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3. 发明申请

WO2006116565A2 PEPTIDE SUSTAINED RELEASE COMPOSITIONS AND USES THEREOF 审中-公开
标题翻译：肽持续释放组合物及其用途
公开(公告)号：WO2006116565A2
公开(公告)日：2006-11-02
申请号：PCT/US2006/015949
申请日：2006-04-25
申请人： AMGEN INC. , WU, Cindy, W. , BURKE, Paul , GOLDENBERG, Merrill, S. , SHAN, Daxian
发明人： WU, Cindy, W. , BURKE, Paul , GOLDENBERG, Merrill, S. , SHAN, Daxian
CPC分类号： A61K38/08 , A61K9/0019 , A61K9/1647
摘要： Sustained delivery compositions that modulate the release of incorporated prophylactic, therapeutic, and/or diagnostic agents, and methods of preparation and use thereof, are disclosed. In particular embodiments, the compositions include a polymeric matrix; a prophylactic, therapeutic, and/or diagnostic agent dispersed and/or dissolved within the polymeric matrix; and a carbohydrate component that is separately dispersed within the polymeric matrix. The carbohydrate component modulates the release of the incorporated agent from the polymeric matrix. The compositions can be prepared by dissolving a biocompatible polymer in a solvent to form a polymer solution, and separately dispersing a carbohydrate and a prophylactic, therapeutic, and/or diagnostic agent within the polymer solution. The polymer solution is then solidified to form a polymeric matrix, wherein a significant amount of the carbohydrates is dispersed in the polymeric matrix separately from the incorporated agent. In particular embodiments, the compositions include a polymeric matrix and a B1 peptide antagonist dispersed within the polymeric matrix.
摘要翻译：公开了调节掺入的预防，治疗和/或诊断剂的释放的持续递送组合物及其制备和使用方法。在具体实施方案中，组合物包括聚合物基质; 在聚合物基质中分散和/或溶解的预防，治疗和/或诊断剂; 和分别分散在聚合物基质内的碳水化合物组分。碳水化合物组分调节从聚合物基质中引入的试剂的释放。组合物可以通过将生物相容性聚合物溶解在溶剂中以形成聚合物溶液，并且在聚合物溶液中分别分散碳水化合物和预防，治疗和/或诊断剂来制备。然后将聚合物溶液固化以形成聚合物基质，其中大量的碳水化合物与掺入的试剂分开分散在聚合物基质中。在具体实施方案中，组合物包括分散在聚合物基质内的聚合物基质和B1肽拮抗剂。

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