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1. 发明申请

WO2009154566A1 PRODUCTION OF HYDROXYMETHYLFURFURAL 审中-公开
标题翻译：生产羟基甲基纤维素
公开(公告)号：WO2009154566A1
公开(公告)日：2009-12-23
申请号：PCT/SG2008/000215
申请日：2008-06-18
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , ZHANG, Yugen , YING, Jackie Y , YONG, Gen
发明人： ZHANG, Yugen , YING, Jackie Y , YONG, Gen
IPC分类号： C07D307/48 , C07B35/08 , C07B35/04 , C07D307/50
CPC分类号： C07D307/50 , B01J31/2269 , B01J31/2273 , B01J2231/70 , B01J2531/62 , C10G2300/1011 , C10G2300/1014 , C10G2300/44 , Y02P20/582 , Y02P30/20
摘要： The invention provides a process for making hydroxymethylfurfural comprising exposing a saccharide, e.g. glucose or fructose, to a metal complex of an N-heterocyclic carbene.
摘要翻译：本发明提供了一种制备羟甲基糠醛的方法，包括将糖，例如葡萄糖或果糖，涉及N-杂环卡宾的金属络合物。

2. 发明申请

WO2017184085A1 CORE-SHELL PARTICLES 审中-公开
标题翻译：核壳颗粒
公开(公告)号：WO2017184085A1
公开(公告)日：2017-10-26
申请号：PCT/SG2017/050226
申请日：2017-04-21
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
发明人： YONG, Gen , LIU, Ye
IPC分类号： A61K9/51 , A61K9/54
CPC分类号： A61K9/5115
摘要： There is provided a core-shell particle comprising a core comprising at least one active agent and a method of forming said core-shell particle, wherein said core having ions of an additive surrounding a surface of said core; and an encapsulating shell comprising (i) a polymer and/or (ii) a metal or a semi-metal oxide, phosphate or carbonate. In a preferred embodiment, chondroitin sulphate nanocrystals is first prepared by using pH recrystallization method. Sodium citrate is then added to form citrate ions-capped chondroitin sulphate particles. Poly L-lysine (PLL) and tetramethoxysilane (TMOS) are subsequently added to form a silica shell surrounding the citrate-ions capped chondroitin sulphate particles, and thus forming the claimed core-shell particle. The particles may be used as sustained release formulations in therapy.
摘要翻译：提供了包含含有至少一种活性剂的核的核 - 壳颗粒和形成所述核 - 壳颗粒的方法，其中所述核具有围绕所述核的表面的添加剂的离子 ; 和包含（i）聚合物和/或（ii）金属或半金属氧化物，磷酸盐或碳酸盐的包封壳。在一个优选的实施方案中，首先通过使用pH重结晶方法制备硫酸软骨素纳米晶体。然后加入柠檬酸钠以形成柠檬酸根离子封端的硫酸软骨素颗粒。随后加入聚L-赖氨酸（PLL）和四甲氧基硅烷（TMOS）以形成围绕柠檬酸盐离子封端的硫酸软骨素颗粒的二氧化硅壳，并因此形成要求保护的核 - 壳颗粒。这些颗粒可以在治疗中用作缓释制剂。

3. 发明申请

WO2017127021A1 HEXAGONAL SILICA PLATELETS AND METHODS OF SYNTHESIS THEREOF 审中-公开
标题翻译：六方晶系二氧化硅薄片及其合成方法
公开(公告)号：WO2017127021A1
公开(公告)日：2017-07-27
申请号：PCT/SG2017/050025
申请日：2017-01-18
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
发明人： YONG, Gen , XU, Weiyin , LIU, Connie Kin Man
IPC分类号： C01B33/12 , C01B33/18 , B82Y30/00 , C07F7/02 , C08K3/36 , A61K8/25
CPC分类号： A61K8/25 , A61Q17/04 , B82Y30/00 , C01B33/18 , C01P2004/52 , C01P2006/12 , C01P2006/22 , C01P2006/64 , C08K3/36
摘要： The present invention relates to a method for forming silica nanoparticles in an aqueous medium, the method comprising steps of providing a surfactant solution comprising a cationic surfactant in an aqueous medium; and mixing a silane source with the surfactant solution under pH conditions of about pH 5 to 8 for forming said silica nanoparticles. The present invention also relates to silica suspension comprising a plurality of hexagonally shaped silica platelets, said platelets being substantially monodisperse and having a width dimension from around 50 to 1000 nm, said platelets being suspended in an aqueous medium, wherein said aqueous medium comprises a single type of cationic surfactant. Furthermore, the invention relates to a silica nanoparticle prepared by reacting a silane source with a volumetric excess of a surfactant under pH of about 5 to about 8 in the presence of an aqueous solvent. Also, the present invention relates to a silica platelet obtainable by a method as disclosed herein.
摘要翻译：本发明涉及一种在水性介质中形成二氧化硅纳米粒子的方法，所述方法包括以下步骤：在水性介质中提供包含阳离子表面活性剂的表面活性剂溶液; 以及在约pH5至8的pH条件下将硅烷源与表面活性剂溶液混合以形成所述二氧化硅纳米粒子。本发明还涉及包含多个六角形二氧化硅小片的二氧化硅悬浮液，所述小片基本上是单分散的并且具有约50-1000nm的宽度尺寸，所述小片悬浮在含水介质中，其中所述含水介质包含单一阳离子表面活性剂类型此外，本发明涉及通过在水性溶剂存在下在约5至约8的pH下使硅烷源与体积过量的表面活性剂反应制备的二氧化硅纳米粒子。而且，本发明涉及可通过本文公开的方法获得的二氧化硅小片。

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