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1. 发明申请

WO2003085125A1 USE OF BIOMOLECULAR TARGETS IN THE TREATMENT AND VISUALIZATION OF BRAIN TUMORS 审中-公开
标题翻译：生物分子靶向在脑肿瘤治疗和可视化中的应用
公开(公告)号：WO2003085125A1
公开(公告)日：2003-10-16
申请号：PCT/US2003/010407
申请日：2003-04-03
申请人： AGY THERAPEUTICS, INC. , NAGAVARAPU, Usha , SHIVAK, David, A. , CHIN, Daniel , GONZALEZ-ZULUETA, Mirella , FOEHR, Erik
发明人： NAGAVARAPU, Usha , SHIVAK, David, A. , CHIN, Daniel , GONZALEZ-ZULUETA, Mirella , FOEHR, Erik
IPC分类号： C12Q1/00
CPC分类号： G01N33/566 , G01N33/57407 , G01N2333/912
摘要： The present invention relates to the use of proteins that are differentially expressed in primary brain tumor tissues, as compared to normal brain tissues, as biomolecular targets for brain tumor treatment therapies. Specifically, the present invention relates to the use of therapeutic and imaging agents, which specifically bind to one or more of the identified brain tumor protein targets. The present invention also provides compounds and pharmaceutically acceptable compositions for administration in the methods of the invention. Nucleic acid probes specific for the spliced mRNA encoding these variants and affinity reagents specific for the novel proteins are also provided.
摘要翻译：本发明涉及与正常脑组织相比，在原发性脑肿瘤组织中差异表达的蛋白质作为脑肿瘤治疗疗法的生物分子靶标的用途。具体地，本发明涉及特异性结合一种或多种所鉴定的脑肿瘤蛋白靶标的治疗和显像剂的用途。本发明还提供了用于本发明方法中给药的化合物和药学上可接受的组合物。还提供了针对编码这些变体的剪接mRNA特异性的核酸探针和对新蛋白特异的亲和试剂。

2. 发明申请

WO2003057148A2 USE OF BIOMOLECULAR TARGETS IN THE TREATMENT AND VISUALIZATION OF TUMORS 审中-公开
标题翻译：生物分子靶在肿瘤治疗和可视化中的应用
公开(公告)号：WO2003057148A2
公开(公告)日：2003-07-17
申请号：PCT/US2002/041419
申请日：2002-12-23
申请人： AGY THERAPEUTICS, INC. , GONZALEZ-ZULUETA, Mirella , MUELLER, Sabine , FOEHR, Erik , CHIN, Daniel
发明人： GONZALEZ-ZULUETA, Mirella , MUELLER, Sabine , FOEHR, Erik , CHIN, Daniel
IPC分类号： A61K
CPC分类号： A61K49/0004 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/574
摘要： The present invention relates to the use of a protein that is differentially expressed in primary brain tumor tissues, as compared to normal brain tissues, as a biomolecular target for tumor treatment therapies. The protein is also expressed in tissues from adenocarcinoma, non-melanoma, and renal carcinoma cells. Immunotherapeutic and immunoimaging agents that specifically bind to an identified brain tumor target protein are provided. The present invention also provides compounds and pharmaceutically acceptable compositions for administration in the methods of the invention.
摘要翻译：本发明涉及与正常脑组织相比，在原发性脑肿瘤组织中差异表达的蛋白质作为肿瘤治疗疗法的生物分子靶标的用途。该蛋白质也在来自腺癌，非黑素瘤和肾癌细胞的组织中表达。提供特异性结合鉴定的脑肿瘤靶蛋白的免疫治疗和免疫成像剂。本发明还提供了用于本发明方法中给药的化合物和药学上可接受的组合物。

3. 发明申请

WO2003057148A3 USE OF BIOMOLECULAR TARGETS IN THE TREATMENT AND VISUALIZATION OF TUMORS 审中-公开
公开(公告)号：WO2003057148A3
公开(公告)日：2003-07-17
申请号：PCT/US2002/041419
申请日：2002-12-23
申请人： AGY THERAPEUTICS, INC. , GONZALEZ-ZULUETA, Mirella , MUELLER, Sabine , FOEHR, Erik , CHIN, Daniel
发明人： GONZALEZ-ZULUETA, Mirella , MUELLER, Sabine , FOEHR, Erik , CHIN, Daniel
IPC分类号： C12N15/12
摘要： The present invention relates to the use of a protein that is differentially expressed in primary brain tumor tissues, as compared to normal brain tissues, as a biomolecular target for tumor treatment therapies. The protein is also expressed in tissues from adenocarcinoma, non-melanoma, and renal carcinoma cells. Immunotherapeutic and immunoimaging agents that specifically bind to an identified brain tumor target protein are provided. The present invention also provides compounds and pharmaceutically acceptable compositions for administration in the methods of the invention.

4. 发明申请

WO2015131818A8 PROCESS AND PLANT FOR PERFORMING CO SHIFT 审中-公开
公开(公告)号：WO2015131818A8
公开(公告)日：2015-09-11
申请号：PCT/CN2015/073621
申请日：2015-03-04
申请人： L'AIR LIQUIDE, SOCIETE ANONYME POUR L'ETUDE ET L'EXPLOITATION DES PROCEDES GEORGES CLAUDE , CHIN, Daniel
发明人： CHIN, Daniel
IPC分类号： C10J3/46 , C01B3/38
摘要： A process and a plant for converting a carbon monoxide containing crude synthesis gas stream, generated in a multi-stage reformer and/or gasifier plant, by CO shift into a treated syngas stream depleted with regard to carbon monoxide, but enriched with regard to hydrogen and carbon dioxide. To this end, the crude synthesis gas stream is routed to a CO shift reaction section, comprising at least a first shift reactor and possibly also comprising further downstream shift reactors, wherein the first shift reactor comprises at least two subreactors(7a, 7b) which are operated in parallel, wherein the at least two subreactors(7a, 7b) contain different volumes of the shift catalyst.

5. 发明申请

WO2013003520A1 COMPOSITIONS AND METHODS FOR INHIBITING GENE EXPRESSION OF HEPATITIS B VIRUS 审中-公开
标题翻译：用于抑制乙型肝炎病毒基因表达的组合物和方法
公开(公告)号：WO2013003520A1
公开(公告)日：2013-01-03
申请号：PCT/US2012/044505
申请日：2012-06-28
申请人： ARROWHEAD RESEARCH CORPORATION , CHIN, Daniel , DECKERT, Jochen , ROSSBACH, Markus , JOHN, Matthias
发明人： CHIN, Daniel , DECKERT, Jochen , ROSSBACH, Markus , JOHN, Matthias
IPC分类号： C12N15/113
CPC分类号： A61K31/713 , C12N15/1131 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/335 , C12N2310/3521 , A61K2300/00
摘要： The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a Hepatitis B Virus gene. The invention also relates to a pharmaceutical composition comprising the dsRNA or nucleic acid molecules or vectors encoding the same together with a pharmaceutically acceptable carrier; methods for treating diseases caused by Hepatitis B Virus infection using said pharmaceutical composition: and methods for inhibiting the expression of a Hepatitis B Virus gene in a cell.
摘要翻译：本发明涉及用于抑制乙型肝炎病毒基因表达的双链核糖核酸（dsRNA）。本发明还涉及包含dsRNA或核酸分子的药物组合物或其编码与其药学上可接受的载体的载体; 使用所述药物组合物治疗由乙型肝炎病毒感染引起的疾病的方法以及抑制细胞中乙型肝炎病毒基因表达的方法。

6. 发明申请

WO2008008293A2 METHOD AND DEVICE FOR ENHANCING IMAGES IN DISPLAY DEVICES 审中-公开
标题翻译：用于增强显示装置中的图像的方法和装置
公开(公告)号：WO2008008293A2
公开(公告)日：2008-01-17
申请号：PCT/US2007/015630
申请日：2007-07-09
申请人： WELLS-GARDNER ELECTRONICS CORPORATION , CHIN, Daniel
发明人： CHIN, Daniel
IPC分类号： G06K9/00 , G06K9/40
CPC分类号： G09G5/028 , G09G5/06
摘要： An image enhancement system includes a data source providing image data of an object, an enhancement data storage including image enhancement information, an image enhancement unit configured to enhance the image data based on the image enhancement information, and a color display configured to display a monochrome image representing the enhanced image data on a screen thereof. The enhanced image data may include a gray level scale of at least 32 bits per pixel.
摘要翻译：图像增强系统包括提供对象的图像数据的数据源，包括图像增强信息的增强数据存储器，被配置为基于图像增强信息来增强图像数据的图像增强单元和被配置为显示单色在其屏幕上表示增强图像数据的图像。增强图像数据可以包括每像素至少32位的灰度级。

7. 发明申请

WO2015131818A9 PROCESS AND PLANT FOR PERFORMING CO SHIFT 审中-公开
公开(公告)号：WO2015131818A9
公开(公告)日：2015-09-11
申请号：PCT/CN2015/073621
申请日：2015-03-04
申请人： L'AIR LIQUIDE, SOCIETE ANONYME POUR L'ETUDE ET L'EXPLOITATION DES PROCEDES GEORGES CLAUDE , CHIN, Daniel
发明人： CHIN, Daniel
IPC分类号： C10J3/46 , C01B3/38
摘要： A process and a plant for converting a carbon monoxide containing crude synthesis gas stream, generated in a multi-stage reformer and/or gasifier plant, by CO shift into a treated syngas stream depleted with regard to carbon monoxide, but enriched with regard to hydrogen and carbon dioxide. To this end, the crude synthesis gas stream is routed to a CO shift reaction section, comprising at least a first shift reactor and possibly also comprising further downstream shift reactors, wherein the first shift reactor comprises at least two subreactors (7a, 7b) which are operated in parallel, wherein the at least two subreactors (7a, 7b) contain different volumes of the shift catalyst.

8. 发明申请

WO2015131818A1 PAINT FORMULATION AND PROCESS OF MAKING THEREOF 审中-公开
标题翻译：涂料制剂及其制备方法
公开(公告)号：WO2015131818A1
公开(公告)日：2015-09-11
申请号：PCT/CN2015/073621
申请日：2015-03-04
申请人： L'AIR LIQUIDE, SOCIETE ANONYME POUR L'ETUDE ET L'EXPLOITATION DES PROCEDES GEORGES CLAUDE , CHIN, Daniel
发明人： CHIN, Daniel
IPC分类号： C10J3/46 , C01B3/38
CPC分类号： C10K3/04 , C01B3/16 , C01B3/48 , C01B2203/0205 , C01B2203/0288 , C01B2203/0294 , C01B2203/169 , C10J2300/093
摘要： A process and a plant for converting a carbon monoxide containing crude synthesis gas stream, generated in a multi-stage reformer and/or gasifier plant, by CO shift into a treated syngas stream depleted with regard to carbon monoxide, but enriched with regard to hydrogen and carbon dioxide. To this end, the crude synthesis gas stream is routed to a CO shift reaction section, comprising at least a first shift reactor and possibly also comprising further downstream shift reactors, wherein the first shift reactor comprises at least two subreactors(7a, 7b) which are operated in parallel, wherein the at least two subreactors(7a, 7b) contain different volumes of the shift catalyst.
摘要翻译：一种用于将通过CO转化成在多级重整器和/或气化器装置中产生的含一氧化碳的粗合成气流的方法和装置，其转化为经一氧化碳消耗的经处理的合成气流，但富含氢和二氧化碳。为此，粗合成气流被引导至CO转移反应段，其包括至少第一变换反应器，并且可能还包括另外的下游变换反应器，其中第一变换反应器包括至少两个子反应器（7a，7b），其中其中所述至少两个子反应器（7a，7b）包含不同体积的变换催化剂。

9. 发明申请

WO2008008312A2 UNIFORM IMAGE DISPLAY FOR MULTIPLE DISPLAY DEVICES 审中-公开
标题翻译：用于多个显示设备的均匀图像显示
公开(公告)号：WO2008008312A2
公开(公告)日：2008-01-17
申请号：PCT/US2007/015687
申请日：2007-07-10
申请人： WELLS-GARDNER ELECTRONICS CORPORATION , CHIN, Daniel , LUBE, Robert, R.
发明人： CHIN, Daniel , LUBE, Robert, R.
IPC分类号： G06K9/00 , G06K9/40
CPC分类号： G06F3/1438 , G06F3/1446 , G09G2320/0233 , G09G2320/0606 , G09G2320/0626
摘要： Methods and systems for equalizing visual characteristics of images displayed on display units arranged proximate each other. The method may includes generating first and second video signals for first and second display units, respectively, displaying images on the first and second display units based on the first and second video signals, respectively, deriving first and second display correction information for the first and second display units, respectively, deriving image equalization information for the second display unit based on the first and second display correction information, respectively, adjusting the first video signal based on the first display correction information, adjusting the second video signal based on the image equalization information, and displaying images on the first and second images based on the adjusted first and second video signals.
摘要翻译：用于均衡显示在彼此靠近布置的显示单元上的图像的视觉特征的方法和系统。该方法可以包括分别为第一和第二显示单元产生第一和第二视频信号，分别基于第一和第二视频信号在第一和第二显示单元上显示图像，导出第一和第二显示校正信息，第二显示单元，分别基于第一和第二显示校正信息导出第二显示单元的图像均衡信息，基于第一显示校正信息调整第一视频信号，基于图像均衡来调整第二视频信号信息，并且基于经调整的第一和第二视频信号在第一和第二图像上显示图像。

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