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1. 发明申请

WO1997034893A1 PHARMACEUTICALLY USEFUL COMPOUNDS 审中-公开
标题翻译：药物有用的化合物
公开(公告)号：WO1997034893A1
公开(公告)日：1997-09-25
申请号：PCT/SE1997000471
申请日：1997-03-20
申请人： ASTRA PHARMACEUTICALS LTD. , ASTRA AKTIEBOLAG , BANTICK, John , BONNERT, Roger , CAGE, Peter , DONALD, David , FURBER, Mark , HIRST, Simon , PERRY, Matthew , PHILLIPS, Eifion
发明人： ASTRA PHARMACEUTICALS LTD. , ASTRA AKTIEBOLAG
IPC分类号： C07D471/04
CPC分类号： C07D231/56 , C07D401/04 , C07D471/04 , C07D487/04
摘要： The invention relates to 2-arylpyrazolisoquinoline and cinnolinone derivatives, methods for their preparation, their use as medicaments, and pharmaceutical formulations including them.
摘要翻译：本发明涉及2-芳基吡唑并喹啉和噌啉酮衍生物，其制备方法，它们作为药物的用途，以及包括它们的药物制剂。

2. 发明申请

WO1998009969A1 NOVEL ARYL-PYRIDAZINES 审中-公开
标题翻译：新亚美尼亚
公开(公告)号：WO1998009969A1
公开(公告)日：1998-03-12
申请号：PCT/SE1997001359
申请日：1997-08-19
申请人： ASTRA PHARMACEUTICALS LTD. , ASTRA AKTIEBOLAG , BANTICK, John , HIRST, Simon , PERRY, Matthew , PHILLIPS, Eifion
发明人： ASTRA PHARMACEUTICALS LTD. , ASTRA AKTIEBOLAG
IPC分类号： C07D491/052
CPC分类号： C07D495/04 , C07D231/54 , C07D237/26 , C07D237/36 , C07D471/04 , C07D491/04 , C07D491/14 , C07D495/14
摘要： Use of a compound of formula (I) wherein, A, A , A and A are all CH or CR or one of A, A , A or A is nitrogen and the others are all CH or CR ; Ar and Ar are independently phenyl, pyridyl, benzothiazolyl, quinolyl or quinoxalinyl all of which are optionally substituted by one or more substituents, X, Y, Z, R , R , R , R are as described in the specification or a pharmaceutically acceptable derivative thereof in the manufacture of a medicament for the treatment of an allergic or an inflammatory condition.
摘要翻译：其中A，A 1，A 2和A 3的式（I）化合物均为CH或CR 4或A，A 1，A 2或 A 3为氮，其余为CH或CR 4; Ar 1和Ar 2独立地是苯基，吡啶基，苯并噻唑基，喹啉基或喹喔啉基，它们全部被一个或多个取代基X，Y，Z，R 1，R 2， 3>，R 4如说明书或其药学上可接受的衍生物所述，用于制备用于治疗过敏或炎性疾病的药物。

3. 发明申请

WO1997045428A1 NOVEL PYRIDAZINE COMPOUNDS 审中-公开
标题翻译：新颖的吡咯烷酮化合物
公开(公告)号：WO1997045428A1
公开(公告)日：1997-12-04
申请号：PCT/SE1997000818
申请日：1997-05-20
申请人： ASTRA PHARMACEUTICALS LTD. , ASTRA AKTIEBOLAG , BANTICK, John , HIRST, Simon , PERRY, Matthew
发明人： ASTRA PHARMACEUTICALS LTD. , ASTRA AKTIEBOLAG
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： The invention relates to fused pyridazine compounds, in particular pyrido[h]cinnoline, pyrido[h]cinnolinone, pyridocyclopenta[1,2-c]pyridazine, pyridocyclopenta[1,2-c]pyridazinone, pyridocyclohepta[1,2-c]pyridazine and pyridocyclohepta[1,2-c]pyridazinone derivatives, their use as medicaments and pharmaceutical compositions comprising them.
摘要翻译：本发明涉及稠合的哒嗪化合物，特别是吡啶并[h]噌啉，吡啶并[h]噌啉酮，吡啶并环戊[1,2-c]哒嗪，吡啶并环戊[1,2-c]哒嗪酮，吡啶并杂庚环[1,2-c] 哒嗪和吡啶并环庚三烯并[1,2-c]哒嗪酮衍生物，它们用作药物和包含它们的药物组合物。

4. 发明申请

WO1998028301A1 PYRROLO[3,4-D]PYRIMIDINONE DERIVATIVES AND THEIR USE AS MEDICAMENTS 审中-公开
标题翻译： PYRROLO [3,4-D]嘧啶酮衍生物及其作为药物使用
公开(公告)号：WO1998028301A1
公开(公告)日：1998-07-02
申请号：PCT/SE1997002157
申请日：1997-12-18
申请人： ASTRA PHARMACEUTICALS LTD. , ASTRA AKTIEBOLAG , COOPER, Martin , CHESHIRE, David , DONALD, David , FURBER, Mark , PERRY, Matthew , HARRISON, Richard , TOMKINSON, Nicholas
发明人： ASTRA PHARMACEUTICALS LTD. , ASTRA AKTIEBOLAG
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： The invention provides certain novel 5-substituted pyrrolo[3,4-d]pyrimidine-2,4-diones according to general formula (I), processes for their preparation, pharmaceutical compositions containing them, a process for preparing the pharmaceutical compositions, and methods of treatment involving their use.
摘要翻译：本发明提供了一些根据通式（I）的5-取代吡咯并[3,4-d]嘧啶-2,4-二酮，其制备方法，含有它们的药物组合物，制备该药物组合物的方法和涉及其使用的治疗方法。

5. 发明申请

WO1997023470A1 BIOLOGICALLY ACTIVE BENZOTHIAZOLONE ETHANAMINES 审中-公开
标题翻译：生物活性苯并噻唑酮ETHANAMINES
公开(公告)号：WO1997023470A1
公开(公告)日：1997-07-03
申请号：PCT/SE1996001650
申请日：1996-12-13
申请人： ASTRA PHARMACEUTICALS LTD. , ASTRA AKTIEBOLAG , BONNERT, Roger , BROWN, Roger , CAGE, Peter , CHESHIRE, David , INCE, Francis
发明人： ASTRA PHARMACEUTICALS LTD. , ASTRA AKTIEBOLAG
IPC分类号： C07D277/68
CPC分类号： C07D277/68
摘要： Compounds of formula (I), wherein X represents naphthyl optionally substituted by alkyl or halogen; and p, q and r independently represent 2 or 3, and pharmaceutically acceptable salts thereof; processes for their preparation and methods for their use.
摘要翻译：式（I）化合物，其中X表示任选被烷基或卤素取代的萘基; 和p，q和r独立地表示2或3，及其药学上可接受的盐; 其准备过程及其使用方法。

6. 发明申请

WO1998001449A1 NOVEL COMPOUNDS 审中-公开
标题翻译：新型化合物
公开(公告)号：WO1998001449A1
公开(公告)日：1998-01-15
申请号：PCT/SE1997001219
申请日：1997-07-04
申请人： ASTRA PHARMACEUTICALS LTD. , ASTRA AKTIEBOLAG , BANTICK, John , PERRY, Matthew , THORNE, Philip
发明人： ASTRA PHARMACEUTICALS LTD. , ASTRA AKTIEBOLAG
IPC分类号： C07D487/04
CPC分类号： C07D491/04 , C07D239/70 , C07D471/04 , C07D487/04
摘要： The invention relates to pharmaceutically useful pyrimidine compounds of formula (I), methods for their preparation, their use as medicaments, and pharmaceutical formulations including them.
摘要翻译：本发明涉及药学上有用的式（I）嘧啶化合物，其制备方法，它们作为药物的用途，以及包括它们的药物制剂。

7. 发明申请

WO1998028300A1 TRIAZOLO[4,5-D]PYRIMIDINYL DERIVATIVES AND THEIR USE AS MEDICAMENTS 审中-公开
标题翻译：三唑并[4,5-D]吡啶衍生物及其作为药物使用
公开(公告)号：WO1998028300A1
公开(公告)日：1998-07-02
申请号：PCT/SE1997002091
申请日：1997-12-12
申请人： ASTRA PHARMACEUTICALS LTD. , ASTRA AKTIEBOLAG , BONNERT, Roger , INGALL, Anthony , SPRINGTHORPE, Brian , WILLIS, Paul
发明人： ASTRA PHARMACEUTICALS LTD. , ASTRA AKTIEBOLAG
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： The invention relates to triazolo[4,5-d]pyrimidin-3-yl derivatives of formula (I), which are useful in the treatment of platelet aggregation disorders.
摘要翻译：本发明涉及式（I）的三唑并[4,5-d]嘧啶-3-基衍生物，其可用于治疗血小板聚集障碍。

8. 发明申请

WO1998027052A1 PROCESS FOR THE PREPARATION OF NMDA ANTAGONISTS 审中-公开
标题翻译：制备NMDA拮抗剂的方法
公开(公告)号：WO1998027052A1
公开(公告)日：1998-06-25
申请号：PCT/SE1997002092
申请日：1997-12-12
申请人： ASTRA PHARMACEUTICALS LTD. , ASTRA AKTIEBOLAG , HARRIS, Alan, Richard
发明人： ASTRA PHARMACEUTICALS LTD. , ASTRA AKTIEBOLAG
IPC分类号： C07C231/02
CPC分类号： C07C231/02 , Y02P20/55 , C07C237/06
摘要： This invention relates to an improved process for the production of known amine compounds of formula (I) which are useful as medicaments, wherein: R and R are independently phenyl or 4-fluorophenyl; R is hydrogen, alkyl C1-4 or methoxycarbonyl; R is hydrogen or methyl; which comprises reaction of a compound of formula (II) with a compound of formula (III) in which R , R , R , R , R and R are independently C1-6 alkyl followed by deprotection and optionally thereafter forming a pharmaceutically acceptable salt.
摘要翻译：本发明涉及可用作药物的已知的式（I）胺化合物的改进方法，其中：R 1和R 2独立地是苯基或4-氟苯基; R 3是氢，烷基C 1-4或甲氧基羰基; R 4是氢或甲基; 其包括式（II）化合物与其中R 5，R 6，R 7，R 8，R 9和R 10的式（III）化合物的反应，独立地是C 1-6烷基，然后去保护，然后任选地形成药学上可接受的盐。

9. 发明申请

WO1997020815A1 COMPOUNDS 审中-公开
标题翻译：化合物
公开(公告)号：WO1997020815A1
公开(公告)日：1997-06-12
申请号：PCT/SE1996001595
申请日：1996-12-04
申请人： ASTRA PHARMACEUTICALS LTD. , ASTRA AKTIEBOLAG , CHESHIRE, David , CLADINGBOEL, David , HARDERN, David , STOCKS, Michael
发明人： ASTRA PHARMACEUTICALS LTD. , ASTRA AKTIEBOLAG
IPC分类号： C07D213/28
CPC分类号： C07D213/30 , C07D213/32 , C07D417/12
摘要： A compound of formula (I), wherein X represents (CH2)nO, (CH2)nS or C2 alkylene; n represents 1 or 2; Ar represents indanyl, tetrahydronaphthyl, naphthyl or phenyl, which latter two groups may be substituted by one or more substituents selected from chloro, fluoro, OR , O(CH2)mCONR R , C(O)R , C1-6 alkyl (optionally substituted by one or more fluorine atoms), pyridyl, thiazinyl, phenyl or C7-9 alkylphenyl which latter two groups are optionally substituted by one or more substituent selected from halo, nitro, OR , C1-6alkyl (optionally substituted by one or more fluorine atoms), C(O)R , C(O)OR , C(O)N(R )R , CN, CH2OR , CH2NR R , N(R )R , N(R )SO2R , N(R )C(O)R , OC(O)R and SO2NR R ; m represents an integer 1 to 3; R , R and R independently represent H, C1-10 alkyl (optionally substituted by one or more fluorine atoms), C7-9 alkylphenyl or phenyl, which latter group is optionally substituted by hydroxy; and R , R , R , R , R , R , R , R , R , R , R , R , R , R , R , R , R and R independently represent H, C1-6 alkyl (optionally substituted by one or more fluorine atoms) or phenyl; in which any alkyl group represent may be interrupted by one or more oxygen atoms; provided that when X represents CH2CH2, Ar may not represent phenyl or phenyl substituted with one or more substituents OR , in which R represents C1-10 alkyl; or a pharmaceutically acceptable derivative thereof, may be used for the treatment of reversible obstructive airways disease or allergic conditions of the skin, nose and eye.
摘要翻译：式（I）的化合物，其中X表示（CH 2）n O，（CH 2）n S或C 2亚烷基; n表示1或2; Ar 1表示茚满基，四氢萘基，萘基或苯基，后两个基团可以被一个或多个选自氯，氟，OR 1，O（CH 2）m CONR 20 R 21，C （O）R 2，任选被一个或多个氟原子取代的C 1-6烷基，吡啶基，噻嗪基，苯基或C 7-9烷基苯基，后两个基团任选被一个或多个选自卤素，硝基，OR 3，C 1-6烷基（任选被一个或多个氟原子取代），C（O）R 4，C（O）OR 5，C（O）N（R 6）R N，R（R 8）R 9，N（R 10）SO 2 R 11，N（R 12））C（O）R 13，OC（O）R 19和SO 2 NR 17 R 18; m表示1〜3的整数， R 1，R 2和R 3独立地表示H，任选被一个或多个氟原子取代的C 1-10烷基，C 7-9烷基苯基或苯基，后者基团任选被羟基取代; R 4，R 5，R 6，R 7，R 8，R 9，R 10，R 11，R 12，R 13， R 14，R 15，R 16，R 17，R 18，R 19，R 20和R 21独立地代表H，C 1-6烷基（任选地被一个或多个氟原子取代）或苯基; 其中任何烷基可以被一个或多个氧原子中断; 条件是当X表示CH 2 CH 2时，Ar 1不表示被一个或多个取代基OR 1取代的苯基或苯基，其中R 1表示C 1-10烷基; 或其药学上可接受的衍生物可用于治疗可逆性阻塞性气道疾病或皮肤，鼻子和眼睛的过敏状况。

10. 发明申请

WO1998028009A1 PHARMACEUTICAL COMPOSITIONS FOR FREEZE DRYING 审中-公开
标题翻译：用于冻干的药物组合物
公开(公告)号：WO1998028009A1
公开(公告)日：1998-07-02
申请号：PCT/SE1997002068
申请日：1997-12-11
申请人： ASTRA PHARMACEUTICALS LTD. , ASTRA AKTIEBOLAG , BLAND, Chris , STEELE, Gerald
发明人： ASTRA PHARMACEUTICALS LTD. , ASTRA AKTIEBOLAG
IPC分类号： A61K47/26
CPC分类号： A61K31/7076 , A61K9/0019 , A61K9/19 , A61K31/704 , A61K47/02 , A61K47/26 , Y10S514/951
摘要： A pharmaceutical composition comprising a nucleotide analogue, mannitol and a modifying additve which is sodium chloride or a polyol which is suitable for freeze drying.
摘要翻译：一种药物组合物，其包含核苷酸类似物，甘露糖醇和改性添加剂，其是适合于冷冻干燥的氯化钠或多元醇。

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