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1. 发明申请

WO2003051344A1 METHODS OF INDUCING OVULATION_USING A NON-POLYPEPTIDE CAMP LEVEL MODULATOR 审中-公开
标题翻译：诱导OVULATION的方法_非多肽CAMP水平调节剂
公开(公告)号：WO2003051344A1
公开(公告)日：2003-06-26
申请号：PCT/EP2001/014730
申请日：2001-12-14
申请人： APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. , PALMER, Stephen , TEPPER, Mark , MCKENNA, Sean , MACNAMEE, Michael, C. , ESHKOL, Aliza
发明人： PALMER, Stephen , TEPPER, Mark , MCKENNA, Sean , MACNAMEE, Michael, C. , ESHKOL, Aliza
IPC分类号： A61K31/00
CPC分类号： A61K31/437 , A61K31/00 , A61K31/138 , A61K31/277 , A61K31/352 , A61K31/4196 , A61K31/44 , A61K31/4535 , A61K31/502 , A61K31/519 , A61K31/522 , A61K38/24 , A61K45/06 , A61K2300/00
摘要： The present invention relates to methods of inducing ovulation in a female host comprising the administration of a non-polypeptide cyclic adenosine monophosphate (cAMP) level modulator to the female host. In another aspect, the invention provides for specific administration of the phosphodiesterase inhibitor prior to the luteal phase of the host's ovulatory cycle. Preferred non-polypeptide cAMP level modulator include phosphodiesterase inhibitors, particularly inhibitors of phosphodiesterase 4 isoforms.
摘要翻译：本发明涉及在雌性宿主中诱导排卵的方法，包括向雌性宿主施用非多肽环状腺苷一磷酸（cAMP）水平调节剂。另一方面，本发明提供在宿主排卵周期的黄体期之前特异性施用磷酸二酯酶抑制剂。优选的非多肽cAMP水平调节剂包括磷酸二酯酶抑制剂，特别是磷酸二酯酶4同种型的抑制剂。

2. 发明申请

WO2004087211A2 INHIBITORS OF PHOSPHODIESTERASES IN INFERTILITY 审中-公开
标题翻译：磷酸化酶抑制剂在感染中的作用
公开(公告)号：WO2004087211A2
公开(公告)日：2004-10-14
申请号：PCT/US2004/010346
申请日：2004-04-01
申请人： APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. , PALMER, Stephen, S. , McKENNA, Sean, D. , ARKINSTALL, Stephen, J. , ESHKOL, Aliza , MACNAMEE, Michael, C.
发明人： PALMER, Stephen, S. , McKENNA, Sean, D. , ARKINSTALL, Stephen, J. , ESHKOL, Aliza , MACNAMEE, Michael, C.
IPC分类号： A61K45/00
CPC分类号： A61K45/06 , A61K31/505 , A61K31/517 , A61K31/519 , A61K31/53 , A61K38/09 , A61K38/24 , A61K2300/00
摘要： The present invention is directed to methods of increasing oocyte production in a mammal. More specifically, the specification describes methods and compositions for inducing follicular maturation using a PDE inhibitor. The inhibitor may be used alone at high doses. Alternatively, the follicular maturation is achieved by combining a low dose of FSH with the PDE inhibitor treatment.
摘要翻译：本发明涉及增加哺乳动物卵母细胞产生的方法。更具体地说，本说明书描述了使用PDE抑制剂诱导滤泡成熟的方法和组合物。抑制剂可以高剂量单独使用。或者，通过将低剂量FSH与PDE抑制剂治疗组合来实现滤泡成熟。

3. 发明申请

WO2003039466A2 METHOD OF TREATING OESTROGEN RESPONSIVE BREAST CANCER 审中-公开
标题翻译：治疗雌激素反应性乳腺癌的方法
公开(公告)号：WO2003039466A2
公开(公告)日：2003-05-15
申请号：PCT/US2002/035438
申请日：2002-11-05
申请人： APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. , WONG, Grace , ESHKOL, Aliza , DELUCA, Giampiero
发明人： WONG, Grace , ESHKOL, Aliza , DELUCA, Giampiero
IPC分类号： A61K
CPC分类号： A61K38/217 , A61K2300/00
摘要： The present invention is directed to a method of treating estrogen responsive breast cancer in an individual comprising administering to an individual a therapeutically effective estradiol inhibiting amount of interferon gamma (IFN-γ) and/or a tumor necrosis factor (TNF) antagonist and/or an interleukin-1 (IL-1) antagonists. The invention is based upon the surprising discovery that IFN-γ and/or a tumor necrosis factor (TNF) antagonist and/or an interleukin-1 (IL-1) antagonists inhibit estradiol production in human adipocytes. This discovery is not only important because it allows for the treatment and/or prevention of estrogen dependent breast cancer using IFN-γ, TNF antagonists or IL-1 antagonist each alone or in combination, but also because IFN-γ and/or TNF antagonists and/or IL-1 antagonists can be used in conjunction with standard anti-estrogen therapy, e.g., tamoxifen and/or aromatase inhibitor, to result in lower estrogen levels than seen with standard anti-estrogen therapy alone. Moreover, the ability to lower estrogen levels by means of the present invention, when combined with standard anti-estrogen therapy, provides an important therapeutic option in that it allows the dose of the anti-estrogen to be reduced, reducing the likelihood of side effects and complications commonly seen with anti-estrogen therapy.
摘要翻译：本发明涉及一种治疗个体中雌激素反应性乳腺癌的方法，包括向个体施用治疗有效的雌二醇抑制量的干扰素γ（IFN-γ）和/或肿瘤坏死因子（TNF）拮抗剂和/或白细胞介素-1（IL-1）拮抗剂。本发明基于惊人的发现，即IFN-γ和/或肿瘤坏死因子（TNF）拮抗剂和/或白介素-1（IL-1）拮抗剂抑制人脂肪细胞中的雌二醇产生。该发现不仅重要，因为它允许单独或组合使用IFN-γ，TNF拮抗剂或IL-1拮抗剂治疗和/或预防雌激素依赖性乳腺癌，而且还因为IFN-γ和/或TNF拮抗剂和/或IL-1拮抗剂可以与标准的抗雌激素疗法结合使用，例如他莫昔芬和/或芳香酶抑制剂，与单独的标准抗雌激素疗法相比，可以降低雌激素水平。此外，通过本发明降低雌激素水平的能力，当与标准抗雌激素治疗组合时，提供了重要的治疗选择，因为其允许降低抗雌激素的剂量，降低副作用的可能性和抗雌激素治疗常见的并发症。

4. 发明申请

WO2003039466A3 METHOD OF TREATING ESTROGEN RESPONSIVE BREAST CANCER 审中-公开
公开(公告)号：WO2003039466A3
公开(公告)日：2003-05-15
申请号：PCT/US2002/035438
申请日：2002-11-05
申请人： APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. , WONG, Grace , ESHKOL, Aliza , DELUCA, Giampiero
发明人： WONG, Grace , ESHKOL, Aliza , DELUCA, Giampiero
IPC分类号： A61K38/00
摘要： The present invention is directed to a method of treating estrogen responsive breast cancer in an individual comprising administering to an individual a therapeutically effective estradiol inhibiting amount of interferon gamma (IFN-γ) and/or a tumor necrosis factor (TNF) antagonist and/or an interleukin-1 (IL-1) antagonists. The invention is based upon the surprising discovery that IFN-γ and/or a tumor necrosis factor (TNF) antagonist and/or an interleukin-1 (IL-1) antagonists inhibit estradiol production in human adipocytes. This discovery is not only important because it allows for the treatment and/or prevention of estrogen dependent breast cancer using IFN-γ, TNF antagonists or IL-1 antagonist each alone or in combination, but also because IFN-γ and/or TNF antagonists and/or IL-1 antagonists can be used in conjunction with standard anti-estrogen therapy, e.g., tamoxifen and/or aromatase inhibitor, to result in lower estrogen levels than seen with standard anti-estrogen therapy alone. Moreover, the ability to lower estrogen levels by means of the present invention, when combined with standard anti-estrogen therapy, provides an important therapeutic option in that it allows the dose of the anti-estrogen to be reduced, reducing the likelihood of side effects and complications commonly seen with anti-estrogen therapy.

5. 发明申请

WO2003039455A3 METHODS OF TREATING ENDOMETREOSIS 审中-公开
公开(公告)号：WO2003039455A3
公开(公告)日：2003-05-15
申请号：PCT/US2002/034440
申请日：2002-10-29
申请人： APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. , WONG, Grace , ESHKOL, Aliza
发明人： WONG, Grace , ESHKOL, Aliza
IPC分类号： A61K38/21
摘要： The present invention relates to the treatment of a woman for endometriosis comprising the administration of IFN-γ, a cytokine antagonist and/or an anti-estrogenic agent.

6. 发明申请

WO2003039455A2 METHODS OF TREATING ENDOMETREOSIS 审中-公开
标题翻译：治疗子宫内膜异位症的方法
公开(公告)号：WO2003039455A2
公开(公告)日：2003-05-15
申请号：PCT/US2002/034440
申请日：2002-10-29
申请人： APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. , WONG, Grace , ESHKOL, Aliza
发明人： WONG, Grace , ESHKOL, Aliza
IPC分类号： A61K
CPC分类号： A61K38/217 , A61K2300/00
摘要： The present invention relates to the treatment of a woman for endometriosis comprising the administration of IFN-γ, a cytokine antagonist and/or an anti-estrogenic agent.
摘要翻译：本发明涉及妇女治疗子宫内膜异位症的方法，包括施用IFN-γ，细胞因子拮抗剂和/或抗雌激素剂。

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