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1. 发明申请

WO2008147817A2 COATED HYALURONIC ACID PARTICLES 审中-公开
标题翻译：涂覆的羟丙酸颗粒
公开(公告)号：WO2008147817A2
公开(公告)日：2008-12-04
申请号：PCT/US2008/064378
申请日：2008-05-21
申请人： ALLERGAN, INC. , CHAMPION, Julie, A. , MITRAGOTRI, Samir , TEZEL, Ahmet
发明人： CHAMPION, Julie, A. , MITRAGOTRI, Samir , TEZEL, Ahmet
IPC分类号： A61L27/20 , A61L27/58 , A61K9/16 , A61K31/728
CPC分类号： A61L27/20 , A61K9/0019 , A61K9/5031 , A61K9/5036 , A61K9/5052 , A61K31/728 , A61L27/58 , A61L2430/34
摘要： The present invention generally relates to particles comprising hyaluronic acid, wherein the particles are coated or encapsulated with a coating. The coating preferably comprises a polymer, protein, polysaccharide, or combination thereof that decreases the rate of degradation of the hyaluronic acid once the particles are placed in an aqueous environment, such as inside mammalian skin. The compositions of the present invention comprising such coated hyaluronic acid are useful for soft tissue augmentation, and are particularly useful as dermal fillers.
摘要翻译：本发明一般涉及包含透明质酸的颗粒，其中颗粒被涂层包被或包封。涂层优选包含聚合物，蛋白质，多糖或其组合，其一旦将颗粒置于水性环境（例如哺乳动物皮肤内）中，则降低透明质酸的降解速率。包含这种涂覆的透明质酸的本发明的组合物可用于软组织增加，并且特别可用作皮肤填充剂。

2. 发明申请

WO2008031035A2 ENGINEERING SHAPE OF POLYMERIC MICRO-AND NANOPARTICLES 审中-公开
标题翻译：聚合微波和纳米粒子的工程形态
公开(公告)号：WO2008031035A2
公开(公告)日：2008-03-13
申请号：PCT/US2007/077889
申请日：2007-09-07
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , MITRAGOTRI, Samir , CHAMPION, Julie, A. , KATARE, Yogesh, K.
发明人： MITRAGOTRI, Samir , CHAMPION, Julie, A. , KATARE, Yogesh, K.
IPC分类号： A61K9/16 , A61K9/51 , A61K9/00
CPC分类号： A61K9/1694 , A61K9/0097 , A61K9/5192
摘要： Compositions containing polymeric micro- and nanopartioles with non- spherical shapes and methods for making and using such particles are described herein. The particles have one or more dimensions ranging from about 5 nm to about 100 μm, preferably about 100 nm to 10 μm. The particles can have any of a wide variety of non-spherical shapes. The particles are generally formed by manipulation of spherical particles embedded in a polymeric film. A wide variety of resulting shapes can be made, The resulting shape is a function of whether the films are manipulated in a first and/or second dimension, and the processes used to liquefy the microparticles. Variations of the method of manufacture may be used to generate particles having the desired shapes in large, reproducible quantities. The resulting non-spherical shaped particles can be used to alter uptake by phagocytic cells and thereby clearance by the reticuloendothelial system.
摘要翻译：包含具有非球形形状的聚合物微米和纳米液的组合物以及用于制备和使用这些颗粒的方法在本文中描述。颗粒具有约5nm至约100μm，优选约100nm至10μm的一个或多个维度。颗粒可以具有各种各样的非球形形状。颗粒通常通过操纵嵌入聚合物膜中的球形颗粒来形成。可以形成多种所得到的形状。所得到的形状是膜是否在第一和/或第二维度中被操纵的功能，以及用于液化微粒的过程的功能。可以使用制造方法的变化来以大的，可重复的量产生具有所需形状的颗粒。所得的非球形颗粒可用于改变吞噬细胞的摄取，从而改变网状内皮系统的清除。

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