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1. 发明申请

WO2003033045A2 CATHETERS WITH SUCTION CAPABILITY AND RELATED METHODS AND SYSTEMS FOR OBTAINING BIOSAMPLES IN VIVO 审中-公开
标题翻译：具有吸收能力的吸管和用于在体内获取生物体的相关方法和系统
公开(公告)号：WO2003033045A2
公开(公告)日：2003-04-24
申请号：PCT/US2002/030354
申请日：2002-09-25
申请人： ARGOMED LTD. , CIOANTA, Iulian , LAZAROVITZ, Jacob , KLEIN, Richard, Barry
发明人： CIOANTA, Iulian , LAZAROVITZ, Jacob , KLEIN, Richard, Barry
IPC分类号： A61M
CPC分类号： A61B18/04 , A61B10/0045 , A61B2017/00274 , A61B2017/22051 , A61B2017/22069 , A61B2018/00547 , A61B2018/046 , A61M25/0017 , A61M25/0032 , A61M25/007 , A61M25/1011 , A61M2025/0036
摘要： Methods, systems, and computer program products for obtaining a sample in vivo and/or treating a subject include positioning an elongated transurethral catheter in the prostatic urethra of a subject, the catheter having a bladder anchoring balloon, at least one biosample entry port disposed axially away from the bladder anchoring balloon, and an axially extending biosample flow channel in fluid communication with the biosample entry port held internally in the catheter. The anchoring balloon is inflated to position the catheter so that the fluid entry port is proximate the prostatic urethra of the subject and prostatic fluid is suctioned from the prostatic urethra into the biosample entry port and into the biosample flow channel. The catheter can include a thermal treatment balloon and/or dilatation balloon and the suctioned sample can be obtained concurrently with, during, or proximate in time to the applied treatment. The catheter can be configured to allow urine to drain therethrough during the treatment/collection of the sample while keeping the urine isolated from the collected prostatic fluid sample.
摘要翻译：用于在体内获得样品和/或治疗受试者的方法，系统和计算机程序产品包括将细长的经尿道导管定位在受试者的前列腺尿道中，所述导管具有膀胱锚定球囊，至少一个生物样本入口端口远离气囊锚定气囊，以及轴向延伸的生物样品流动通道，其与保持在导管内部的生物样品入口端口流体连通。锚定气囊被充气以定位导管，使得流体进入端口靠近受试者的前列腺尿道，并且前列腺液体从前列腺尿道吸入生物样品入口并进入生物样品流动通道。导管可以包括热处理球囊和/或扩张球囊，并且抽吸样品可以在施用的治疗时间期间，期间或接近时间获得。导管可以被配置成允许尿液在样品的处理/收集期间从其中排出，同时保持尿液与收集的前列腺液体样品分离。

2. 发明申请

WO2002058578A1 TREATMENT CATHETERS WITH THERMALLY INSULATED REGIONS 审中-公开
标题翻译：治疗导管与热绝缘区域
公开(公告)号：WO2002058578A1
公开(公告)日：2002-08-01
申请号：PCT/US2001/047793
申请日：2001-11-13
申请人： ARGOMED, LTD. , CIOANTA, Iulian , KLEIN, Richard, Barry , LAZAROVITZ, Jacob
发明人： CIOANTA, Iulian , KLEIN, Richard, Barry , LAZAROVITZ, Jacob
IPC分类号： A61B18/08
CPC分类号： A61B18/04 , A61B2017/00274 , A61B2017/22069 , A61B2018/00547 , A61B2018/046 , A61F7/123 , A61M31/00 , A61M2210/166
摘要： Flexible treatment catheters are configured to be inserted into a body lumen or cavity to deliver heated fluid through at least one fluid lumen therein to thermally treat or ablate a targeted site in a biological subject. The flexible treatment catheters can include improved thermally insulated regions comprising a mixture formed of liquid elastomeric (such as a polyurethane) mixture (which transitions to a solid state) and miniaturized hollow plastic bodies positioned between the outer wall of the treatment catheter and the fluid lumen. The thermally insulated region is configured such that, measured ex vivo, the treatment catheter can present a maximum temperature of below about 45°C on the external surface of the outer wall of the treatment catheter when the treatment catheter circulates fluid having an inlet temperature of above or between about 60°-62°C. Alternatively or additionally, the treatment catheter can include an elongated insert positioned in a catheter fluid lumen to inhibit the closure of the lumen after exposure to fluids in the treatment catheter at temperatures sufficient to thermal ablate targeted tissue over a thermal ablation treatment period. The treatment catheter can include a urinary drainage lumen with an elongated insert frictionally engaged therewith, the drainage lumen and insert are configured to provide a fluid volume throughput through the drainage lumen of greater than about 20-25 ml/min during and after (for about 12-72 hours after) a thermal ablation session.
摘要翻译：柔性治疗导管被构造成插入体腔或空腔中以将加热的流体通过其中的至少一个流体腔传递到热处理或消融生物学对象中的靶位点。柔性治疗导管可以包括改进的热绝缘区域，其包括由液体弹性体（例如聚氨酯）混合物（其转变为固体状态）和位于治疗导管的外壁和流体内腔之间的小型化中空塑料体形成的混合物。隔热区域被构造成使得，离体测量时，当处理导管循环具有入口温度的流体的流体时，治疗导管可以在治疗导管的外壁的外表面上呈现低于约45℃的最高温度或者或另外，治疗导管可以包括定位在导管流体腔中的细长插入物，以在暴露于治疗导管中的流体以在足以热消融的温度下抑制内腔闭合在热消融治疗期间的靶组织。治疗导管可以包括具有与其摩擦接合的细长插入件的排尿腔，排液腔和插入物被配置成在其期间和之后提供大于约20-25ml / min的流体体积通过排液腔 12-72小时后）热消融术。

3. 发明申请

WO2003011114A2 METHODS FOR TREATING PROSTATITIS 审中-公开
标题翻译：治疗前景的方法
公开(公告)号：WO2003011114A2
公开(公告)日：2003-02-13
申请号：PCT/US2002/024221
申请日：2002-07-24
申请人： ARGOMED, LTD. , CIOANTA, Iulian , KLEIN, Richard, Barry , DIMITRIKOV, Jordan
发明人： CIOANTA, Iulian , KLEIN, Richard, Barry , DIMITRIKOV, Jordan
IPC分类号： A61B
CPC分类号： A61F7/12 , A61B2017/00274 , A61B2018/00547 , A61H9/0078 , A61H21/00 , A61H2201/0207 , A61H2201/0214 , A61H2201/0242 , A61H2201/0257 , A61H2201/0292 , A61H2201/10 , A61H2201/5007
摘要： Methods, systems, and computer program products for providing thermal therapies or internal thermal massage therapy for treating prostatitis by expanding and contracting a treatment balloon with inflation media and currently applying heat to a portion of the prostatic urethra.
摘要翻译：方法，系统和计算机程序产品，用于通过用膨胀介质扩张和收缩治疗气球并且目前对前列腺尿道的一部分施加热量来提供热治疗或内部热按摩治疗来治疗前列腺炎。

4. 发明申请

WO2003054660A2 MODULAR THERMAL TREATMENT SYSTEMS WITH SINGLE-USE DISPOSABLE CATHETER ASSEMBLIES AND RELATED METHODS 审中-公开
标题翻译：具有单个使用的导管组件的模块化热处理系统及相关方法
公开(公告)号：WO2003054660A2
公开(公告)日：2003-07-03
申请号：PCT/US2002/039758
申请日：2002-12-12
申请人： WIT IP CORPORATION , CIOANTA, Iulian , GORKY, Peter , KLEIN, Richard, Barry
发明人： CIOANTA, Iulian , GORKY, Peter , KLEIN, Richard, Barry
IPC分类号： G06F
CPC分类号： A61F7/123 , A61F7/0085 , A61F2007/0054
摘要： Methods, systems and computer program products include modular single -use disposable catheter assemblies with cassettes configured to matably engage with a console to circulate liquid to a treatment balloon in a closed loop circulation system. The console is portable, compact, and can be programmed to administer a plurality of different therapy types and to engage with different catheter configurations via the cassette body.
摘要翻译：方法，系统和计算机程序产品包括模块化的一次性导管组件，其具有被配置成与控制台配合地接合以使液体循环到闭环循环系统中的治疗球囊的盒。控制台是便携式的，紧凑的，并且可以被编程为管理多种不同的治疗类型并且经由盒体接合不同的导管配置。

5. 发明申请

WO2003023562A3 THERMAL TREATMENT SYSTEMS WITH ENHANCED TISSUE PENETRATION DEPTH USING ADJUSTABLE TREATMENT PRESSURES AND RELATED METHODS 审中-公开
公开(公告)号：WO2003023562A3
公开(公告)日：2003-03-20
申请号：PCT/US2002/028688
申请日：2002-09-09
申请人： WIP IP CORPORATION , CIOANTA, Iulian , KLEIN, Richard, Barry
发明人： CIOANTA, Iulian , KLEIN, Richard, Barry
IPC分类号： A61F7/00
摘要： Methods, systems and computer program products include pressure monitoring and pressure adjustment devices in closed loop systems which control and adjust the pressure in a closed loop system configured to circulate heated liquid to a treatment balloon and concurrently heats and exerts pressures onto targeted tissue. The systems and methods can adjust the pressure to account for the physiology of the subject and the operational losses due to material relaxation over the duration of the thermal treatment.

6. 发明申请

WO2003011114A3 METHODS FOR TREATING PROSTATITIS 审中-公开
公开(公告)号：WO2003011114A3
公开(公告)日：2003-02-13
申请号：PCT/US2002/024221
申请日：2002-07-24
申请人： WIT IP CORPORATION , CIOANTA, Iulian , KLEIN, Richard, Barry , DIMITRIKOV, Jordan
发明人： CIOANTA, Iulian , KLEIN, Richard, Barry , DIMITRIKOV, Jordan
IPC分类号： A61F2/00
摘要： Methods, systems, and computer program products for providing thermal therapies or internal thermal massage therapy for treating prostatitis by expanding and contracting a treatment balloon with inflation media and currently applying heat to a portion of the prostatic urethra.

7. 发明申请

WO2002058577A1 HYPERTHERMY TREATMENT OF THE PROSTATE AND IMPLANTATION OF BIODEGRADABLE URETHRAL STENT 审中-公开
标题翻译：预防和植入可生物降解的硬膜支架的高效治疗
公开(公告)号：WO2002058577A1
公开(公告)日：2002-08-01
申请号：PCT/US2001/047789
申请日：2001-11-13
申请人： ARGOMED, LTD. , CIONTA, Iulian , KLEIN, Richard, Barry
发明人： CIONTA, Iulian , KLEIN, Richard, Barry
IPC分类号： A61B18/08
CPC分类号： A61B18/04 , A61B2017/00274 , A61B2017/22069 , A61B2018/00547 , A61B2018/046 , A61F7/123 , A61M31/00 , A61M2210/166
摘要： Methods of treating the prostate include administering a thermal ablation therapy and inhibiting the obstruction or closure of the prostatic urethral opening by forming a biodegradable stent in situ in the subject such that the stent attaches to the walls of the prostatic urethra. A related method of treating BPH includes thermally treating or ablating localized tissue in the prostate with a treatment catheter and inserting flowable stent material via the treatment catheter into the prostate (either before, during, or after the thermal treatment), forming the flowable stent material so that it defines a stent that remains in position after removal of the treatment catheter to inhibit the closure of the urinary passage. Associated stents and catheters are included.
摘要翻译：治疗前列腺的方法包括施用热消融治疗并通过在受试者中原位形成可生物降解的支架来阻止前列腺尿道开口的阻塞或闭合，使得支架附着在前列腺尿道的壁上。治疗BPH的相关方法包括用处理导管热处理或消融前列腺中的局部组织，并将可流动的支架材料经由治疗导管插入前列腺（在热处理之前，期间或之后），形成可流动支架材料使得其限定了在移除治疗导管以保持尿路闭合之后保持就位的支架。包括相关的支架和导管。

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