖车的相应轮子（7）的侧壁（6）相关联，使得它们可以围绕与拖车（1）的前进方向（A）横向的各个轴线旋转，。凹槽（8）设置在两个侧壁（6）中的每一个上并且至少部分地容纳相应的轮（7）。每个空腔（8）的深度至少等于容纳在其内的相应轮子（7）的轴向空间占有量，使得在平面图中，轮子（7）不从推车（2）的轮廓突出）。

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