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1. 发明申请

WO2009042435A8 PYRIDIN-2 -YL-AMINO-I, 2, 4 -THIADIAZOLE DERIVATIVES AS GLUCOKINASE ACTIVATORS FOR THE TREATMENT OF DIABETES MELLITUS 审中-公开
标题翻译：吡啶-2-基氨基-1,2,4-噻二唑衍生物作为用于治疗糖尿病的葡糖激酶活化剂
公开(公告)号：WO2009042435A8
公开(公告)日：2009-10-08
申请号：PCT/US2008076401
申请日：2008-09-15
申请人： ARRAY BIOPHARMA INC , AICHER THOMAS DANIEL , BOYD STEVEN ARMEN , CHICARELLI MARK JOSEPH , CONDROSKI KEVIN RONALD , FELL JAY BRADFORD , FISCHER JOHN P , GUNAWARDANA INDRANI W , HINKLIN RONALD JAY , SINGH AJAY , TURNER TIMOTHY M , WALLACE ELI M
发明人： AICHER THOMAS DANIEL , BOYD STEVEN ARMEN , CHICARELLI MARK JOSEPH , CONDROSKI KEVIN RONALD , FELL JAY BRADFORD , FISCHER JOHN P , GUNAWARDANA INDRANI W , HINKLIN RONALD JAY , SINGH AJAY , TURNER TIMOTHY M , WALLACE ELI M
IPC分类号： C07D417/12 , A61K31/433 , A61P3/10 , C07D417/14
CPC分类号： C07D401/14 , C07D213/75 , C07D401/12 , C07D417/12 , C07D417/14
摘要： Provided are compounds of Formula (I): wherein R2, R3, R13, L and D2 are as defined in the specification, which are useful in the treatment and/or prevention of diseases or disorders mediated by deficient levels of glucokinase activity or which can be treated by activating glucokinase including, but not limited to, diabetes mellitus, impaired glucose tolerance, IFG (impaired fasting glucose) and IFG (impaired fasting glycemia), as well as other diseases and disorders such as those discussed herein.
摘要翻译：提供了式（I）的化合物：其中R 2，R 3，R 13，L和D 2如说明书中所定义，其可用于治疗和/或预防由葡萄糖激酶活性水平不足所介导的疾病或病症，通过激活包括但不限于糖尿病，葡萄糖耐量降低，IFG（空腹葡萄糖受损）和IFG（空腹血糖受损）以及其他疾病和病症（例如本文讨论的那些）的葡萄糖激酶来治疗。

2. 发明申请

WO2008118718A3 2-AMINOPYRIDINE ANALOGS AS GLUCOKINASE ACTIVATORS 审中-公开
标题翻译： 2-氨基吡啶类似物作为GLUCOKINASE激活剂
公开(公告)号：WO2008118718A3
公开(公告)日：2008-11-13
申请号：PCT/US2008057543
申请日：2008-03-19
申请人： ARRAY BIOPHARMA INC , AICHER THOMAS DANIEL , BOYD STEVEN ARMEN , CHICARELLI MARK JOSEPH , CONDROSKI KEVIN RONALD , HINKLIN RONALD JAY , SINGH AJAY
发明人： AICHER THOMAS DANIEL , BOYD STEVEN ARMEN , CHICARELLI MARK JOSEPH , CONDROSKI KEVIN RONALD , HINKLIN RONALD JAY , SINGH AJAY
IPC分类号： C07D417/14 , A61K31/427 , A61K31/4427 , A61P3/10 , C07D471/04 , C07D495/04 , C07D498/04
CPC分类号： C07D417/14 , C07D471/04 , C07D495/04 , C07D498/04
摘要： Provided are compounds of formula (I) that are useful in the treatment and/or prevention of diseases mediated by deficient levels of glucokinase activity, such as diabetes mellitus. Also provided are methods of treating or preventing diseases and disorders characterized by underactivity of glucokinase or which can be treated by activating glucokinase.
摘要翻译：提供式（I）化合物，其可用于治疗和/或预防由缺乏水平的葡糖激酶活性（例如糖尿病）介导的疾病。还提供了治疗或预防以葡萄糖激酶不足活性为特征的疾病和病症的方法，或者可以通过激活葡糖激酶治疗。

3. 发明申请

WO2007117381A9 2 -AMINOPYRIDINE ANALOGS AS GLUCOKINASE ACTIVATORS 审中-公开
标题翻译： 2-氨基吡啶类似物作为葡糖激酶活化剂
公开(公告)号：WO2007117381A9
公开(公告)日：2008-03-27
申请号：PCT/US2007007444
申请日：2007-03-23
申请人： ARRAY BIOPHARMA INC , AICHER THOMAS DANIEL , BOYD STEVEN ARMEN , CHICARELLI MARK JOSEPH , CONDROSKI KEVIN RONALD , HINKLIN RONALD JAY , SINGH AJAY
发明人： AICHER THOMAS DANIEL , BOYD STEVEN ARMEN , CHICARELLI MARK JOSEPH , CONDROSKI KEVIN RONALD , HINKLIN RONALD JAY , SINGH AJAY
IPC分类号： C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/04 , C07D495/04 , C07D498/04 , C07D513/04
CPC分类号： C07D417/12 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/04 , C07D495/04 , C07D513/04
摘要： Provided are compounds of formula I that are useful in the treatment and/or prevention of diseases mediated by deficient levels of glucokinase activity, such as diabetes meilitus. Also provided are methods of treating or preventing diseases and disorders characterized by underactivity of glucokinase or which can be treated by activating glucokinase.
摘要翻译：提供可用于治疗和/或预防由葡萄糖激酶活性水平不足（例如糖尿病）引起的疾病的式I化合物。还提供治疗或预防葡萄糖激酶活性降低或可通过激活葡萄糖激酶进行治疗的疾病和病症的方法。

4. 发明申请

WO2007117381A3 2 -AMINOPYRIDINE ANALOGS AS GLUCOKINASE ACTIVATORS 审中-公开
标题翻译： 2-氨基吡啶类似物作为GLUCOKINASE激活剂
公开(公告)号：WO2007117381A3
公开(公告)日：2008-02-14
申请号：PCT/US2007007444
申请日：2007-03-23
申请人： ARRAY BIOPHARMA INC , AICHER THOMAS DANIEL , BOYD STEVEN ARMEN , CHICARELLI MARK JOSEPH , CONDROSKI KEVIN RONALD , HINKLIN RONALD JAY , SINGH AJAY
发明人： AICHER THOMAS DANIEL , BOYD STEVEN ARMEN , CHICARELLI MARK JOSEPH , CONDROSKI KEVIN RONALD , HINKLIN RONALD JAY , SINGH AJAY
IPC分类号： C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/04 , C07D495/04 , C07D498/04 , C07D513/04
CPC分类号： C07D417/12 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/04 , C07D495/04 , C07D513/04
摘要： Provided are compounds of formula I that are useful in the treatment and/or prevention of diseases mediated by deficient levels of glucokinase activity, such as diabetes meilitus. Also provided are methods of treating or preventing diseases and disorders characterized by underactivity of glucokinase or which can be treated by activating glucokinase.
摘要翻译：提供式I化合物，其可用于治疗和/或预防由缺乏葡萄糖激酶水平的活性介导的疾病，例如糖尿病。还提供了治疗或预防以葡萄糖激酶不足活性为特征的疾病和病症的方法，或者可以通过激活葡糖激酶治疗。

5. 发明申请

WO2013086397A1 UREA COMPOUNDS AS GKA ACTIVATORS 审中-公开
标题翻译：尿素化合物作为GKA激活剂
公开(公告)号：WO2013086397A1
公开(公告)日：2013-06-13
申请号：PCT/US2012068547
申请日：2012-12-07
申请人： ARRAY BIOPHARMA INC , AMGEN INC
发明人： HOUZE JONATHAN B , DRANSFIELD PAUL , PATTAROPONG VATEE , DU XIAOHUI , FU ZICE , LAI SUJEN , PARK JAEHYEON , JIAO XIANYUN , KOHN TODD J , AICHER THOMAS DANIEL , BOYD STEVEN ARMEN , BENCSIK JOSEF , CONDROSKI KEVIN RONALD , HINKLIN RONALD JAY , KRASER CHRISTOPHER F , PRATT SCOTT , SINGH AJAY , WENGLOWSKY STEVEN MARK , BOYS MARK LAURENCE , CHICARELLI MARK JOSEPH , MOHR PETER J , CARDOZO MARIO G
IPC分类号： C07C275/00
CPC分类号： C07D401/14 , C07D213/75 , C07D213/85 , C07D401/04 , C07D401/12 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/14 , C07D411/04 , C07D413/04 , C07D417/04 , C07D419/04 , C07D471/04 , C07D491/052 , C07D493/04 , C07D493/10 , C07D498/04 , C07D513/04
摘要： The present invention relates to compounds, to pharmaceutical compositions comprising the compounds, to a process for making the compounds and to the use of the compounds in therapy. More particularly, it relates to certain glucokinase activators of Formulas 1 and 1a, useful in the treatment of diseases and disorders that would benefit from activation of glucokinase.
摘要翻译：本发明涉及化合物，包含该化合物的药物组合物，涉及制备化合物的方法和该化合物在治疗中的用途。更具体地说，本发明涉及式1和1a的某些葡糖激酶活化剂，可用于治疗可受益于葡萄糖激酶活化的疾病和病症。

6. 发明申请

WO2010125361A3 METHODS AND APPARATUS FOR HANDLING MEASUREMENT REPORTS 审中-公开
标题翻译：处理测量报告的方法和设备
公开(公告)号：WO2010125361A3
公开(公告)日：2010-12-23
申请号：PCT/GB2010000881
申请日：2010-04-30
申请人： RESEARCH IN MOTION LTD , RES IN MOTION JAPAN LTD , RESEARCH IN MOTION UK LTD , YOUNG GORDON PETER , TOD ANTHONY , SINGH AJAY , BURBIDGE RICHARD CHARLES , ARZELIER CLAUDE JEAN-FREDERIC
发明人： YOUNG GORDON PETER , TOD ANTHONY , SINGH AJAY , BURBIDGE RICHARD CHARLES , ARZELIER CLAUDE JEAN-FREDERIC
IPC分类号： H04W36/00
CPC分类号： H04W36/0083 , H04W36/18
摘要： A network comprising a component configured to update an active set (AS) of cells based on a collective consideration of a plurality of cell measurement reports received during radio reconfiguration. Also included is a user equipment (UE), comprising a component configured such that the UE combines a plurality of cell measurement reports triggered briefly before and/or during radio reconfiguration, the combined measurement report used to update an AS of cells. Also included is a method comprising transmitting a radio bearer reconfiguration message, receiving a plurality of cell measurement reports, receiving a radio bearer reconfiguration complete message, and updating a plurality of AS cells using the combined cell measurement reports. Also included is a method comprising receiving a radio bearer reconfiguration message, obtaining a plurality of cell measurement reports, and sending a combined cell measurement report based on the cell measurement reports.
摘要翻译：一种网络，包括被配置为基于在无线电重新配置期间接收到的多个小区测量报告的集体考虑来更新小区的活动集（AS）的组件。还包括用户设备（UE），其包括被配置为使得UE在无线电重新配置之前和/或期间短暂地触发的多个小区测量报告的组合测量报告，所述组合测量报告用于更新小区AS。还包括一种方法，包括：发送无线电承载重新配置消息，接收多个小区测量报告，接收无线电承载重新配置完成消息，以及使用组合的小区测量报告更新多个AS小区。还包括一种方法，包括：接收无线电承载重新配置消息，获得多个小区测量报告，以及基于小区测量报告发送组合小区测量报告。

7. 发明申请

WO2009134662A3 IN-LINE CONTENT BASED SECURITY FOR DATA AT REST IN A NETWORK STORAGE SYSTEM 审中-公开
标题翻译：在网络存储系统中基于在线内容的数据保护
公开(公告)号：WO2009134662A3
公开(公告)日：2010-02-18
申请号：PCT/US2009041459
申请日：2009-04-22
申请人： NETAPP INC , SINGH AJAY , SUBRAMANIAN ANANTHAN , KOGELNIK CHRISTOPH
发明人： SINGH AJAY , SUBRAMANIAN ANANTHAN , KOGELNIK CHRISTOPH
IPC分类号： G06F21/24 , G06F21/00
CPC分类号： G06F21/6218
摘要： A network storage server receives multiple write requests from a set of clients via a network and internally buffers multiple data blocks written by the write requests. At a consistency point, the storage server commits the data blocks to a nonvolatile mass storage facility. The consistency point process includes using a storage operating system in the network storage server to compress the data blocks, encrypt selected data blocks, and store the compressed and (possibly) encrypted data blocks in the nonvolatile mass storage facility. Data blocks can also be fingerprinted in parallel with compression and/or encryption, to facilitate subsequent deduplication. Data blocks can be indexed and classified according to content or attributes of the data. Encryption can be applied at different levels of logical container granularity, where a separate, unique cryptographic key is used for each encrypted logical container.
摘要翻译：网络存储服务器通过网络从一组客户端接收多个写入请求，并且内部缓冲由写入请求写入的多个数据块。在一致性点，存储服务器将数据块提交到非易失性大容量存储设备。一致性处理包括使用网络存储服务器中的存储操作系统来压缩数据块，加密所选择的数据块，并将压缩和（可能）加密的数据块存储在非挥发性大容量存储设施中。数据块也可以与压缩和/或加密并行进行指纹化，以便于后续重复数据删除。数据块可以根据数据的内容或属性进行索引和分类。加密可以应用于逻辑容器粒度的不同级别，其中每个加密的逻辑容器使用单独的唯一密码密钥。

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