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1. 发明申请

WO2016068975A1 TOPICAL COMPOSITIONS AND METHODS OF USE THEREOF 审中-公开
标题翻译：主题组合物及其使用方法
公开(公告)号：WO2016068975A1
公开(公告)日：2016-05-06
申请号：PCT/US2014/063317
申请日：2014-10-31
申请人： AVON PRODUCTS, INC.
发明人： XI, Kai , IDKOWIAK BALDYS, Jolanta , SANTHANAM, Uma , LYGA, John W.
IPC分类号： A61K31/4164
CPC分类号： A61K31/4164 , A61K8/4946 , A61K31/4406 , A61K2800/78 , A61Q19/06 , A61Q19/08
摘要： The invention is generally directed to compositions useful for improving the aesthetic appearance of human skin and the use of those compounds for improving the appearance of human skin, including improving skin tone, reducing the appearance of dark circles under the eyes, and reducing inflammation in the skin. The compositions typically comprise adrenergic receptor agonists.
摘要翻译：本发明一般涉及用于改善人体外观美观的组合物，以及这些化合物用于改善人体皮肤外观的用途，包括改善皮肤色调，减少眼睛下方黑眼圈的外观以及减少眼睛中的炎症皮肤。组合物通常包含肾上腺素能受体激动剂。

2. 发明申请

WO2014099112A1 COLLAGEN STIMULATORS AND THEIR USE IN THE TREATMENT OF SKIN 审中-公开
标题翻译：胶原刺激物及其在治疗皮肤中的用途
公开(公告)号：WO2014099112A1
公开(公告)日：2014-06-26
申请号：PCT/US2013/064091
申请日：2013-10-09
申请人： AVON PRODUCTS, INC.
发明人： SANTHANAM, Uma , KHUSIAL, Permanan Raaj
IPC分类号： A61K8/02 , A61K31/53
CPC分类号： A61K8/4966 , A61K8/365 , A61K8/368 , A61K8/671 , A61K2800/78 , A61Q19/00 , A61Q19/007 , A61Q19/02 , A61Q19/08 , C07D401/06
摘要： Methods for preventing, ameliorating, or reducing dermatological signs of aging are provided which employ a cosmetic composition comprising novel 1,2,4-triazone derivatives or cosmetically acceptable salts thereof, which promote the production of pro-collagen, collagen, and/or elastin in human skin. The cosmetic formulations further comprise an alpha-hydroxy acid selected from salicylic acid and glycolic acid and may further comprise a retinoid.
摘要翻译：提供了用于预防，改善或减少皮肤老化症状的方法，其采用包含新颖的1,2,4-三嗪酮衍生物或其美容上可接受的盐的化妆品组合物，其促进前胶原，胶原和/或弹性蛋白的产生在人的皮肤。化妆品制剂还包含选自水杨酸和乙醇酸的α-羟基酸，并且还可以包含类视色素。

3. 发明申请

WO2014092686A1 STEPHANOTIS JASMINOIDES EXTRACTS AND METHODS OF USE 审中-公开
标题翻译： STEPHANOTIS JASMINOIDES提取物和使用方法
公开(公告)号：WO2014092686A1
公开(公告)日：2014-06-19
申请号：PCT/US2012/068866
申请日：2012-12-11
申请人： AVON PRODUCTS, INC.
发明人： KHUSIAL, Permanan Raaj , SANTHANAM, Uma , LYGA, John W. , THORN LEESON, Daniel
IPC分类号： A01N65/00 , A61K36/00
CPC分类号： A61Q19/08 , A61K8/97 , A61K36/00 , A61K2800/78 , A61K2800/782 , A61Q19/02
摘要： Methods of using extracts of Stephanotis jasminoides to impart anti-aging benefits to skin and/or improve skin conditions resulting from aging or damaged skin.
摘要翻译：使用栀子提取物的方法可以对皮肤赋予抗老化效果和/或改善由老化或受损皮肤引起的皮肤状况。

4. 发明申请

WO2014035401A1 DICKKOPF-1 EXPRESSION MODULATING COMPOSITIONS AND USES THEREOF 审中-公开
标题翻译： DICKKOPF-1表达调节组合物及其用途
公开(公告)号：WO2014035401A1
公开(公告)日：2014-03-06
申请号：PCT/US2012/053116
申请日：2012-08-30
申请人： AVON PRODUCTS, INC. , SANTHANAM, Uma , HONG, Qi , YIM, Sungham
发明人： SANTHANAM, Uma , HONG, Qi , YIM, Sungham
IPC分类号： A61K8/00 , A61K36/00
CPC分类号： A61K8/676 , A61K8/67 , A61K8/735 , A61K8/97 , A61K8/99 , A61K9/0014 , A61K36/064 , A61K2800/522 , A61Q15/00 , A61Q17/04 , A61Q19/00 , A61Q19/02 , A61Q19/06 , A61Q19/08
摘要： The present invention relates generally to compositions for topical application to the skin which comprise at least one DICKKOPF-1 expression modulator and the use of such compositions to provide benefits to the skin, including but not limited to lightening or darkening skin; treating hyper or hypopigmented skin; increasing or decreasing skin thickness; reducing or increasing skin hirsuteness; and/or changing skin phenotype from non-palmoplantar to palmoplantar.
摘要翻译：本发明一般涉及用于局部施用于皮肤的组合物，其包含至少一种DICKKOPF-1表达调节剂以及使用这些组合物为皮肤提供益处，包括但不限于减轻或变暗的皮肤; 治疗皮肤过度或色素沉着; 增加或减少皮肤厚度; 减少或增加皮肤多毛性; 和/或改变皮肤表型从非掌跖到掌跖。

5. 发明申请

WO2013130446A1 USE OF CPT-1 MODULATORS AND COMPOSITIONS THEREOF 审中-公开
标题翻译：使用CPT-1调节剂及其组合物
公开(公告)号：WO2013130446A1
公开(公告)日：2013-09-06
申请号：PCT/US2013/027763
申请日：2013-02-26
申请人： AVON PRODUCTS, INC.
发明人： HWANG, Cheng S. , YIM, Sunghan , SANTHANAM, Uma , LYGA, John W.
IPC分类号： A61Q19/00 , A61Q17/04 , A61K8/97
CPC分类号： A61K8/18 , A61K8/97 , A61Q19/00 , A61Q19/06 , A61Q19/08
摘要： The disclosure describes methods for improving the appearance of skin, particularly, treating, ameliorating, preventing, delaying, and/or improving one or more signs of excess accumulation and/or production of subcutaneous fat, such as cellulite, and conditions related thereto, by topically applying compositions comprising Carnitine PalmitoyI Transferase-I (CPT -I) modulators, optionally with other anti- lipid agents. Also described are compositions and methods for treating, preventing and improving the appearance of skin, particularly, treating, preventing, ameliorating, reducing and/or eliminating loss of subcutaneous fat in the skin, wherein the compositions include natural plant constituents that stimulate lipid synthesis.
摘要翻译：本公开描述了用于改善皮肤外观的方法，特别是治疗，改善，预防，延迟和/或改善皮肤脂肪过量积累和/或产生的一种或多种迹象，例如脂肪团及其相关条件，通过局部施用包含肉碱棕榈酰转移酶I（CPT-1）调节剂的组合物，任选地与其它抗脂质剂一起使用。还描述了用于治疗，预防和改善皮肤外观的组合物和方法，特别是治疗，预防，改善，减少和/或消除皮肤中皮下脂肪的损失，其中组合物包括刺激脂质合成的天然植物成分。

6. 发明申请

WO2011025635A2 COSMETIC USES OF MODIFIED STRESSED YEAST EXTRACTS AND RELATED COMPOSITIONS 审中-公开
标题翻译：化学应用改性的应力YEAST萃取物及相关组合物
公开(公告)号：WO2011025635A2
公开(公告)日：2011-03-03
申请号：PCT/US2010/044360
申请日：2010-08-04
申请人： SANTHANAM, Uma , KYROU, Christos D. , MAZICH, Desiree , HONG, Qi , SHAHEEN, Hussam H. , AVON PRODUCTS, INC.
发明人： SANTHANAM, Uma , KYROU, Christos D. , MAZICH, Desiree , HONG, Qi , SHAHEEN, Hussam H.
IPC分类号： A61K38/08 , A61K8/64 , A61K8/18 , A61P17/10 , A61Q5/08 , A61Q19/02 , A61Q19/06 , A61Q19/08
CPC分类号： A61Q19/02 , A61K8/64 , A61K38/08 , A61K2800/28 , A61K2800/58 , A61Q17/04 , A61Q19/00 , A61Q19/007 , A61Q19/008 , A61Q19/06 , A61Q19/08 , A61Q19/10
摘要： Cosmetic compositions comprising a metal-complexed peptide fraction of stressed yeast extracts and/or a calcium influx inhibitor are disclosed, as well as methods of using such compositions to impart exfoliating, anti-aging, anti-lipid, anti-inflammatory, and/or lightening benefits to the skin; and/or lightening benefits to the hair. These compositions are believed to have modulatory activity against at least one biochemical pathway implicated in skin aging, inflammation, lipid synthesis, and melanin production.
摘要翻译：公开了包含应力酵母提取物和/或钙内流抑制剂的金属络合肽级分的化妆品组合物，以及使用这些组合物赋予去角质，抗衰老，抗脂质，抗炎和/或减轻对皮肤的益处; 和/或减轻对头发的益处。据信这些组合物具有针对涉及皮肤老化，炎症，脂质合成和黑色素生成的至少一种生物化学途径的调节活性。

7. 发明申请

WO2016204841A1 PEPTIDES AND THEIR USE IN THE TREATMENT OF SKIN 审中-公开
标题翻译：皮肤及其在治疗皮肤中的用途
公开(公告)号：WO2016204841A1
公开(公告)日：2016-12-22
申请号：PCT/US2016/023569
申请日：2016-03-22
申请人： AVON PRODUCTS, INC.
发明人： IDKOWIAK BALDYS, Jolanta , LYGA, John W. , SANTHANAM, Uma
IPC分类号： A61K8/64 , A61K38/18 , A61P17/00 , A61Q19/08
CPC分类号： A61K8/64 , A61K8/342 , A61K8/347 , A61K8/36 , A61K8/361 , A61K8/365 , A61K8/368 , A61K8/46 , A61K8/4926 , A61K8/671 , A61K8/675 , A61Q19/08
摘要： Peptides derived from the Growth Differentiation Factor 11 (GDF- 11 ) protein and derivatives thereof, topical compositions, and methods of diminishing signs of aging and/or improving health of human integuments are provided. The present invention provides active agents comprising peptides and topical formulations. One aspect of the invention provides compositions for topical use comprising an active agent comprising one or more GDF-1 1-derived peptides or fragments or derivatives thereof. In another aspect, methods are provided for ameliorating and/or preventing signs of human skin photoaging and intrinsic aging (e.g., diminishing the appearance of wrinkles and/or fine lines, tightening sagging skin, thickening thinning skin, evening skin tone, treating hyperpigmentation, etc.) comprising topically applying to the skin (e.g., skin of the face) a composition comprising, in a topically acceptable vehicle, one or more GDF-11-derived peptides of the invention.
摘要翻译：提供了衍生自生长分化因子11（GDF-11）蛋白及其衍生物的肽，局部组合物和减少老化迹象和/或改善人类皮肤健康的方法。本发明提供包含肽和局部制剂的活性剂。本发明的一个方面提供用于局部使用的组合物，其包含含有一种或多种GDF-11衍生肽或其片段或衍生物的活性剂。另一方面，提供了用于改善和/或预防人皮肤光老化和内在衰老迹象的方法（例如，减少皱纹和/或细纹的出现，紧缩下垂的皮肤，增厚变薄的皮肤，傍晚肤色，治疗色素沉着过度，等），其包括局部施用于皮肤（例如，脸部的皮肤）组合物，其在局部可接受的载体中包含一种或多种本发明的衍生自GDF-11的肽。

8. 发明申请

WO2016105607A1 PEPTIDES AND THEIR USE IN THE TREATMENT OF SKIN 审中-公开
标题翻译：皮肤及其在治疗皮肤中的用途
公开(公告)号：WO2016105607A1
公开(公告)日：2016-06-30
申请号：PCT/US2015/048240
申请日：2015-09-03
申请人： AVON PRODUCTS, INC.
发明人： IDKOWIAK BALDYS, Jolanta , SANTHANAM, Uma
IPC分类号： A61K38/18 , A61P17/00
CPC分类号： A61K8/64 , A61K8/36 , A61K8/365 , A61K8/49 , A61K38/04 , A61Q19/08 , C07K5/08 , C07K5/10 , C07K7/00
摘要： Embodiments of the invention are related generally to the methods of diminishing the signs of aging in and/or improving health of human integuments, such as skin, and compositions comprising peptides useful therefor. The compositions according to the invention may comprise one or more peptides or fragments or derivatives thereof derived from a growth factor, e.g ., Growth Differentiation Factor 11 (GDF11), in a topically acceptable vehicle.
摘要翻译：本发明的实施方案一般涉及减少人皮肤如皮肤老化和/或改善健康的迹象的方法，以及包含其中有用的肽的组合物的方法。根据本发明的组合物可以包含一种或多种源自生长因子的肽或其衍生物，例如生长分化因子11（GDF11），在局部可接受的载体中。

9. 发明申请

WO2016105375A1 PEPTIDES AND THEIR USE IN THE TREATMENT OF SKIN 审中-公开
标题翻译：皮肤及其在治疗皮肤中的用途
公开(公告)号：WO2016105375A1
公开(公告)日：2016-06-30
申请号：PCT/US2014/072080
申请日：2014-12-23
申请人： AVON PRODUCTS, INC.
发明人： IDKOWIAK BALDYS, Jolanta , SANTHANAM, Uma
IPC分类号： A61K38/00
CPC分类号： A61K8/64 , A61K8/342 , A61K9/0014 , A61K9/107 , A61K31/045 , A61K31/05 , A61K31/07 , A61K31/19 , A61K31/194 , A61K31/225 , A61K31/455 , A61K31/60 , A61K38/063 , A61K38/07 , A61K38/08 , A61K38/10 , A61Q19/00 , A61Q19/02 , A61Q19/08 , A61K2300/00
摘要： Provided are methods of diminishing the signs of aging and/or improving the health of human integuments, such as skin, and compositions comprising peptides useful therefor. The compositions according to the invention comprise a peptide comprising the sequence selected from LRLK (SEQ ID NO: 1), MVV (SEQ ID NO: 2), TAKDGAP (SEQ ID NO: 3), IFGGTVYRS (SEQ ID NO: 4), and RTPKISKPIKFELSG (SEQ ID NO: 5) or a derivative, or fragment thereof, in a topically acceptable vehicle.
摘要翻译：提供减少老化迹象和/或改善人类皮肤如皮肤的健康的方法，以及包含对其有用的肽的组合物的方法。根据本发明的组合物包含含有选自LRLK（SEQ ID NO：1），MVV（SEQ ID NO：2），TAKDGAP（SEQ ID NO：3），IFGGTVYRS（SEQ ID NO：4），和RTPKISKPIKFELSG（SEQ ID NO：5）或其衍生物或片段，在局部可接受的载体中。

10. 发明申请

WO2016053284A1 TOPICAL COMPOSITIONS AND METHODS FOR SKIN LIGHTENING 审中-公开
标题翻译：用于皮肤护理的主题组合物和方法
公开(公告)号：WO2016053284A1
公开(公告)日：2016-04-07
申请号：PCT/US2014/058231
申请日：2014-09-30
申请人： AVON PRODUCTS, INC.
发明人： HU, Hong , YIM, Sunghan , SANTHANAM, Uma , LYGA, John W.
IPC分类号： A61K8/18 , A61Q19/00 , A61K31/165
CPC分类号： A61K8/4926 , A61K8/42 , A61K8/892 , A61K9/0014 , A61K31/165 , A61K31/203 , A61K31/4453 , A61K47/34 , A61K2800/592 , A61K2800/95 , A61Q19/02 , A61K2300/00
摘要： Embodiments of the invention are generally directed to compositions useful for reducing histamine-induced pigmentation in the skin. The composition may further include other depigmenting agents such as nicotinamide and its melanasome transfer-inhibiting derivatives, 3,3'-thiodipropanoic acid and its tyrosinase-inhibiting derivatives, or resorcinol and its tyrosinase-inhibiting derivatives, in a cosmetically acceptable vehicle.
摘要翻译：本发明的实施方案通常涉及可用于减少组织胺诱导的皮肤色素沉着的组合物。该组合物还可以包括其它脱色素如烟酰胺及其黑素素转移抑制衍生物，3,3'-硫代二丙酸及其酪氨酸酶抑制衍生物，或间苯二酚及其酪氨酸酶抑制衍生物。

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