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1. 发明申请

WO2012061342A3 SUBSTITUTED BENZO-IMIDAZO-PYRIDO-DIAZEPINE COMPOUNDS 审中-公开
标题翻译：取代的苯并咪唑 - 吡啶二重氮化合物
公开(公告)号：WO2012061342A3
公开(公告)日：2012-08-16
申请号：PCT/US2011058716
申请日：2011-11-01
申请人： ARQULE INC , ASHWELL MARK A , EATHIRAJ SUDHARSHAN , FILIKOV ANTON , KOERNER STEFFI , LAPIERRE JEAN-MARC , LIU YANBIN , PALMA ROCIO , VENSEL DAVID , IIMURA SHIN , SHIINA AKIKO , YOSHIDA KENICHI , YAMAZAKI TAKANORI , MATSUDA AKIHISA
发明人： ASHWELL MARK A , EATHIRAJ SUDHARSHAN , FILIKOV ANTON , KOERNER STEFFI , LAPIERRE JEAN-MARC , LIU YANBIN , PALMA ROCIO , VENSEL DAVID , IIMURA SHIN , SHIINA AKIKO , YOSHIDA KENICHI , YAMAZAKI TAKANORI , MATSUDA AKIHISA
IPC分类号： C07D471/14 , A61K31/5513 , A61K31/5517 , A61P35/00 , C07D487/14
CPC分类号： C07D471/14 , A61K31/551
摘要： The present invention relates to substituted benzo-imidazo-pyrido-diazepine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted benzo-imidazo-pyrido-diazepine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.
摘要翻译：本发明涉及取代的苯并咪唑并 - 吡啶并二氮杂化合物及其合成方法。本发明还涉及含有取代的苯并咪唑并 - 吡啶并二氮杂化合物的药物组合物和通过将这些化合物和药物组合物给予有需要的受试者来治疗细胞增殖性疾病如癌症的方法。

2. 发明申请

WO2012177844A3 SUBSTITUTED IMIDAZOPYRIDINYL-AMINOPYRIDINE COMPOUNDS 审中-公开
标题翻译：取代的咪唑啉氨基亚氨基吡啶化合物
公开(公告)号：WO2012177844A3
公开(公告)日：2013-04-04
申请号：PCT/US2012043501
申请日：2012-06-21
申请人： ARQULE INC , ASHWELL MARK A , BRASSARD CHRIS , FILIKOV ANTON , HILL JASON , KOERNER STEFFI , LAPIERRE JEAN-MARC , LIU YANBIN , NAMDEV NIVEDITA , NICEWONGER ROBERT , PALMA ROCIO , TANDON MANISH , VENSEL DAVID , MATSUDA AKIHISA , IIMURA SHIN , YOSHIDA KENICHI , YAMAZAKI TAKANORI , KITAMURA TAKAHIRO , ISOYAMA TAKESHI
发明人： ASHWELL MARK A , BRASSARD CHRIS , FILIKOV ANTON , HILL JASON , KOERNER STEFFI , LAPIERRE JEAN-MARC , LIU YANBIN , NAMDEV NIVEDITA , NICEWONGER ROBERT , PALMA ROCIO , TANDON MANISH , VENSEL DAVID , MATSUDA AKIHISA , IIMURA SHIN , YOSHIDA KENICHI , YAMAZAKI TAKANORI , KITAMURA TAKAHIRO , ISOYAMA TAKESHI
IPC分类号： C07D471/04 , A61K31/4745 , A61P35/00 , C07D401/04 , C07D413/14
CPC分类号： C07D471/04 , C07D451/02 , C07D491/08 , C07D498/08
摘要： The present invention relates to substituted imidazopyridinyl-aminopyridine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted imidazopyridinyl- aminopyridine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.
摘要翻译：本发明涉及取代的咪唑并吡啶基 - 氨基吡啶化合物和合成这些化合物的方法。本发明还涉及含有取代的咪唑并吡啶基 - 氨基吡啶化合物的药物组合物和通过将这些化合物和药物组合物给予有需要的受试者来治疗细胞增殖性疾病如癌症的方法。

3. 发明申请

WO2011082270A3 SUBSTITUTED IMIDAZOPYRIDINYL-AMINOPYRIDINE COMPOUNDS 审中-公开
标题翻译：取代的咪唑并吡啶基 - 氨基吡啶化合物
公开(公告)号：WO2011082270A3
公开(公告)日：2011-11-17
申请号：PCT/US2010062440
申请日：2010-12-29
申请人： ARQULE INC , ASHWELL MARK A , BRASSARD CHRIS , FILIKOV ANTON , HILL JASON , KOERNER STEFFI , LAPIERRE JEAN-MARC , LIU YANBIN , NAMDEV NIVEDITA , NICEWONGER ROBERT , PALMA ROCIO , TANDON MANISH , VENSEL DAVID , MATSUDA AKIHISA , IIMURA SHIN , YAMAMOTO YUKO
发明人： ASHWELL MARK A , BRASSARD CHRIS , FILIKOV ANTON , HILL JASON , KOERNER STEFFI , LAPIERRE JEAN-MARC , LIU YANBIN , NAMDEV NIVEDITA , NICEWONGER ROBERT , PALMA ROCIO , TANDON MANISH , VENSEL DAVID , MATSUDA AKIHISA , IIMURA SHIN , YAMAMOTO YUKO
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00 , C07D401/04 , C07D401/14
CPC分类号： C07D471/04
摘要： The present invention relates to substituted imidazopyridinyl-aminopyridine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted imidazopyridinyl- aminopyridine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.
摘要翻译：本发明涉及取代的咪唑并吡啶基 - 氨基吡啶化合物和合成这些化合物的方法。本发明还涉及含有取代的咪唑并吡啶基 - 氨基吡啶化合物的药物组合物和通过将这些化合物和药物组合物施用于有需要的受试者来治疗细胞增殖性病症如癌症的方法。

4. 发明申请

WO2011123678A3 SUBSTITUTED BENZO-PYRIDO-TRIAZOLO-DIAZEPINE COMPOUNDS 审中-公开
标题翻译：取代的苯并吡喃三唑并 - 二氮杂萘化合物
公开(公告)号：WO2011123678A3
公开(公告)日：2012-01-12
申请号：PCT/US2011030774
申请日：2011-03-31
申请人： ARQULE INC , ALI SYED M , ASHWELL MARK A , KELLEHER EUGENE , KOERNER STEFFI , LAPIERRE JEAN-MARC , LINK JEFFREY S , LIU YANBIN , MOUSSA MAGDI , PALMA ROCIO , TANDON MANISH , VENSEL DAVID , WESTLUND NEIL , WU HUI , YANG RUI-YANG
发明人： ALI SYED M , ASHWELL MARK A , KELLEHER EUGENE , KOERNER STEFFI , LAPIERRE JEAN-MARC , LINK JEFFREY S , LIU YANBIN , MOUSSA MAGDI , PALMA ROCIO , TANDON MANISH , VENSEL DAVID , WESTLUND NEIL , WU HUI , YANG RUI-YANG
IPC分类号： C07D471/14 , A61K31/5517 , A61P35/00 , C07D401/04 , C07D405/04 , C07D487/04
CPC分类号： C07D471/14 , C07D487/04
摘要： The present invention relates to substituted benzo-pyrido-triazolo-diazepine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted benzo-pyrido-triazolo- diazepine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds or pharmaceutical compositions to subjects in need thereof.
摘要翻译：本发明涉及取代的苯并吡啶并三唑并二氮杂化合物及其合成方法。本发明还涉及含有取代的苯并吡啶并三唑并二氮杂化合物的药物组合物和通过将这些化合物或药物组合物给予有需要的受试者来治疗细胞增殖性疾病如癌症的方法。

5. 发明申请

WO2010078421A1 SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F] ISOQUINOLIN-2-AMINE COMPOUNDS 审中-公开
标题翻译：取代的5,6-二羟基-6-苯基[F]异喹啉-2-胺化合物
公开(公告)号：WO2010078421A1
公开(公告)日：2010-07-08
申请号：PCT/US2009069813
申请日：2009-12-30
申请人： ARQULE INC , ALI SYED M , ASHWELL MARK , TANDON MANISH , YANG RUI-YANG , LIU YANBIN , VENSEL DAVID , EATHIRAJ SUDHARSHAN , PALMA ROCIO , LAPIERRE JEAN-MARC , WESTLUND NEIL , WU HUI , NAMDEV NIVEDITA , KELLEHER EOIN , KELLEHER EUGENE
发明人： ALI SYED M , ASHWELL MARK , TANDON MANISH , YANG RUI-YANG , LIU YANBIN , VENSEL DAVID , EATHIRAJ SUDHARSHAN , PALMA ROCIO , LAPIERRE JEAN-MARC , WESTLUND NEIL , WU HUI , NAMDEV NIVEDITA , KELLEHER EOIN , KELLEHER EUGENE
IPC分类号： C07D221/10 , A61K31/55 , A61P35/00 , C07D401/12 , C07D471/10
CPC分类号： C07D239/70 , C07D221/10 , C07D401/12 , C07D403/12 , C07D409/12 , C07D471/10
摘要： The present invention relates to substituted 5,6-dihydro-6- phenylbenzo[f]isoquinolin-2-amine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.
摘要翻译：本发明涉及取代的5,6-二氢-6-苯基苯并[f]异喹啉-2-胺化合物和合成这些化合物的方法。本发明还涉及含有取代的5,6-二氢-6-苯基苯并[f]异喹啉-2-胺化合物的药物组合物和通过将这些化合物和药物组合物给予受试者来治疗细胞增殖性疾病如癌症的方法需要。

6. 发明申请

WO2009002808A3 QUINAZOLINONE COMPOUNDS AND METHODS OF USE THEREOF 审中-公开
标题翻译：喹唑啉酮化合物及其使用方法
公开(公告)号：WO2009002808A3
公开(公告)日：2009-07-23
申请号：PCT/US2008067571
申请日：2008-06-19
申请人： ARQULE INC , LIU JIFENG , ALI SYED M , ASHWELL MARK A , YE PING , GUAN YOUSHENG , NG SHI-CHUNG , PALMA ROCIO , YOHANNES DAN
发明人： LIU JIFENG , ALI SYED M , ASHWELL MARK A , YE PING , GUAN YOUSHENG , NG SHI-CHUNG , PALMA ROCIO , YOHANNES DAN
IPC分类号： C07D239/90 , A61K31/517 , A61P35/00
CPC分类号： C07D239/90
摘要： The present invention relates to quinazolinone compounds, and methods of preparation of these compounds. The present invention also relates to pharmaceutical compositions comprising the quinazolinone compounds. The present invention provides methods of treating a cell proliferative disorder, such as a cancer, by administering to a subject in need thereof a therapeutically effective amount of a quinazolinone compound of the present invention
摘要翻译：本发明涉及喹唑啉酮化合物及其制备方法。本发明还涉及包含喹唑啉酮化合物的药物组合物。本发明提供了通过向有需要的受试者施用治疗有效量的本发明的喹唑啉酮化合物来治疗细胞增殖性疾病如癌症的方法

7. 发明申请

WO2009049305A3 5- (2-HYDROXYPHENYL) TETRAZOLES AS HSP90 INHIBITORS AGAINST CANCER 审中-公开
标题翻译： 5-（2-羟基苯基）四氢叶酸作为HSP90抗癌剂抑制剂
公开(公告)号：WO2009049305A3
公开(公告)日：2009-07-02
申请号：PCT/US2008079755
申请日：2008-10-14
申请人： ARQULE INC , YANG RUI-YANG , ALI SYED M , ASHWELL MARK A , KELLEHER EUGENE , PALMA ROCIO , WESTLUND NEIL
发明人： YANG RUI-YANG , ALI SYED M , ASHWELL MARK A , KELLEHER EUGENE , PALMA ROCIO , WESTLUND NEIL
IPC分类号： C07D257/04 , A61K31/41 , A61P35/00 , C07D401/10 , C07D403/04 , C07D403/10 , C07D403/12
CPC分类号： C07D257/04 , C07D401/10 , C07D403/04 , C07D403/10 , C07D403/12
摘要： The present invention provides tetrazole compounds, and methods of preparation of these compounds. The present invention also relates to pharmaceutical compositions comprising the tetrazole compounds. The present invention provides methods of treating a cell proliferative disorder, such as a cancer, by administering to a subject in need thereof a therapeutically effective amount of a compound of the present invention, formula (I) wherein: R1 is selected from the group consisting of hydrogen, CH3, F, Cl, Br, and I; R2 is selected from the group consisting of hydrogen, OH, SH, CH3, -CONH2, NHR16, -CH2OH, - CH2SH, and -CH2NH2; R16 is hydrogen, CH3, or C2H3; R3 is selected from the group consisting of hydrogen, F, Cl, Br, I, NO2, CN, -(C1-C6) alkyl, -(C1 -C6) substituted alkyl, C2-C6 alkenyl, (C3-C9) cycloalkyl, (C3-C9) substituted cycloalkyl; -OR8, -NR9R10, -C(=O)-, WR11, -C(=O)-NR12R13, and formula (II); R4 is selected from the group consisting of hydrogen, (C1 -C6) alkyl, (C1-C6) substituted alkyl, (C3-C9) cycloalkyl, (C3-C9) substituted cycloalkyl; aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclyl, substituted heterocyciyl, -OR14, and formula (III). The present invention relates to tetrazole compounds and the use of as HSP90 inhibitors for cancer.
摘要翻译：本发明提供了四唑化合物，以及这些化合物的制备方法。本发明还涉及包含四唑化合物的药物组合物。本发明提供了通过向有需要的受试者施用治疗有效量的本发明化合物式（I）的式（I）化合物，其中：R1选自下组：治疗细胞增殖性疾病如癌症的方法，的氢，CH3，F，Cl，Br和I; R 2选自氢，OH，SH，CH 3，-CONH 2，NHR 16，-CH 2 OH，-CH 2 SH和-CH 2 NH 2; R 16是氢，CH 3或C 2 H 3; R3选自氢，F，Cl，Br，I，NO2，CN， - （C1-C6）烷基， - （C1-C6）取代的烷基，C2-C6烯基，（C3-C9），（C 3 -C 9）取代的环烷基; -OR8，-NR9R10，-C（= O） - ，WR11，-C（= O）-NR12R13和式（Ⅱ）; R4选自氢，（C1-C6）烷基，（C1-C6）取代的烷基，（C3-C9）环烷基，（C3-C9）取代的环烷基; 芳基，取代的芳基，杂芳基，取代的杂芳基，杂环基，取代的杂胞基，-OR14和式（III）。本发明涉及四唑化合物和作为HSP90抑制剂用于癌症的用途。

8. 发明申请

WO2011082273A3 SUBSTITUTED PYRROLO-AMINOPYRIMIDINE COMPOUNDS 审中-公开
标题翻译：取代的吡咯 - 氨基吡啶化合物
公开(公告)号：WO2011082273A3
公开(公告)日：2011-10-20
申请号：PCT/US2010062444
申请日：2010-12-29
申请人： ARQULE INC , LIU YANBIN , NAMDEV NIVEDITA , PALMA ROCIO , TANDON MANISH , WANG JIANQIANG , WU HUI
发明人： LIU YANBIN , NAMDEV NIVEDITA , PALMA ROCIO , TANDON MANISH , WANG JIANQIANG , WU HUI
IPC分类号： C07D487/04 , A61K31/519 , A61P35/00
CPC分类号： C07D487/04
摘要： The present invention relates to substituted pyrrolo-aminopyrimidine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted pyrrolo-aminopyrimidine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.
摘要翻译：本发明涉及取代的吡咯并 - 氨基嘧啶化合物及其合成方法。本发明还涉及含有取代的吡咯并 - 氨基嘧啶化合物的药物组合物和通过将这些化合物和药物组合物施用于有需要的受试者来治疗细胞增殖性疾病如癌症的方法。

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