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    • 2. 发明申请
    • LINER-BASED SHIPPING AND DISPENSING CONTAINERS
    • 基于线路的运输和配送集装箱
    • WO2012135267A2
    • 2012-10-04
    • PCT/US2012/030822
    • 2012-03-28
    • ATMI PACKAGING, INC.CRAIG, JeffLIU, WeiPETHE, VishwasWARE, DonDAVIS, JohnHEALY, MattTOM, GlennBOTET, Alfredo, Daniel
    • CRAIG, JeffLIU, WeiPETHE, VishwasWARE, DonDAVIS, JohnHEALY, MattTOM, GlennBOTET, Alfredo, Daniel
    • B65D77/06B65D81/32B67D1/04B67D7/72B65D25/18B65D85/84
    • A61J1/1443B67D1/045B67D1/0462B67D7/0238B67D7/0255B67D7/0288B67D7/0294Y10T29/49
    • In one aspect, the present disclosure relates to the substantially sterile transport of a substantially sterile substance using a liner-based assembly having an overpack and a flexible or semi-rigid liner disposed within the overpack configured for pressure dispense, and a connector securable to at least one of the overpack or liner. The connector may include a first port operably connected with a quick connector configured for substantially aseptic filling of the liner. The first port may be configured for substantially aseptic sealing after filling of the liner. The connector may be configured for substantially aseptic dispense of the substance of the liner via the first port after unsealing of the first port or via a second port. In some particular embodiments, the second port may be operably connected with a quick connector, and dispense of the substance of the liner occurs via the quick connector of the second port. The assembly may include one or more of a mixer, a sparger, a sensor, or combinations thereof, and may be arranged to form a bioreactor. Related methods are also described.
    • 在一个方面,本公开涉及基本上无菌的物质的基本上无菌的运输,所述基本上无菌物质使用基于衬套的组件,所述组件具有外包层和布置在用于压力分配的外包层内的柔性或半刚性衬套,以及可固定到 至少一个包装或衬里。 连接器可以包括与快速连接器可操作地连接的第一端口,该快速连接器被配置为基本上无菌填充衬管。 第一端口可以构造成在填充衬垫之后实质上无菌密封。 连接器可以被配置为在开封第一端口之后或经由第二端口经由第一端口基本上无菌地分配衬里的物质。 在一些具体实施例中,第二端口可以与快速连接器可操作地连接,并且通过第二端口的快速连接器分配衬里的物质。 组件可以包括混合器,分布器,传感器或其组合中的一个或多个,并且可以被布置成形成生物反应器。 还描述了相关方法。
    • 3. 发明申请
    • LINER-BASED SHIPPING AND DISPENSING CONTAINERS FOR THE SUBSTANTIALLY STERILE STORAGE, SHIPMENT, AND DISPENSE OF MATERIALS
    • 用于物质储存,运输和物料分析的基于衬管的运输和分配容器
    • WO2013055988A1
    • 2013-04-18
    • PCT/US2012/059865
    • 2012-10-12
    • ADVANCED TECHNOLOGY MATERIALS, INC.
    • BOTET, Alfredo, Daniel
    • B65D77/06B65D25/18B65D83/00B65D83/76B67D7/02
    • B65D25/14A61J1/05A61J1/16B65D25/18B65D77/0486B65D77/06B67D1/0462
    • A. liner-based assembly including an overpack, a liner disposed within the overpack, and a filling connector securable to at least one of the overpack and the liner and ineloding a membrane for substantially aseptic filling. The membrane may be an elastomeric stopper, which may be configured, for re-sealing with or without the assistance of heat The !iner-based assembly may further include a dispense connector that is operably connected with the overpack and/or the li.oer. The dispense connector may comprise or be operably connected to a one-way valve, the one-way valve having. -an elastomeric portion defining an opening and generally operably coupled with a plug member positioned within the- opening. In a closed position, the elastomeric portion may be sealed against the plug member, and when a pressure is applied against the elastomeric portion, the elastomeric portion may flex in a manner configured -to permit only one- way flow through the opening.
    • A.基于衬套的组件,其包括外包装,设置在外包装内的衬里,以及可固定到外包装和衬里中的至少一个的填充连接器,并且用于基本上无菌填充的膜。 膜可以是弹性体塞子,其可以被配置为用于在或不加热的情况下重新密封。基于组件的组件还可以包括分配连接器,其与外包装和/或包装器可操作地连接 。 分配连接器可以包括或可操作地连接到单向阀,单向阀具有。 - 弹性体部分限定开口并且通常可操作地与定位在开口内的塞子构件耦合。 在关闭位置,弹性体部分可以密封抵靠插塞构件,并且当对弹性体部分施加压力时,弹性体部分可以以配置为仅允许单向流动通过开口的方式弯曲。