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2. 发明申请

WO2006113407A2 HYDROGEL BIOSCAFFOLDINGS AND BIOMEDICAL DEVICE COATINGS 审中-公开
标题翻译： HYDROGEL生物医药和生物医疗器械涂料
公开(公告)号：WO2006113407A2
公开(公告)日：2006-10-26
申请号：PCT/US2006014021
申请日：2006-04-13
申请人： ADVANCED CARDIOVASCULAR SYSTEM , CLAUDE CHARLES , KWOK CONNIE , MICHAL GENE , QU JIHONG , LIAO SOPHIA
发明人： CLAUDE CHARLES , KWOK CONNIE , MICHAL GENE , QU JIHONG , LIAO SOPHIA
CPC分类号： A61L27/3834 , A61L27/26 , A61L27/3826 , A61L27/383 , A61L27/3873 , A61L27/52 , C08L89/06 , C08L5/08
摘要： Bioscaffoldings formed of hydrogels that are crosslinked in situ in an infarcted region of the heart (myocardium) by a Michael's addition reaction or by a disulfide bond formed by an oxidative process are described. Each of the bioscaffoldings described includes hyaluronan as one of the hydrogel components and the other component is selected from collagen, collagen-laminin, poly-1- lysine, and fibrin. The bioscaffolding may further include an alginate component. The bioscaffoldings may have biofunctional groups such as angiogenic factors and stem cell homing factors bound to the collagen, collagen-laminin, poly-1- lysine, or fibrinogen hydrogel component. In particular, the biofunctional groups may be PRl 1, PR39, VEGF, bFGF, a polyarginine/DNA plasmid complex, or a DNA/polyethyleneimine (PEI) complex. Additionally, the hydrogel components may be injected into the infarct region along with stem cells and microspheres containing stem cell homing factors. The bioscaffolding may be formed on a stent or a cardiac medical device.
摘要翻译：描述了由水凝胶形成的生物支架，其通过迈克尔加成反应或通过氧化过程形成的二硫键在心脏（心肌）的梗死区域原位交联。所描述的每个生物支架包括透明质酸作为水凝胶组分之一，另一组分选自胶原，胶原 - 层粘连蛋白，聚-1-赖氨酸和纤维蛋白。生物支架还可包括藻酸盐组分。生物支架可以具有生物功能组，例如血管生成因子和与胶原，胶原 - 层粘连蛋白，聚-1-赖氨酸或纤维蛋白原水凝胶组分结合的干细胞归巢因子。特别地，生物功能基团可以是PR11，PR39，VEGF，bFGF，聚精氨酸/ DNA质粒复合物或DNA /聚乙烯亚胺（PEI）复合物。此外，水凝胶组分可以与含有干细胞归巢因子的干细胞和微球一起注射到梗死区域中。生物支架可以形成在支架或心脏医疗装置上。

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