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1. 发明申请

WO1998017227A1 MULTIPLE FLOW PATH DEVICE FOR ORAL DELIVERY OF DISCRETE UNITS 审中-公开
标题翻译：用于口头传送离散单位的多流道路装置
公开(公告)号：WO1998017227A1
公开(公告)日：1998-04-30
申请号：PCT/US1997018754
申请日：1997-10-14
申请人： ALZA CORPORATION
发明人： ALZA CORPORATION , ROTH, Nathan , WONG, Patrick, S.-L. , FERRARI, Vincent, J.
IPC分类号： A61J07/00
CPC分类号： A61J7/0038 , A47G21/183 , A61K9/0004
摘要： The present invention is directed to an oral active agent delivery system and method for delivering discrete units of an active agent to a patient. An elongate tubular member (10) having first and second ends (12, 14) comprises first (16) and second (26, 28, 30, 32) flow paths. Either of both of said flow paths contains an active agent (18). Liquid is drawn up into the first end of the member, and the liquid and active agent is drawn out of the second end of the member and into the patient's mouth.
摘要翻译：本发明涉及一种口服活性剂递送系统和方法，用于将活性剂的离散单元递送至患者。具有第一和第二端（12,14）的细长管状构件（10）包括第一（16）和第二（26,28,30,32）流动路径。两个所述流动路径中的任一个包含活性剂（18）。液体被吸入构件的第一端，液体和活性剂被从构件的第二端引出并进入患者的口中。

2. 发明申请

WO1996000065A1 TACRINE PHARMACEUTICAL COMPOSITIONS 审中-公开
标题翻译： TACRINE药物组合物
公开(公告)号：WO1996000065A1
公开(公告)日：1996-01-04
申请号：PCT/US1995007726
申请日：1995-06-14
申请人： ALZA CORPORATION
发明人： ALZA CORPORATION , GUITTARD, George, V. , CHILDERS, Jerry, D. , WONG, Patrick, S.-L. , GUMUCIO, Fernando, E. , KIDNEY, David, J.
IPC分类号： A61K31/47
CPC分类号： A61K31/00 , A61K9/0004 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K45/06 , A61K2300/00
摘要： A dosage form is disclosed for administering 10 ng to 1200 mg tacrine to a patient in need of tacrine therapy.
摘要翻译：公开了给需要他克林治疗的患者施用10ng至1200mg他克林的剂型。

3. 发明申请

WO1995003823A1 THERAPEUTIC COMPOSITIONS COMPRISING A POLYPEPTIDE 审中-公开
标题翻译：包含多肽的治疗组合物
公开(公告)号：WO1995003823A1
公开(公告)日：1995-02-09
申请号：PCT/US1994008560
申请日：1994-07-29
申请人： ALZA CORPORATION
发明人： ALZA CORPORATION , YANG, Heechung , NGUYEN, Vu, Anh , DONG, Liang, C. , WONG, Patrick, S.-L.
IPC分类号： A61K38/27
CPC分类号： A61K38/27 , A61K9/1617 , A61K38/28 , A61K47/12 , A61K47/44
摘要： The present invention is directed to a pharmaceutical formulation of a therapeutic polypeptide together with a permeation-enhancing mixture of sodium salicylate and an oil to provide enhanced absorption of the polypeptide through the wall of the gastrointestinal tract, and particularly of the colon, after oral administration, the amount of oil being from about 10 wt % to about 30 wt %, preferably from about 15 wt % to about 25 wt %, of the total formulation and the amount of sodium salicylate being from about 70 wt % to about 90 wt %, preferably from about 75 wt % to about 85 wt %, of the total formulation. The polypeptide may be non-lyophilized. The pharmaceutical formulation is characterized as a solid, which provides a convenient and improved format for handling and storage and for the preparation of oral dosage forms (such as pills, capsules and delivery vessels) containing a homogeneous mixture of ingredients.
摘要翻译：本发明涉及治疗性多肽的药物制剂以及水杨酸钠和油的渗透增强混合物，以在口服给药之后通过胃肠道的壁，特别是结肠壁增强吸收多肽，油的量为总制剂的约10重量％至约30重量％，优选约15重量％至约25重量％，水杨酸钠的量为约70重量％至约90重量％，优选约75重量％至约85重量％。多肽可以是非冻干的。药物制剂的特征在于固体，其提供用于处理和储存的方便和改进的形式，以及用于制备含有均匀成分混合物的口服剂型（例如丸剂，胶囊和递送容器）。

4. 发明申请

WO1992013521A1 OSMOTIC DEVICE FOR DELAYED DELIVERY OF AGENT 审中-公开
标题翻译：用于延迟交付代理的OSMOTIC设备
公开(公告)号：WO1992013521A1
公开(公告)日：1992-08-20
申请号：PCT/US1992000635
申请日：1992-01-27
申请人： ALZA CORPORATION
发明人： ALZA CORPORATION , WONG, Patrick, S.-L. , THEEUWES, Felix , LARSEN, Steven, D.
IPC分类号： A61K09/00
CPC分类号： A61K9/0004 , A61K9/4808
摘要： The present invention is directed to a fluid-imbibing dispensing device (1) for the initially delayed delivery of an active agent (20) to a fluid environment of use and to a method of using the dispensing device. The dispenser comprises a housing (12) having a first wall section (14) and a second wall section (16) in slidably telescoping arrangement with each other, which housing (12) maintains its integrity in the environment of use; an internal compartment (18) surrounded and defined by the housing (12); at least one active agent formulation (20) in the compartment; and an expansion means (22) and a partition layer (24) in the compartment for separating apart the first and second wall sections (14, 16) of the housing (12) after exposure to the environment of use to expose the active agent formulations (20) to the environment of use.
摘要翻译：本发明涉及一种流体吸入分配装置（1），用于将活性剂（20）最初延迟递送到使用的流体环境和使用分配装置的方法。分配器包括具有彼此可滑动地伸缩布置的第一壁部分（14）和第二壁部分（16）的壳体（12），该壳体（12）在使用环境中保持其完整性; 由所述壳体（12）包围和限定的内部隔室（18）; 所述隔室中的至少一种活性剂制剂（20）; 以及在隔室中的膨胀装置（22）和分隔层（24），用于在暴露于使用环境之后将壳体（12）的第一和第二壁部分（14,16）分开以暴露活性剂配方（20）使用环境。

5. 发明申请

WO1996008253A1 HYDROCODONE COMPOSITIONS 审中-公开
标题翻译：氢醌组合物
公开(公告)号：WO1996008253A1
公开(公告)日：1996-03-21
申请号：PCT/US1995011192
申请日：1995-09-01
申请人： ALZA CORPORATION
发明人： ALZA CORPORATION , CHILDERS, Jerry, D. , GUITTARD, George, V. , BARCLAY, Glen, E. , KUCZYNSKI, Anthony, L. , WONG, Patrick, S.-L.
IPC分类号： A61K31/485
CPC分类号： A61K9/2031 , A61K9/0004 , A61K9/2054 , A61K31/485
摘要： A hydrocodone composition, a hydrocodone dosage form, and a method of administering hydrocodone are disclosed and indicated for hydrocodone therapy.
摘要翻译：公开了氢可酮组合物，氢可酮剂型和给予氢可酮的方法，并表明用于氢可酮治疗。

6. 发明申请

WO1995006460A1 DISPENSER CONTAINING HYDROPHOBIC AGENT 审中-公开
标题翻译：含有疏水剂的分配器
公开(公告)号：WO1995006460A1
公开(公告)日：1995-03-09
申请号：PCT/US1994009709
申请日：1994-08-31
申请人： ALZA CORPORATION
发明人： ALZA CORPORATION , DONG, Liang, C. , ESPINAL, Steven, D. , WONG, Patrick, S.-L. , GUITTARD, George, V. , HAMEL, Lawrence, G.
IPC分类号： A61K09/00
CPC分类号： A61K9/0004 , A61K9/2013 , A61K9/2054
摘要： The present invention is directed to a formulation for the delivery of hydrophobic active agents to a fluid environment of use while avoiding aggregation of the hydrophobic agents in the environment, the formulation comprising a hydrophobic active agent in an amount of 50 wt% (percent by weight) or greater together with polyoxyethylene 40 stearate and a disintegrant. The present invention is also directed to an improvement in a fluid-activated delivery device (10) wherein the delivery device includes a housing (12) defining an internal compartment (14), an active agent formulation (15) in the compartment, exit means (13) in the housing (12) for delivering the active agent formulation (15) from the delivery device, a fluid-activated expandable driving member (16) in the compartment, optionally a partition layer between the active agent formulation (15) and the driving member (16), and optionally a lubricant subcoat (18); wherein the improvement comprises an active agent formulation (15) comprising a hydrophobic active agent in an amount of 50 wt% (percent by weight) or greater together with polyoxyethylene 40 stearate and a disintegrant.
摘要翻译：本发明涉及用于将疏水性活性剂递送至使用的流体环境的制剂，同时避免疏水剂在环境中的聚集，所述制剂包含50重量％（重量百分比）的疏水性活性剂）或更大，与聚氧乙烯40硬脂酸酯和崩解剂一起。本发明还涉及流体激活的输送装置（10）的改进，其中输送装置包括限定内部隔室（14）的壳体（12），隔室中的活性剂制剂（15），出口装置（13），用于从所述输送装置输送活性剂制剂（15），所述隔室中的流体活化的可膨胀驱动构件（16），任选地在所述活性剂制剂（15）和驱动构件（16）和任选的润滑剂底涂层（18）; 其中所述改进包括活性剂制剂（15），其包含50重量％（重量百分比）以上的疏水性活性剂以及聚氧乙烯40硬脂酸酯和崩解剂。

7. 发明申请

WO1994027587A2 SUSTAINED ANTIEPILEPTIC THERAPY 审中-公开
标题翻译：可持续的抗精神病药
公开(公告)号：WO1994027587A2
公开(公告)日：1994-12-08
申请号：PCT/US1994006083
申请日：1994-05-27
申请人： ALZA CORPORATION
发明人： ALZA CORPORATION , AYER, Atul, Devdatt , YIEH, Richard, L.-C. , POLLACK, Brenda, J. , WONG, Patrick, S.-L.
IPC分类号： A61K31/13
CPC分类号： A61K31/22 , A61K9/0004 , A61K9/1641 , A61K9/2031 , A61K9/2054 , A61K9/5047 , A61K31/16 , A61K31/19
摘要： This invention pertains to a dosage form for the management of epilepsis wherein the dosage form (10) comprises administering valproic acid or a valproic acid derivative at a continuous rate over an extended time.
摘要翻译：本发明涉及用于治疗癫痫症的剂型，其中剂型（10）包括在延长的时间内以连续速率施用丙戊酸或丙戊酸衍生物。

8. 发明申请

WO1993003711A1 DOSAGE FORM FOR DELIVERING DRUG IN SHORT-TIME PERIOD 审中-公开
标题翻译：在短时间内递送药物的剂型
公开(公告)号：WO1993003711A1
公开(公告)日：1993-03-04
申请号：PCT/US1992007034
申请日：1992-08-19
申请人： ALZA CORPORATION
发明人： ALZA CORPORATION , GUITTARD, George, V. , CARPENTER, Howard, A. , QUAN, Ernest, S. , WONG, Patrick, S.-L. , HAMEL, Lawrence, G.
IPC分类号： A61K09/20
CPC分类号： A61K9/0004
摘要： The invention pertains to a dosage form (10) for orally administering a drug (15) in eight hours or less to the stomach and small intestine for a therapeutic result. Dosage form (10) comprising wall (12) containing a high fluid-flux agent (18) that surrounds drug (15) for administering drug (15) in the given period of time.

9. 发明申请

WO1991015196A1 OSMOTIC DOSAGE SYSTEM FOR LIQUID DRUG DELIVERY 审中-公开
标题翻译：用于液体药物输送的OSMOTIC剂量系统
公开(公告)号：WO1991015196A1
公开(公告)日：1991-10-17
申请号：PCT/US1991002176
申请日：1991-03-28
申请人： ALZA CORPORATION
发明人： ALZA CORPORATION , WONG, Patrick, S.-L. , THEEUWES, Felix , BARCLAY, Brian, L. , DEALEY, Michael, Howard
IPC分类号： A61K09/22
CPC分类号： A61K9/0004
摘要： An osmotic system (10) is disclosed for delivering a beneficial agent formulation (16) to an environment of use. The osmotic system (10) comprises (a) an outside semipermeable wall (12), (b) a middle osmotically active layer (13), (c) a capsule (14) comprising a liquid formulation comprising a beneficial agent (16), and (d) a passageway (21) for dispensing the beneficial agent (16) from the osmotic system (10).
摘要翻译：渗透系统（10）被公开用于将有益剂制剂（16）递送到使用环境。渗透系统（10）包括（a）外部半渗透壁（12），（b）中间渗透活性层（13），（c）包含含有有益剂（16）的液体制剂的胶囊（14）和（d）用于从渗透系统（10）分配有益剂（16）的通道（21）。

10. 发明申请

WO1995019174A1 PENTOXIFYLLINE DOSAGE FORM 审中-公开
标题翻译： PENTOXIFYLLINE剂型
公开(公告)号：WO1995019174A1
公开(公告)日：1995-07-20
申请号：PCT/US1995000200
申请日：1995-01-04
申请人： ALZA CORPORATION
发明人： ALZA CORPORATION , WONG, Patrick, S.-L. , GUITTARD, George, V. , AYER, Atul, Devdatt
IPC分类号： A61K31/52
CPC分类号： A61K9/2031 , A61K9/0004 , A61K9/2054 , A61K31/52
摘要： A dosage form (10) is disclosed for delivering pentoxifylline to a patient in need of pentoxifylline therapy. A method is discussed for delivering pentoxifylline to a patient at a dosage form controlled rate over an extended period of time.
摘要翻译：公开了用于将己酮可可碱递送至需要己酮可可碱治疗的患者的剂型（10）。讨论了一种在长时间内以剂型形式控制的速率将己酮可可碱递送给患者的方法。

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