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1. 发明申请

WO2007133627A2 METHOD FOR MAKING LIPOSOMES CONJUGATED WITH TEMPERATURE-SENSITIVE LIGANDS 审中-公开
标题翻译：制备与温度敏感配体结合的脂质体的方法
公开(公告)号：WO2007133627A2
公开(公告)日：2007-11-22
申请号：PCT/US2007/011294
申请日：2007-05-09
申请人： ALZA CORPORATION , HUANG, Ken, Shi Kun , LI, Zengji , WANG, Jinkang , ZHANG, Guoyang , GRIGSBY, John
发明人： HUANG, Ken, Shi Kun , LI, Zengji , WANG, Jinkang , ZHANG, Guoyang , GRIGSBY, John
IPC分类号： A61K47/48
CPC分类号： A61K9/1271 , A61K47/6849 , A61K47/6913
摘要： The present invention relates to a method of making a liposome composition. In particular, the invention relates to a method of making liposomes targeted to a specific cell receptor for delivery of a liposome-entrapped drug to the cell. In one embodiment, the process involves the incorporation of lipid-linkers to the surface of pre-formed liposomes, preferably at a higher temperature, followed by the conjugation of one or more temperature-sensitive ligands to the linkers associated with the liposome surface at a lower temperature to avoid deactivation of the temperature sensitive ligands. The present invention also is directed to a product prepared according to the foregoing process, and its use to treat subjects. The present invention is also directed to a kit containing lipid-linker, ligand and pre-formed liposome.
摘要翻译：本发明涉及制备脂质体组合物的方法。特别地，本发明涉及制备靶向特定细胞受体的脂质体以将脂质体截留的药物递送至细胞的方法。在一个实施方案中，该方法包括将脂质连接体掺入预先形成的脂质体的表面，优选在较高温度下，随后将一种或多种温度敏感性配体与在脂质体表面相关联的接头共轭降低温度以避免温度敏感性配体失活。本发明还涉及根据前述方法制备的产品及其用于治疗受试者的用途。本发明还涉及含有脂质连接体，配体和预形成脂质体的试剂盒。

2. 发明申请

WO2007100798A2 METHOD AND SYSTEM OF CONTROLLING AND/OR CONFIGURING AN ELECTRONIC AUDIO RECORDER, PLAYER, PROCESSOR AND/OR SYNTHESIZER 审中-公开
标题翻译：控制和/或配置电子音频记录器，播放器，处理器和/或合成器的方法和系统
公开(公告)号：WO2007100798A2
公开(公告)日：2007-09-07
申请号：PCT/US2007/005023
申请日：2007-02-27
申请人： GRIGSBY, John
发明人： GRIGSBY, John , CRAGG, Noel
CPC分类号： G10H1/0091 , G10H7/002 , G10H2240/305
摘要： A method and system of controlling and/or configuring an electronic audio recorder, player, processor, and/or synthesizer, comprises a network or bi-directional data port that allows such a device to be connected to a computer or computer network, as well as within the memory of the device, or within memory or other data storage attached to or integrated with the device, the software required for the user to control and/or configure the device itself from a computer, such that the software can be transferred to the computer, executed, and used to control and/or configure the device without requiring the user to have previously found and installed such control and/or configuration software on the computer through means other than those described herein.
摘要翻译：控制和/或配置电子音频记录器，播放器，处理器和/或合成器的方法和系统包括允许这样的设备连接到计算机或计算机网络的网络或双向数据端口在设备的存储器内，或者在与设备连接或集成的存储器或其他数据存储器内，用户需要的软件从计算机控制和/或配置设备本身，使得软件可以被传送到计算机，执行和用于控制和/或配置设备，而不需要用户先前通过除本文所描述的以外的手段在计算机上找到并安装了这样的控制和/或配置软件。

3. 发明申请

WO2008039364A2 METHOD AND SYSTEM OF LABELING USER CONTROLS OF A MULTI-FUNCTION COMPUTER-CONTROLLED DEVICE 审中-公开
标题翻译：多功能计算机控制设备的用户控制标记方法与系统
公开(公告)号：WO2008039364A2
公开(公告)日：2008-04-03
申请号：PCT/US2007/020458
申请日：2007-09-22
申请人： GRIGSBY, John
发明人： GRIGSBY, John
IPC分类号： G06F19/00
CPC分类号： H01H13/83 , H01H2219/002 , H01H2219/0026 , H01H2219/006 , H01H2219/028
摘要： A method and system of labeling user controls of a multi-function computer-controlled device comprises a data storage medium with attached labeling and a user-accessible port by which the medium can be attached to the device, such that the data stored on the medium affects the actions performed by one or more of the user controls of the device, such that the attached labeling is physically visible to the user while operating the user controls of the device from a reasonable operating position, and such that this visible labeling comprises textual and/or graphical elements that describe the function of one or more of said user controls of said device, as enabled or determined partially or completely by the data. It is preferable, though not necessary to all embodiments, that the labeling be as close as is practical to the user controls, and that the layout of the labeling correspond as closely as is practical to the layout of the user controls.
摘要翻译：一种标记多功能计算机控制设备的用户控制的方法和系统包括具有附加标签的数据存储介质和用户可访问端口，通过该端口可以将介质附加到设备，使得存储在介质上的数据影响由设备的一个或多个用户控制执行的操作，使得附接的标签对于用户来说是物理上可见的，同时从合理的操作位置操作设备的用户控制，并且使得该可见标签包括文本和 /或描述所述设备的一个或多个所述用户控件的功能的图形元素，如部分或完全由数据所启用或确定的。尽管对于所有实施例都不必要，但优选的是，标签与用户控件的实用程度相近，并且标签的布局与用户控件的布局相当接近。

4. 发明申请

WO2008141278A1 METHOD FOR PREPARING ANTIBODY CONJUGATES 审中-公开
标题翻译：制备抗体结合蛋白的方法
公开(公告)号：WO2008141278A1
公开(公告)日：2008-11-20
申请号：PCT/US2008/063413
申请日：2008-05-12
申请人： CENTOCOR, INC. , GRIGSBY, John
发明人： GRIGSBY, John
IPC分类号： A61K39/00 , C07K16/00
CPC分类号： C07K16/2839 , C07K2317/21 , C07K2317/55 , C07K2317/56 , C07K2317/622 , C07K2317/73
摘要： The subject matter described herein relates to a process for preparing an antibody, in one embodiment a Fab', in very good yields and purity, under conditions where the presence of heavy and light chain antibody fragments is minimized. More particularly, the subject matter described herein relates to a process for reducing F(ab) 2 to primarily heavy and light chains, followed by a reoxidation step that is selective for making Fab' in very good yields and purity by reforming the disulfide bridge between the heavy and light chains. The reoxidation step is carried out to minimize the presence of heavy and light chain, minimize the generation of F(ab')2 and maximize Fab'. In one embodiment, the subject matter described herein relates to a process for preparing an antibody composition, in one embodiment a Fab' liposome composition, having specific binding activity for alpha-V- integrin receptors. The composition is intended for use in treating conditions characterized by cells that express any alpha-V-comprising integrin, such as αvβ3, αvβ5, and αvβ6 receptors.
摘要翻译：本文描述的主题涉及在一个实施方案中制备抗体的方法，其在重链和轻链抗体片段的存在被最小化的条件下以非常好的产率和纯度制备Fab'。更具体地说，本文所述的主题涉及一种将F（ab）2还原成主要重链和轻链的方法，随后是以非常好的产率选择性地制备Fab'的再氧化步骤，通过重构重链和轻链之间的二硫桥，纯度。进行再氧化步骤以使重链和轻链的存在最小化，使F（ab'）2的产生最小化并使Fab'最大化。在一个实施方案中，本文所述的主题涉及在一个实施方案中制备抗体组合物的方法，所述抗体组合物具有对α-V整合素受体具有特异性结合活性的Fab'脂质体组合物。该组合物旨在用于治疗特征在于表达任何含α-V的整联蛋白，例如avß3，avß5和avß6受体的细胞的病症。

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