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1. 发明申请

WO2006043752A1 PROCESS FOR PREPARING EXTRACT FROM RHUS VERNICIFLUA AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME 审中-公开
标题翻译：从RHUS VERNICIFLUA制备提取物的方法和含有它的药物组合物
公开(公告)号：WO2006043752A1
公开(公告)日：2006-04-27
申请号：PCT/KR2005/002976
申请日：2005-09-08
申请人： AZI Co., Ltd. , CHOI, Won-Cheol , PARK, Sang-Jae , KWON, Sung-Pil
发明人： CHOI, Won-Cheol , PARK, Sang-Jae , KWON, Sung-Pil
IPC分类号： A61K35/78
CPC分类号： A61K36/22
摘要： The present invention provides a process for preparing an extract of Rhus verniciflua by using water and organic solvents to extract active ingredients, which comprises (a) adding water or a mixture of water and alcohol as the solvent to Rhus verniciflua to extract the soluble components, then filtering the resultant product to obtain a filtrate, and concentrating and drying the filtrate to obtain a solid fraction; (b) re-extracting the solid fraction obtained in the previous step with highly purified ethanol, then filtering the resultant product to obtain a filtrate, and concentrating and drying the filtrate to obtain a solid fraction; (c) adding a saturated hydrocarbon having 5 to 7 carbon atoms to the solid fraction obtained in the previous step to dissolve allergy- inducing components, and then removing the hydrocarbon to obtain a solid fraction; and (d) adding water to the solid fraction obtained in the previous step to extract water-soluble components. The extract obtained according to the process for preparing an extract of Rhus verniciflua of the invention does not induce allergies, since toxic substances of lacquer are effectively removed, and various inherent active ingredients of lacquer can be extracted with high yield, compared with conventional processes.
摘要翻译：本发明提供了一种通过使用水和有机溶剂提取活性成分来制备紫菜提取物的方法，其包括（a）将水或水和醇的混合物作为溶剂加入到紫苏中以提取可溶性成分，然后过滤所得产物以获得滤液，并浓缩并干燥滤液以获得固体部分; （b）用高纯度乙醇重新萃取上一步得到的固体馏分，然后过滤得到的产物，得到滤液，浓缩并干燥滤液得到固体部分; （c）向前述步骤中得到的固体部分加入碳原子数为5〜7的饱和烃，溶解过敏诱导成分，然后除去烃，得到固体成分。和（d）向前述步骤中得到的固体部分加水，以提取水溶性成分。根据制备本发明的提取物的方法获得的提取物不会诱导过敏，因为与常规方法相比，有效除去有毒物质的漆，并且能够以高产率提取各种固有的漆的活性成分。

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