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1. 发明申请

WO2008063670A1 HETEROBICYCLIC MATRIX METALLOPROTEASE INHIBITORS 审中-公开
标题翻译：异源基质金属蛋白酶抑制剂
公开(公告)号：WO2008063670A1
公开(公告)日：2008-05-29
申请号：PCT/US2007/024365
申请日：2007-11-20
申请人： ALANTOS PHARMACEUTICALS HOLDING, INC. , HOCHGÜRTEL, Matthias , BLUHM, Harald , ESSERS, Michael , KROTH, Heiko , GEGE, Christian , TAVERAS, Arthur
发明人： HOCHGÜRTEL, Matthias , BLUHM, Harald , ESSERS, Michael , KROTH, Heiko , GEGE, Christian , TAVERAS, Arthur
IPC分类号： C07D487/04 , C07D495/04 , A61K31/495 , A61K31/53 , A61P35/00 , A61P29/00
CPC分类号： C07D487/04 , C07D519/00
摘要： The present invention provides a new class of heterobicyclic MMP-3 and/or MMP-13 inhibiting compounds, of Formula (I) that exhibit an increased potency and selectivity in relation to currently known MMP-13 and MMP-3 inhibitors. The heterobicyclic metalloprolease inhibiting compounds of the present invention may be used in the treatment of metalloprotease mediated diseases, such as rheumatoid arthritis, osteoarthritis, abdominal aortic aneurysm, cancer, inflammation, atherosclerosis, multiple sclerosis, chronic obstructive pulmonary disease, ocular diseases, neurological diseases, psychiatric diseases, thrombosis, bacterial infection, Parkinson's disease, fatigue, tremor, diabetic retinopathy, vascular diseases of the retina, aging, dementia, cardiomyopathy, renal tubular impairment, diabetes, psychosis, dyskinesia, pigmentary abnormalities, deafness, inflammatory and fibrotic syndromes, intestinal bowel syndrome, allergies, Alzheimer's disease, arterial plaque formation, periodontal, viral infection, stroke, cardiovascular disease, reperfusion injury, trauma, chemical exposure or oxidative damage to tissues, wound healing, hemorroid, skin beautifying, pain, inflammatory pain, bone pain and joint pain.
摘要翻译：本发明提供了与目前已知的MMP-13和MMP-3抑制剂相比显示增加的效力和选择性的新一类式（I）的杂双环MMP-3和/或MMP-13抑制化合物。本发明的杂双环金属蛋白酶抑制化合物可用于治疗金属蛋白酶介导的疾病，例如类风湿性关节炎，骨关节炎，腹主动脉瘤，癌症，炎症，动脉粥样硬化，多发性硬化，慢性阻塞性肺病，眼病，神经系统疾病精神疾病，血栓形成，细菌感染，帕金森病，疲劳，震颤，糖尿病性视网膜病变，视网膜血管疾病，衰老，痴呆，心肌病，肾小管损伤，糖尿病，精神病，运动障碍，色素异常，耳聋，炎性和纤维化综合征肠道综合征，过敏症，阿尔茨海默病，动脉斑块形成，牙周病，病毒感染，中风，心血管疾病，再灌注损伤，创伤，化学暴露或对组织的氧化损伤，伤口愈合，血红细胞，皮肤美化，疼痛，炎性疼痛，骨痛和关节疼痛。

2. 发明申请

WO2008063669A1 HETEROBICYCLIC MATRIX METALLOPROTEASE INHIBITORS 审中-公开
标题翻译：异源基质金属蛋白酶抑制剂
公开(公告)号：WO2008063669A1
公开(公告)日：2008-05-29
申请号：PCT/US2007/024364
申请日：2007-11-20
申请人： ALANTOS PHARMACEUTICALS HOLDING, INC. , BLUHM, Harald , HOCHGÜRTEL, Matthias , KROTH, Heiko , ESSERS, Michael , GEGE, Christian , RICHTER, Frank , TAVERAS, Arthur
发明人： BLUHM, Harald , HOCHGÜRTEL, Matthias , KROTH, Heiko , ESSERS, Michael , GEGE, Christian , RICHTER, Frank , TAVERAS, Arthur
IPC分类号： C07D487/04 , C07D495/04 , A61K31/495 , A61K31/53 , A61P35/00 , A61P29/00
CPC分类号： C07D487/04 , C07D519/00
摘要： The present invention relates generally to amide containing heterobicyclic containing pharmaceutical agents, and in particular, to amide containing heterobicyclic metalloprotease inhibiting compounds. More particularly, the present invention provides a new class of heterobicyclic MMP-3 and/or MMP-13 inhibiting compounds, that exhibit an increased potency and selectivity in relation to currently known MMP-13 and MMP-3 inhibitors.
摘要翻译：本发明一般涉及含酰胺的含杂双环的药剂，特别涉及含酰胺的杂双环金属蛋白酶抑制化合物。更具体地说，本发明提供了一类新型的杂双环MMP-3和/或MMP-13抑制化合物，与目前已知的MMP-13和MMP-3抑制剂相比，其表现出增加的效力和选择性。

3. 发明申请

WO2008063667A1 HETEROTRICYCLIC METALLOPROTEASE INHIBITORS 审中-公开
标题翻译：异源金属蛋白酶抑制剂
公开(公告)号：WO2008063667A1
公开(公告)日：2008-05-29
申请号：PCT/US2007/024362
申请日：2007-11-20
申请人： ALANTOS PHARMACEUTICALS HOLDING, INC. , GEGE, Christian , CHEVRIER, Carine , SCHNEIDER, Matthias , BLUHM, Harald , HOCHGÜRTEL, Matthias , DENG, Hongbo , GALLAGHER, Brian M. , SUCHOLEIKI, Irving , TAVERAS, Arthur
发明人： GEGE, Christian , CHEVRIER, Carine , SCHNEIDER, Matthias , BLUHM, Harald , HOCHGÜRTEL, Matthias , DENG, Hongbo , GALLAGHER, Brian M. , SUCHOLEIKI, Irving , TAVERAS, Arthur
IPC分类号： C07D413/12 , C07D491/04 , C07D495/04 , C07D495/14 , C07D495/22 , A61K31/519 , A61P29/00
CPC分类号： C07D495/04 , C07D239/88 , C07D401/12 , C07D413/12 , C07D471/04 , C07D487/04 , C07D491/04 , C07D495/14 , C07D495/22 , C07D498/04 , C07D513/04
摘要： The present invention relates generally to azatricyclic containing pharmaceutical agents, and in particular, to azatricyclic metalloprotease inhibiting compounds. More particularly, the present invention provides a new class of azatricyclic MMP-3, MMP-8 and/or MMP-13 inhibiting compounds, that exhibit an increased potency and selectivity in relation to currently known MMP-13, MMP-8 and MMP-3 inhibitors.
摘要翻译：本发明一般涉及含氮杂环类药物，尤其涉及氮杂三环金属蛋白酶抑制化合物。更具体地说，本发明提供了一类新型的azatricyclic MMP-3，MMP-8和/或MMP-13抑制化合物，其与当前已知的MMP-13，MMP-8和MMP- 3抑制剂。

4. 发明申请

WO2008109179A1 METALLOPROTEASE INHIBITORS CONTAINING A SQUARAMIDE MOIETY 审中-公开
标题翻译：含有SQUARAMIDE MOIETY的金属蛋白酶抑制剂
公开(公告)号：WO2008109179A1
公开(公告)日：2008-09-12
申请号：PCT/US2008/003194
申请日：2008-03-07
申请人： ALANTOS PHARMACEUTICALS HOLDING, INC.
发明人： BLUHM, Harald , GEGE, Christian , HOCHGÜRTEL, Matthias , TAVERAS, Arthur
IPC分类号： C07D217/04 , C07D401/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/02 , C07D495/02 , C07D498/02 , A61P19/00 , A61K31/4709
CPC分类号： C07D498/02 , C07D487/02 , C07D519/00
摘要： The present invention relates generally to pharmaceutical agents of Formula (I) containing a heterocyclic moiety, and in particular, to heterocyclic metalloprotease inhibiting compounds. More particularly, the present invention provides a new class of heterocyclic MMP- 13 inhibiting compounds with a squaramide moiety, that exhibit an increased potency and selectivity in relation to currently known MMP- 13 inhibitors.
摘要翻译：本发明一般涉及含有杂环部分的式（I）的药物，特别涉及杂环金属蛋白酶抑制化合物。更具体地说，本发明提供了一类具有方标酰胺部分的杂环基MMP-13抑制化合物，其相对于目前已知的MMP-13抑制剂表现出增加的效力和选择性。

5. 发明申请

WO2008109180A2 METALLOPROTEASE INHIBITORS CONTAINING A HETEROCYCLIC MOIETY 审中-公开
标题翻译：含有杂环化合物的金属蛋白酶抑制剂
公开(公告)号：WO2008109180A2
公开(公告)日：2008-09-12
申请号：PCT/US2008/003195
申请日：2008-03-07
申请人： ALANTOS PHARMACEUTICALS HOLDING, INC.
发明人： GEGE, Christian , BLUHM, Harald , HOCHGÜRTEL, Matthias , SCHNEIDER, Matthias , CHEVRIER, Carine , TAVERAS, Arthur
CPC分类号： C07D498/02 , C07D487/02 , C07D519/00
摘要： The present invention relates generally to pharmaceutical agents containing a heterocyclic moiety, and in particular, to heterocyclic metalloprotease inhibiting compounds. More particularly, the present invention provides a new class of heterocyclic MMP-13 inhibiting compounds with a benzoxazinone moiety, that exhibit an increased potency and selectivity in relation to currently known MMP-13 inhibitors.
摘要翻译：本发明一般涉及含有杂环部分的药剂，尤其涉及杂环金属蛋白酶抑制化合物。更具体地说，本发明提供了一类新的具有苯并恶嗪酮部分的杂环基MMP-13抑制化合物，其相对于目前已知的MMP-13抑制剂表现出增加的效力和选择性。

6. 发明申请

WO2008063668A1 HETEROBICYCLIC METALLOPROTEASE INHIBITORS 审中-公开
标题翻译：异源环氧化酶抑制剂
公开(公告)号：WO2008063668A1
公开(公告)日：2008-05-29
申请号：PCT/US2007/024363
申请日：2007-11-20
申请人： ALANTOS PHARMACEUTICALS HOLDING, INC. , GEGE, Christian , SCHNEIDER, Matthias , CHEVRIER, Carine , DENG, Hongbo , SUCHOLEIKI, Irving , GALLAGHER, JR., Brian M. , BOSIES, Michael , STEENECK, Christoph , WU, Xinyuan , HOCHGÜRTEL, Matthias , NOLTE, Bert , TAVERAS, Arthur
发明人： GEGE, Christian , SCHNEIDER, Matthias , CHEVRIER, Carine , DENG, Hongbo , SUCHOLEIKI, Irving , GALLAGHER, JR., Brian M. , BOSIES, Michael , STEENECK, Christoph , WU, Xinyuan , HOCHGÜRTEL, Matthias , NOLTE, Bert , TAVERAS, Arthur
IPC分类号： C07D239/88 , C07D401/12 , C07D471/04 , C07D487/04 , C07D498/04 , C07D513/04 , A61K31/519 , A61P29/00
CPC分类号： C07D495/04 , C07D239/88 , C07D401/12 , C07D413/12 , C07D471/04 , C07D487/04 , C07D491/04 , C07D495/14 , C07D495/22 , C07D498/04 , C07D513/04
摘要： The present invention relates generally to azabicyclic containing pharmaceutical agents, and in particular, to azabicyclic metalloprotease inhibiting compounds. More particularly, the present invention provides a new class of azabicyclic MMP-3, MMP-8 and/or MMP-13 inhibiting compounds, which exhibit an increased potency and selectivity in relation to currently known MMP-13, MMP-8 and MMP-3 inhibitors.
摘要翻译：本发明一般涉及含有氮杂双环的药物，特别涉及氮杂双环金属蛋白酶抑制化合物。更具体地说，本发明提供了一类新的氮杂双环MMP-3，MMP-8和/或MMP-13抑制化合物，其相对于目前已知的MMP-13，MMP-8和MMP- 3抑制剂。

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