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1. 发明申请

WO2009126225A8 SYSTEM AND METHOD FOR LIQUID DELIVERY EVALUATION USING SOLUTIONS WITH MULTIPLE LIGHT ABSORBANCE SPECTRAL FEATURES 审中-公开
标题翻译：使用具有多个光吸收光谱特征的解决方案进行液体交付评估的系统和方法
公开(公告)号：WO2009126225A8
公开(公告)日：2010-01-28
申请号：PCT/US2009002096
申请日：2009-04-03
申请人： ARTEL INC
发明人： CURTIS RICHARD H , MCNALLY CEARA , EWING CHARLES A , BRADSHAW JOHN THOMAS
IPC分类号： B05B5/16 , B05B5/00 , F04B19/00
CPC分类号： G01N21/00 , B01L3/0234 , B01L2200/14 , B01L2200/148 , G01F25/0092
摘要： A system and related method for improved liquid delivery evaluation using a solution containing one or more dyes such that the solution exhibits multiple distinct detectable light absorbance spectral features for calibrating or testing over extended volume or dilution ranges are described. The system includes: a photometric instrument capable of measuring optical absorbance at multiple wavelengths; one or more sample solutions to be dispensed using the liquid delivery system whose performance is being tested or calibrated; and vessels optionally pre-filled, or filled by the user, with diluent solution. The sample solutions contain one or more dyes, chosen so that multiple distinct detectable light absorbance spectral features, such as peaks and/or valleys and/or plateaus of the solution can be distinguished for volume or dilution ranges of interest. The concentrations of the dyes may be chosen so that a large volume delivery device is calibrated using a spectral feature in the solution with a low absorbance per unit pathlength, while a small volume delivery device is calibrated with the same sample solution but using a different spectral feature with a high absorbance per unit pathlength.
摘要翻译：描述了使用含有一种或多种染料的溶液改进液体递送评价的系统和相关方法，使得溶液表现出用于在扩展体积或稀释范围上校准或测试的多个不同的可检测光吸收光谱特征。该系统包括：能够测量多个波长的光吸收的光度仪; 使用其性能正在测试或校准的液体输送系统来分配的一种或多种样品溶液; 和任选地预先填充或由使用者填充的容器用稀释剂溶液。样品溶液含有一种或多种染料，其选择使得可以区分感兴趣的体积或稀释范围的多种不同的可检测光吸收光谱特征，例如溶液的峰和/或谷和/或平台。可以选择染料的浓度，使得使用溶液中的光谱特征来校准大体积输送装置，每单位通路长度具有低吸光度，而小体积输送装置用相同的样品溶液校准，但使用不同的光谱特征具有每单位光程长的高吸光度。

2. 发明申请

WO2009126225A3 SYSTEM AND METHOD FOR LIQUID DELIVERY EVALUATION USING SOLUTIONS WITH MULTIPLE LIGHT ABSORBANCE SPECTRAL FEATURES 审中-公开
标题翻译：使用具有多光吸收谱特征的解决方案进行液体递送评估的系统和方法
公开(公告)号：WO2009126225A3
公开(公告)日：2009-12-17
申请号：PCT/US2009002096
申请日：2009-04-03
申请人： ARTEL INC
发明人： CURTIS RICHARD H , MCNALLY CEARA , EWING CHARLES A , BRADSHAW JOHN THOMAS
IPC分类号： B05B5/16 , B05B5/00 , F04B19/00
CPC分类号： G01N21/00 , B01L3/0234 , B01L2200/14 , B01L2200/148 , G01F25/0092
摘要： A system and related method for improved liquid delivery evaluation using a solution containing one or more dyes such that the solution exhibits multiple distinct detectable light absorbance spectral features for calibrating or testing over extended volume or dilution ranges are described. The system includes: a photometric instrument capable of measuring optical absorbance at multiple wavelengths; one or more sample solutions to be dispensed using the liquid delivery system whose performance is being tested or calibrated; and vessels optionally pre-filled, or filled by the user, with diluent solution. The sample solutions contain one or more dyes, chosen so that multiple distinct detectable light absorbance spectral features, such as peaks and/or valleys and/or plateaus of the solution can be distinguished for volume or dilution ranges of interest. The concentrations of the dyes may be chosen so that a large volume delivery device is calibrated using a spectral feature in the solution with a low absorbance per unit pathlength, while a small volume delivery device is calibrated with the same sample solution but using a different spectral feature with a high absorbance per unit pathlength.
摘要翻译：描述了使用含有一种或多种染料的溶液改进液体递送评估的系统和相关方法，使得该溶液表现出多个不同的可检测光吸收光谱特征用于在扩展体积或稀释范围上校准或测试。该系统包括：能够测量多个波长处的光吸收率的光度测量仪器; 使用其性能正在测试或校准的液体输送系统分配的一种或多种样品溶液; 以及可选地预先填充或由使用者填充稀释剂溶液的容器。样品溶液含有一种或多种染料，所选择的染料可以针对感兴趣的体积或稀释范围区分溶液的多个不同的可检测光吸收光谱特征，例如峰和/或谷和/或平台。可以选择染料的浓度，以便使用溶液中的光谱特征来校准大体积递送装置，其中每单位光程长度具有低吸光度，而小体积递送装置用相同的样品溶液校准，但使用不同的光谱具有每单位光程长度的高吸光度。

3. 发明申请

WO2008033521A2 QUANTITATIVE DUAL-DYE PHOTOMETRIC METHOD FOR DETERMINING DILUTION IMPACT 审中-公开
标题翻译：用于确定稀释影响的定量双色光学方法
公开(公告)号：WO2008033521A2
公开(公告)日：2008-03-20
申请号：PCT/US2007020036
申请日：2007-09-14
申请人： ARTEL INC
发明人： BRADSHAW JOHN THOMAS , CURTIS RICHARD H , ALBERT KEITH J , KNAIDE TANYA R , MCNALLY CEARA , ROGERS ALEX L
IPC分类号： G01N21/75
CPC分类号： G01N21/31 , Y10T436/25625 , Y10T436/2575
摘要： The invention provides ways to determine the impact of diluting a solution wherein the diluting may be carried out for any of a variety of purposes. In one embodiment, the method enables accurate volume dispensation calculations independent of meniscus shape. In another embodiment, the method enables accurate determination of plate washing efficiency. In yet another embodiment, the method enables the accurate determination of dilution ratio over a plurality of dilution steps. The methods described may be carried out using one or more systems arranged to perform the steps. A kit of the invention includes instructions for carrying out the steps of the methods and, optionally, one or more solutions suitable for conducting photometric measurements.
摘要翻译：本发明提供了确定稀释溶液的影响的方法，其中稀释可以用于各种目的中的任何一种。在一个实施例中，该方法能够实现与弯液面形状无关的精确的体积分配计算。在另一个实施方案中，该方法能够准确地确定洗板效率。在另一个实施方案中，该方法能够在多个稀释步骤中精确测定稀释比。所描述的方法可以使用布置成执行步骤的一个或多个系统来执行。本发明的试剂盒包括用于执行所述方法和任选的一种或多种适于进行光度测量的溶液的步骤的说明书。

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