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1. 发明申请

WO2018069416A1 TRIPLE VECTOR FOR EXPRESSING ANTIBODY MOLECULES IN FULL THERAPEUTIC FORMAT 审中-公开
标题翻译：用于在完整治疗形式中表达抗体分子的三重载体
公开(公告)号：WO2018069416A1
公开(公告)日：2018-04-19
申请号：PCT/EP2017/075983
申请日：2017-10-11
申请人： ARGENX BVBA , FAIRJOURNEY BIOLOGICS
发明人： PAJUELO, Maria Gonzales , DE HAARD, Johannes Joseph Wilhelmus
IPC分类号： C12N15/63
CPC分类号： C07K16/005 , C07K2317/52 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/569 , C12N15/63 , C12N15/86 , C12N2830/00 , C12N2840/00
摘要： A triple expression vector is disclosed for expressing an antibody molecule comprising an Fc domain in prokaryotic cells and in eukaryotic cells. The triple expression vector comprises a polynucleotide encoding an Fc domain; a polynucleotide encoding a phage coat protein; a cloning site for cloning genes encoding an antibody molecule or a part thereof wherein the antibody molecule or part thereof does not comprise an Fc domain; a prokaryotic secretion signal sequence and a eukaryotic secretion signal sequence, or a secretion signal sequence that drives efficient secretion in both prokaryotic and eukaryotic cells; a promoter for mediating expression in eukaryotic cells; and a stop codon for preventing expression of the phage coat protein in eukaryotic cells. The triple expression vector can be used for expressing an antibody molecule in a phage display format; for producing the antibody molecule in a prokaryotic cell, for example in the periplasm of a prokaryotic cell; and for producing the antibody molecule in a eukaryotic cell, for example a mammalian cell, more particularly a human cell. The antibody molecule contains an Fc domain, and may be for example a VHH-Fc molecule or an scFv-Fc molecule or a VH-Fc or a VL-Fc. Phage display libraries produced with the vector present the antibody molecule in its therapeutic format. Use of the vector avoids the need for repeated cloning when moving from one expression medium to another.
摘要翻译：公开了用于在原核细胞和真核细胞中表达包含Fc结构域的抗体分子的三重表达载体。三重表达载体包含编码Fc结构域的多核苷酸; 编码噬菌体外壳蛋白的多核苷酸; 克隆编码抗体分子或其部分的基因的克隆位点，其中抗体分子或其部分不包含Fc结构域; 原核分泌信号序列和真核分泌信号序列，或驱动原核细胞和真核细胞中有效分泌的分泌信号序列; 用于介导真核细胞中的表达的启动子; 和用于防止真核细胞中噬菌体外壳蛋白表达的终止密码子。三重表达载体可用于以噬菌体展示形式表达抗体分子; 用于在原核细胞中产生抗体分子，例如在原核细胞的周质中; 并且用于在真核细胞例如哺乳动物细胞，更特别是人细胞中产生抗体分子。抗体分子含有Fc结构域，并且可以是例如VHH-Fc分子或scFv-Fc分子或VH-Fc或VL-Fc。用载体产生的噬菌体展示文库以其治疗形式呈递抗体分子。使用载体避免了从一种表达载体移动到另一种载体时需要重复克隆。

2. 发明申请

WO2018083122A1 HUMAN FCRN BINDING ANTIBODY FOR USE IN TREATMENT OF ANTIBODY MEDIATED DISEASE 审中-公开
标题翻译：人FCRN结合抗体用于治疗抗体介导的疾病
公开(公告)号：WO2018083122A1
公开(公告)日：2018-05-11
申请号：PCT/EP2017/077966
申请日：2017-11-01
申请人： ARGENX BVBA
发明人： ULRICHTS, Peter , DREIER, Torsten , DE HAARD, Johannes Joseph Wilhelmus
IPC分类号： A61K38/17 , A61K9/00 , A61K47/42 , C07K16/28 , A61P37/06 , A61K39/00
摘要： A treatment regimen is disclosed for the treatment of human subjects afflicted with antibody mediated disease. The regimen comprises administering to the human subject an antibody molecule that binds to the human FcRn receptor with at least one of its CDRs and with a binding affinity at pH=6 of at least 10 nM. The regimen comprises administering a loading dose of at least 20 nM/Kg, and at least one maintenance dose of at least 10 nM/Kg.
摘要翻译：公开了用于治疗患有抗体介导的疾病的人受试者的治疗方案。该方案包括向人受试者施用抗体分子，该抗体分子与其至少一个CDR结合人FcRn受体并且在pH = 6时具有至少10nM的结合亲和力。该方案包括施用至少20nM / Kg的负荷剂量和至少10nM / Kg的至少一种维持剂量。

3. 发明申请

WO2018011420A1 ANTI-IL-22R ANTIBODIES 审中-公开
标题翻译：抗IL-22R抗体
公开(公告)号：WO2018011420A1
公开(公告)日：2018-01-18
申请号：PCT/EP2017/067923
申请日：2017-07-14
申请人： ARGENX BVBA
发明人： BLANCHETOT, Christophe Frederic Jerome , URSØ, Birgitte , SKAK-NIELSEN, Tine , BERTELSEN, Malene , VAN DER WONING, Sebastian , SAUNDERS, Michael , DE HAARD, Johannes Joseph Wilhelmus
IPC分类号： C07K16/28
摘要： The present invention relates to antibodies and antigen binding fragments thereof which bind to the cytokine receptor IL-22R, particularly human IL-22R. The invention also relates to pharmaceutical compositions comprising said antibodies or antigen binding fragments thereof, and methods of treating psoriasis, psoriatic arthritis or atopic dermatitis.
摘要翻译：本发明涉及结合细胞因子受体IL-22R，特别是人IL-22R的抗体及其抗原结合片段。本发明还涉及包含所述抗体或其抗原结合片段的药物组合物，以及治疗牛皮癣，银屑病关节炎或特应性皮炎的方法。

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