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1. 发明申请

WO2007056466A3 IMMUNOSUPPRESSION COMPOUND AND TREATMENT METHOD 审中-公开
标题翻译：免疫抑制复合物和治疗方法
公开(公告)号：WO2007056466A3
公开(公告)日：2007-07-26
申请号：PCT/US2006043507
申请日：2006-11-08
申请人： AVI BIOPHARMA INC , MOURICH DAN V , IVERSEN PATRICK L , WELLER DWIGHT D
发明人： MOURICH DAN V , IVERSEN PATRICK L , WELLER DWIGHT D
IPC分类号： C12Q1/68 , A01N43/04 , A61K31/07 , C07H21/04 , C12N15/113
CPC分类号： C12N15/1138 , C12N2310/11 , C12N2310/3233 , C12N2310/3513
摘要： A method and compound for suppressing an immune response in a mammalian subject, for the treatment or prevention of an autoimmune condition or transplantation rejection are disclosed. The compound is an antisense oligonucleotide analog compound having a targeting sequence complementary to a preprocessed CTLA-4 mRNA region identified by SEQ ID NO: 1 , spanning the splice junction between intron 1 and exon 2 of the preprocessed mRNA of the subject. The compound is effective, when administered to a subject, to form within host cells, a heteroduplex structure (i) composed of the preprocessed CTLA-4 mRNA and the oligonucleotide compound, (ii) characterized by a Tm of dissociation of at least 450C, and (iii) resulting in an increased ratio of processed mRNA encoding ligand-independent CTLA-4 to processed mRNA encoding full- length CTLA-4.
摘要翻译：公开了用于抑制哺乳动物受试者中的免疫应答以治疗或预防自身免疫病症或移植排斥的方法和化合物。该化合物是反义寡核苷酸类似物化合物，其具有与由SEQ ID NO：1鉴定的预加工CTLA-4mRNA区域互补的靶向序列，跨越受试者的预加工mRNA的内含子1和外显子2之间的剪接点。（i）由预处理的CTLA-4 mRNA和寡核苷酸化合物组成，（ii）以至少45℃的解离T m为特征，所述化合物在施用于受试者时在宿主细胞内形成是有效的，和（iii）导致处理的编码配体非依赖性CTLA-4的mRNA与处理的编码全长CTLA-4的mRNA之间的比例增加。

2. 发明申请

WO2005041874A9 METHOD AND ANTISENSE COMPOSITION FOR SELECTIVE INHIBITION OF HIV INFECTION IN HEMATOPOIETIC CELLS 审中-公开
标题翻译：用于选择性抑制HEMATOPOIETIC细胞中HIV感染的方法和抗原组合物
公开(公告)号：WO2005041874A9
公开(公告)日：2010-01-14
申请号：PCT/US2004035121
申请日：2004-10-22
申请人： AVI BIOPHARMA INC , MOURICH DAN V , IVERSEN PATRICK L
发明人： MOURICH DAN V , IVERSEN PATRICK L
IPC分类号： A61K20060101 , A61K31/675 , A61K48/00 , C12N15/113
CPC分类号： A61K31/675 , C07K2319/10 , C12N15/1132 , C12N2310/11 , C12N2810/6054

3. 发明申请

WO2009086469A3 IMMUNOMODULATORY AGENTS AND METHODS OF USE 审中-公开
标题翻译：免疫组化试剂和使用方法
公开(公告)号：WO2009086469A3
公开(公告)日：2009-12-30
申请号：PCT/US2008088339
申请日：2008-12-24
申请人： AVI BIOPHARMA INC , MOURICH DAN V , IVERSEN PATRICK L
发明人： MOURICH DAN V , IVERSEN PATRICK L
IPC分类号： C07H21/04
CPC分类号： C12N15/1136 , C12N2310/11 , C12N2310/315 , C12N2310/3233
摘要： An antisense oligonucleotide compound, composition, vaccine and methods for treating a variety of conditions characterized by up-regulation of IL-10 in a mammalian subject are disclosed. The compound (i) is composed of morpholino subunits and phosphorus-containing intersubunit linkages joining a morpholino nitrogen of one subunit to a 5' exocyclic carbon of an adjacent subunit, (ii) is capable of uptake by monocytes, lymphocytes, and dendritic cells in a mammalian subject, (iii) contains between 10-40 nucleotide bases, and (iv) has a base sequence effective to hybridize to at least 12 contiguous bases of a target sequence contained in an exon-2 or exon-4 slice site region of human IL-10 pre-mRNA.
摘要翻译：公开了一种反义寡核苷酸化合物，组合物，疫苗和用于治疗特征在哺乳动物受试者中上调IL-10的各种病症的方法。化合物（i）由吗啉基亚单位和含有一个亚基的吗啉代氮与相邻亚基的5'环外碳键合的含磷亚基间键组成，（ii）能够被单核细胞，淋巴细胞和树突状细胞吸收哺乳动物受试者，（iii）含有10-40个核苷酸碱基，和（iv）具有有效杂交到包含在外显子2或外显子-4切片位点区域中的靶序列的至少12个连续碱基的碱基序列人IL-10前mRNA。

4. 发明申请

WO2006105479A3 IMMUNOMODULATING COMPOSITIONS AND METHODS FOR USE IN THE TREATMENT OF HUMAN AUTOIMMUNE DISEASES 审中-公开
标题翻译：免疫调节组合物和用于治疗人类自发性疾病的方法
公开(公告)号：WO2006105479A3
公开(公告)日：2009-05-22
申请号：PCT/US2006012262
申请日：2006-03-31
申请人： AVI BIOPHARMA INC , HINRICHS DAVID J , MOURICH DAN V , IVERSEN PATRICK L
发明人： HINRICHS DAVID J , MOURICH DAN V , IVERSEN PATRICK L
IPC分类号： A61K38/00 , A61K38/04 , A61K39/00 , A61K39/385 , C07K16/00 , C07K17/00
CPC分类号： A61K39/0008 , A61K2039/64 , A61K2039/645
摘要： A composition and method for treating an autoimmune condition are disclosed. The composition includes of an immunomodulating compound composed of a central amino acid core having a plurality of chemical attachment groups, and a plurality of antigenic peptides which are (i) associated with an auto-immune disorder and (Ë) attached to the core groups with the same N-terminus to C-terminus orientation. The compound is carried in a pharmaceutically acceptable carrier. An exemplary compound has an octomeric polylysine core and eight antigenic peptides, such as the peptides identified by SEQ ID NOS: 1-11, attached thereto. The compound is effective in treating an autoimmune disorder, by administering to a subject in need of the treatment, a pharmaceutically effective amount of the compound.
摘要翻译：公开了一种用于治疗自身免疫病症的组合物和方法。该组合物包括由具有多个化学连接基团的中心氨基酸核心组成的免疫调节化合物和（i）与自身免疫性疾病相关的多种抗原肽和（Ë）附着于核心组的多个抗原肽，相同的N末端到C末端取向。该化合物携带在药学上可接受的载体中。示例性化合物具有八聚体聚赖氨酸核心和八个抗原肽，例如与其连接的SEQ ID NO：1-11所鉴定的肽。该化合物通过向需要治疗的受试者施用药学有效量的该化合物来治疗自身免疫性疾病是有效的。

5. 发明申请

WO2007030576A3 ANTISENSE ANTIVIRAL COMPOUND AND METHOD FOR TREATING PICORNAVIRUS INFECTION 审中-公开
标题翻译：反义抗病毒化合物和治疗PICORNAVIRUS感染的方法
公开(公告)号：WO2007030576A3
公开(公告)日：2007-06-14
申请号：PCT/US2006034786
申请日：2006-09-08
申请人： AVI BIOPHARMA INC , STEIN DAVID A , RIJNBRAND CORNELIS A , IVERSEN PATRICK L , WELLER DWIGHT D
发明人： STEIN DAVID A , RIJNBRAND CORNELIS A , IVERSEN PATRICK L , WELLER DWIGHT D
IPC分类号： A61K31/70 , C07H21/02 , C07H21/04 , C12N15/113 , C12Q1/68
CPC分类号： C12N15/1131 , C12N2310/11 , C12N2310/3145 , C12N2310/3233 , C12N2310/3513 , C12N2770/32311 , C12N2770/32711
摘要： The invention provides antisense antiviral compounds and methods of their use and production in inhibition of growth of viruses of the Picornaviridae family and in the treatment of a viral infection. The compounds are particularly useful in the treatment of Enterovirus and/or Rhinovirus infection in a mammal. The antisense antiviral compounds are substantially uncharged, including partially positively charged, morpholino oligonucleotides have a sequence of 12-40 subunits, including at least 12 subunits having a targeting sequence that is complementary to a region associated with viral RNA sequences within a 32 nucleotide region of the viral 5' untranslated region identified by SEQ ID NO:4.
摘要翻译：本发明提供了反义抗病毒化合物及其在抑制小核糖核酸病毒科病毒生长和治疗病毒感染中的应用和生产方法。这些化合物特别适用于治疗哺乳动物的肠道病毒和/或鼻病毒感染。反义抗病毒化合物是基本上不带电荷，包括部分带正电荷的，吗啉代寡核苷酸具有12-40亚基的序列，包括具有靶向序列是与病毒RNA序列的32个核苷酸区域内相关联的区域互补的至少12亚基由SEQ ID NO：4鉴定的病毒5'非翻译区。

6. 发明申请

WO2006121951A3 ANTISENSE ANTIVIRAL COMPOUNDS AND METHODS FOR TREATING FOOT AND MOUTH DISEASE 审中-公开
标题翻译：抗真菌化合物和治疗足部疾病的方法
公开(公告)号：WO2006121951A3
公开(公告)日：2009-04-16
申请号：PCT/US2006017580
申请日：2006-05-05
申请人： AVI BIOPHARMA INC , US AGRICULTURE , RIEDFER AIDA E , STEIN DAVID A , VAGNOZZI ARIEL E , WELLER DWIGHT D , IVERSEN PATRICK L
发明人： RIEDFER AIDA E , STEIN DAVID A , VAGNOZZI ARIEL E , WELLER DWIGHT D , IVERSEN PATRICK L
IPC分类号： A01N43/04 , C07H21/02 , C07H21/04 , C12N15/113 , C12N15/63 , C12N15/88 , C12P19/34 , C12Q1/68
CPC分类号： C12N15/1131 , C12N2310/11 , C12N2310/3233 , C12N2310/3513
摘要： An antiviral antisense composition and method for treating foot-and-mouth disease virus (FMDV) in veterinary animals is disclosed. The composition contains an antisense compound that has a sequence effective to target at least 12 contiguous bases of an FMDV RNA sequence within a region of the positive-strand genomic RNA defined by SEQ ID NO:25, and preferably, one of the viral sequences within SEQ ID NO:25 identified by SEQ ID NOS: 26-28. The composition is administered in a therapeutically effective amount in treating FMDV.
摘要翻译：公开了用于在兽医中治疗口蹄疫病毒（FMDV）的抗病毒反义组合物和方法。该组合物含有反义化合物，该反义化合物具有有效靶向SEQ ID NO：25所定义的正链基因组RNA区域内的FMDV RNA序列的至少12个连续碱基的序列，优选其中一个病毒序列由SEQ ID NO：26-28鉴定的SEQ ID NO：25。组合物以治疗有效量施用于治疗FMDV。

7. 发明申请

WO2005115479A3 PEPTIDE CONJUGATED, INOSINE-SUBSTITUTED ANTISENSE OLIGOMER COMPOUND AND METHOD 审中-公开
标题翻译：肽联合，非取代的抗原寡聚化合物和方法
公开(公告)号：WO2005115479A3
公开(公告)日：2007-11-22
申请号：PCT/US2005018213
申请日：2005-05-24
申请人： AVI BIOPHARMA INC , IVERSEN PATRICK L , WELLER DWIGHT D , HASSINGER JED N
发明人： IVERSEN PATRICK L , WELLER DWIGHT D , HASSINGER JED N
IPC分类号： A61K38/00 , A61K31/70 , A61K48/00 , C12N15/11 , C12N15/113 , C12N15/85
CPC分类号： C12N15/113 , A61K48/0008 , C12N15/111 , C12N15/1135 , C12N2310/11 , C12N2310/3145 , C12N2310/3233 , C12N2310/331 , C12N2310/3513 , C12N2320/32
摘要： A therapeutic oligomer-peptide conjugate, and methods of using the conjugate are disclosed. The conjugate includes (a) a substantially uncharged oligonucleotide analog compound having a base sequence that includes a string of bases that are complementary to four or more contiguous cytosine bases in a target nucleic acid region to which the compound is intended to bind, and (b) conjugated to the compound, an arginine-rich peptide effective to enhance the uptake of the compound into target cells. The string of bases in the compound includes at least one inosine base positioned in the string so as to limit the number of contiguous guanine bases in said string to three or fewer. The conjugate has greater cellular uptake than the compound alone, by virtue of the arginine-rich peptide, and substantially greater antisense activity greater activity than the conjugate in the absence of inosine-for guanine substitutions.
摘要翻译：公开了治疗性低聚物 - 肽缀合物和使用该缀合物的方法。缀合物包括（a）具有碱基序列的基本上不带电的寡核苷酸类似物化合物，其碱基序列包括与化合物所要结合的靶核酸区域中的四个或更多个连续胞嘧啶碱基互补的碱基序列，和（b ），富含精氨酸的肽有效地增强化合物进入靶细胞的摄取。所述化合物中的碱基串包括位于所述串中的至少一个肌苷碱基，以将所述串中的连续鸟嘌呤碱基的数目限制为三个或更少。通过富含精氨酸的肽，缀合物比单独的化合物具有更大的细胞摄取，并且在不存在肌苷 - 用于鸟嘌呤取代的情况下，具有比缀合物更大的反义活性。

8. 发明申请

WO2007030691A3 ANTISENSE ANTIVIRAL COMPOUND AND METHOD FOR TREATING PICORNAVIRUS INFECTION 审中-公开
标题翻译：抗真菌化合物和治疗PICORNAVIRUS感染的方法
公开(公告)号：WO2007030691A3
公开(公告)日：2007-06-14
申请号：PCT/US2006034986
申请日：2006-09-08
申请人： AVI BIOPHARMA INC , STEIN DAVID A , BESTWICK RICHARD K , IVERSEN PATRICK L , WELLER DWIGHT D
发明人： STEIN DAVID A , BESTWICK RICHARD K , IVERSEN PATRICK L , WELLER DWIGHT D
IPC分类号： A61K31/70 , C07H21/02 , C07H21/04 , C12N15/113 , C12Q1/68
CPC分类号： A61K38/00 , C12N15/1131 , C12N2310/11 , C12N2310/314 , C12N2310/3233 , C12N2770/32311 , C12N2770/32711
摘要： The invention provides antisense antiviral compounds and methods of their use and production in inhibition of growth of viruses of the Picornaviridae family and in the treatment of a viral infection. The compounds are particularly useful in the treatment of Enterovirus and/or Rhinovirus infection in a mammal. The antisense antiviral compounds are substantially uncharged, morpholino oligonucleotides have a sequence of 12-40 subunits, including at least 12 subunits having a targeting sequence that is complementary to a region associated with viral RNA sequences within a 32 nucleotide region of the viral 51 untranslated region identified by SEQ ID NO:7.
摘要翻译：本发明提供反义抗病毒化合物及其在抑制小核糖核酸病毒科家族病毒生长和用于病毒感染治疗中的用途和生产方法。所述化合物特别可用于治疗哺乳动物中的肠病毒和/或鼻病毒感染。反义抗病毒化合物基本上不带电，吗啉代寡核苷酸具有12-40个亚基的序列，包括至少12个亚基，其具有与病毒51非翻译区的32个核苷酸区域内的病毒RNA序列相关的区域互补的靶向序列由SEQ ID NO：7鉴定。

9. 发明申请

WO2006033933A3 ANTISENSE ANTIVIRAL COMPOUND AND METHOD FOR TREATING SSRNA VIRAL INFECTION 审中-公开
标题翻译：反义抗病毒化合物和治疗SSRNA病毒感染的方法
公开(公告)号：WO2006033933A3
公开(公告)日：2006-07-27
申请号：PCT/US2005032815
申请日：2005-09-15
申请人： AVI BIOPHARMA INC , IVERSEN PATRICK L , STEIN DAVID A
发明人： IVERSEN PATRICK L , STEIN DAVID A
IPC分类号： C12Q1/70 , C12N15/11 , C12N15/113
CPC分类号： C12N15/1131 , C07K19/00 , C12N15/111 , C12N2310/11 , C12N2310/314 , C12N2310/3233 , C12N2310/3513 , C12N2310/531 , C12N2320/11 , C12N2770/00011 , C12N2770/10011 , C12N2770/12011 , C12N2770/16011 , C12N2770/20011 , C12N2770/24011 , C12N2770/28011 , C12N2770/32011 , C12N2770/36011
摘要： The invention provides antisense antiviral compounds and methods of their use and production in inhibition of growth of viruses of the Flaviviridae, Picornoviridae, Caliciviridae, Togaviridae, Arteriviridae, Coronaviridae, Astroviridae and Hepeviridae families in the treatment of a viral infection. The antisense antiviral compounds are substantially uncharged morpholino oligonucleotides having a sequence of 12-40 subunits, including at least 12 subunits having a targeting sequence that is complementary to a region associated with stem-loop secondary structure within the 5'-terminal end 40 bases of the positive-sense RNA strand of the virus.
摘要翻译：本发明提供了反义抗病毒化合物及其在抑制病毒感染治疗中黄病毒科，Picornoviridae，杯状病毒科，披膜病毒科，动脉炎病毒科，冠状病毒科，星状病毒科和Hepeviridae科病毒生长中的应用和生产的方法。反义抗病毒化合物是基本上不带电荷的吗啉代寡核苷酸，其具有12-40个亚基的序列，包括至少12个亚基，其具有与在5'-末端40个碱基中与茎环二级结构相关的区域互补的导向序列病毒的正义RNA链。

10. 发明申请

WO2005007805A3 ANTISENSE ANTIVIRAL AGENT AND METHOD FOR TREATING ssRNA VIRAL INFECTION 审中-公开
标题翻译：抗感染药物和治疗ssRNA病毒感染的方法
公开(公告)号：WO2005007805A3
公开(公告)日：2006-05-04
申请号：PCT/US2004012623
申请日：2004-04-22
申请人： AVI BIOPHARMA INC , STEIN DAVID A , SKILLING DOUGLAS E , IVERSEN PATRICK L , SMITH ALVIN W
发明人： STEIN DAVID A , SKILLING DOUGLAS E , IVERSEN PATRICK L , SMITH ALVIN W
IPC分类号： A61K38/00 , C07H21/04 , C12N20060101 , C12N15/113 , A61K39/12 , A61K39/215
CPC分类号： C12N15/1131 , A61K38/00 , C12N2310/11 , C12N2310/3145 , C12N2310/3233 , C12N2770/20011 , C12N2770/24111
摘要： The invention provides antisense antiviral compounds and methods of their use in inhibition of growth of viruses of the picornavirus, calicivirus, togavirus, coronavirus, and flavivirus families, as in treatment of a viral infection. In particular embodiments, the virus is an RNA virus from the coronavirus family or a West Nile, Yellow Fever or Dengue virus from the flavivirus family. The antisense antiviral compounds are substantially uncharged oligomers having a targeting base sequence that is substantially complementary to a viral target sequence which spans the AUG start site of the first open reading frame of the viral genome.
摘要翻译：本发明提供反义抗病毒化合物及其用于抑制小核糖核酸病毒，杯状病毒，披膜病毒，冠状病毒和黄病毒家族病毒生长的方法，如治疗病毒感染。在具体实施方案中，病毒是来自冠状病毒家族的RNA病毒或来自黄病毒科的西尼罗河，黄热病或登革热病毒。反义抗病毒化合物是具有与病毒基因组的第一开放阅读框的AUG起始位点跨越的病毒靶序列基本互补的靶向碱基序列的基本上不带电荷的寡聚体。

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