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1. 发明申请

WO2003048209A1 BISPECIFIC ANTI-CD19 X ANTI-CD16 ANTIBODIES AND USES THEREOF 审中-公开
标题翻译： BISPECIFIC抗CD19 X抗CD16抗体及其用途
公开(公告)号：WO2003048209A1
公开(公告)日：2003-06-12
申请号：PCT/EP2002/012776
申请日：2002-11-14
申请人： AFFIMED THERAPEUTICS AG , KIPRIYANOV, Sergey , LE GALL, Fabrice , LITTLE, Melvyn , SCHÄFER, Holger , MOLDENHAUER, Gerhard , COCHLOVIUS, Björn
发明人： KIPRIYANOV, Sergey , LE GALL, Fabrice , LITTLE, Melvyn , SCHÄFER, Holger , MOLDENHAUER, Gerhard , COCHLOVIUS, Björn
IPC分类号： C07K16/28
CPC分类号： C07K16/2803 , A61K2039/505 , C07K16/283 , C07K2317/34 , C07K2317/622 , C07K2317/626 , C07K2319/00
摘要： Described are multivalent multimeric antibodies comprising at least two binding sites specific for the human B cell marker CD19 and human Fcγ receptor III (CD16). Also described are polynucleotides encoding said antibodies as well as vectors comprising said polynucleotides, host cells transformed therewith and their use in the production of said antibodies. Finally, compositions are described comprising any of above mentioned antibodies, polynucleotides or vectors. The pharmaceutical compositions are useful for immunotherapy, preferably against B cell malignancies such as non-Hodgkin's lymphoma.
摘要翻译：描述了包含至少两个对人B细胞标志物CD19和人Fcγ受体III（CD16）特异的结合位点的多价多聚体抗体。还描述了编码所述抗体的多核苷酸以及包含所述多核苷酸的载体，用其转化的宿主细胞及其在产生所述抗体中的用途。最后，描述包含任何上述抗体，多核苷酸或载体的组合物。药物组合物可用于免疫治疗，优选抗B细胞恶性肿瘤，例如非霍奇金淋巴瘤。

2. 发明申请

WO2003088998A1 ANTIBODY COMBINATION USEFUL FOR TUMOR THERAPY 审中-公开
标题翻译：用于肿瘤治疗的抗体组合
公开(公告)号：WO2003088998A1
公开(公告)日：2003-10-30
申请号：PCT/EP2003/003928
申请日：2003-04-15
申请人： AFFIMED THERAPEUTICS AG , KIPRIYANOV, Sergey , LE GALL, Fabrice , COCHLOVIUS, Björn , LITTLE, Melvyn
发明人： KIPRIYANOV, Sergey , LE GALL, Fabrice , COCHLOVIUS, Björn , LITTLE, Melvyn
IPC分类号： A61K39/395
CPC分类号： C07K16/2809 , C07K16/283 , C07K16/2878 , C07K2317/626 , C07K2319/00
摘要： Described is a combination of at least two antibodies, characterized by the following properties: (a) it comprises at least two different multivalent antibodies, each one having at least two specificities and being characterized by features: (b) + (d) for at least one of said two different multivalent antibodies, and (b) + (c) for at least one of said two different multivalent antibodies,( b) is an antigen-binding domain specific to a tumor antigen, (c) is antigen-binding domain specific to an antigen present on human T cells, and (d) is an antigen-binding domain specific to an antigen present on CD3-epsilon negative human effector cells. Also disclosed are polynucleotides encoding said antibodies as well as vectors comprising said polynucleotides, host cells transformed therewith and their use in the production of said antibodies. Finally, compositions, preferably pharmaceutical and diagnostic compositions, are disclosed comprising the above mentioned polynucleotides, antibodies or vectors. The pharmaceutical compositions are useful for immunotherapy, preferably against B-cell malignancies, B-cell mediated autoimmune diseases and diseases associated with depletion of B-cells.
摘要翻译：描述了至少两种抗体的组合，其特征在于以下性质：（a）其包含至少两种不同的多价抗体，每种抗体具有至少两个特异性，并且其特征在于：（b）+（d）所述两种不同多价抗体中的至少一种，和（b）+（c）对于所述两种不同的多价抗体中的至少一种，（b）是对肿瘤抗原特异性的抗原结合结构域，（c）是抗原结合对于存在于人T细胞上的抗原具有特异性结构域，和（d）是存在于CD3-ε阴性人效应细胞上的抗原特异性的抗原结合结构域。还公开了编码所述抗体的多核苷酸以及包含所述多核苷酸的载体，用其转化的宿主细胞及其在所述抗体的产生中的用途。最后，公开了包含上述多核苷酸，抗体或载体的组合物，优选药物和诊断组合物。药物组合物可用于免疫治疗，优选抗B细胞恶性肿瘤，B细胞介导的自身免疫性疾病和与B细胞耗竭相关的疾病。

3. 发明申请

WO2003025018A2 DIMERIC AND MULTIMERIC ANTIGEN BINDING STRUCTURE 审中-公开
标题翻译：二聚体和多种抗原结合结构
公开(公告)号：WO2003025018A2
公开(公告)日：2003-03-27
申请号：PCT/EP2002/010307
申请日：2002-09-13
申请人： AFFIMED THERAPEUTICS AG , LE GALL, Fabrice , KIPRIYANOV, Sergey , REUSCH, Uwe , MOLDENHAUER, Gerhard , LITTLE, Melvyn
发明人： LE GALL, Fabrice , KIPRIYANOV, Sergey , REUSCH, Uwe , MOLDENHAUER, Gerhard , LITTLE, Melvyn
IPC分类号： C07K16/00
CPC分类号： C07K16/00 , A61K2039/505 , C07K16/28 , C07K2317/31 , C07K2317/34 , C07K2317/622 , C07K2319/00
摘要： The present invention relates to dimeric and multimeric antigen binding structures, expression vectors encoding said structures, diagnostic as well as therapeutic uses of said structures. The antigen binding structures are preferably in the form of a Fv-antibody construct.
摘要翻译：本发明涉及二聚体和多聚体抗原结合结构，编码所述结构的表达载体，所述结构的诊断以及治疗用途。抗原结合结构优选为Fv-抗体构建体的形式。

4. 发明申请

WO2006105954A2 Use of an antibody against the laminin receptor or laminin receptor precursor for the treatment or diagnosis of several cancer types 审中-公开
标题翻译：使用针对层粘连蛋白受体或层粘连蛋白受体前体的抗体用于治疗或诊断几种癌症类型
公开(公告)号：WO2006105954A2
公开(公告)日：2006-10-12
申请号：PCT/EP2006/003104
申请日：2006-04-05
申请人： AFFIMED THERAPEUTICS AG , KNACKMUSS, Stefan , LITTLE, Melvyn , REUSCH, Uwe , KIPRIYANOV, Sergey , LE GALL, Fabrice , MICK, Vera , HOFFMANN, Karin , RÖTTGEN, Peter
发明人： LITTLE, Melvyn , REUSCH, Uwe , KIPRIYANOV, Sergey , LE GALL, Fabrice , MICK, Vera , HOFFMANN, Karin , RÖTTGEN, Peter
CPC分类号： C07K16/28 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/92
摘要： Use of an antibody against the laminin receptor or laminin receptor precursor for the treatment of various cancers. Described is the use of a recombinant antibody comprising a binding site specific for an epitope of the laminin receptor or laminin receptor precursor for the treatment or diagnosis of various cancers, particularly B-CLL. Preferably, this antibody additionally comprises a binding site for at least one particular cell surface antigen.
摘要翻译：使用针对层粘连蛋白受体或层粘连蛋白受体前体的抗体来治疗各种癌症。描述了包含对层粘连蛋白受体或层粘连蛋白受体前体的表位特异的结合位点用于治疗或诊断各种癌症，特别是B-CLL的重组抗体的用途。优选地，该抗体另外包含至少一种特定细胞表面抗原的结合位点。

5. 发明申请

WO2004024771A1 HUMAN CD3-SPECIFIC ANTIBODY WITH IMMUNOSUPPRESSIVE PROPERTIES 审中-公开
标题翻译：具有免疫特性的人CD3特异性抗体
公开(公告)号：WO2004024771A1
公开(公告)日：2004-03-25
申请号：PCT/EP2003/010064
申请日：2003-09-10
申请人： AFFIMED THERAPEUTICS AG , LE GALL, Fabrice , KIPRIYANOV, Sergey , LITTLE, Melvin , REUSCH, Uwe
发明人： LE GALL, Fabrice , KIPRIYANOV, Sergey , LITTLE, Melvin , REUSCH, Uwe
IPC分类号： C07K16/28
CPC分类号： A61K39/3955 , A61K2039/505 , C07K16/2809 , C07K2317/34 , C07K2317/622 , C07K2317/626 , C07K2317/73 , C07K2319/00
摘要： Described are mono- and multivalent scFv-antibodies comprising the binding sites specific for the human T cell marker CD3. These antibodies are strongly immunosuppressive and do not cause a significant release of cytokines. Furthermore, polynucleotides encoding said antibodies are described as well as vectors comprising said polynucleotides, host cells transformed therewith and their use in the production of said antibodies. Pharmaceutical compositions containing any of the above mentioned polynucleotides, antibodies or vectors are useful for immunotherapy, preferably against acute transplant rejections.
摘要翻译：描述了包含人T细胞标记CD3特异性的结合位点的单价和多价scFv-抗体。这些抗体具有强烈的免疫抑制作用，并且不会引起细胞因子的显着释放。此外，描述了编码所述抗体的多核苷酸以及包含所述多核苷酸的载体，转化的宿主细胞及其在产生所述抗体中的用途。含有任何上述多核苷酸，抗体或载体的药物组合物可用于免疫治疗，优选抗急性移植排斥反应。

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