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1. 发明申请

WO2006125805A1 THIAZOLE DERIVATIVES AND USE THEREOF 审中-公开
标题翻译：噻唑衍生物及其用途
公开(公告)号：WO2006125805A1
公开(公告)日：2006-11-30
申请号：PCT/EP2006/062595
申请日：2006-05-24
申请人： APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. , QUATTROPANI, Anna , DORBAIS, Jérôme , COVINI, David , DESFORGES, Gwenaelle , RUECKLE, Thomas
发明人： QUATTROPANI, Anna , DORBAIS, Jérôme , COVINI, David , DESFORGES, Gwenaelle , RUECKLE, Thomas
IPC分类号： C07D277/46 , C07D277/48 , C07D277/56 , C07D417/14 , C07D491/10 , C07D493/08 , A61K31/427 , A61K31/433 , A61K31/454 , A61K31/496 , A61K31/497 , A61K31/5377 , A61K31/553 , A61P9/00 , A61P25/00
CPC分类号： C07D277/46 , C07D277/48 , C07D277/56 , C07D417/14 , C07D491/10 , C07D493/08
摘要： The present invention is related to thiazole derivatives of Formula (I) in particular for the treatment and/or prophylaxis of autoimmune disorders and/or inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, bacterial or viral infections, kidney diseases, platelet aggregation, cancer, transplantation, graft rejection or lung injuries.
摘要翻译：本发明涉及式（I）的噻唑衍生物，特别是用于治疗和/或预防自身免疫疾病和/或炎性疾病，心血管疾病，神经变性疾病，细菌或病毒感染，肾脏疾病，血小板聚集，癌症，移植，移植排斥或肺部损伤。

2. 发明申请

WO2006125807A1 THIAZOLE DERIVATIVES AND USE THEREOF 审中-公开
标题翻译：噻唑衍生物及其用途
公开(公告)号：WO2006125807A1
公开(公告)日：2006-11-30
申请号：PCT/EP2006/062602
申请日：2006-05-24
申请人： Applied Research Systems ARS Holding N.V. , QUATTROPANI, Anna , COVINI, David , POMEL, Vincent , DORBAIS, Jérôme , RUECKLE, Thomas
发明人： QUATTROPANI, Anna , COVINI, David , POMEL, Vincent , DORBAIS, Jérôme , RUECKLE, Thomas
IPC分类号： C07D417/04 , A61K31/427 , A61P37/00 , A61P25/00 , A61P31/00
CPC分类号： C07D417/14 , C07D417/04
摘要： The present invention is related to thiazolc derivatives of Formula (I) in particular for the treatment and/or prophylaxis of autoimmune disorders and/or inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, bacterial or viral infections, kidney diseases, platelet aggregation, cancer, transplantation, graft rejection or lung injuries.
摘要翻译：本发明涉及式（I）的噻唑衍生物，特别是用于治疗和/或预防自身免疫疾病和/或炎性疾病，心血管疾病，神经变性疾病，细菌或病毒感染，肾脏疾病，血小板聚集，癌症，移植，移植排斥或肺部损伤。

3. 发明申请

WO2006125803A1 THIAZOLE DERIVATIVES AND USE THEREOF 审中-公开
公开(公告)号：WO2006125803A1
公开(公告)日：2006-11-30
申请号：PCT/EP2006/062592
申请日：2006-05-24
申请人： APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. , QUATTROPANI, Anna , COVINI, David , POMEL, Vincent , DORBAIS, Jérôme , RUECKLE, Thomas
发明人： QUATTROPANI, Anna , COVINI, David , POMEL, Vincent , DORBAIS, Jérôme , RUECKLE, Thomas
IPC分类号： C07D417/04 , A61K31/427 , A61P37/00 , A61P25/00 , A61P31/00
CPC分类号： C07D417/14 , C07D417/04
摘要： The present invention is related to thiazole derivatives of Formula (I) in particular for the treatment and/or prophylaxis of autoimmune disorders and/or inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, bacterial or viral infections, kidney diseases, platelet aggregation, cancer, transplantation, graft rejection or lung injuries.

4. 发明申请

WO2006024666A1 PYRIDINE METHYLENE AZOLIDINONES AND USE THEREOF PHOSPHOINOSITIDE INHIBITORS 审中-公开
标题翻译：吡啶甲基亚胺嘧啶酮及其用途磷酰胺抑制剂
公开(公告)号：WO2006024666A1
公开(公告)日：2006-03-09
申请号：PCT/EP2005/054339
申请日：2005-09-02
申请人： APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. , RUECKLE, Thomas , QUATTROPANI, Anna , POMEL, Vincent , DORBAIS, Jérôme , COVINI, David , BISCHOFF, Alexander
发明人： RUECKLE, Thomas , QUATTROPANI, Anna , POMEL, Vincent , DORBAIS, Jérôme , COVINI, David , BISCHOFF, Alexander
IPC分类号： C07D471/04 , C07D491/04 , A61K31/4355 , A61K31/519 , C07D487/04
CPC分类号： C07D471/04 , C07D487/04 , C07D491/04
摘要： The present invention is related to fused pyridine methylene azolidinone derivatives of Formula (I) in particular for the treatment and/or prophylaxis of autoimmune disorders and/or inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, bacterial or viral infections, kidney diseases, platelet aggregation, cancer, transplantation, graft rejection or lung injuries.
摘要翻译：本发明涉及式（I）的稠合吡啶亚甲基唑烷酮衍生物，特别是用于治疗和/或预防自身免疫性疾病和/或炎性疾病，心血管疾病，神经变性疾病，细菌或病毒感染，肾脏疾病，血小板聚集，癌症，移植，移植排斥或肺部损伤。

5. 发明申请

WO2004005249A1 PYRROLIDINE DERIVATIVES AS OXYTOCIN ANTAGONISTS 审中-公开
标题翻译：吡咯烷衍生物作为氧化物拮抗剂
公开(公告)号：WO2004005249A1
公开(公告)日：2004-01-15
申请号：PCT/EP2003/050286
申请日：2003-07-04
申请人： APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. , JORAND-LEBRUN, Catherine , DORBAIS, Jérôme , QUATTROPANI, Anna , SCHWARZ, Matthias , VALOGNES, Delphine
发明人： JORAND-LEBRUN, Catherine , DORBAIS, Jérôme , QUATTROPANI, Anna , SCHWARZ, Matthias , VALOGNES, Delphine
IPC分类号： C07D207/22
CPC分类号： C07D231/12 , C07D207/22 , C07D233/56 , C07D249/08 , C07D403/06
摘要： The present invention relates to novel pyrrolidine derivative of formula (I), its geometrical isomers, its optically active forms as enantiomers, diastereomers, mixtures of these and its racemate forms, as well as salts thereof, wherein R 1 is selected from the group comprising or consisting of H and C 1 -C 6 -alkyl, for the prevention and/or treatment of preterm labor, premature birth or dysmenorrhea.
摘要翻译：本发明涉及式（I）的新型吡咯烷衍生物，其几何异构体，其作为对映异构体的光学活性形式，非对映异构体，这些及其外消旋体形式的混合物，以及其盐，其中R 1选自由H和C 1 -C 6烷基组成或组成的组，用于预防和/或治疗早产，早产或痛经。

6. 发明申请

WO2010069949A1 OXADIAZOLE FUSED HETEROCYCLIC DERIVATIVES USEFUL FOR THE TREATMENT OF MULTIPLE SCLEROSIS 审中-公开
标题翻译：用于治疗多发性硬化症的OXADIAZOLE FUSED HETEROCYCLIC DERIVATIVES
公开(公告)号：WO2010069949A1
公开(公告)日：2010-06-24
申请号：PCT/EP2009/067171
申请日：2009-12-15
申请人： MERCK SERONO S.A. , MUZERELLE, Mathilde , QUATTROPANI, Anna , MONTAGNE, Cyril , DORBAIS, Jérôme
发明人： MUZERELLE, Mathilde , QUATTROPANI, Anna , MONTAGNE, Cyril , DORBAIS, Jérôme
IPC分类号： C07D413/04 , C07D413/14 , A61K31/4525 , A61K31/435 , A61K31/4245 , A61P21/00 , A61P29/00 , A61P37/00
CPC分类号： C07D413/04 , C07D413/14
摘要： The invention provides compounds of Formula (I) for the treatment of multiple sclerosis and other diseases.
摘要翻译：本发明提供式（I）化合物用于治疗多发性硬化症和其它疾病。

7. 发明申请

WO2002074741A1 PYRROLIDINE ESTER DERIVATIVES WITH OXYTOCIN MODULATING ACITVITY 审中-公开
标题翻译：具有氧化调节作用的吡咯烷酮衍生物
公开(公告)号：WO2002074741A1
公开(公告)日：2002-09-26
申请号：PCT/EP2002/003005
申请日：2002-03-19
申请人： APPLIED RESEARCH SYSTEMS ARS HOLDING NV , SCHWARZ, Matthias , QUATTROPANI, Anna , SCHEER, Alexander , DORBAIS, Jérôme , POMEL, Vincent
发明人： SCHWARZ, Matthias , QUATTROPANI, Anna , SCHEER, Alexander , DORBAIS, Jérôme , POMEL, Vincent
IPC分类号： C07D207/20
CPC分类号： C07D401/10 , A61K31/401 , C07D207/22 , C07D403/10
摘要： The present invention is related to the use of pyrrolidine esters of formula (I) for the treatment and/or prevention of premature labor, premature birth and dysmenorrhea. In particular, the present invention is related to the use of pyrrolidine esters of formula (I) to modulate, notably to antagonise the oxytocin receptor. The present invention is furthermore related to novel pyrrolidine esters. X is selected from the group consisting of CR 6 R 7 , NOR 6 , NNR 6 R 7 ;R is selected from the group comprising or consisting of C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, saturated or unsaturated 3-8-membered cycloalkyl which may contain 1 to 3 heteroatoms selected of N, O, S, aryl, heteroaryl, C 1 -C 6 -alkyl aryl, C 1 -C 6 -alkyl heteroaryl. R 1 is selected from the group comprising or consisting of C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, aryl, heteroaryl, 3-8-membered cycloalkyl, acyl, C 1 -C 6 -alkyl aryl, C 1 -C 6 -alkyl heteroaryl, said cycloalkyl or aryl or heteroaryl groups may be fused with 1-2 further cycloalkyl or aryl or heteroaryl group.
摘要翻译：本发明涉及式（I）的吡咯烷酯用于治疗和/或预防早产，早产和痛经的用途。特别地，本发明涉及式（I）的吡咯烷酯的用途，特别是拮抗催产素受体。本发明还涉及新的吡咯烷酯。 X选自CR 6 R 7，NOR 6，NNR 6 R 7; R选自C 1 -C 6烷基，C 2 -C 6烯基 C 2 -C 6炔基，饱和或不饱和的3-8元环烷基，其可以含有1-3个选自N，O，S，芳基，杂芳基，C 1 -C 6烷基芳基，C 1 -C 6烷基杂芳基的杂原子。 R 1选自由C 1 -C 6 - 烷基，C 2 -C 6 - 烯基，C 2 -C 6 - 炔基，芳基，杂芳基，3-8元环烷基，酰基，C 1 -C 6 - 烷基芳基，C 1 -C 6烷基杂芳基，所述环烷基或芳基或杂芳基可与1-2个其它环烷基或芳基或杂芳基稠合。

8. 发明申请

WO2008101979A1 QUINOXALINE COMPOUNDS AND USE THEREOF 审中-公开
标题翻译：喹啉化合物及其用途
公开(公告)号：WO2008101979A1
公开(公告)日：2008-08-28
申请号：PCT/EP2008/052102
申请日：2008-02-21
申请人： LABORATOIRES SERONO SA , GAILLARD, Pascale , POMEL, Vincent , JEANCLAUDE-ETTER, Isabelle , DORBAIS, Jérôme , KLICIC, Jasna , MONTAGNE, Cyril
发明人： GAILLARD, Pascale , POMEL, Vincent , JEANCLAUDE-ETTER, Isabelle , DORBAIS, Jérôme , KLICIC, Jasna , MONTAGNE, Cyril
IPC分类号： C07D241/44 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D407/12 , C07D407/14 , C07D409/14 , C07D451/02 , A61K31/498 , A61P35/00
CPC分类号： C07D403/12 , C07D241/44 , C07D401/12 , C07D401/14 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D451/02
摘要： The present invention is related to quinoxaline compounds of Formula (I) in particular for the treatment of autoimmune disorders and/or inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, bacterial or viral infections, kidney diseases, platelet aggregation, cancer, transplantation, graft rejection or lung injuries.
摘要翻译：本发明涉及式（I）的喹喔啉化合物，特别是用于治疗自身免疫性疾病和/或炎性疾病，心血管疾病，神经变性疾病，细菌或病毒感染，肾脏疾病，血小板聚集，癌症，移植，移植排斥或肺部受伤。

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