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1. 发明申请

WO2003004068A1 HYPERTENSION TREATMENT 审中-公开
标题翻译：高血压治疗
公开(公告)号：WO2003004068A1
公开(公告)日：2003-01-16
申请号：PCT/NZ2002/000118
申请日：2002-07-04
申请人： AUCKLAND UNISERVICES LIMITED , VICKERS, Mark, Hedley , BREIER, Bernhard, Hermann, Heinrich , GLUCKMAN, Peter, David
发明人： VICKERS, Mark, Hedley , BREIER, Bernhard, Hermann, Heinrich , GLUCKMAN, Peter, David
IPC分类号： A61K031/401
CPC分类号： A61K31/5025 , A61K31/401 , A61K31/405 , A61K31/417 , A61K31/4178 , A61K31/4184 , A61K31/472 , A61K38/27 , A61K2300/00
摘要： A method of delaying or preventing the onset of hypertension in mammals, including predisposed mammals, is disclosed. The method includes the administering of an effective amount of or increasing the effective concentration of growth hormone, an analog thereof or a functionally equivalent ligand.
摘要翻译：公开了延迟或预防哺乳动物（包括易感哺乳动物）中高血压发作的方法。该方法包括施用有效量或增加生长激素的有效浓度，其类似物或功能等同的配体。

2. 发明申请

WO2007129113A2 PHENOTYPE PREDICTION 审中-公开
标题翻译： PHENOTYPE预测
公开(公告)号：WO2007129113A2
公开(公告)日：2007-11-15
申请号：PCT/GB2007/050229
申请日：2007-05-02
申请人： UNIVERSITY OF SOUTHAMPTON , AUCKLAND UNISERVICES LIMITED , GOODFREY, Keith, Malcolm , HANSON, Mark, Adrian , BURDGE, Graham, Charles , LILLYCROP, Karen, Ann , COOPER, Cyrus , GLUCKMAN, Peter, David , VICKERS, Mark, Hedley
发明人： GOODFREY, Keith, Malcolm , HANSON, Mark, Adrian , BURDGE, Graham, Charles , LILLYCROP, Karen, Ann , COOPER, Cyrus , GLUCKMAN, Peter, David , VICKERS, Mark, Hedley
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6876 , C12Q1/6883 , C12Q2600/154 , C12Q2600/158
摘要： Detection of epigenetic alteration, especially methylation, of a gene or a combination of genes, preferably in a perinatal tissue sample such as umbilical cord, for predicting diverse phenotypic characteristics such as propensity for obesity, altered body composition, impaired cognition, low bone mineral content, neuro-behavioural problems and altered cardiovascular structure and function occurring in an individual.
摘要翻译：检测基因或基因组合的表观遗传改变，特别是甲基化，优选在围产期组织样品例如脐带中，用于预测多种表型特征如肥胖倾向，改变的身体组成，认知受损，低骨矿物质含量，神经行为问题和改变的心血管结构和功能发生在个体。

3. 发明申请

WO2011062509A2 SYSTEM AND METHOD FOR PARAMETER ESTIMATION IN BIOLOGICAL PROCESSES 审中-公开
标题翻译：生物过程参数估计的系统与方法
公开(公告)号：WO2011062509A2
公开(公告)日：2011-05-26
申请号：PCT/NZ2010/000226
申请日：2010-11-15
申请人： AUCKLAND UNISERVICES LIMITED , PLEASANTS, Anthony, Bryan , MCLEAN, Cameron, Angus , WAKE, Graeme, Charles , SHEPPARD, Allan, Michael , GLUCKMAN, Peter, David
发明人： PLEASANTS, Anthony, Bryan , MCLEAN, Cameron, Angus , WAKE, Graeme, Charles , SHEPPARD, Allan, Michael , GLUCKMAN, Peter, David
IPC分类号： G06F19/12 , C12Q1/68
CPC分类号： G06F19/24

4. 发明申请

WO2005042000A1 NEUROPROTECTIVE EFFECTS OF GLY-PRO-GLU FOLLOWING INTRAVENOUS INFUSION 审中-公开
标题翻译： GLY-PRO-GLU在下腔静脉输注下的神经保护作用
公开(公告)号：WO2005042000A1
公开(公告)日：2005-05-12
申请号：PCT/US2004/035165
申请日：2004-10-22
申请人： NEUREN PHARMACEUTICALS LTD. , NEUREN PHARMACEUTICALS INC. , GUAN, Jian , THOMAS, Gregory, Brian , BATCHELOR, David, Charles , GLUCKMAN, Peter, David
发明人： GUAN, Jian , THOMAS, Gregory, Brian , BATCHELOR, David, Charles , GLUCKMAN, Peter, David
IPC分类号： A61K38/00
CPC分类号： A61K38/06 , A61K2300/00
摘要： Gly-Pro-Glu (GPE) is rapidly metabolized in vivo. We found that GPE infusion elicits potent and consistent neuroprotection in all brain regions examined, and in certain embodiments, the effects were greater than those of a bolus injection followed by infusion ("loading dose/infusion"). GPE reduced apoptosis in the hippocampus and inhibited microglial proliferation and prevented the injury-induced loss of astrocytes and improved long-term somatofunction. GPE after infusion showed a broad effective dose range (0.3-30mg/kg/h) and had a surprisingly extended window of treatment efficacy, permitting its use from 1 to at least as late as 24 h after neural injury. We also found that neuroprotective effects of acute GPE administration were prolonged and therefore capable of being used effectively to treat a variety of neurodegenerative conditions, even when administered after a neural injury. Thus, GPE can be an effective neuroprotective agent used either alone or co-administered along with other neuroprotective agents, antiinflammatory agents or peptidase or protease inhibitors. Compositions of GPE and protease and/or peptidase inhibitors are provided.
摘要翻译： Gly-Pro-Glu（GPE）在体内迅速代谢。我们发现GPE输注在所检查的所有脑区域中引起有效和一致的神经保护作用，并且在某些实施方案中，效果大于推注剂量，然后输注（“加载剂量/输注”）的效果。 GPE减少海马细胞凋亡并抑制小胶质细胞增殖，并防止损伤诱导的星形胶质细胞的丧失和改善长期的生物功能。输注后的GPE显示广泛的有效剂量范围（0.3-30mg / kg / h），并具有令人惊讶的延长的治疗效果窗口，允许其在神经损伤后至少至迟24小时使用。我们还发现，急性GPE给药的神经保护作用延长，因此即使在神经损伤后施用，也能有效地用于治疗各种神经退行性疾病。因此，GPE可以是单独使用或与其它神经保护剂，抗炎剂或肽酶或蛋白酶抑制剂一起使用的有效的神经保护剂。提供GPE和蛋白酶和/或肽酶抑制剂的组合物。

5. 发明申请

WO2003039487A3 CYCLO(PROLYL-GLYCINE) AND METHODS OF USE TO TREAT NEURAL DISORDERS 审中-公开
公开(公告)号：WO2003039487A3
公开(公告)日：2003-05-15
申请号：PCT/US2002/036235
申请日：2002-11-12
申请人： NEURONZ LIMITED , NEURONZ BIOSCIENCES, INC. , GUAN, Jian , GLUCKMAN, Peter, David , SIEG, Frank
发明人： GUAN, Jian , GLUCKMAN, Peter, David , SIEG, Frank
IPC分类号： A61K38/00
摘要： Embodiments of pharmaceutical compositions comprising cyclo(Pro-Gly) and methods for use in treating neural degeneration are provided. Cyclic PG substantially prevents toxic neural degeneration and cell death, and promotes neurite outgrowth in neurons, especially cerebellar neurons. The neuroprotective and neurorenenerative effects of cPG are useful to treat behavioural neurological deficits involving motor control pathways.

6. 发明申请

WO2003039487A2 CYCLO(PROLYL-GLYCINE) AND METHODS OF USE TO TREAT NEURAL DISORDERS 审中-公开
标题翻译： CYCLO（PROLYL-GLYCINE）及其使用方法治疗神经疾病
公开(公告)号：WO2003039487A2
公开(公告)日：2003-05-15
申请号：PCT/US2002/036235
申请日：2002-11-12
申请人： NEURONZ LIMITED , NEURONZ BIOSCIENCES, INC. , GUAN, Jian , GLUCKMAN, Peter, David , SIEG, Frank
发明人： GUAN, Jian , GLUCKMAN, Peter, David , SIEG, Frank
IPC分类号： A61K
CPC分类号： A61K45/06 , A61K38/12 , A61K38/30 , Y02A50/411 , A61K2300/00
摘要： Embodiments of pharmaceutical compositions comprising cyclo(Pro-Gly) and methods for use in treating neural degeneration are provided. Cyclic PG substantially prevents toxic neural degeneration and cell death, and promotes neurite outgrowth in neurons, especially cerebellar neurons. The neuroprotective and neurorenenerative effects of cPG are useful to treat behavioural neurological deficits involving motor control pathways.
摘要翻译：提供了包含环（Pro-Gly）和用于治疗神经变性的方法的药物组合物的实施方案。循环PG基本上防止有毒的神经变性和细胞死亡，并促进神经元，特别是小脑神经元中的神经突生长。 cPG的神经保护和神经再生作用可用于治疗涉及运动控制途径的行为神经缺陷。

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