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1. 发明申请

WO2014163622A1 MULTIFUNCTIONAL QUINOLINE DERIVATIVES AS ANTI-NEURODEGENERATIVE AGENTS 审中-公开
标题翻译：多功能喹啉衍生物作为抗神经退行性剂
公开(公告)号：WO2014163622A1
公开(公告)日：2014-10-09
申请号：PCT/US2013/034960
申请日：2013-04-02
申请人： ANNJI PHARMACEUTICAL CO., LTD. , HEALTHBANKS USA INC.
发明人： CHERN, Ji-wang , HUANG, Chen-wei , CHANG, Pei-teh , TALEKAR, Rahul, Subhash
IPC分类号： C07D215/26
CPC分类号： C07D215/28 , C07D215/26
摘要： Novel quinolone derivatives are disclosed. Also disclosed are synthesis and use thereof for treating neurodegenerative diseases. In an aspect, the invention relates to a composition comprising a therapeutically effective amount of the compound as aforementioned, or a pharmaceutically acceptable salt, a solvate or hydrate, a prodrug, or a metabolite thereof and a pharmaceutically acceptable diluent or carrier. Further in another aspect, the invention relates to a composition comprising a compound as aforementioned, or a pharmaceutically acceptable salt, a solvate or hydrate, a prodrug, or a metabolite thereof, and a pharmaceutically acceptable diluent or carrier tor use in treating a neurodegenerative disease. Yet in another aspect, the invention relates to a use of a compound as aforementioned in the manufacture of a medicament for treating a neurodegenerative disease. In one embodiment, the medicament is for treating.Alzheimer's disease.
摘要翻译：公开了新的喹诺酮衍生物。还公开了用于治疗神经变性疾病的合成及其用途。一方面，本发明涉及包含治疗有效量的上述化合物或其药学上可接受的盐，溶剂化物或水合物，前药或代谢物以及药学上可接受的稀释剂或载体的组合物。进一步在另一方面，本发明涉及包含如上所述的化合物或其药学上可接受的盐，溶剂合物或水合物，前药或代谢物以及用于治疗神经变性疾病的药学上可接受的稀释剂或载体的组合物。另一方面，本发明涉及如上所述的化合物在制备用于治疗神经退行性疾病的药物中的用途。在一个实施方案中，该药物用于治疗阿尔茨海默氏病。

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