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1. 发明申请

WO2016140626A1 COMPOSITE MATERIAL FOR DRUG DELIVERY 审中-公开
标题翻译：用于药物递送的复合材料
公开(公告)号：WO2016140626A1
公开(公告)日：2016-09-09
申请号：PCT/SG2016/050104
申请日：2016-03-04
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , NANYANG TECHNOLOGICAL UNIVERSITY
发明人： LIU, Hui , BIRCH, William , COOL, Simon , TEOH, Swee Hin , NURCOMBE, Victor , BHAKTA, Gajadhar
IPC分类号： A61K47/10 , A61K47/20 , A61K47/30 , A61L31/12 , A61L27/40
CPC分类号： A61L27/56 , A61L27/46 , A61L27/54 , A61L2300/236 , C08L67/04
摘要： The present disclosure describes a composite material for delivering an active ingredient, the composite material comprising a substantially homogeneous mixture of a biodegradable polyester; a ceramic; and a porogen. In particular, said composite material comprises a polycaprolactone (PCL), tricalcium phosphate (TCP) and polyethylene glycol (PEG). The present disclosure also describes a composite material for delivering an active ingredient, the composite material comprising a substantially homogeneous mixture of a biodegradable polyester and a ceramic; wherein the composite material comprises pores. The composite material putatively forms pores and delivery of the active ingredient relies on the formation of an interconnected pore network. The composite material displays tunable and sustained release of the active ingredient. This is contrasted with the short-term, burst release of the active ingredient from either a hydrophobic polycaprolactone (PCL) matrix or PCL/tricalcium phosphate (TCP) composite.
摘要翻译：本公开描述了用于递送活性成分的复合材料，所述复合材料包含可生物降解聚酯的基本上均匀的混合物; 陶瓷和致孔剂。特别地，所述复合材料包括聚己内酯（PCL），磷酸三钙（TCP）和聚乙二醇（PEG）。本公开还描述了用于递送活性成分的复合材料，所述复合材料包含可生物降解的聚酯和陶瓷的基本上均匀的混合物; 其中所述复合材料包括孔。复合材料推测形成孔，活性成分的递送依赖于形成互连孔网络。复合材料显示活性成分的可调和持续释放。这与活性成分从疏水性聚己内酯（PCL）基质或PCL /磷酸三钙（TCP）复合材料的短期，爆发释放形成对照。

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