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1. 发明申请

WO2009144494A1 PHENOXYPYRIDINYLAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF PDE4 MEDIATED DISEASE STATES 审中-公开
标题翻译：磷酸吡啶衍生物及其在治疗PDE4介导疾病状态中的应用
公开(公告)号：WO2009144494A1
公开(公告)日：2009-12-03
申请号：PCT/GB2009/050566
申请日：2009-05-26
申请人： ASTRAZENECA AB , ASTRAZENECA UK LIMITED , ANDREWS, Glen , COX, Rhona, Jane , DE SAVI, Christopher , MEGHANI, Premji , SANGANEE, Hitesh, Jayantilal , WARNER, Daniel, Jon
发明人： ANDREWS, Glen , COX, Rhona, Jane , DE SAVI, Christopher , MEGHANI, Premji , SANGANEE, Hitesh, Jayantilal , WARNER, Daniel, Jon
IPC分类号： C07D213/82 , C07D401/12 , C07D401/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D498/04 , A61K31/455 , A61P25/00 , A61P9/00 , A61P37/00 , A61P35/00
CPC分类号： C07D471/04 , C07D213/82 , C07D401/12 , C07D401/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D487/04 , C07D498/04
摘要： The present invention provides a compound of a formula (I), wherein the variables are defined herein; to a process for preparing such a compound; and to the use of such a compound in the treatment of a PDE4 mediated disease state.
摘要翻译：本发明提供式（I）化合物，其中变量在本文中定义; 涉及制备这种化合物的方法; 以及使用这种化合物治疗PDE4介导的疾病状态。

2. 发明申请

WO2014191726A1 CHEMICAL COMPOUNDS 审中-公开
标题翻译：化学化合物
公开(公告)号：WO2014191726A1
公开(公告)日：2014-12-04
申请号：PCT/GB2014/051607
申请日：2014-05-27
申请人： ASTRAZENECA AB , ASTRAZENECA UK LIMITED
发明人： AKHTAR, Nadim , BRADBURY, Robert, Hugh , BUTTAR, David , CURRIE, Gordon, Stuart , DE SAVI, Christopher , DONALD, Craig, Samuel , NORMAN, Richard, Albert , OSBORNE, Matthew , RABOW, Alfred, Arthur , REDFEARN, Heather, Marie , WILLIAMS, Helen, Elizabeth , YAVARI, Neda
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
CPC分类号： A61K31/437 , A61K31/519 , A61K45/06 , C07B2200/07 , C07B2200/13 , C07C57/145 , C07D471/04 , C07D487/04
摘要： The invention concerns compounds of Formula (I) or pharmaceutically-acceptable salts thereof, wherein R 1 to R 5 have any of the meanings defined hereinbefore in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of cell proliferative disorders.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐，其中R 1至R 5具有本说明书中以前定义的任何含义; 其制备方法，含有它们的药物组合物及其在治疗细胞增殖性疾病中的用途。

3. 发明申请

WO2017001354A1 POLYCYCLIC AMIDE DERIVATIVES AS CDK9 INHIBITORS 审中-公开
标题翻译：多环酰胺衍生物作为CDK9抑制剂
公开(公告)号：WO2017001354A1
公开(公告)日：2017-01-05
申请号：PCT/EP2016/064899
申请日：2016-06-27
申请人： ASTRAZENECA AB
发明人： PIKE, Kurt, Gordon , BARLAAM, Bernard, Christophe , HAWKINS, Janet , DE SAVI, Christopher , VASBINDER, Melissa, Marie , HIRD, Alexander , LAMB, Michelle
IPC分类号： C07D471/04 , C07D487/04 , C07D498/04 , A61K31/437 , A61P35/00
CPC分类号： C07D498/04 , C07B2200/13 , C07D471/04 , C07D487/04
摘要： Provided are a series of novel pyridine or pyrimidine derivatives of Formula (I) which inhibit CDK9 and may be useful for the treatment of hyperproliferative diseases. In particular the compounds are of use in the treatment of proliferative diseases such as cancer including hematological malignancies such as acute myeloid leukemia, multiple myeloma, chronic lymphocytic leukemia, diffuse large B cell lymphoma, Burkitt's lymphoma, follicular lymphoma and solid tumors such as breast cancer, lung cancer, neuroblastoma and colon cancer. A is C(R 5 ) or N; R 5 is H, C 1-3 alkyl, CN or halogen; R 2 is optionally substituted 3-7 membered heterocycloalkyl or 3-7 membered cycloalkyl; R 4 is (A) or (B) wherein X and Y together with the atoms to which they are attached form an optionally substituted, saturated or partially saturated 5 to 7 membered heterocycloalkyl ring which, in addition to the bridge nitrogen, may contain one or two heteroatoms selected from N, O, and S; J is N or CR 11 ; and R 11 is H or C 1-3 alkyl.
摘要翻译：提供一系列抑制CDK9的式（I）的吡啶或嘧啶衍生物，可用于治疗过度增殖性疾病。特别地，这些化合物可用于治疗增殖性疾病如癌症，包括血液恶性肿瘤例如急性骨髓性白血病，多发性骨髓瘤，慢性淋巴细胞白血病，弥漫性大B细胞淋巴瘤，伯基特淋巴瘤，滤泡淋巴瘤和实体瘤如乳腺癌，肺癌，成神经细胞瘤和结肠癌。 A为C（R5）或N; R5是H，C1-3烷基，CN或卤素; R2是任选取代的3-7元杂环烷基或3-7元环烷基; R4是（A）或（B）其中X和Y与它们连接的原子一起形成任选取代的，饱和或部分饱和的5至7元杂环烷基环，除了桥氮之外，其还可以含有一个或多个两个选自N，O和S的杂原子; J为N或CR11; R 11为H或C 1-3烷基。

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