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1. 发明申请

WO2012061658A3 DRUG-ELUTING SELF-RETAINING SUTURES AND METHODS RELATING THERETO 审中-公开
标题翻译：药物自我保留缝合和与其相关的方法
公开(公告)号：WO2012061658A3
公开(公告)日：2012-07-19
申请号：PCT/US2011059238
申请日：2011-11-03
申请人： ANGIOTECH PHARM INC , TISSUEGEN INC , GROSS JEFFREY M , DRUBETSKY LEV , NAIMAGON ALEXANDER , AVELAR RUI , D AGOSTINO WILLIAM L , NELSON KEVIN DON , CROW BRENT B , GRIFFIN NICKOLAS B
发明人： GROSS JEFFREY M , DRUBETSKY LEV , NAIMAGON ALEXANDER , AVELAR RUI , D AGOSTINO WILLIAM L , NELSON KEVIN DON , CROW BRENT B , GRIFFIN NICKOLAS B
IPC分类号： A61B17/04 , A61L17/14 , A61L27/54 , D02J3/00
CPC分类号： A61L17/005 , A61B17/0401 , A61B2017/00526 , A61B2017/00893 , A61B2017/06057 , A61B2017/0608 , A61B2017/06176 , A61L2300/414 , A61L2300/602 , A61L2430/32
摘要： A drug-eluting self-retaining suture comprises a filament, a plurality of retainers, and a drug impregnated in or coated on the filament. The shape and distribution of retainers modifies the in vivo release kinetics of the drug. The drug release kinetics may be modified uniformly or region by region. The self-retaining suture may for example be used for reattaching severed nerves and release nerve growth factor or other regeneration accelerating agents into the region of the nerve injury.
摘要翻译：药物洗脱自固位缝合线包括细丝，多个保持器以及浸渍或涂覆在细丝上的药物。保持器的形状和分布改变了药物的体内释放动力学。药物释放动力学可以被均匀地或逐区域地修改。自固定缝合线可以例如用于重新连接切断的神经并将神经生长因子或其他再生促进剂释放到神经损伤的区域中。

2. 发明申请

WO2011140283A2 SELF-RETAINING SYSTEMS HAVING LASER-CUT RETAINERS 审中-公开
标题翻译：具有激光切割保持器的自保留系统
公开(公告)号：WO2011140283A2
公开(公告)日：2011-11-10
申请号：PCT/US2011035271
申请日：2011-05-04
申请人： ANGIOTECH PHARM INC , GROSS JEFFREY M , D AGOSTINO WILLIAM L , DRUBETSKY LEV , NAIMAGON ALEXANDER
发明人： GROSS JEFFREY M , D AGOSTINO WILLIAM L , DRUBETSKY LEV , NAIMAGON ALEXANDER
IPC分类号： A61B17/04 , A61B17/08 , D02J3/02 , D02J3/10
CPC分类号： A61B17/06166 , A61B17/0401 , A61B17/0644 , A61B2017/00526 , A61B2017/0417 , A61B2017/0427 , A61B2017/06038 , A61B2017/06176 , A61B2090/3937 , B23K26/032 , B23K26/0652 , B23K26/0665 , B23K26/083 , B23K26/1462 , B23K26/361 , B23K26/362 , B23K37/04
摘要： Self-retaining suture systems including a suture thread bearing a plurality of laser-cut retainers are disclosed. A laser system allows the creation of retainers and self-retaining suture systems in configurations which are difficult and/or impossible to achieve using mechanical cutting technology.
摘要翻译：公开了包括具有多个激光切割保持器的缝合线的自固定缝线系统。激光系统允许在使用机械切割技术难以和/或不可能实现的构造中创建保持器和自固位缝合系统。

3. 发明申请

WO2011139916A3 HIGH-DENSITY SELF-RETAINING SUTURES, MANUFACTURING EQUIPMENT AND METHODS 审中-公开
标题翻译：高密度自保护件，制造设备和方法
公开(公告)号：WO2011139916A3
公开(公告)日：2012-04-05
申请号：PCT/US2011034660
申请日：2011-04-29
申请人： ANGIOTECH PHARM INC , GROSS JEFFREY M , DRUBETSKY LEV , NAIMAGON ALEXANDER , D AGOSTINO WILLIAM L
发明人： GROSS JEFFREY M , DRUBETSKY LEV , NAIMAGON ALEXANDER , D AGOSTINO WILLIAM L
IPC分类号： A61B17/064 , A61L17/00 , D01F6/06 , D02J3/00
CPC分类号： A61B17/06166 , A61B17/0644 , A61B2017/00526 , A61B2017/0417 , A61B2017/0427 , A61B2017/06038 , A61B2017/06176 , A61L17/00 , B26D7/01 , D02J3/02 , Y10T83/051 , Y10T83/748
摘要： A self-retaining suture has a suture thread less than 1 millimeter nominal diameter. A plurality of retainers is cut into the suture thread using a high accuracy retainer cutting machine. The retainer cutting machine has sufficient accuracy and repeatability to cut consistent and effective retainers at high density on suture threads less than 1mm nominal diameter.
摘要翻译：自固位缝合线具有小于1毫米公称直径的缝线。使用高精度保持器切割机将多个保持器切割成缝合线。保持切割机具有足够的精度和重复性，可以在小于1mm公称直径的缝合线上以高密度切割一致且有效的保持器。

4. 发明申请

WO2011140282A2 LASER CUTTING SYSTEM AND METHODS FOR CREATING SELF-RETAINING SUTURES 审中-公开
标题翻译：激光切割系统和创建自我保护的方法
公开(公告)号：WO2011140282A2
公开(公告)日：2011-11-10
申请号：PCT/US2011035270
申请日：2011-05-04
申请人： ANGIOTECH PHARM INC , GROSS JEFFREY M , D AGOSTINO WILLIAM L , DRUBETSKY LEV , NAIMAGON ALEXANDER , CONNER JACOB D , WHITWORTH KEVIN R , WOOLSEY RYAN T , DICKEY FRED M
发明人： GROSS JEFFREY M , D AGOSTINO WILLIAM L , DRUBETSKY LEV , NAIMAGON ALEXANDER , CONNER JACOB D , WHITWORTH KEVIN R , WOOLSEY RYAN T , DICKEY FRED M
IPC分类号： A61B17/04 , A61B17/08 , D02J3/02 , D02J3/10
CPC分类号： A61B17/06166 , A61B17/0401 , A61B17/0644 , A61B2017/00526 , A61B2017/0417 , A61B2017/0427 , A61B2017/06038 , A61B2017/06176 , A61B2090/3937 , B23K26/032 , B23K26/0652 , B23K26/0665 , B23K26/083 , B23K26/1462 , B23K26/361 , B23K26/362 , B23K37/04
摘要： A laser-machining system and method is disclosed for forming retainers on a suture thread. The laser system is preferably a femtosecond laser system which is capable of creating submicron features on the suture thread while preserving strength of the suture thread. The laser-machining system enables creation of retainers and self-retaining suture systems in configurations which are difficult and/or impossible to achieve using mechanical cutting technology.
摘要翻译：公开了一种用于在缝合线上形成保持器的激光加工系统和方法。激光系统优选是飞秒激光系统，其能够在缝合线上产生亚微米特征，同时保持缝合线的强度。激光加工系统能够在使用机械切割技术难以和/或不可能实现的构造中创建保持器和自固位缝合系统。

5. 发明申请

WO2012129534A2 SELF-RETAINING VARIABLE LOOP SUTURES 审中-公开
标题翻译：自保持可变环形缝合
公开(公告)号：WO2012129534A2
公开(公告)日：2012-09-27
申请号：PCT/US2012030441
申请日：2012-03-23
申请人： ANGIOTECH PHARM INC , GROSS JEFFREY M , DRUBETSKY LEV , D AGOSTINO WILLIAM L , HUNTER WILLIAM L
发明人： GROSS JEFFREY M , DRUBETSKY LEV , D AGOSTINO WILLIAM L , HUNTER WILLIAM L
IPC分类号： A61B17/04 , A61B17/06 , A61L17/14 , D02J3/00
CPC分类号： A61B17/06166 , A61B17/0485 , A61B2017/00004 , A61B2017/0417 , A61B2017/044 , A61B2017/0462 , A61B2017/0464 , A61B2017/0475 , A61B2017/0477 , A61B2017/0496 , A61B2017/06176
摘要： A suture having a first end for penetrating tissue, an elongated suture body having a periphery; a plurality of retainers on the periphery, and a second end having a variable loop of variable circumference, wherein the variable loop includes a fixed loop slidably engaging the elongated body for slidingly varying the circumference of the variable loop, and wherein the first end may pass through the variable loop to secure tissue as an anchor, the anchor preventing movement of the suture in the direction of deployment of the first end.
摘要翻译：具有用于穿透组织的第一端的缝合线，具有周边的细长缝合线本体; 在周边上的多个保持器以及具有可变环的可变环的第二端，其中可变环包括可滑动地接合细长体的固定环，用于滑动地改变可变环的周长，并且其中第一端可以通过穿过可变环以将组织固定为锚，锚固件防止缝合线在第一端的展开方向上移动。

6. 发明申请

WO2009105663A3 METHOD AND APPARATUS FOR ELEVATING RETAINERS ON SELF-RETAINING SUTURES 审中-公开
标题翻译：用于在自保留缝隙上提起固定器的方法和设备
公开(公告)号：WO2009105663A3
公开(公告)日：2009-12-03
申请号：PCT/US2009034703
申请日：2009-02-20
申请人： ANGIOTECH PHARM INC , GORALTCHOUK ALEXEI , HERRMANN ROBERT A , DRUBETSKY LEV , GROSS JEFFREY MENDEL , D AGOSTINO WILLIAM L , GONZALEZ RESENDIZ CARLOS
发明人： GORALTCHOUK ALEXEI , HERRMANN ROBERT A , DRUBETSKY LEV , GROSS JEFFREY MENDEL , D AGOSTINO WILLIAM L , GONZALEZ RESENDIZ CARLOS
IPC分类号： A61B17/068 , A61B17/03 , A61B17/06
CPC分类号： A61B17/06166 , A61B2017/00526 , A61B2017/00867 , A61B2017/00871 , A61B2017/00995 , A61B2017/06176 , D02J3/10 , Y10T83/02
摘要： A method and device to elevate retainers on a suture thread to a desired angle such that the retainers can retain the desired elevation. The retainers can be elevated using an apparatus having at least one roller and at least one bending bar, wherein the bending bar contacts the retainers adjacent to the at least one roller to apply a force to the retainers. The retainers can also be elevated using a tube-shaped apparatus which allows the retainers on a suture thread to be bent by the inner surface of the tube-shaped apparatus. In various embodiments of the invention, a suture can be made up of an inner core and a coating that upon a stimuli increases the protrusion of the retainers away from the suture core thereby ensuring that the suture is held securely in place, preventing wound separation and dehiscence. In an embodiment of the invention, the application of the coating to the outer face of the retainer and attractive forces between the coating at different points results in the distension of the retainers away from the suture core. In an alternative embodiment of the invention, the coating inserts into the cut associated with the retainer and repulsive or expansive forces result in a pushing out of the cut and thereby the distending of the retainers away from the suture core.
摘要翻译：一种将缝合线上的保持器升高到期望角度的方法和装置，使得保持器能够保持期望的高度。可以使用具有至少一个滚子和至少一个弯曲杆的装置升高保持器，其中弯曲杆接触与至少一个滚子相邻的保持器以向保持器施加力。保持器也可以使用管状装置升高，该装置允许缝合线上的保持器被管状装置的内表面弯曲。在本发明的各种实施例中，缝合线可以由内芯和涂层组成，所述内芯和涂层在刺激时增加保持器远离缝合线芯的突出，由此确保缝合线牢固地保持在位，防止伤口分离和裂开。在本发明的一个实施例中，将涂层施加到保持器的外表面以及不同点处的涂层之间的吸引力导致保持器远离缝合线芯延伸。在本发明的可选实施例中，涂层插入与保持器相关联的切口中，并且排斥力或膨胀力导致切口的推出并且因此保持器远离缝合线芯扩张。

7. 发明申请

WO2011090628A2 BIDIRECTIONAL SELF-RETAINING SUTURES WITH LASER-MARKED AND/OR NON-LASER MARKED INDICIA AND METHODS 审中-公开
标题翻译：具有激光标记和/或非激光标记的指标的双向自保留方法和方法
公开(公告)号：WO2011090628A2
公开(公告)日：2011-07-28
申请号：PCT/US2010060889
申请日：2010-12-16
申请人： ANGIOTECH PHARM INC , GROSS JEFFREY M , D AGOSTINO WILLIAM L , AVELAR RUI , GORALTCHOUK ALEXEI , HERRMANN ROBERT A , LUSCOMBE BRIAN H
发明人： GROSS JEFFREY M , D AGOSTINO WILLIAM L , AVELAR RUI , GORALTCHOUK ALEXEI , HERRMANN ROBERT A , LUSCOMBE BRIAN H
IPC分类号： A61B17/04 , D02G3/34 , D02J3/00
CPC分类号： A61B17/06166 , A61B17/0469 , A61B34/30 , A61B90/90 , A61B90/92 , A61B90/94 , A61B90/98 , A61B2017/00115 , A61B2017/00526 , A61B2017/06009 , A61B2017/06014 , A61B2017/06057 , A61B2017/06176 , A61B2090/064 , A61B2090/0809 , A61B2090/365
摘要： A marked heterofunctional suture thread has two or more sections having different features. One or more sections of the suture thread are provided with laser-marked and non-laser marked indicia in order that they may be identified and differentiated from other sections. The suture thread may have retainers on the surface of one or more sections such that the suture thread can engage and retain tissue without knots. The markers may be used to indicate fixed features of a section of suture thread such as the presence and/orientation of retainers. In particular embodiments, laser-marked and non-laser marked indicia are used to identify the transition section of a bidirectional self-retaining suture.
摘要翻译：标记的异型功能缝合线具有两个或多个具有不同特征的部分。缝合线的一个或多个部分设置有激光标记和非激光标记的标记，以便它们可以被识别并且与其它部分区分开。缝合线可以在一个或多个部分的表面上具有保持器，使得缝合线可以接合并保持组织而没有结。标记可以用于指示缝合线的一部分的固定特征，例如保持器的存在和/取向。在特定实施例中，使用激光标记和非激光标记标记来识别双向自固位缝合线的过渡部分。

8. 发明申请

WO2012064902A2 EMERGENCY SELF-RETAINING SUTURES AND PACKAGING 审中-公开
标题翻译：紧急自保和包装
公开(公告)号：WO2012064902A2
公开(公告)日：2012-05-18
申请号：PCT/US2011060069
申请日：2011-11-09
申请人： ANGIOTECH PHARM INC , D AGOSTINO WILLIAM L , MERKEL MATT , BOWSER RON , HOYT MARK
发明人： D AGOSTINO WILLIAM L , MERKEL MATT , BOWSER RON , HOYT MARK
IPC分类号： A61B17/04 , A61B17/03 , A61L17/14 , D02J3/00
CPC分类号： A61B17/06166 , A61B17/04 , A61B17/0466 , A61B17/06133 , A61B17/06138 , A61B50/30 , A61B90/92 , A61B2017/0042 , A61B2017/0472 , A61B2017/0479 , A61B2017/06052 , A61B2017/06057 , A61B2017/06142 , A61B2017/06147 , A61B2017/06176 , A61B2050/314 , A61B2090/037
摘要： A removable self-retaining suture system and methods for use thereof in emergency situations. The system comprises one or more self-retaining suture segments and a grasp engagement element. The system may be used for temporary wound closure in a trauma victim, and may be easily removed upon the availability of proper medical care to the victim.
摘要翻译：可拆卸的自固定缝合系统及其在紧急情况下的使用方法。该系统包括一个或多个自固位缝合线段和抓握接合元件。该系统可用于创伤受害者的临时伤口闭合，并且可以在向受害者提供适当的医疗护理后容易地移除。

9. 发明申请

WO2011060446A3 BRAIDED SELF-RETAINING SUTURES AND METHODS 审中-公开
标题翻译：编织自固定缝合和方法
公开(公告)号：WO2011060446A3
公开(公告)日：2011-10-06
申请号：PCT/US2010056898
申请日：2010-11-16
申请人： ANGIOTECH PHARM INC , AVELAR RUI , D AGOSTINO WILLIAM L
发明人： AVELAR RUI , D AGOSTINO WILLIAM L
IPC分类号： A61B17/04 , A61L17/04 , D02G3/36
CPC分类号： A61B17/06166 , A61B2017/00526 , A61B2017/06057 , A61B2017/06176 , A61B2017/0618 , D04C1/12 , D10B2509/04
摘要： A self-retaining braided suture comprises a braided suture with tissue retainers formed on the surface such that the suture can engage and retain tissue without knots. The suture includes a plurality of braided fibers which may be covered by a non-braided sheath of a material which enhances the formation, elevation and/or deployment of the retainers. The retainers can be formed so as not to disrupt the braided fibers. The self-retaining braided suture has properties which enhance the tensile strength of the suture while preserving flexibility and durability. Methods for manufacturing and using self-retaining braided suture are also described.
摘要翻译：自保持编织缝合线包括编织缝合线，其具有形成在表面上的组织保持器，使得缝合线可以接合并保持没有结的组织。缝合线包括多根编织纤维，其可以由增强保持器的形成，升高和/或展开的材料的非编织鞘覆盖。保持器可以形成为不破坏编织纤维。自保持编织缝合线具有提高缝合线拉伸强度同时保持柔韧性和耐久性的性质。还描述了制造和使用自保持编织缝线的方法。

10. 发明申请

WO2009151876A3 CODED HETEROFUNCTIONAL SUTURES AND METHODS 审中-公开
标题翻译：编码的异常方法和方法
公开(公告)号：WO2009151876A3
公开(公告)日：2010-04-22
申请号：PCT/US2009044274
申请日：2009-05-16
申请人： ANGIOTECH PHARM INC , AVELAR RUI , GORALTCHOUK ALEXEI , HERRMANN ROBERT A , LUSCOMBE BRIAN H , D AGOSTINO WILLIAM L
发明人： AVELAR RUI , GORALTCHOUK ALEXEI , HERRMANN ROBERT A , LUSCOMBE BRIAN H , D AGOSTINO WILLIAM L
IPC分类号： A61B17/064
CPC分类号： A61B17/06166 , A61B90/92 , A61B90/94 , A61B2017/06176
摘要： A marked heterofunctional surgical filament. The filament comprises two or more sections having different features, and the different sections of the filament are provided with markers in order that they may be identified and differentiated. The filament may have retainers on the surface of one or more sections such that the filament can engage and retain tissue without knots. The markers may be used to indicate fixed features of a section of filament such as the presence and/orientation of retainers. The markers may be utilized to indicate conditions of the filament such as tension. The markers may be directly readable or be machine-readable. The surgical filament is thin and flexible and may be used for suturing.
摘要翻译：标记异型手术丝。灯丝包括具有不同特征的两个或更多个部分，并且灯丝的不同部分设置有标记，以便它们可以被鉴定和分化。长丝可以在一个或多个部分的表面上具有保持器，使得细丝可以接合并保持组织而没有结。标记可用于表示细丝部分的固定特征，例如保持器的存在和/取向。标记可以用于指示细丝的状况，例如张力。标记可以是直接可读的或机器可读的。外科手术细丝薄而柔软，可用于缝合。

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