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1. 发明申请

WO2004103404A1 CD20 BINDING MOLECULES 审中-公开
标题翻译： CD20结合分子
公开(公告)号：WO2004103404A1
公开(公告)日：2004-12-02
申请号：PCT/US2004/015786
申请日：2004-05-20
申请人： APPLIED MOLECULAR EVOLUTION , WATKINS, Jeffry, D. , DAVIES, Julian , MARQUIS, David, M. , ALLAN, Barrett, W. , ONDEK, Brian
发明人： WATKINS, Jeffry, D. , DAVIES, Julian , MARQUIS, David, M. , ALLAN, Barrett, W. , ONDEK, Brian
IPC分类号： A61K39/395
CPC分类号： C07K16/2887 , A61K2039/505 , C07K2317/24 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/92
摘要： The present invention relates to CD20 binding molecules and nucleic acid sequences encoding CD20 binding molecules. In particular, the present invention relates to CD20 binding molecules with a high binding affinity, and a low dissociation rate, with regard to human CD20. Preferably, the CD20 binding molecules of the present invention comprise light and/or heavy chain variable regions with fully human frameworks (e.g. human germline frameworks).
摘要翻译：本发明涉及CD20结合分子和编码CD20结合分子的核酸序列。特别地，本发明涉及关于人CD20具有高结合亲和力和低解离速率的CD20结合分子。优选地，本发明的CD20结合分子包含具有完全人骨架（例如人种系框架）的轻链和/或重链可变区。

2. 发明申请

WO2005070963A1 FC REGION VARIANTS 审中-公开
标题翻译： FC区域变量
公开(公告)号：WO2005070963A1
公开(公告)日：2005-08-04
申请号：PCT/US2005/000013
申请日：2005-01-10
申请人： APPLIED MOLECULAR EVOLUTION, INC , ALLAN, Barrett, W. , MARQUIS, David, Matthew , TANG, Ying , WATKINS, Jeffry, Dean
发明人： ALLAN, Barrett, W. , MARQUIS, David, Matthew , TANG, Ying , WATKINS, Jeffry, Dean
IPC分类号： C07K16/00
CPC分类号： C07K16/2896 , C07K16/00 , C07K2317/21 , C07K2317/52 , C07K2317/565 , C07K2317/732 , C07K2317/734
摘要： The present invention provides polypeptide Fc region variants and oligonucleotides encoding Fc region variants. Specifically, the present invention provides compositions comprising novel Fc region variants, methods for identifying useful Fc region variants, and methods for employing Fc region variants for treating disease.
摘要翻译：本发明提供多肽Fc区变体和编码Fc区变体的寡核苷酸。具体地，本发明提供包含新型Fc区变体的组合物，用于鉴定有用的Fc区变体的方法，以及使用Fc区变体用于治疗疾病的方法。

3. 发明申请

WO2002072891A1 FLUORESCENCE ASSAY FOR DNA MODIFYING ENZYMES 审中-公开
标题翻译： DNA修饰酶的荧光测定
公开(公告)号：WO2002072891A1
公开(公告)日：2002-09-19
申请号：PCT/US2002/007413
申请日：2002-03-11
申请人： UNIVERSITY OF CALIFORNIA , REICH, Norbert, O. , ALLAN, Barrett, W. , LINDSTROM, William, Jr. , PUNTZKE, Aaron, P.
发明人： REICH, Norbert, O. , ALLAN, Barrett, W. , LINDSTROM, William, Jr. , PUNTZKE, Aaron, P.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6837 , C12Q2565/107
摘要： A method of assaying compounds for their ability to effect enzymes including enhancing or inhibiting the effect of those enzymes on double stranded DNA sequences is disclosed. The method comprises providing a modified nucleotide sequence comprised of a base analogue which analogue is characterized by increased fluorescence when moved out of its normal helical position, the sequence having a complimentary sequence hybridized thereto to provide a double stranded sequence. The modified sequence containing the base analogue is brought into contact with the enzyme which enzyme is characterized by effecting the 3-dimensional position of the analogue within the sequence. The enzyme is brought into contact with the sequences in the presence of a compound being assayed. By knowing the amount of increased fluorescence the enzyme would normally have on the sequence is possible to determine the inhibitory or enhancing effect of the compound on the enzyme.
摘要翻译：公开了一种测定化合物其影响酶的能力的方法，包括增强或抑制这些酶对双链DNA序列的影响。所述方法包括提供由碱基类似物组成的修饰的核苷酸序列，所述碱基类似物的特征在于当其从其正常螺旋位置移出时增加荧光，所述序列具有与其杂交的互补序列以提供双链序列。使含有碱基类似物的修饰的序列与该酶的酶接触，酶的特征在于在序列内实现类似物的3维位置。在待测化合物存在下使酶与序列接触。通过了解酶通常对该序列具有的荧光增加的量可以确定化合物对酶的抑制或增强的作用。

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