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1. 发明申请

WO0221138A3 THE M30 GENE FAMILY AND THE UTILIZATION THEREOF 审中-公开
标题翻译： M30的基因家族及其用途
公开(公告)号：WO0221138A3
公开(公告)日：2003-03-20
申请号：PCT/EP0110366
申请日：2001-09-07
申请人： AXARON BIOSCIENCE AG , SCHNEIDER ARMIN , HIEMISCH HOLGER , ROSSNER MORITZ , KLUGMANN MATTHIAS , NAIM JOMANA , EISENHARDT GISELA , KUNER ROHINI , LANAHAN ANTHONY , WORLEY PAUL , SPIELVOGEL DANIELA , SCHEEK SIGRID
发明人： SCHNEIDER ARMIN , HIEMISCH HOLGER , ROSSNER MORITZ , KLUGMANN MATTHIAS , NAIM JOMANA , EISENHARDT GISELA , KUNER ROHINI , LANAHAN ANTHONY , WORLEY PAUL , SPIELVOGEL DANIELA , SCHEEK SIGRID
IPC分类号： A61P25/28 , A61P35/00 , G01N33/68 , A01K67/027 , A61K48/00 , C07K14/00 , C07K16/00 , C12N5/00 , G01N33/574
CPC分类号： G01N33/6896 , G01N2800/28
摘要： The invention relates to, among other things, a method for diagnosing neurodegenerative diseases. According to the invention, the concentration of a protein, which shares similarities with the protein Pellino, or of a mammal homologue of this protein or of a mutein of this protein, which, over a domain of 50 amino acids of the amino sequence thereof, shares a sequence identity of over 60 % with one of the sequences, is determined in a body sample. The invention also relates to the utilization of ligands, which bind to M30 and to the homologues thereof, and to the utilization of functional inhibitors for producing a medicament for treating neurodegenerative diseases. The invention additionally relates to a screening method for identifying and/or characterizing functional inhibitors and/or ligands of M30 or of a homologue of M30.
摘要翻译：本发明涉及尤其用于神经变性疾病的诊断的方法，其中，其具有与蛋白Pellino，或该蛋白质的哺乳动物同源物，或该蛋白的突变蛋白，相似性的蛋白质的浓度，其在一定范围的在其氨基酸序列中的50个氨基酸序列同一性的其身体样品中测定的超过60％的序列中的一个。此外，本发明涉及使用结合于M30及其同系物的配体，并以使用功能抑制剂在制备用于神经变性疾病的治疗的药物中的用途。此外，本发明涉及用于功能抑制剂和/或M30的配体的鉴定和/或表征或M30的同源物的筛选方法。

2. 发明申请

WO0161001A9 NOVEL, CENTRAL NERVOUS PROTEIN, THAT MODULATES K<+> FLOWS 审中-公开
标题翻译： NEW中枢神经蛋白，第k <+> - FLOWS调制
公开(公告)号：WO0161001A9
公开(公告)日：2002-08-08
申请号：PCT/EP0101730
申请日：2001-02-15
申请人： BASF LYNX BIOSCIENCE AG , SPIELVOGEL DANIELA , KORNAU HANS-CHRISTIAN , KUNER ROHINI , EISENHARDT GISELA , TRUTZEL ANNETTE
发明人： SPIELVOGEL DANIELA , KORNAU HANS-CHRISTIAN , KUNER ROHINI , EISENHARDT GISELA , TRUTZEL ANNETTE
IPC分类号： A61K38/00 , C07K14/705 , C12N15/12 , A01K67/027 , A61K38/17 , A61K39/395 , C07K16/28 , C12N15/10 , C12N15/66 , C12Q1/68 , G01N33/53 , G01N33/566
CPC分类号： C07K14/705 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K2039/505
摘要： The invention relates to nucleic acid sequences and isolated proteins which are novel interaction partners of inwardly rectifying potassium channels (Kirs), especially G protein-coupled inwardly rectifying potassium channels (GIRKs). Said interaction partners, together with the Kirs or GIRKs, form protein complexes. The invention also relates to a charged domain of the inventive interaction partners. Said domain binds to the complex intracellular area of Kirs and influences the activity of Kirs in general or of GIRKs in particular. The invention further relates to protein complexes of interaction partners and inwardly rectifying potassium channels, nucleic acid sequences or recombinant nucleic acid constructs which code for such proteins or domains and to the use thereof. The invention relates to protein complexes consisting of the inventive protein and further proteins. The invention also relates to host organisms and specially transgenic animals which contain the inventive nucleic acid sequences or the recombinant nucleic acid constructs as well as to mono- or polyclonal antibodies which are directed against the isolated proteins. The invention further relates to methods for finding partners, i.e. low-molecular or high-molecular substances that specifically bind to the inventive interaction partners.
摘要翻译：本发明涉及核酸序列和分离的蛋白质，其内向整流钾通道（KIR的），尤其是G蛋白偶联内向整流钾通道（GIRKs）的新的交互伙伴是。这种互动合作伙伴一起与KIR的或GIRKs蛋白复合物。本发明进一步涉及的是结合性KIR的复杂的细胞内区域与KIR的的一般的活性，或者特别是通过GIRKs影响erfindugsgemässen相互作用配偶的带电域。此外，本发明涉及相互作用伴侣蛋白复合物和内向整流钾通道，核酸序列或编码这样的蛋白质或结构域，以及它们的用途的重组核酸构建体。此外，本发明还涉及与其它蛋白质本发明的蛋白质的蛋白质复合物。本发明还涉及宿主生物体含有针对分离的蛋白质，本发明核酸序列或重组核酸构建体，以及单 - 或多克隆抗体特异性的转基因动物。另外，本发明涉及寻找伙伴，即低分子量的或特异性结合本发明的相互作用伴侣的高分子量物质的，的方法。

3. 发明申请

WO0161001A2 NOVEL, CENTRAL NERVOUS PROTEIN, THAT MODULATES K<+> FLOWS 审中-公开
标题翻译： NEW中枢神经蛋白，第k <+> - FLOWS调制
公开(公告)号：WO0161001A2
公开(公告)日：2001-08-23
申请号：PCT/EP0101730
申请日：2001-02-15
申请人： BASF LYNX BIOSCIENCE AG , SPIELVOGEL DANIELA , KORNAU HANS CHRISTIAN , KUNER ROHINI , EISENHARDT GISELA , TRUTZEL ANNETTE
发明人： SPIELVOGEL DANIELA , KORNAU HANS-CHRISTIAN , KUNER ROHINI , EISENHARDT GISELA , TRUTZEL ANNETTE
IPC分类号： A61K38/00 , C07K14/705 , C12N15/12 , A61K38/17 , A61K39/395 , C07K16/28 , C12N15/10 , C12N15/66 , C12Q1/68 , G01N33/53 , G01N33/566 , A61K67/027
CPC分类号： C07K14/705 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K2039/505
摘要： The invention relates to nucleic acid sequences and isolated proteins which are novel interaction partners of inwardly rectifying potassium channels (Kirs), especially G protein-coupled inwardly rectifying potassium channels (GIRKs). Said interaction partners, together with the Kirs or GIRKs, form protein complexes. The invention also relates to a charged domain of the inventive interaction partners. Said domain binds to the complex intracellular area of Kirs and influences the activity of Kirs in general or of GIRKs in particular. The invention further relates to protein complexes of interaction partners and inwardly rectifying potassium channels, nucleic acid sequences or recombinant nucleic acid constructs which code for such proteins or domains and to the use thereof. The invention relates to protein complexes consisting of the inventive protein and further proteins. The invention also relates to host organisms and specially transgenic animals which contain the inventive nucleic acid sequences or the recombinant nucleic acid constructs as well as to mono- or polyclonal antibodies which are directed against the isolated proteins. The invention further relates to methods for finding partners, i.e. low-molecular or high-molecular substances that specifically bind to the inventive interaction partners.
摘要翻译：本发明涉及核酸序列和分离的蛋白质，其内向整流钾通道（KIR的），尤其是G蛋白偶联内向整流钾通道（GIRKs）的新的交互伙伴是。这种互动合作伙伴一起与KIR的或GIRKs蛋白复合物。本发明进一步涉及的是结合性KIR的复杂的细胞内区域与KIR的的一般的活性，或者特别是通过GIRKs影响erfindugsgemässen相互作用配偶的带电域。此外，本发明涉及相互作用伴侣蛋白复合物和内向整流钾通道，核酸序列或编码这样的蛋白质或结构域，以及它们的用途的重组核酸构建体。此外，本发明还涉及与其它蛋白质本发明的蛋白质的蛋白质复合物。本发明还涉及宿主生物体含有针对分离的蛋白质，本发明核酸序列或重组核酸构建体，以及单 - 或多克隆抗体特异性的转基因动物。另外，本发明涉及寻找伙伴，即低分子量的或特异性结合本发明的相互作用伴侣的高分子量物质的，的方法。

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