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1. 发明申请

WO2009029044A1 A SYSTEM AND METHOD FOR DETECTING SKIN PENETRATION 审中-公开
标题翻译：一种用于检测皮肤渗透的系统和方法
公开(公告)号：WO2009029044A1
公开(公告)日：2009-03-05
申请号：PCT/SG2007/000279
申请日：2007-08-24
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , LIM, Chee Yen , LAI, Szu Cheng
发明人： LIM, Chee Yen , LAI, Szu Cheng
IPC分类号： A61B5/15 , A61B5/053 , A61M5/00
CPC分类号： A61M5/46 , A61B5/0531 , A61B5/150022 , A61B5/150954 , A61B5/150984 , A61B5/415 , A61B5/418 , A61B5/685 , A61M37/0015
摘要： A system and method for detecting skin penetration. The system comprises an invasive component for penetrating the skin; a dummy electrode for making contact with the surface of the skin; at least one penetrating electrode disposed in the invasive component; and a Wheatstone bridge circuit; wherein a resistance across the dummy electrode and the penetrating electrode constitutes one of the resistive legs of the Wheatstone bridge circuit and skin penetration of the invasive component is detected based on a differential output voltage from the Wheatstone bridge circuit.
摘要翻译：用于检测皮肤渗透的系统和方法。该系统包括用于穿透皮肤的侵入性组件; 用于与皮肤表面接触的虚拟电极; 设置在所述侵入性成分中的至少一个穿透电极; 和惠斯登电桥电路; 其中穿过所述虚拟电极和所述穿透电极的电阻构成所述惠斯通电桥电路的电阻支路之一，并且基于所述惠斯通电桥电路的差分输出电压来检测所述侵入性部件的皮肤穿透。

2. 发明申请

WO2008027011A1 MICRONEEDLES AND METHODS FOR FABRICATING MICRONEEDLES 审中-公开
标题翻译：麦克风和制备麦克风的方法
公开(公告)号：WO2008027011A1
公开(公告)日：2008-03-06
申请号：PCT/SG2006/000246
申请日：2006-08-28
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , LIM, Chee Yen
发明人： LIM, Chee Yen
IPC分类号： A61M37/00 , A61M5/32
CPC分类号： A61B5/151 , A61B5/14514 , A61B5/150022 , A61B5/150236 , A61B5/150244 , A61B5/150282 , A61B5/150984 , A61B17/205 , A61M37/0015 , A61M2037/003 , A61M2037/0053 , B29C33/3878
摘要： A plastic microneedle comprising: a body portion tapering from a larger end of the body portion towards a tip portion of the body portion; at least one side port; and a lumen extending from the larger end of the body portion and within the body portion of the microneedle, wherein the side port extends into the lumen such that the side port and the lumen are in fluid communication with each other.
摘要翻译：一种塑料微针，包括：主体部分，其从所述主体部分的较大端朝向所述主体部分的尖端部分渐缩; 至少一个侧端口; 以及从所述主体部分的较大端部延伸并且在所述微针的主体部分内延伸的内腔，其中所述侧部端口延伸到所述内腔中，使得所述侧端口和所述内腔彼此流体连通。

3. 发明申请

WO2010016807A1 CONTACTLESS CONDUCTIVITY DETECTOR 审中-公开
标题翻译：无连接电导率检测器
公开(公告)号：WO2010016807A1
公开(公告)日：2010-02-11
申请号：PCT/SG2009/000277
申请日：2009-08-07
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , MAHABADI, Kambiz Ansari , RODRIGUEZ FERNANDEZ, Isabel , LIM, Chee Yen
发明人： MAHABADI, Kambiz Ansari , RODRIGUEZ FERNANDEZ, Isabel , LIM, Chee Yen
IPC分类号： G01N27/07 , B81B7/02 , G01N27/22 , B81B1/00 , G01N27/02
CPC分类号： G01N27/4473 , G01N27/44791
摘要： The contactless conductivity detector in one embodiment includes a microfluidic chip having a channel (102) thereon and four detection electrodes: first and second emitting electrodes (10Oa, 101a), and first and second receiving electrodes (100b, 101b). The channel (102) is defined by channel walls. The first emitting electrode (100a) and the first receiving electrode (100b) are adjacent a first channel wall, and the second emitting electrode (101a) and the second receiving electrode (101b) are adjacent a second channel wall, the second channel wall being opposite the first channel wall.
摘要翻译：一个实施例中的非接触电导检测器包括其上具有通道（102）的微流体芯片和四个检测电极：第一和第二发射电极（100a，101a）以及第一和第二接收电极（100b，101b）。通道（102）由通道壁限定。第一发光电极（100a）和第一接收电极（100b）与第一通道壁相邻，第二发光电极（101a）和第二接收电极（101b）相邻于第二通道壁，第二通道壁为在第一个通道墙对面。

4. 发明申请

WO2006057619A1 METHOD AND APPARATUS FOR FORMING MICROSTRUCTURES 审中-公开
标题翻译：用于形成微结构的方法和装置
公开(公告)号：WO2006057619A1
公开(公告)日：2006-06-01
申请号：PCT/SG2004/000374
申请日：2004-11-26
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , TAN, Yuan Ling, Christina , LIM, Chee Yen , XU, Yuan , KAIS, Hbaieb
发明人： LIM, Chee Yen , XU, Yuan , KAIS, Hbaieb
IPC分类号： B26F1/00 , B26F1/14 , B26F1/24
CPC分类号： A61M37/0015 , A61M2037/0053 , B21G1/08 , B21J13/02 , B21K23/00
摘要： A method of micro forming an array of microstructures comprising: advancing a punch having an array of protrusions (620) towards a sheet of material (640) disposed between the punch (620) and a die (630), each protrusion (625) shaped to deform the sheet of material (640) into a corresponding microstructure; providing a holder for holding the sheet of material (640) in place; and punching the sheet of material (640) with the protrusions on the punch (620) to form the array of microstructures on the sheet of material(640).
摘要翻译：一种微观形成微结构阵列的方法，其特征在于，包括：朝向设置在冲头（620）和模具（630）之间的材料片（640）前进具有突起阵列（620）的冲头，每个凸起（625）成形使所述材料片（640）变形成相应的微结构; 提供用于将材料片（640）保持在适当位置的保持器; 以及用所述冲头（620）上的突起冲压所述材料片（640）以在所述材料片（640）上形成所述微结构阵列。

5. 发明申请

WO2005044364A1 MICRONEEDLES AND MICRONEEDLE FABRICATION 审中-公开
标题翻译： MICRONEEDLES和MICRONEEDLE制造
公开(公告)号：WO2005044364A1
公开(公告)日：2005-05-19
申请号：PCT/SG2003/000260
申请日：2003-11-10
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , XU, Yuan , CHEN, Mei Ma , LI, Zhongli , LIM, Chee Yen , TAN, Pei Ying, Joyce
发明人： XU, Yuan , CHEN, Mei Ma , LI, Zhongli , LIM, Chee Yen , TAN, Pei Ying, Joyce
IPC分类号： A61M37/00
CPC分类号： B81C1/00111 , A61M37/0015 , A61M2037/003 , A61M2037/0046 , A61M2037/0053 , B29C33/3878 , B29C33/42 , B29C45/00 , B29C2045/0094 , B29L2031/7544 , B29L2031/756 , B81B2201/055 , B81C2201/034
摘要： A master mould is made by wire cutting a plate in two or more directions to provide a base with an array of master mould needles protruding therefrom. The size and shape of the master mould needles can readily be varied by varying the angles of upward and downward cuts in the two or more directions. The master mould is used to make a secondary mould by hot embossing a secondary mould plate onto the master mould. This forms through-holes inthe secondary mould. The secondary mould is plated with a layer of metal, which forms a microneedle array.
摘要翻译：主模具通过在两个或更多个方向上对板进行线切割来制造，以提供具有从其突出的主模具针阵列的基座。通过改变在两个或更多个方向上的向上和向下切割的角度，可以容易地改变主模具针的尺寸和形状。主模具用于通过将二次模板热压在主模上来制造二次模具。这在二次模具中形成通孔。二次模具镀有一层金属，形成微针阵列。

6. 发明申请

WO2005044342A1 LIQUID HOUSING CHAMBER AND LIQUID DELIVERING DEVICE CONTAINING SUCH CHAMBER 审中-公开
标题翻译：液体室和包含这种室的液体输送装置
公开(公告)号：WO2005044342A1
公开(公告)日：2005-05-19
申请号：PCT/SG2003/000257
申请日：2003-11-07
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , XU, Yuan , LIM, Chee Yen , TAN, Yuan Ling , TAN, Pei Ying
发明人： XU, Yuan , LIM, Chee Yen , TAN, Yuan Ling , TAN, Pei Ying
IPC分类号： A61M5/145
CPC分类号： A61M37/0015 , A61B17/205 , A61M5/14593 , A61M5/155 , A61M2005/14513 , A61M2037/0023 , A61M2037/003
摘要： A liquid housing chamber for use in a device for administering liquid to a subject, said liquid chamber comprising a cavity defined by a base and a surrounding sidewall, said sidewall including an upper rim; a deformable membrane attached to the upper rim and covering said cavity; and an outlet located in the base; wherein said base is inclined from about said outlet to said surrounding sidewall and is formed of a substantially rigid material.
摘要翻译：一种液体容纳室，用于向受试者施用液体的装置，所述液体室包括由基部和周围侧壁限定的空腔，所述侧壁包括上缘; 可变形膜，附接到上边缘并覆盖所述空腔; 和位于基座中的出口; 其中所述基座从大约所述出口倾斜到所述周围的侧壁，并且由基本刚性的材料形成。

7. 发明申请

WO2018208222A1 PYRAMIDAL MICRONEEDLES WITH ENHANCED DRUG LOADING CAPACITY AND METHOD FOR MANUFACTURING 审中-公开
公开(公告)号：WO2018208222A1
公开(公告)日：2018-11-15
申请号：PCT/SG2017/050243
申请日：2017-05-10
申请人： LIM, Chee Yen
发明人： LIM, Chee Yen
IPC分类号： A61M37/00
摘要： The present invention provides a solution to increase the drug loading capacity and drug delivery precision of dissolving microneedles. These solutions include: (a) increasing the base of the microneedle cavities without substantially changing the microneedle's height and geometry, (b) use of drug suspension and sedimentation of drug by centrifugation, and (c) a specific centrifugation order for filling drug and matrix material. In the first preferred embodiment, a microneedle master mould comprising a plurality of pyramidal microneedles (5100), wherein each of the pyramidal microneedles further comprising a chamfered base (5200) which extends to and adjoins with its neighbouring chamfered bases is provided. In the second preferred embodiment, a method of making dissolving microneedles is provided, comprising (a) providing a microneedle template comprising a plurality of pyramidal microneedle cavities, wherein each of the pyramidal microneedle cavities further comprising a chamfered base which extends to and adjoins with its neighbouring chamfered bases; (b) loading a drug suspension in the substrate cavity on the microneedle template; (c) centrifuging the microneedle template which is loaded with a drug suspension, (d) loading a matrix material solution in the substrate cavity on the microneedle template; (d) centrifuging the microneedle template loaded with the drug suspension and the matrix material solution; and (e) drying the centrifuged microneedle template in a controlled environment.

8. 发明申请

WO2014107138A1 METALLIC MICRONEEDLES 审中-公开
标题翻译：金属麦克风
公开(公告)号：WO2014107138A1
公开(公告)日：2014-07-10
申请号：PCT/SG2013/000007
申请日：2013-01-07
申请人： LIM, Chee Yen
发明人： LIM, Chee Yen
IPC分类号： A61M37/00 , B24B19/16 , B81B1/00
CPC分类号： A61M37/0015 , A61M2037/0046 , A61M2037/0053 , B24B19/16 , Y10T83/04
摘要： The present invention relates to fabrication of metallic microneedles 200 which involves two process steps: firstly providing a rough cut on a metallic block to form approximate microneedle shapes, and secondly providing a finishing cut on the rough-cut metallic block to achieve final microneedles with required surface smoothness and tip sharpness. Providing the rough cut can be achieved by using conventional manufacturing methods such as Electro- Discharge Machining (EDM) or Computerised Numerical Controlled (CNC) machining by first forming a rough cut a metallic block 500 of the microneedle array 600. The finishing cut is achieved by polishing the individual microneedles 720 on the rough-cut metallic block 500 to desired sharpness and surface finish. The microneedles 720 formed are partial or full pyramidal structures which normally have heights of 100 microns to 1,000 microns with sharp tips that can penetrate the skin painlessly and effectively. Hollow microneedles can be achieved by drilling a through hole on the solid microneedles.
摘要翻译：本发明涉及金属微针200的制造，其包括两个工艺步骤：首先在金属块上提供粗切割以形成近似的微针形状，其次在粗切金属块上提供精加工切割以实现所需的最终微针表面平滑度和尖锐度。可以通过使用诸如放电加工（EDM）或计算机数控（CNC）加工的常规制造方法来实现粗切割，首先形成微针阵列600的金属块500的粗切割。实现精加工切割通过将粗切割的金属块500上的各个微针720抛光成希望的清晰度和表面光洁度。形成的微针720是通常具有100微米至1,000微米高度的部分或全金字塔形结构，其尖锐的尖端可以无痛和有效地穿透皮肤。中空微针可以通过在固体微针上钻一个通孔来实现。

9. 发明申请

WO2016130082A1 PAINLESS DRUG IMPLANTER 审中-公开
标题翻译：无痛药物植入物
公开(公告)号：WO2016130082A1
公开(公告)日：2016-08-18
申请号：PCT/SG2015/050022
申请日：2015-02-13
申请人： LIM, Chee Yen
发明人： LIM, Chee Yen , CHIA, Yong Wei , LEE, Wei Siong
IPC分类号： A61M37/00
CPC分类号： A61M37/0069 , A61M5/158 , A61M5/3134 , A61M5/3148 , A61M37/0015
摘要： The present invention relates to a drug implant device which delivers a drug load to the body painlessly. The present invention achieves the painless drug implantation by adopting two principles: (1) rapid perpendicular insertion of fine cannula is painless and that (2) pain is incurred only when the occupied volume caused by the implant process is increased. Therefore, instead of inserting a cannula and injection a volume of drug, which increases the occupied volume of the injection process due to additional volume of the drug, the present invention retracts the cannula in order to dispose the drug into the body. The retraction of cannula does not increase the occupied volume therefore incurs no pain. In the preferred embodiment, the drug implant device (100) comprises a cannula (300) with a bevelled tip, a drug load (320) and an inner rod (340), wherein the drug load (320) and the inner rod (340) are slidably disposed within the cannula (300), and that the drug load (320) is disposed at the bevelled end of the cannula (300) and that the inner rod (340) is disposed adjacent to the drug load (320).
摘要翻译：本发明涉及一种将药物负荷无痛地输送到身体的药物注入装置。本发明通过采用两个原理实现无痛药物植入：（1）精细插管的快速垂直插入是无痛的，并且（2）仅当植入过程引起的占有体积增加时才产生疼痛。因此，本发明代替插入插管并注射一定体积的药物，这增加了由于药物的额外体积而引起的注射过程的占据体积，本发明缩回了套管以将药物置于体内。套管的收缩不会增加占用体积，因此不会产生疼痛。在优选实施例中，药物注入装置（100）包括具有倾斜尖端的插管（300），药物负载（320）和内杆（340），其中药物负载（320）和内杆（340））可滑动地设置在套管（300）内，并且药物负载（320）设置在套管（300）的倾斜端部，并且内杆（340）邻近药物负载（320）设置。

10. 发明申请

WO2015020609A1 A BLOOD EXTRACTION SYSTEM FOR EXTRACTING AND COLLECTING CAPILLARY WHOLE BLOOD 审中-公开
标题翻译：一种提取和收集全身毛细血管的血液提取系统
公开(公告)号：WO2015020609A1
公开(公告)日：2015-02-12
申请号：PCT/SG2013/000338
申请日：2013-08-07
申请人： LIM, Chee Yen
发明人： LIM, Chee Yen , LEE, Wei Siong , CHIA, Yong Wei
IPC分类号： A61B5/15 , A61B5/145
CPC分类号： A61B5/157 , A61B5/150022 , A61B5/150343 , A61B5/150412 , A61B5/150503 , A61B5/150618 , A61B5/150717 , A61B5/150824 , A61B5/15111 , A61B5/15117 , A61B5/15144
摘要： The present invention relates generally to finger-pricking devices for extracting capillary whole blood for in-vitro diagnostic testing. More particularly, the present invention relates to devices that prick fingers, collect and dispense capillary whole blood on a test media for the purpose of carrying out in-vitro diagnostic (IVD) testing. In the preferred embodiment, the blood collection means is a measurement and collection tube. The incorporated blood measurement and collection tube enables a user single-handedly to prick his finger with safety lancet, milk the lanced site to obtain a desirable size of blood droplet, and collect and measure at the same time the desired volume of blood with the present invention. The user may estimate the blood volume collected in the tube by seeing the blood column's movement relative to the graduation scale on the device, and he may stop the collection process by separating the tube from the blood. Alternatively, the capillary tube may be made to have a predetermined capacity to only collect the predetermined amount of blood sample for a particular IVD test. This is particularly crucial for advanced point-of-care testing systems which provide quantitative and high accuracy results. Result accuracy often requires that the blood sample by filling up the predetermined capacity. Lastly, the user may dispense the collected blood onto a test media by making physical contact between the tube's opening and the test media.
摘要翻译：本发明一般涉及用于提取毛细血管全血用于体外诊断测试的手指装置。更具体地说，本发明涉及用于进行体外诊断（IVD）测试的手指刺入毛细血管全血并在测试介质上分配的装置。在优选实施例中，采血装置是测量和收集管。结合的血液测量和收集管使得用户能够单独地用安全刺针刺伤他的手指，将切割的位置牛奶以获得期望的血滴大小，并且同时收集并测量所需体积的血液发明。用户可以通过观察血柱相对于装置上的分度标度的运动来估计在管中收集的血量，并且可以通过将血管分离出来来停止收集过程。或者，毛细管可以制成具有预定容量，以便仅针对特定的IVD测试收集预定量的血样。这对于提供定量和高精度结果的先进的点对点测试系统尤其重要。结果准确性通常需要通过填充血液样本的预定容量。最后，用户可以通过在管的开口和测试介质之间进行物理接触来将收集的血液分配到测试介质上。

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