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1. 发明申请

WO2005087723A1 AN IMPROVED PREPARATION OF ATORVASTATIN 审中-公开
标题翻译：改进ATORVASTATIN的制备
公开(公告)号：WO2005087723A1
公开(公告)日：2005-09-22
申请号：PCT/CA2005/000368
申请日：2005-03-11
申请人： APOTEX PHARMACHEM INC. , GUNTOORI, Bhaskar, Reddy , CHE, Daqing , WANG, Fan , ZHAO, Yajun , MURTHY, Keshava, K.S. , HORNE, Stephen, E.
发明人： GUNTOORI, Bhaskar, Reddy , CHE, Daqing , WANG, Fan , ZHAO, Yajun , MURTHY, Keshava, K.S. , HORNE, Stephen, E.
IPC分类号： C07D207/416
CPC分类号： C07D207/416 , C07D207/34
摘要： A process for preparing (R)-5-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4[(phenylamino)carbonyl]-1H-pyrrol-1-yl]-5-hydroxy-3-oxo-l-heptanoic acid, tert-butylester comprising: (a) reduction of 5-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4[(phenylamino)carbonyl]-1H-pyrrol-l-yl]-3-oxo-l-pentanoic acid, (R)-2-hydroxy1,2,2-triphenylethyl ester; (b) hydrolysis of (R)-5-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4[(phenylamino)carbonyl]-1H-pyrrol-1-yl]-3-hydroxy-l-pentanoic acid, (R)-2hydroxy-1,2,2-triphenylethyl ester using an alkali base in a solvent to form the acid; (c) alkylation of the acid forming (R)-5-[2-(4-fluorophenyl)-5-(1-methylethyl)-3phenyl-4-[(phenylamino)carbonyl]-1 H-pyrrol-1-yl]-5-hydroxy-3-oxo- l -heptanoic acid, tert-butylester.
摘要翻译：制备（R）-5- [2-（4-氟苯基）-5-（1-甲基乙基）-3-苯基-4 [（苯基氨基）羰基] -1H-吡咯-1-基] -5- 包括：（a）还原5- [2-（4-氟苯基）-5-（1-甲基乙基）-3-苯基-4 [（苯基氨基）羰基）-2-羟基-3-氧代-1-庚酸 ] -1H-吡咯-1-基] -3-氧代-1-戊酸，（R）-2-羟基-1,2,2-三苯乙基酯; （b）（R）-5- [2-（4-氟苯基）-5-（1-甲基乙基）-3-苯基-4 [（苯基氨基）羰基] -1H-吡咯-1-基] -3 - 羟基-1-戊酸，（R）-2-羟基-1,2,2-三苯乙基酯，使用碱在溶剂中形成酸; （c）酸形成（R）-5- [2-（4-氟苯基）-5-（1-甲基乙基）-3苯基-4 - [（苯基氨基）羰基] -1H-吡咯-1-基吡啶-3-基] -5-羟基-3-氧代-1-庚酸叔丁酯。

2. 发明申请

WO2006089401A1 AN IMPROVED PROCESS FOR THE PREPARATION OF ATORVASTATIN AND INTERMEDIATES 审中-公开
标题翻译：改进ATORVASTATIN和中间体的制备方法
公开(公告)号：WO2006089401A1
公开(公告)日：2006-08-31
申请号：PCT/CA2006/000243
申请日：2006-02-21
申请人： APOTEX PHARMACHEM INC. , WANG, Fan , CHE, Daqing , GUNTOORI, Bhaskar Reddy , ZHAO, Yajun , KINSMAN, Aaron, C. , FAUGHT, Jody , CHOW, Alan
发明人： WANG, Fan , CHE, Daqing , GUNTOORI, Bhaskar Reddy , ZHAO, Yajun , KINSMAN, Aaron, C. , FAUGHT, Jody , CHOW, Alan
IPC分类号： C07D207/34
CPC分类号： C07D207/34
摘要： A process is provided for preparing (R)-5-[2-(4-fluorophenyl)-5-(l- methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-lH-pyrrol-l-yl]-5-hydroxy-3-oxo- 1-heptanoic acid, R-substituted ester 9 comprising: (a) reacting 5-(4-fluorophenyl)-2-(l -methylethyl)-l -(3-oxopropyl)-N,4- diphenyl-lH-pyrrole-3-carboxamide, 1, with the enolate form of (S)-2- hydroxy- 1 ,2,2-triphenylethyl acetate substituent in a chelating co- solvent; (b) hydrolysis of (R,S)-5-[2-(4-fluorophenyl)-5-(l -methylethyl)-3-phenyl- 4-[(phenylamino)carbonyl]- 1 H-pyrrol- 1 -yl]-3-hydroxy- 1 -pentanoic acid, (S)-2 -hydroxy- 1 ,2,2-triphenylethyl ester (2a and 2b) using a base, preferably an alkali metal base, preferably in a solvent to form the (R,S)-5-[2-(4-fluorophenyl)-5-(l -methylethyl)-3-phenyl-4- [(phenylamino)carbonyl]- 1 H-pyrrol- 1 -yl]-3 -hydroxy- 1 -pentanoic acid, 7; (c) treating the carboxylic acid 7 with a chiral base to form a salt and purifying the salt to obtain enantiomerically enriched (R)-7 chiral base salt; (d) alkylation of the (R)-7 chiral base salt or the free acid derived from (R)-7, forming (R)-5-[2-(4-fluorophenyl)-5-(l-methylethyl)-3-phenyl- 4-[(phenylamino)carbonyl]-lH-pyrrol-l-yl]-5-hydroxy-3-oxo-l- heptanoic acid, R-substituted ester 9, wherein the R substituent is a Cl to C6 alkyl, C6 to C9 aryl or C7 to Cl0 aralkyl. Subsequently, R-substituted ester 9 may be converted into atorvastatin calcium 6 based on procedures known in the art.
摘要翻译：提供了制备（R）-5- [2-（4-氟苯基）-5-（1-甲基乙基）-3-苯基-4 - [（苯基氨基）羰基] -1H-吡咯-1-基] -5-羟基-3-氧代-1-庚酸，R-取代的酯9，其包含：（a）使5-（4-氟苯基）-2-（1-甲基乙基）-1-（3-氧代丙基）-N ，4-二苯基-1H-吡咯-3-甲酰胺，1，在螯合助溶剂中具有（S）-2-羟基-1,2-二苯基乙基乙酸酯取代基的烯醇化物形式; （b）（R，S）-5- [2-（4-氟苯基）-5-（1-甲基乙基）-3-苯基-4 - [（苯基氨基）羰基] -1H-吡咯-1-基吡啶-3-基] -3-羟基-1-戊酸，（S）-2-羟基-1,2-二苯基乙酯（2a和2b），使用碱，优选碱金属碱，优选在溶剂中形成（R，S）-5- [2-（4-氟苯基）-5-（1-甲基乙基）-3-苯基-4 - [（苯基氨基）羰基] -1H-吡咯-1-基] 羟基-1-戊酸，7; （c）用手性碱处理羧酸7以形成盐并纯化该盐以获得对映体富集的（R）-7手性碱盐; （d）（R）-7手性碱盐或衍生自（R）-7的游离酸的烷基化，形成（R）-5- [2-（4-氟苯基）-5-（1-甲基乙基） 3-苯基-4 - [（苯基氨基）羰基] -1H-吡咯-1-基] -5-羟基-3-氧代-1-庚酸R-取代的酯9，其中R取代基是C1至C6 烷基，C 6至C 9芳基或C 7至C 10芳烷基。随后，基于本领域已知的方法，R取代的酯9可以转化成阿托伐他汀钙6。

3. 发明申请

WO2010083597A1 METHODS OF MAKING LUBIPROSTONE AND INTERMEDIATES THEREOF 审中-公开
标题翻译：制备LUBIPROSTONE及其中间体的方法
公开(公告)号：WO2010083597A1
公开(公告)日：2010-07-29
申请号：PCT/CA2010/000083
申请日：2010-01-22
申请人： APOTEX PHARMACHEM INC. , KOTHAKONDA, Kiran, Kumar , WANG, Fan , GUNTOORI, Bhaskar, Reddy , NGUYEN, Minh, T.N. , CECCARELLI, Alfredo, Paul , ZHAO, Yajun , KOTIPALLI, Uma , DUNCAN, Sammy, Chris , MILNEE, Kaarina, K. , KELLS, Kevin, W. , MONTEMAYOR, Laura, Kaye
发明人： KOTHAKONDA, Kiran, Kumar , WANG, Fan , GUNTOORI, Bhaskar, Reddy , NGUYEN, Minh, T.N. , CECCARELLI, Alfredo, Paul , ZHAO, Yajun , KOTIPALLI, Uma , DUNCAN, Sammy, Chris , MILNEE, Kaarina, K. , KELLS, Kevin, W. , MONTEMAYOR, Laura, Kaye
IPC分类号： C07C69/734 , C07C59/66 , C07C69/738 , C07D307/935 , C07D311/94 , C07F7/18
CPC分类号： C07F7/1892 , C07C69/734 , C07C69/738 , C07C405/00 , C07C2601/08 , C07D307/935
摘要： There is provided processes for preparing Lubiprostone and intermediates thereof. Also provided are compounds, including intermediates for preparing Lubiprostone as well as compositions comprising Lubiprostone and other compounds, including intermediates for preparing Lubiprostone and other compounds. (I)
摘要翻译：提供了用于制备柳普罗石及其中间体的方法。还提供了化合物，包括用于制备兰比罗石的中间体以及包含卢比石和其它化合物的组合物，包括用于制备兰普罗石和其他化合物的中间体。（一世）

4. 发明申请

WO2007140608A1 A NOVEL PROCESS FOR THE PREPARATION OF ESOMEPRAZOLE AND SALTS THEREOF 审中-公开
标题翻译：用于制备异喹诺酮和其盐的新方法
公开(公告)号：WO2007140608A1
公开(公告)日：2007-12-13
申请号：PCT/CA2007/001005
申请日：2007-06-08
申请人： APOTEX PHARMACHEM INC. , WANG, Fan , MONTEMAYOR, Laura, Kaye , CHE, Daqing , HORNE, Stephen, E.
发明人： WANG, Fan , MONTEMAYOR, Laura, Kaye , CHE, Daqing , HORNE, Stephen, E.
IPC分类号： C07D401/12
CPC分类号： C07D401/12 , Y02P20/55
摘要： A novel process for the preparation of omeprazole and its enantiomers, such as esomeprazole, as well as the preparation of related 2-(2-pyridinylmethyl-sulphinyl)-1H-benzimidazoles, including pantoprazole, lansoprazole and rabeprazole, as recemates or single enantiomers, and their alkali or alkaline salts has been developed. The novel process involves the surprising discovery that protection of the free-base benzimidazole sulfoxide (e.g. omeprazole or esomeprazole), by reaction with an alkyl, aryl or aralkyl chloroformate following oxidation of the corresponding sulfide, eliminates the need for its direct isolation. Subsequent removal of the protecting group with a solution of alkali or alkaline earth alkoxide in a C1-C4 alcohol directly provides the corresponding salt. By eliminating the need to handle the free-base benzimidazole sulfoxide, this advantageous procedure provides increased chemical yields over processes described in the art.
摘要翻译：一种用于制备奥美拉唑及其对映异构体的新方法，例如艾美拉唑，以及相关的2-（2-吡啶基甲基 - 亚磺酰基）-1H-苯并咪唑（包括泮托拉唑，兰索拉唑和雷贝拉唑）作为受体或单一对映异构体的制备，并开发了它们的碱金属盐或碱金属盐。该新方法涉及令人惊奇的发现：在相应的硫化物氧化后，通过与烷基，芳基或氯甲酸烷基酯反应来保护游离碱性苯并咪唑亚砜（例如奥美拉唑或埃索美拉唑）消除了对其直接分离的需要。随后用碱金属或碱土金属醇溶液在C1-C4醇中除去保护基团直接提供相应的盐。通过消除处理游离碱性苯并咪唑亚砜的需要，与本领域中描述的方法相比，该有利的方法提供了增加的化学产率。

5. 发明申请

WO2011072383A1 PROCESSES FOR THE PURIFICATION OF LUBIPROSTONE 审中-公开
标题翻译： LUBIPROSTONE的纯化方法
公开(公告)号：WO2011072383A1
公开(公告)日：2011-06-23
申请号：PCT/CA2010/001987
申请日：2010-12-17
申请人： APOTEX PHARMACHEM INC. , WEERATUNGA, Gamini , KOTHAKONDA, Kiran Kumar , CECCARELLI, Alfredo, Paul , GUNTOORI, Bhaskar, Reddy , WANG, Fan
发明人： WEERATUNGA, Gamini , KOTHAKONDA, Kiran Kumar , CECCARELLI, Alfredo, Paul , GUNTOORI, Bhaskar, Reddy , WANG, Fan
IPC分类号： C07D311/94 , A61K31/558
CPC分类号： C07D311/94 , C07C405/00 , C07C2601/08
摘要： There is provided processes for purification of Lubiprostone by formation of amine salts. Also provided are compounds of the Lubiprostone amine salt. Also provided are compositions comprising Lubiprostone and amines.
摘要翻译：提供了通过形成胺盐来纯化卢比石的方法。还提供了卢比石盐胺的化合物。还提供了包含柳普鲁石和胺的组合物。

6. 发明申请

WO2011020189A1 FORMS OF DEXLANSOPRAZOLE AND PROCESSES FOR THE PREPARATION THEREOF 审中-公开
标题翻译：苯并噻唑的形式及其制备方法
公开(公告)号：WO2011020189A1
公开(公告)日：2011-02-24
申请号：PCT/CA2010/001276
申请日：2010-08-19
申请人： APOTEX PHARMACHEM INC. , WANG, Fan , KELLS, Kevin W. , MILNES, Kaarina , MCPHAIL, Cameron L.
发明人： WANG, Fan , KELLS, Kevin W. , MILNES, Kaarina , MCPHAIL, Cameron L.
IPC分类号： C07D401/12 , A61K31/4439 , A61K47/10
CPC分类号： C07D401/12 , A61K31/4439 , C07D235/28
摘要： Provided is dexlansoprazole propylene glycolate hydrate. Polymorphic forms thereof are also provided. The dexlansoprazole propylene glycolate hydrate maybe such that the propylene glycol component is present in approximately equal proportions of (R) absolute configuration and (S) absolute configuration, or present in predominantly (R) absolute configuration, or predominantly (S) absolute configuration. Salts of dexlansoprazole are also provided. In particular, crystalline dexlansoprazole isopropylammonium salt and crystalline MTBE solvate of dexlansoprazole t-butylammonium salt are provided. Pharmaceutical formulations comprising dexlansoprazole propylene glycolate hydrate are also provided. Furthermore, processes for preparation of dexlansoprazole propylene glycolate hydrate are provided.
摘要翻译：提供了右兰索拉唑丙酸乙醇酸酯水合物。还提供了其多晶型。右兰索拉唑丙二醇酸水合物可以使得丙二醇组分以大致相等比例的（R）绝对构型和（S）绝对构型存在，或以主要（R）绝对构型或主要（S）绝对构型存在。还提供了右兰索拉唑盐。特别地，提供了结晶右兰索拉唑异丙基铵盐和右兰索拉唑叔丁基铵盐的结晶MTBE溶剂合物。还提供了包含右兰索拉唑丙二醇水合物的药物制剂。此外，提供了右兰索拉唑丙酸羟乙酸酯水合物的制备方法。

7. 发明申请

WO2017133780A1 USER DEVICE, NETWORK NODE AND METHODS THEREOF 审中-公开
标题翻译：用户设备，网络节点及其方法
公开(公告)号：WO2017133780A1
公开(公告)日：2017-08-10
申请号：PCT/EP2016/052443
申请日：2016-02-05
申请人： HUAWEI TECHNOLOGIES CO., LTD. , WANG, Fan , BERGGREN, Fredrik
发明人： WANG, Fan , BERGGREN, Fredrik
IPC分类号： H04W74/08 , H04W72/04 , H04W72/12
CPC分类号： H04W74/0816 , H04W72/0453 , H04W72/1294
摘要： The invention relates to a user device and a network node for a wireless communication system (500). The user device (100) comprises a transceiver (102) configured to receive a transmission grant (TG) indicating a set of frequency resources assigned for transmission to a network node (300); a processor (104) configured to determine a channel access outcome based on a channel access procedure performed in the set of frequency resources; wherein the transceiver (102) is configured to transmit a first signal (S1) to the network node (300) in the set of frequency resources according to the channel access outcome. The network node (300) comprises a transceiver (302) configured to transmit a transmission grant (TG) to a user device (100), the transmission grant indicating (TG) a set of frequency resources assigned for transmission from the user device (100) to the network node (300) and for performing a channel access procedure; receive a first signal (S1) from the user device (100) in the set of frequency resources. Furthermore, the invention also relates to corresponding methods, a wireless communication system, a computer program, and a computer program product.
摘要翻译：本发明涉及用于无线通信系统（500）的用户装置和网络节点。用户设备（100）包括：收发器（102），被配置为接收指示被分配用于向网络节点（300）传输的频率资源集合的传输许可（TG）; 处理器（104），其被配置为基于在所述一组频率资源中执行的信道接入过程来确定信道接入结果; 其中所述收发器（102）配置成根据所述信道接入结果在所述一组频率资源中向所述网络节点（300）发送第一信号（S1）。所述网络节点（300）包括被配置为向用户设备（100）发送传输授权（TG）的收发器（302），所述传输授权指示（TG）分配用于从所述用户设备）到网络节点（300）并用于执行信道接入过程; 在该组频率资源中接收来自用户设备（100）的第一信号（S1）。此外，本发明还涉及相应的方法，无线通信系统，计算机程序和计算机程序产品。

8. 发明申请

WO2017025147A1 TRANSMITTER AND RECEIVER FOR A WIRELESS COMMUNICATION SYSTEM 审中-公开
标题翻译：无线通信系统的发射机和接收机
公开(公告)号：WO2017025147A1
公开(公告)日：2017-02-16
申请号：PCT/EP2015/068673
申请日：2015-08-13
申请人： HUAWEI TECHNOLOGIES CO., LTD. , WANG, Fan , BERGGREN, Fredrik
发明人： WANG, Fan , BERGGREN, Fredrik
IPC分类号： H04W74/08
CPC分类号： H04W72/1289 , H04L5/0048 , H04W48/16 , H04W72/0446 , H04W74/0808 , H04W74/0825
摘要： The present invention presents a transmitter for a wireless communication system, configured to stop a transmission of a first downlink burst such that it ends before a predetermined gap interval before a downlink subframe in a Discovery signal Measurement Timing Configuration, DMTC, window of the wireless communication system.
摘要翻译：本发明提供一种用于无线通信系统的发射机，其被配置为停止第一下行链路脉冲串的传输，使得其在无线通信的发现信号测量定时配置DMTC窗口中的下行链路子帧之前在预定的间隔间隔之前结束系统。

9. 发明申请

WO2016180451A1 SUBFRAME TIMING WITH VARIABLE STARTING TIME 审中-公开
标题翻译：具有可变启动时间的子帧时序
公开(公告)号：WO2016180451A1
公开(公告)日：2016-11-17
申请号：PCT/EP2015/060242
申请日：2015-05-08
申请人： HUAWEI TECHNOLOGIES CO., LTD. , WANG, Fan , BERGGREN, Fredrik
发明人： WANG, Fan , BERGGREN, Fredrik
IPC分类号： H04L5/00
CPC分类号： H04L5/0048 , H04L5/0007 , H04L5/0044 , H04L5/0053 , H04L5/0078 , H04W72/0446 , H04W72/1273
摘要： The present invention relates to a transmitter device and a receiver device. The transmitter device (100) comprises a processer (102) configured to map at least one first signal to a first subframe (SF1), map at least one second signal to a second subframe (SF2) having a variable time offset in relation to the first subframe (SF1); and a transceiver (104) configured to transmit the first signal in the first subframe (SF1), transmit the second signal in the second subframe (SF2). The receiver device (300) comprises a receiving device (304) configured to receive a first signal transmitted in a first subframe (SF1), and receive a second signal transmitted in a second subframe (SF2) having a variable time offset in relation to the first subframe (SF1); and a processor (302) configured to process the received first signal, and process the received second signal. Furthermore, the present invention also relates to corresponding methods, a computer program, and a computer program product.
摘要翻译：本发明涉及发射机设备和接收机设备。发射机设备（100）包括被配置为将至少一个第一信号映射到第一子帧（SF1）的处理器（102），将至少一个第二信号映射到具有相对于第一子帧（SF1）的可变时间偏移的第二子帧第一子帧（SF1）; 以及收发器（104），被配置为在所述第一子帧（SF1）中发送所述第一信号，在所述第二子帧（SF2）中发送所述第二信号。接收机设备（300）包括接收设备（304），接收设备（304）被配置为接收在第一子帧（SF1）中发送的第一信号，并且接收在第二子帧（SF2）中发送的第二信号，该第二子帧具有相对于第一子帧（SF1）; 以及处理器（302），被配置为处理所接收的第一信号，并处理所接收的第二信号。此外，本发明还涉及相应的方法，计算机程序和计算机程序产品。

10. 发明申请

WO2011019906A1 LAYERED PROTECTION AND VALIDATION OF IDENTITY DATA DELIVERED ONLINE VIA MULTIPLE INTERMEDIATE CLIENTS 审中-公开
标题翻译：通过多个中间客户在线提供的身份数据的分层保护和验证
公开(公告)号：WO2011019906A1
公开(公告)日：2011-02-17
申请号：PCT/US2010/045310
申请日：2010-08-12
申请人： GENERAL INSTRUMENT CORPORATION , TSAI, Annie , MEDVINSKY, Sasha , QIU, Xin , STEWART, Kyle , WANG, Fan
发明人： TSAI, Annie , MEDVINSKY, Sasha , QIU, Xin , STEWART, Kyle , WANG, Fan
IPC分类号： H04L29/06
CPC分类号： H04L63/045 , G06F21/6218 , G06F21/64 , H04L9/006 , H04L9/0825 , H04L9/3234 , H04L9/3265 , H04L63/062 , H04L63/0823 , H04L63/123 , H04L2463/062
摘要： A method is provided for securely delivering identity data units over a communications network to a client device. The method includes receiving a selection from a customer identifying a final zipped package to be unpacked. The final zipped package is unpacked to obtain a common package and a digital signature file signed by an entity generating identity data requested by the customer. The digital signature in the digital signature file is verified and the common package is unpacked to obtain a plurality of outer packages and an encrypted symmetric key. The symmetric key is decrypted with a private key associated with the customer and each of the outer packages is decrypted with the symmetric key to obtain a plurality of identity data units.
摘要翻译：提供了一种用于通过通信网络将身份数据单元安全地传送到客户端设备的方法。该方法包括从客户接收标识要解包的最终压缩包的选择。最后的压缩包解包以获得由生成客户请求的身份数据的实体签名的公用包和数字签名文件。验证数字签名文件中的数字签名，并解压缩公用包以获得多个外包和加密对称密钥。对称密钥用与客户相关联的私钥解密，并且每个外部包都用对称密钥解密以获得多个身份数据单元。

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