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1. 发明申请

WO2005075429B1 NOVEL QUINOLINE-CARBAXAMIDES AS JACK3 KINASE MODULATORS 审中-公开
标题翻译：新型QUINOLINE-CARBAXAMIDES作为JACK3激酶调节剂
公开(公告)号：WO2005075429B1
公开(公告)日：2005-11-10
申请号：PCT/SE2005000156
申请日：2005-02-07
申请人： ASTRAZENECA AB , DAVID LAURENT , GUSTAFSSON JOERGEN , LAWITZ KAROLINA , MUSSIE TESFALEDET , NIKITIDIS ANTONIOS
发明人： DAVID LAURENT , GUSTAFSSON JOERGEN , LAWITZ KAROLINA , MUSSIE TESFALEDET , NIKITIDIS ANTONIOS
IPC分类号： C07D215/54 , C07D401/12 , C07D405/12 , C07D409/12 , C07D417/12 , A61K31/47 , A61P11/06 , A61P37/00 , C07D413/12
CPC分类号： C07D409/12 , C07D215/54 , C07D401/12 , C07D405/12 , C07D417/12
摘要： The present invention relates to novel compounds which are JAK3 Kinase inhibitors, methods for their preparation and pharmaceutical compositions comprising them. A compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof, wherein X is -CHOH or -C=O;
摘要翻译：本发明涉及作为JAK3激酶抑制剂的新化合物，其制备方法以及包含它们的药物组合物。式（I）化合物或其药学上可接受的盐或溶剂化物，其中X是-CHOH或-C = O;

2. 发明申请

WO2009050389A3 FILAMENT CONTAINING HYALURONIC ACID IN FREE ACIDIC FORM AND METHOD FOR MAKING SAME 审中-公开
标题翻译：含有游离酸形式的透明质酸的细丝及其制备方法
公开(公告)号：WO2009050389A3
公开(公告)日：2009-11-26
申请号：PCT/FR2008051729
申请日：2008-09-26
申请人： UNIV CLAUDE BERNARD LYON , CENTRE NAT RECH SCIENT , DOMARD ALAIN , DAVID LAURENT , DUPASQUIER FLORENCE
发明人： DOMARD ALAIN , DAVID LAURENT , DUPASQUIER FLORENCE
IPC分类号： D01D5/06 , A61L15/00 , A61L15/28 , C08B37/08 , D01D5/00 , D01F2/00 , D01F9/00 , D01F11/00 , D01F11/02
CPC分类号： A61K9/70 , A61K47/36 , A61L27/20 , C08J7/04 , C08J7/065 , C08J2305/08 , D01D5/06 , D01F9/00 , D01F11/00 , Y10T428/2913 , Y10T428/2933 , Y10T428/298
摘要： The invention relates to a method for producing by wet spinning a continuous filament containing hyaluronic acid in the free acidic and particularly water-soluble form. The preparation method of the invention comprises the following steps: a) preparing an aqueous solution suitable for spinning of hyaluronic acid or a salt thereof, preferably a sodium hyaluronate solution; b) extruding said solution through an extrusion die; c) forming the filament by passing the extruded solution in a bath of concentrated acetic acid, particularly at more than 80%, followed by stretching and drying. The invention also relates to a filament containing hyaluronic acid in the free acidic form, wherein said filament has swelling properties in water and physiological liquids and can be solubilised in water under certain conditions.
摘要翻译：本发明涉及一种通过湿法纺制含有游离酸性和特别是水溶性形式的透明质酸的连续长丝的方法。本发明的制备方法包括以下步骤：a）制备适于透明质酸或其盐，优选透明质酸钠溶液纺丝的水溶液; b）通过挤出模头挤出所述溶液; c）通过使挤出的溶液在浓醋酸浴中通过，特别是超过80％，然后拉伸和干燥来形成长丝。本发明还涉及含有游离酸形式的透明质酸的长丝，其中所述长丝在水和生理液体中具有溶胀性并且可以在某些条件下溶解于水中。

3. 发明申请

WO2007144522A2 MULTI-COLUMN SEQUENTIAL SEPARATION PROCESS 审中-公开
标题翻译：多列顺序分离过程
公开(公告)号：WO2007144522A2
公开(公告)日：2007-12-21
申请号：PCT/FR2007001012
申请日：2007-06-18
申请人： GROUPE NOVASEP , THEOLEYRE MARC-ANDRE , BAUDOUIN STANISLAS , MERRIEN ANNICK , VALERY ERIC , LUDEMANN-HOMBOURGER OLIVIER , DAVID LAURENT , HOLZER MARGIT
发明人： THEOLEYRE MARC-ANDRE , BAUDOUIN STANISLAS , MERRIEN ANNICK , VALERY ERIC , LUDEMANN-HOMBOURGER OLIVIER , DAVID LAURENT , HOLZER MARGIT
IPC分类号： B01D15/18
CPC分类号： B01D15/1871 , B01D15/1828 , B01D15/361 , B01D15/3804
摘要： The subject of the invention is separation on a solid support by multi-column sequential selective retention in order to separate a product of interest from a solution containing such a product of interest, by passing this solution over a fixed chromatographic resin bed comprising at least three zones, liquid flow means being placed between adjacent zones and between the last zone and the first zone, this process comprising several sequences, each sequence comprising at least one step chosen from an absorption step, a rinsing step and a desorption step, carried out either simultaneously or not, each following sequence is carried out by the displacement of the fronts in the zones towards the downstream end substantially of the same increment before the periodic displacement of the points of introduction and of withdrawal, characterized in that the process includes a sub-sequence without injection of the charge.
摘要翻译：本发明的主题是通过多柱顺序选择性保留在固体支持物上进行分离，以便通过将该溶液通过固定的色谱树脂床分离感兴趣的产物和含有目的产物的溶液，所述固定支架包含至少三个区域，液体流动装置被放置在相邻区域之间以及最后区域和第一区域之间，该方法包括若干序列，每个序列包括从吸收步骤，漂洗步骤和解吸步骤中选择的至少一个步骤，通过在引入点和撤出点的周期性移位之前，通过在区域中的前端向下游端基本上相同增量的位移来执行以下每个顺序，其特征在于，序列不注入电荷。

4. 发明申请

WO2007141405A2 SAFETY ROTARY WORK ASSEMBLY FOR HOUSEHOLD ELECTRICAL APPLIANCE AND/OR CULINARY PREPARATION ACCESSORY 审中-公开
标题翻译：家用电器和/或制品附件的安全旋转工作装置
公开(公告)号：WO2007141405A2
公开(公告)日：2007-12-13
申请号：PCT/FR2007000876
申请日：2007-05-25
申请人： SEB SA , DAVID LAURENT , DURRIS CYRIL
发明人： DAVID LAURENT , DURRIS CYRIL
IPC分类号： A47J43/07
CPC分类号： A47J43/0755
摘要： The invention relates to a rotary work assembly (4) comprising an upper drive member (32), a tubular outer jacket (30), and an internal safety component (33) mounted with axial mobility inside the tubular outer jacket (30), against an elastic return means (34), between a lowered rest position and a raised position, the internal safety element (33) having a lower guide cavity (54). In accordance with the invention, the internal safety component (33) keeps the upper drive member (32) in its axial position and the upper drive member (32) can turn the tubular outer jacket (30) when the internal safety component (33) is raised. The invention also relates to a culinary preparation accessory and/or to a household electrical culinary preparation appliance comprising a rotary work assembly of the above type.
摘要翻译：本发明涉及一种旋转工作组件（4），其包括上驱动构件（32），管状外护套（30）和在管状外护套（30）内安装有轴向移动性的内部安全构件（33），抵靠所述内部安全元件（33）具有下引导腔（54），所述弹性返回装置（34）在降低的静止位置和升高位置之间。根据本发明，当内部安全部件（33）在内部安全部件（33）保持上部驱动部件（32）处于其轴向位置时，上部驱动部件（32）能够转动管状外套（30）被提高本发明还涉及烹饪烹饪配件和/或家用烹饪烹饪器具，其包括上述类型的旋转工作组件。

5. 发明申请

WO2007144522A9 MULTI-COLUMN SEQUENTIAL SEPARATION PROCESS 审中-公开
标题翻译：多柱序列分离过程
公开(公告)号：WO2007144522A9
公开(公告)日：2008-03-27
申请号：PCT/FR2007001012
申请日：2007-06-18
申请人： GROUPE NOVASEP , THEOLEYRE MARC-ANDRE , BAUDOUIN STANISLAS , MERRIEN ANNICK , VALERY ERIC , LUDEMANN-HOMBOURGER OLIVIER , DAVID LAURENT , HOLZER MARGIT
发明人： THEOLEYRE MARC-ANDRE , BAUDOUIN STANISLAS , MERRIEN ANNICK , VALERY ERIC , LUDEMANN-HOMBOURGER OLIVIER , DAVID LAURENT , HOLZER MARGIT
IPC分类号： B01D15/18
CPC分类号： B01D15/1871 , B01D15/1828 , B01D15/361 , B01D15/3804
摘要： The subject of the invention is separation on a solid support by multi-column sequential selective retention in order to separate a product of interest from a solution containing such a product of interest, by passing this solution over a fixed chromatographic resin bed comprising at least three zones, liquid flow means being placed between adjacent zones and between the last zone and the first zone, this process comprising several sequences, each sequence comprising at least one step chosen from an absorption step, a rinsing step and a desorption step, carried out either simultaneously or not, each following sequence is carried out by the displacement of the fronts in the zones towards the downstream end substantially of the same increment before the periodic displacement of the points of introduction and of withdrawal, characterized in that the process includes a sub-sequence without injection of the charge.
摘要翻译：本发明的主题是通过多柱顺序选择性保留在固体载体上的分离，以便通过将该溶液通过包含至少三种固定色谱树脂的固定色谱树脂床从感兴趣的产物的溶液中分离感兴趣的产物液体流动装置放置在相邻区域之间以及最后区域与第一区域之间，该过程包括几个序列，每个序列包括至少一个选自吸收步骤，漂洗步骤和解吸步骤的步骤，同时或不同时，通过在导入点和取出点的周期性位移之前，区域中的前端朝向下游端的位移大致相同地增加来执行每个后续序列，其特征在于，没有注入电荷的序列。

6. 发明申请

WO2010070458A3 POLYSACCHARIDE-BASED ADHESIVE 审中-公开
标题翻译：基于多糖的粘合剂
公开(公告)号：WO2010070458A3
公开(公告)日：2010-11-25
申请号：PCT/IB2009008005
申请日：2009-12-18
申请人： SOFRADIM PRODUCTION , CENTRE NAT RECH SCIENT , UNIV CLAUDE BERNARD LYON , SERRERO AURELIE , DOMARD ALAIN , DAVID LAURENT , TROMBOTTO STEPHANE , MONTANARI SUZELEI , BAYON YVES , GRAVAGNA PHILIPPE
发明人： SERRERO AURELIE , DOMARD ALAIN , DAVID LAURENT , TROMBOTTO STEPHANE , MONTANARI SUZELEI , BAYON YVES , GRAVAGNA PHILIPPE
IPC分类号： A61L24/08
CPC分类号： A61L24/08 , C08L5/08
摘要： A biocompatible and bioresorbable adhesive for surgical and therapeutic uses is composed of a chitosan bonded with a functionalized polysaccharide.
摘要翻译：用于手术和治疗用途的生物相容性和生物可吸收性粘合剂由与官能化多糖键合的壳聚糖组成。

7. 发明申请

WO2009044053A3 HOLLOW, PARTICULARLY MULTIPLE-MEMBRANE, FIBRES, THEIR METHOD OF PREPARATION BY SPINNING, AND DEVICE FOR IMPLEMENTING SAID METHOD 审中-公开
标题翻译：中空，特别是多层膜，纤维，纺丝制备方法以及实施所述方法的装置
公开(公告)号：WO2009044053A3
公开(公告)日：2009-08-27
申请号：PCT/FR2008051587
申请日：2008-09-05
申请人： UNIV CLAUDE BERNARD LYON , CENTRE NAT RECH SCIENT , DOMARD ALAIN , DAVID LAURENT , RIVAS RICIO
发明人： DOMARD ALAIN , DAVID LAURENT , RIVAS RICIO
IPC分类号： D01D5/06 , A61L27/50 , B01D69/08 , C08B37/00 , C12M1/12 , C12M3/06 , D01D5/24 , D01F2/28 , D01F4/00 , D01F9/00
CPC分类号： D01D5/24 , B01D69/087 , B01D69/088 , D01D5/06 , D01F2/28 , D01F4/00 , D01F9/00 , D01F9/04
摘要： The present invention relates to a method of preparing fibres, particularly polysaccharide or collagen fibres, by wet spinning under coagulation conditions, said method comprising, in particular: an extrusion step, in which a solution of a coagulable macromolecular assembly is extruded through a standard die; at least one partial coagulation cycle, comprising firstly a coagulation step and secondly a coagulation interruption step; and a collecting step, in which the hollow fibre obtained is collected, in particular by winding it up. The invention also relates to multiple-membrane hollow fibres consisting of the same macromolecular assembly, spinnable by coagulation, especially a natural polysaccharide or a natural polysaccharide modified to the physical hydrogel state or one that is partly dehydrated, said fibres comprising, at least over their length, two superposed coaxial membranes separated from one another by an inter-membrane space. The invention also relates to the spinning device for implementing said method.
摘要翻译：本发明涉及一种通过在凝固条件下湿纺制备纤维，特别是多糖或胶原纤维的方法，所述方法特别包括：挤出步骤，其中可凝结大分子组装体的溶液通过标准模头挤出 ; 至少一个部分凝血循环，首先包括凝血步骤，然后是凝血中断步骤; 和收集步骤，其中收集所获得的中空纤维，特别是通过将其卷起来。本发明还涉及由相同的大分子组装体组成的多膜空心纤维，所述大分子组装体可通过凝固纺丝，特别是天然多糖或改性为物理水凝胶状态的天然多糖或部分脱水的天然多糖，所述纤维至少在它们的通过膜间空间彼此分开的两个叠置的同轴膜。本发明还涉及用于实施所述方法的纺纱装置。

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